U.S. Hereditary Angioedema Therapeutics Market Size & Outlook
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U.S. hereditary angioedema therapeutics market highlights
- The U.S. hereditary angioedema therapeutics market generated a revenue of USD 1,287.0 million in 2025 and is expected to reach USD 2,476.9 million by 2033.
- The U.S. market is expected to grow at a CAGR of 8.1% from 2026 to 2033.
- In terms of segment, kallikrein inhibitor was the largest revenue generating treatment in 2025.
- Kallikrein inhibitor is the most lucrative treatment segment registering the fastest growth during the forecast period.
Hereditary angioedema therapeutics market data book summary
| Market revenue in 2025 | USD 1,287.0 million |
| Market revenue in 2033 | USD 2,476.9 million |
| Growth rate | 8.1% (CAGR from 2026 to 2033) |
| Largest segment | Kallikrein inhibitor |
| Fastest growing segment | Kallikrein inhibitor |
| Historical data | 2021 - 2024 |
| Base year | 2025 |
| Forecast period | 2026 - 2033 |
| Quantitative units | Revenue in USD million |
| Market segmentation | C1-Inhibitor Concentrates, Bradykinin B2 receptor antagonist, Kallikrein inhibitor |
| Key market players worldwide | BioCryst Pharmaceuticals Inc, Ionis Pharmaceuticals Inc, CSL Ltd, Adverum Biotechnologies Inc, KalVista Pharmaceuticals Inc, Takeda Pharmaceutical Co Ltd, Pharming Group, Attune Pharmaceuticals |
Other key industry trends
- In terms of revenue, U.S. accounted for 35.7% of the global hereditary angioedema therapeutics market in 2025.
- Country-wise, U.S. is expected to lead the global market in terms of revenue in 2033.
- In North America, U.S. hereditary angioedema therapeutics market is projected to lead the regional market in terms of revenue in 2033.
- Canada is the fastest growing regional market in North America and is projected to reach USD 285.5 million by 2033.
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Hereditary Angioedema Therapeutics Market Scope
Hereditary Angioedema Therapeutics Market Companies
| Name | Profile | # Employees | HQ | Website |
|---|---|---|---|---|
| Attune Pharmaceuticals | View profile | 1-10 | New York, New York, United States, North America | http://attunepharma.com/ |
| Pharming Group | View profile | 382 | Darwinweg 24, Leiden, ZH, Netherlands, 2333 CR | https://www.pharming.com |
| KalVista Pharmaceuticals Inc | View profile | 118 | 55 Cambridge Parkway, Suite 901 East, Cambridge, MA, United States, 02142 | https://www.kalvista.com |
| Adverum Biotechnologies Inc | View profile | 121 | 100 Cardinal Way, Redwood CIty, CA, United States, 94063 | https://www.adverum.com |
| BioCryst Pharmaceuticals Inc | View profile | 531 | 4505 Emperor Boulevard, Suite 200, Durham, NC, United States, 27703 | https://www.biocryst.com |
| Ionis Pharmaceuticals Inc | View profile | 927 | 2855 Gazelle Court, Carlsbad, CA, United States, 92010 | https://www.ionispharma.com |
| Takeda Pharmaceutical Co Ltd | View profile | 49095 | 1-1, Nihonbashi-Honcho 2-Chome, Chuo-ku, Tokyo, Japan, 103-8668 | https://www.takeda.com |
| CSL Ltd | View profile | 32000 | 655 Elizabeth Street, Melbourne, VIC, Australia, 3000 | https://www.csl.com |
U.S. hereditary angioedema therapeutics market outlook
The databook is designed to serve as a comprehensive guide to navigating this sector. The databook focuses on market statistics denoted in the form of revenue and y-o-y growth and CAGR across the globe and regions. A detailed competitive and opportunity analyses related to hereditary angioedema therapeutics market will help companies and investors design strategic landscapes.
Kallikrein inhibitor was the largest segment with a revenue share of 52% in 2025. Horizon Databook has segmented the U.S. hereditary angioedema therapeutics market based on c1-inhibitor concentrates, bradykinin b2 receptor antagonist, kallikrein inhibitor covering the revenue growth of each sub-segment from 2021 to 2033.
High incidence of HAE, growing awareness about the disease, and availability of advanced pharmaceutical technologies are likely to propel the market in the country. Although the prevalence data is unclear, there are an estimated 15,000 to 30,000 emergency admissions for HAE episodes in the U.S. annually, and around 6,000 people are living with the condition.
The presence of private and public organizations focusing on the wellbeing of patients is further propelling the market. For instance, the U.S. Hereditary Angioedema Association is a nonprofit organization focusing on advancing research to benefit people suffering from HAE.
Furthermore, the presence of key market players and the introduction of technologically advanced are driving the country's market. For instance, in January 2021, Glenmark Pharmaceuticals announced the FDA approval of generic version of Firazyr (icatibant injection) for treatment of swelling attacks in HAE patients in the U.S.
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Horizon Databook provides a detailed overview of country-level data and insights on the U.S. hereditary angioedema therapeutics market, including forecasts for subscribers. This country databook contains high-level insights into U.S. hereditary angioedema therapeutics market from 2021 to 2033, including revenue numbers, major trends, and company profiles.
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U.S. hereditary angioedema hae therapeutics market size, by treatment, 2021-2033 (US$M)
U.S. Hereditary Angioedema Therapeutics Market Share, 2025 & 2033 (US$M)
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