The global protein detection & quantification market size was estimated at USD 1.48 billion in 2016. Detection and quantification of proteins is a crucial step for understanding post-translational modifications as these aid in deciphering the functions of complicated peptide networks for application in cell biology and medicine.
Rising demand for protein quantification in laboratories that deal with versatile activities ranging from protein characterization to clinical diagnostic testing and drug dosing is anticipated to impact industrial growth in the coming years. Selection of an appropriate technology out of the large number of available methods of quantitation for the kind of protein to be detected and its concentration in the sample remains an important step in biotechnology protocols.
Germany protein detection & quantification market by end-use, 2014 - 2025 (USD Million)
Proteomics offers opportunities for stratification, diagnosis, and disease monitoring. The assay has to meet specific requirements in order to be clinically useful. Development of such sensitive tests is anticipated to fuel growth in the proteomics market thus leading to growth in protein detection and quantification market.
Many techniques of proteomics exist to link biologic function and proteins, for example, mammalian two-hybrid system and yeast two-hybrid system to study the inter-protein interactions by gel shift assay. Furthermore, protein-chip technology, ELISA, one- or two- dimensional gel electrophoresis, and mass spectroscopy are instruments witnessing continuous advancements.
Furthermore, proteomic studies carried out on for finding the mechanism of physical and chemical degradation pathways of biologics are anticipated to propel progress. In addition to advancements, development of next generation techniques for the protein concentration estimation are expected to drive market with potential avenues.
FTIR based spectrometer provides a new methodology of protein quantification and enables high accurate IR based examination of amide bonds in protein chains without focusing on other factors such as redox potential dye binding properties, and amino acid composition. Moreover, the direct detection system utilizes approximately two microliters of sample and takes two to three minutes to finish the test, enhancing the adoption of advanced products and thus contributing to the sector growth.
Colorimetry accounted for the largest share with respect to revenue generation as a result of the higher use of this technique, due to its convenience rate and wide availability of the reagents for its implementation. Immunological methods are expected to witness fastest growth due to introduction of advancement in this segment.
In April 2017, MilliporeSigma launched a new Single Molecule Counting Platform, termed SMCxPROTM, during the American Association for Cancer Research annual meet. The SMCxPRO platform is based on the principle of immunoassay and it enables precise and sensitive detection over the conventional methods.
This novel technology is anticipated to enable researchers for detection and monitoring changes in the biomarker concentration, down to a femtogram level, with scope to increase the limit of detection with further fine tuning down the line. Such technological advances are anticipated to propel growth in this industry.
Products employed include assay kits (BCA assay, Bradford assay Lowery assay), biological stains, reagents, sampling devices, and disposables. Low pricing, enhanced functionalities, and wide applicability are some of the latest advancements in the consumables segment. These advancements are attributive for the estimated revenue share of over 64% in 2016.
Launch of novel equipment is anticipated to drive growth with potential avenues in the instrument segment in the coming years. Introduction of next generation protein detection technologies such as FTIR, longitudinal assay screening and the other immunoassay platforms are anticipated to serve as a fillip to revenue generation.
Quantitative estimation of the protein is applicable in several research arenas including drug discovery & development, clinical diagnosis of acute as well as chronic diseased states, food and animal feed testing, and environmental & agricultural applications.
Government and public private partnerships that are intended towards developing advancements in novel drug molecule discovery are supportive for the largest share of the segment with respect to revenue in 2016.
Furthermore, various candidate biomarkers developed through proteomics and genomics research have the potential to serve as predictive indexes for producing safer and more effective drugs. In the discovery stage, differential proteomic analysis with the help of mass spectrometry enables the recognition of candidates which are linked with a specific mechanism relevant to disease progression and affected by drug treatment.
Incorporation of informative biomarkers as predictive tools in clinical trials is increasingly viewed for not only enabling smarter decisions but also as a resource investment for development of potential diagnostics. The aforementioned fact is anticipated to drive the clinical diagnostics segment with fastest rate.
Development of convenient as well as innovative assays that can fit-for-purpose and, match the specific requirements represents a significant challenge with regards to the technical aspects of antibody as well as assay designing. This fact is expected to drive the proteomics studies potentially.
Escalating usage of these amino acid biomolecules in various applications such as clinical diagnosis for detection and development of therapy against disorders, food processing industries, and agriculture biotechnology is generating demand for efficient peptide estimation methods.
End-users for these technologies comprise academic research institutes, contract research organizations, and pharmaceutical & biotechnology companies. Companies and research institutes working in this field are engaged in provision of precise and innovative products that are expected to drive this market in the future. Application of the solutions in research projects that are carried out in the universities and research centers is attributive for the estimated revenue share of the segment.
Study on enzymatic digestion of peptides in gels by mass spectrometry and structural analysis supported by Yale University School of Medicine, explaining the role of enzymatic digestion technique in protein concentration estimation is expected to drive the growth of the segment in the coming years.
Protein Detection & Quantification Market, By Region, 2016 (%)
North America dominated with respect to revenue generation in 2016; particularly the U.S held major share of revenue owing to presence of major players in region coupled with well-established healthcare framework in the region. However, Asia Pacific is expected to emerge as a fastest growing region due to emerging economies such as China and India.
The U.S. is amongst the key market for this market. Combination of factors such as developed infrastructure, increase in R&D investment and growing cases of various diseases in the region is attributive for the market progress in the U.S.
Continuous efforts of government and top-notch private firms in novel drug discovery and development is expected to impact proteomics growth in this country. For instance, recently researchers at The Scripps Research Institute (TSRI) have developed new toolkit which enables them to discover and reveal the new functional characteristics of peptide biomolecules. They have developed new probes based on activity based peptide -profiling (ABPP) for detection of potential drug target.
Some of the key players in the market are Merck & Co., Inc., Danaher, RayBiotech, Inc., Inanovate, Shimadzu Corporation, PerkinElmer Inc, Bio-Rad Laboratories, Inc., Thermo Fisher Scientific, and GE Healthcare. Companies are engaged in proactive optimization of business mix and portfolios.
These companies are focusing on production of novel products based on the upcoming technologies in order to maintain the market share. Strong competition between the established market entities for launch of novel techniques is anticipated to fuel progress.
Base year for estimation
Actual estimates/Historical data
2014 - 2016
2017 - 2025
Revenue in USD Million & CAGR from 2017 to 2025
North America, Europe, Asia Pacific, Latin America, Middle East & Africa
U.S., Canada, UK, Germany, Japan, China, Brazil, South Africa.
Revenue forecast, company share, competitive landscape, growth factors and trends
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Segments Covered in the Report
This report forecasts revenue growth at regional & country level and provides an analysis on the latest trends and opportunities in each of the sub-segments from 2014 to 2025. For the purpose of this report, Grand View Research has segmented the protein detection & quantification market on the basis of technology, product, application, end-use, and regions:
Technology Outlook (Revenue, USD Million; 2014 - 2025)
Product Outlook (Revenue, USD Million; 2014 - 2025)
Kits & Reagents/Consumables
Application Outlook (Revenue, USD Million; 2014 - 2025)
Drug Discovery & Development
End-use Outlook (Revenue, USD Million; 2014 - 2025)
Academic Research Institutes
Biotechnology & Pharmaceutical Companies
Contract Research Organization
Regional Outlook (Revenue, USD Million; 2014 - 2025)
Middle East and Africa (MEA)
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