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South Africa Vaccine Market Size & Outlook, 2026-2033

The vaccine market in South Africa is expected to reach a projected revenue of US$ 528.3 million by 2033. A compound annual growth rate of 5.3% is expected of South Africa vaccine market from 2026 to 2033.

  • Pharmaceuticals
    • Vaccines
      • Vaccine Market Outlook
Revenue, 2025 (US$M)
$344.1
Estimate, 2026 (US$M)
$368.5
Forecast, 2033 (US$M)
$528.3
CAGR, 2026 - 2033
5.3%
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South Africa vaccine market highlights

  • The South Africa vaccine market generated a revenue of USD 344.1 million in 2025 and is expected to reach USD 528.3 million by 2033.
  • The South Africa market is expected to grow at a CAGR of 5.3% from 2026 to 2033.
  • In terms of segment, viral vaccines was the largest revenue generating indication in 2025.
  • Other Indication is the most lucrative indication segment registering the fastest growth during the forecast period.


Vaccine market data book summary

Market revenue in 2025USD 344.1 million
Market revenue in 2033USD 528.3 million
Growth rate5.3% (CAGR from 2026 to 2033)
Largest segmentViral vaccines
Fastest growing segmentOther Indication
Historical data2021 - 2024
Base year2025
Forecast period2026 - 2033
Quantitative unitsRevenue in USD million
Market segmentationViral Vaccines, Bacterial Vaccines, Cancer Vaccines, Allergy Vaccines, Other Indication
Key market players worldwideSerum Institute of India Pvt. Ltd., CSL Ltd, Sanofi SA, GSK PLC, Merck & Co Inc, Pfizer Inc, Sinovac Biotech Ltd, BioNTech SE ADR, AstraZeneca PLC, Moderna Inc


Other key industry trends

  • In terms of revenue, South Africa accounted for 0.5% of the global vaccine market in 2025.
  • Country-wise, U.S. is expected to lead the global market in terms of revenue in 2033.
  • In Middle East & Africa, Saudi Arabia vaccine market is projected to lead the regional market in terms of revenue in 2033.
  • Kuwait is the fastest growing regional market in Middle East & Africa and is projected to reach USD 411.4 million by 2033.

Human (seasonal) influenza viruses are regarded as a global public health threat, causing significant morbidity and mortality in low- & middle-income countries each year, with sub-Saharan Africa witnessing high mortality rates.

The high prevalence of comorbidities in South Africa, such as HIV, tuberculosis, and other noncommunicable chronic diseases, which are associated with an increased risk of severe influenza, intensifies the health & economic burden of seasonal influenza.

This initiative, aimed at promoting South Africa's COVID-19 vaccination campaign, will assist the government in effectively managing the pandemic, especially as the country confronts its fifth wave. Furthermore, the project seeks to empower the GoSA to enhance its health system through the creation of a fiscal room and the establishment of financial & institutional sustainability.

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Publish Date: Jul 28, 2025

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Vaccine Market Companies

NameProfile# EmployeesHQWebsite
Pfizer IncView profile 88,00066 Hudson Boulevard East, New York, NY, United States, 10001-2192www.pfizer.com
Sanofi SAView profile 87,99446, avenue de la Grande Armée, Paris, France, 75017www.sanofi.com
Merck & Co IncView profile 72,000126 East Lincoln Avenue, Rahway, NJ, United States, 07065www.merck.com
GSK PLCView profile 70,200980 Great West Road, Brentford, Middlesex, United Kingdom, TW8 9GSwww.gsk.com
Serum Institute of India Pvt. Ltd.View profile 1001-5000Pune, Maharashtra, India, Asiawww.seruminstitute.com/
AstraZeneca PLCView profile 89,9001 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, United Kingdom, CB2 0AAwww.astrazeneca.com
Sinovac Biotech LtdView profile 3,261No.39, Shangdi Xi Road, Haidan District, Beijing, China, People's Republic of, 100085www.sinovac.com
CSL LtdView profile 32,000655 Elizabeth Street, Melbourne, VIC, Australia, 3000www.csl.com
BioNTech SE ADRView profile 6,133An der Goldgrube 12, Mainz, RP, Germany, D-55131www.biontech.de
Moderna IncView profile 5,600200 Technology Square, Cambridge, MA, United States, 02139www.modernatx.com

South Africa Vaccine Market Outlook

The databook is designed to serve as a comprehensive guide to navigating this sector. The databook focuses on market statistics denoted in the form of revenue and y-o-y growth and CAGR across the globe and regions. A detailed competitive and opportunity analyses related to Vaccine Market Outlook will help companies and investors design strategic landscapes.


Viral Vaccines was the largest segment with a revenue share of 65.94% in 2025.

Horizon Databook has segmented the South Africa vaccine market based on viral vaccines, bacterial vaccines, cancer vaccines, allergy vaccines, other indication covering the revenue growth of each sub-segment from 2021 to 2033.




Human (seasonal) influenza viruses are regarded as a global public health threat, causing significant morbidity and mortality in low- & middle-income countries each year, with sub-Saharan Africa witnessing high mortality rates.

The high prevalence of comorbidities in South Africa, such as HIV, tuberculosis, and other noncommunicable chronic diseases, which are associated with an increased risk of severe influenza, intensifies the health & economic burden of seasonal influenza.

This initiative, aimed at promoting South Africa's COVID-19 vaccination campaign, will assist the government in effectively managing the pandemic, especially as the country confronts its fifth wave. Furthermore, the project seeks to empower the GoSA to enhance its health system through the creation of a fiscal room and the establishment of financial & institutional sustainability.

  • South Africa Vaccine Market Indication Outlook (Revenue, USD Million , 2021-2033)
    • Viral Vaccines
    • Bacterial Vaccines
    • Cancer Vaccines
    • Allergy Vaccines
    • Other Indication
  • South Africa Vaccine Market Type Outlook (Revenue, USD Million , 2021-2033)
    • Subunit Vaccines
    • Inactivated
    • Live Attenuated
    • mRNA Vaccines
    • Viral Vector Vaccines
  • South Africa Vaccine Market Route of Administration Outlook (Revenue, USD Million , 2021-2033)
    • Oral
    • Parenteral
    • Nasal
  • South Africa Vaccine Market Age Group Outlook (Revenue, USD Million , 2021-2033)
    • Pediatric Age Group
    • Adult Age Group
  • South Africa Vaccine Market Distribution Channel Outlook (Revenue, USD Million , 2021-2033)
    • Hospital & Retail Pharmacies
    • Government Suppliers
    • Others Distribution Channel

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Horizon Databook provides a detailed overview of country-level data and insights on the South Africa Vaccine Market Outlook, including forecasts for subscribers. This country databook contains high-level insights into South Africa Vaccine Market Outlook from 2021 to 2033, including revenue numbers, major trends, and company profiles.

South Africa Vaccine Market, 2021-2033 (US$M)

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South Africa vaccine market statistics, by indication, 2021-2033 (US$M)

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South Africa vaccine market statistics, by indication, 2021-2033 (USD Million)

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