U.S. Liquid Biopsy Market Size & Outlook, 2025-2033
- Clinical Diagnostics
- In Vitro Diagnostics
- Liquid Biopsy Market Outlook
- In Vitro Diagnostics
Global Market
Related Markets
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U.S. liquid biopsy market highlights
- The U.S. liquid biopsy market generated a revenue of USD 5,711.3 million in 2025 and is expected to reach USD 13,564.2 million by 2033.
- The U.S. market is expected to grow at a CAGR of 11.4% from 2026 to 2033.
- In terms of segment, blood sample based was the largest revenue generating sample type in 2025.
- Blood Sample Based is the most lucrative sample type segment registering the fastest growth during the forecast period.
Liquid biopsy market data book summary
| Market revenue in 2025 | USD 5,711.3 million |
| Market revenue in 2033 | USD 13,564.2 million |
| Growth rate | 11.4% (CAGR from 2026 to 2033) |
| Largest segment | Blood sample based |
| Fastest growing segment | Blood Sample Based |
| Historical data | 2021 - 2024 |
| Base year | 2025 |
| Forecast period | 2026 - 2033 |
| Quantitative units | Revenue in USD million |
| Market segmentation | Blood Sample Based |
| Key market players worldwide | ANGLE PLC, Guardant Health Inc, Myriad Genetics Inc, Biocept Inc, Lucence Health, Roche, Qiagen NV, Illumina Inc, Thermo Fisher Scientific Inc, Epigenomics AG, Oncimmune, Freenome |
Other key industry trends
- In terms of revenue, U.S. accounted for 42.0% of the global liquid biopsy market in 2025.
- Country-wise, U.S. is expected to lead the global market in terms of revenue in 2033.
- In North America, U.S. liquid biopsy market is projected to lead the regional market in terms of revenue in 2033.
- Mexico is the fastest growing regional market in North America and is projected to reach USD 191.6 million by 2033.
The U.S. accounted for the major revenue share of the liquid biopsy market in 2023. Rapid technological advancements, recent FDA approvals for liquid biopsy tests, and intense competition between companies are expected to boost market growth over the forecast period.
According to the American Cancer Society, in 2021, 235,760 people are estimated to be diagnosed with non-small cell lung cancer, the most common form of lung cancer in the U.S. Overall, around 1 in 17 men and 1 in 15 women are at risk of developing lung cancer in their lifetime.
Roche's cobas liquid biopsy test was approved for use in patients with non-small cell lung cancer to identify specific genetic mutations in the tumor. Moreover, the launch of novel diagnostics solutions is expected to propel the market further.
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Publish Date: Jun 16, 2026
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Liquid Biopsy Market Scope
Liquid Biopsy Market Companies
| Name | Profile | # Employees | HQ | Website |
|---|---|---|---|---|
| Thermo Fisher Scientific Inc | View profile | 122,000 | 168 Third Avenue, Waltham, MA, United States, 02451 | www.thermofisher.com |
| Illumina Inc | View profile | 9,300 | 5200 Illumina Way, San Diego, CA, United States, 92122 | www.illumina.com |
| Qiagen NV | View profile | 5,900 | Hulsterweg 82, Venlo, LI, Netherlands, 5912 PL | www.qiagen.com |
| ANGLE PLC | View profile | 165 | 10 Nugent Road, The Surrey Research Park, Surrey, Guildford, United Kingdom, GU2 7AF | www.angleplc.com |
| Myriad Genetics Inc | View profile | 2,700 | 320 Wakara Way, Salt Lake City, UT, United States, 84108 | www.myriad.com |
| Biocept Inc | View profile | 50 | 9955 Mesa Rim Road, San Diego, CA, United States, 92121 | www.biocept.com |
| Guardant Health Inc | View profile | 1,779 | 3100 Hanover Street, Palo Alto, CA, United States, 94304 | www.guardanthealth.com |
| Epigenomics AG | View profile | 18 | Geneststrasse 5, Berlin, BB, Germany, 10829 | www.epigenomics.com |
| Roche | View profile | 10001+ | Basel, Basel-Stadt, Switzerland, Europe | www.roche.com |
| Lucence Health | View profile | 51-100 | Palo Alto, California, United States, North America | www.lucence.com/ |
U.S. Liquid Biopsy Market Outlook
The databook is designed to serve as a comprehensive guide to navigating this sector. The databook focuses on market statistics denoted in the form of revenue and y-o-y growth and CAGR across the globe and regions. A detailed competitive and opportunity analyses related to Liquid Biopsy Market Outlook will help companies and investors design strategic landscapes.
Blood Sample Based was the largest segment with a revenue share of 80.87% in 2025.
Horizon Databook has segmented the U.S. liquid biopsy market based on blood sample based covering the revenue growth of each sub-segment from 2021 to 2033.
The U.S. accounted for the major revenue share of the liquid biopsy market in 2023. Rapid technological advancements, recent FDA approvals for liquid biopsy tests, and intense competition between companies are expected to boost market growth over the forecast period.
According to the American Cancer Society, in 2021, 235,760 people are estimated to be diagnosed with non-small cell lung cancer, the most common form of lung cancer in the U.S. Overall, around 1 in 17 men and 1 in 15 women are at risk of developing lung cancer in their lifetime.
Roche's cobas liquid biopsy test was approved for use in patients with non-small cell lung cancer to identify specific genetic mutations in the tumor. Moreover, the launch of novel diagnostics solutions is expected to propel the market further.
- U.S. Liquid Biopsy Market Sample Type Outlook (Revenue, USD Million , 2021-2033)
- Blood Sample Based
- Others
- U.S. Liquid Biopsy Market Biomarker Outlook (Revenue, USD Million , 2021-2033)
- Circulating Nucleic Acids
- CTC
- Exosomes/Microvesicles
- Circulating Proteins
- U.S. Liquid Biopsy Market Technology Outlook (Revenue, USD Million , 2021-2033)
- Multi-gene-parallel Analysis (NGS)
- Single Gene Analysis (PCR Microarrays)
- U.S. Liquid Biopsy Market Application Outlook (Revenue, USD Million , 2021-2033)
- Cancer
- Reproductive Health
- Others
- U.S. Liquid Biopsy Market End Use Outlook (Revenue, USD Million , 2021-2033)
- Hospitals and Laboratories
- Specialty Clinics
- Academic and Research Centers
- Others
- U.S. Liquid Biopsy Market Clinical Application Outlook (Revenue, USD Million , 2021-2033)
- Therapy Selection
- Treatment Monitoring
- Early Cancer Screening
- Recurrence Monitoring
- Others
- U.S. Liquid Biopsy Market Product Outlook (Revenue, USD Million , 2021-2033)
- Instruments
- Consumables Kits and Reagents
- Software and Services
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Horizon Databook provides a detailed overview of country-level data and insights on the U.S. Liquid Biopsy Market Outlook, including forecasts for subscribers. This country databook contains high-level insights into U.S. Liquid Biopsy Market Outlook from 2021 to 2033, including revenue numbers, major trends, and company profiles.
U.S. Liquid Biopsy Market, 2021-2033 (US$M)
US Sample Type - Liquid Biopsy Market Statistics, 2024 - 2033 (US$M)
