Global Enzyme Replacement Therapy Market Size & Outlook

The global enzyme replacement therapy market size was estimated at USD 10,373.8 million in 2024 and is projected to reach USD 17,262.7 million by 2030, growing at a CAGR of 9% from 2025 to 2030.
Revenue, 2024 (US$M)
$10,373.8
Forecast, 2030 (US$M)
$17,262.7
CAGR, 2025 - 2030
9%
Report Coverage
Worldwide

Global enzyme replacement therapy market, 2018-2030 (US$M)

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Global enzyme replacement therapy market highlights

  • The global enzyme replacement therapy market generated a revenue of USD 10,373.8 million in 2024 and is expected to reach USD 17,262.7 million by 2030.
  • The market is expected to grow at a CAGR (2025 - 2030) of 9% by 2030.
  • In terms of segment, imiglucerase accounted for a revenue of USD 2,287.4 million in 2024.
  • Imiglucerase is the most lucrative product segment registering the fastest growth during the forecast period.
  • In terms of region, North America was the largest revenue generating market in 2024.
  • Country-wise, South Africa is expected to register the highest CAGR from 2025 to 2030.

Global data book summary

Market revenue in 2024USD 10,373.8 million
Market revenue in 2030USD 17,262.7 million
Growth rate9% (CAGR from 2025 to 2030)
Largest segmentImiglucerase
Fastest growing segmentImiglucerase
Historical data covered2018 - 2023
Base year for estimation2024
Forecast period covered2025 - 2030
Quantitative unitsRevenue in USD million
Market segmentationImiglucerase, Agalsidase Beta, Taliglucerase, Velaglucerase Alfa, Laronidase, Alglucosidase Alfa, Galsulfase, Idursulfase, Pancreatic Enzymes, Pegademase

Other key industry trends

  • In terms of revenue, the North America accounted for 39.6% of the global enzyme replacement therapy market in 2024.
  • By country, the U.S. is projected to lead the global market in terms of revenue in 2030.
  • By country, South Africa is the fastest growing regional market and is projected to reach USD 150.2 million by 2030.

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Enzyme Replacement Therapy Market Companies

Name Profile # Employees HQ Website
Recordati View profile 1001-5000 Lebanon, New Jersey, United States, North America http://www.recordati.it
Janssen View profile 10001+ Beerse, Antwerpen, Belgium, Europe https://www.janssen.com/
Alexion Pharmaceuticals View profile 1001-5000 Cheshire, Connecticut, United States, North America https://alexion.com
Shire Plc (Takeda Pharmaceuticals) View profile - - -
Actelion Pharmaceuticals View profile - - -
Allergan PLC View profile - - -
Amicus Therapeutics Inc View profile 517 47 Hulfish Street, Princeton, NJ, United States, 08542 https://www.amicusrx.com
Horizon Pharma View profile 1001-5000 Northbrook, Illinois, United States, North America https://www.horizontherapeutics.com
Biomarin Pharmaceutical Inc View profile 3401 770 Lindaro Street, San Rafael, CA, United States, 94901 https://www.biomarin.com
Sanofi SA View profile 87994 46, avenue de la Grande Armée, Paris, France, 75017 https://www.sanofi.com
AbbVie Inc View profile 50000 1 North Waukegan Road, North Chicago, IL, United States, 60064-6400 http://www.abbvieinvestor.com

Global enzyme replacement therapy market outlook

The databook is designed to serve as a comprehensive guide to navigating this sector. The databook focuses on market statistics denoted in the form of revenue and y-o-y growth and CAGR across the globe and regions. A detailed competitive and opportunity analyses related to enzyme replacement therapy market will help companies and investors design strategic landscapes.


Imiglucerase was the largest segment with a revenue share of 22.05% in 2024. Horizon Databook has segmented the Global enzyme replacement therapy market based on imiglucerase, agalsidase beta, taliglucerase, velaglucerase alfa, laronidase, alglucosidase alfa, galsulfase, idursulfase, pancreatic enzymes, pegademase covering the revenue growth of each sub-segment from 2018 to 2030.


  • Global Enzyme Replacement Therapy Product Outlook (Revenue, USD Million, 2018-2030)
    • Imiglucerase
    • Agalsidase Beta
    • Taliglucerase
    • Velaglucerase Alfa
    • Laronidase
    • Alglucosidase Alfa
    • Galsulfase
    • Idursulfase
    • Pancreatic Enzymes
    • Pegademase
    • Others
  • Global Enzyme Replacement Therapy Therapeutic Condition Outlook (Revenue, USD Million, 2018-2030)
    • Gaucher Disease
    • Fabry Disease
    • Pompe Disease
    • SCID
    • MPS
      • MPS I – Hurler, Hurler Scheie and Scheie
      • MPS II – Hunter
      • MPS III – Sanfilippo
      • Others
    • Others
  • Global Enzyme Replacement Therapy Route of Administration Outlook (Revenue, USD Million, 2018-2030)
    • Oral
    • Parenteral
  • Global Enzyme Replacement Therapy End Use Outlook (Revenue, USD Million, 2018-2030)
    • Hospitals
    • Infusion Centers
    • Others

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Target buyers of Global enzyme replacement therapy market databook

  • Our clientele includes a mix of enzyme replacement therapy market companies, investment firms, advisory firms & academic institutions.
  • 30% of our revenue is generated working with investment firms and helping them identify viable opportunity areas.
  • Approximately 65% of our revenue is generated working with competitive intelligence & market intelligence teams of market participants (manufacturers, service providers, etc.).
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Horizon Databook provides a detailed overview of global-level data and insights on the Global enzyme replacement therapy market , including forecasts for subscribers. This global databook contains high-level insights into Global enzyme replacement therapy market from 2018 to 2030, including revenue numbers, major trends, and company profiles.

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Global enzyme replacement therapy market size, by regions, 2018-2030 (US$M)

Top 10 countries: Enzyme replacement therapy market size, 2024 (US$M)

Global enzyme replacement therapy market share, by product, 2024 & 2030 (%, US$M)

Enzyme replacement therapy market: Opportunity assessment by country

Global enzyme replacement therapy market, by region, 2024 (US$M)

Global enzyme replacement therapy market size, by regions, 2018-2030 (US$M)

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