Oligonucleotide Synthesis Market To Reach $8.83 Billion By 2030

Oligonucleotide Synthesis Market Growth & Trends

The global oligonucleotide synthesis market size is expected to reach USD 8.83 billion by 2030, registering a CAGR of 13.2% from 2025 to 2030, according to a new report by Grand View Research, Inc. The strong pipeline of oligonucleotide therapeutics in clinical trials, advancements in gene editing technologies, and increasing R&D spending by biotechnology companies are some of the major factors driving the market growth.

Oligonucleotide therapeutics participants are present in the late stages of clinical trials and are expected to be approved & commercialized over the forecast period. Companies have increased investments to develop oligonucleotide-based therapeutics. In October 2023, GSK plc and Arrowhead Pharmaceuticals announced a contract with Janssen Pharmaceuticals, Inc. (Janssen), a Johnson & Johnson company, to assign GSK exclusive worldwide rights to develop and commercialize JNJ-3989. Janssen initially in-licensed JNJ-3989 (previously ARO-HBV) from Arrowhead in 2018. Similar initiatives by well-established pharmaceutical companies are anticipated to drive market growth over the forecast period.

Government bodies, such as the Centers for Medicaid & Medicare Services for labs, the Federal Trade Commission for marketing, and the FDA for kits & information, have played a key role in the success of genomics, as they have been involved in monitoring the safe, appropriate, and accurate application of genomics & genetic tests. International funding bodies, such as NIH and Wellcome Trust, are engaged in providing funds for genetic studies, which is expected to fuel genomic studies in developed and emerging economies.

In May 2021, the UK government announced a funding of USD 43.4 million (GBP 37 million) for genomics research and data-driven initiatives, delivered via the UK Functional Genomics Initiative and Genome UK Implementation Plan, which was started in September 2019. The Genome UK strategy will be implemented with the help of the Genomics England project, which will receive USD 19.9 million (GBP 17 million) to investigate the potential value of newborn sequencing.

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Oligonucleotide Synthesis Market Report Highlights

• The services segment dominated the oligonucleotide synthesis market, accounting for the largest revenue share of 31.5% in 2024.  The oligonucleotides segment is expected to grow at a significant CAGR of 13.0% over the forecast period.

• PCR primers led the oligonucleotide synthesis industry with the largest revenue share in 2024. The sequencing segment is expected to grow at the fastest CAGR over the forecast period.

• The academic research institutes dominated the oligonucleotide synthesis market with the largest revenue share in 2024. The pharmaceutical and biotechnology companies segment is expected to grow significantly over the forecast period.

• The North America oligonucleotide synthesis market dominated the oligonucleotide synthesis industry with the largest revenue share of 31.9% in 2024. The Asia Pacific oligonucleotide synthesis market is expected to grow at the fastest CAGR of 14.9% over the forecast period.

Oligonucleotide Synthesis Market Segmentation

Grand View Research has segmented global oligonucleotide synthesis market report based on product, application, end-use, and region:

Oligonucleotide Synthesis Product Outlook (Revenue, USD Million; 2018 - 2030)

• Oligonucleotides

  • Product Type

    • Column-based Oligos

    • Array-based Oligos

  • Nucleic Acid Type

    • DNA

    • RNA

• Equipment/Synthesizer

• Reagents

• Services

  • Oligo Synthesis

    • 25 nmol

    • 50 nmol

    • 200 nmol

    • 1000nmol

    • 10,000 nmol

  • Purification

  • Modification

Oligonucleotide Synthesis Application Outlook (Revenue, USD Million; 2018 - 2030)

• PCR Primers

• PCR Assays and Panels

• Sequencing

• DNA Microarrays

• Fluorescence In Situ Hybridization (FISH)

• Antisense Oligonucleotides

• Other Applications

Oligonucleotide Synthesis End-use Outlook (Revenue, USD Million; 2018 - 2030)

• Academic Research Institutes

• Diagnostic Laboratories

• Pharmaceutical and Biotechnology Companies

Oligonucleotide Synthesis Regional Outlook (Revenue, USD Million; 2018 - 2030)

• North America

  • U.S.

  • Canada

  • Mexico

• Europe

  • Germany

  • UK

  • France

  • Italy

  • Spain

  • Denmark

  • Sweden

  • Norway

• Asia Pacific

  • China

  • India

  • Japan

  • Australia

  • South Korea

  • Thailand

• Latin America

  • Brazil

  • Argentina

• Middle East & Africa

  • South Africa

  • Saudi Arabia

  • UAE

  • Kuwait

List of Key Players in the Oligonucleotide Synthesis Market

• Thermo Fisher Scientific Inc.

• Merck KGaA

• Danaher

• Revvity Discovery Limited

• Agilent Technologies, Inc.

• Bio-Synthesis, Inc.

• Kaneka Eurogentec S.A.

• LGC Biosearch Technologies

• Biolegio

• Twist Bioscience