GVR Report cover Oligonucleotide Synthesis Market Size, Share & Trends Report

Oligonucleotide Synthesis Market Size, Share & Trends Analysis Report By Product (Column-based, Array-based, Services), By Application (PCR Primer, FISH), By End-user, By Region, And Segment Forecasts, 2023 - 2030

  • Report ID: GVR-2-68038-593-9
  • Number of Pages: 150
  • Format: Electronic (PDF)
  • Historical Range: 2018 - 2021
  • Industry: Healthcare

Report Overview

The global oligonucleotide synthesis market size was estimated at USD 3.29 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 13.22% by 2030. The decreasing prices of sequencing have led to increasing demand for custom-made nucleotides for a preferred sequencing across genetic testing, research, forensics applications, and drug development. This has further boosted the demand for oligonucleotide synthesis. The COVID-19 pandemic has affected every market globally and there has been a surge in the demand for efficient treatment against COVID-19. Healthcare providers and pharmaceutical companies are working on discovering the potential usage of oligonucleotides to contain the spread of virus. For instance, the Innovative Genomics Institute stated that they are working towards the development of new treatments for patients suffering from COVID-19 with acute respiratory symptoms by using antisense oligonucleotide therapeutics.

Brazil oligonucleotide synthesis market size and growth rate, 2023 - 2030

Oligonucleotide therapeutics holds immense potential for treatment of chronic conditions such as cancers, cardiovascular diseases, and retinal disorders. Emerging novel applications of oligo sequences in various fields of biotechnology are anticipated to boost market growth. Demand for molecular diagnostics in precision care is one of the significant emerging fields of application for oligonucleotide synthesis.

Introduction of advanced techniques such as CRISPR and high-throughput sequencing for gene expression analysis has simplified the genetic screening and modification of genomes. Such innovations are observed to influence the demand for oligonucleotide synthesis. Manufacturers invest in development of technology to enable production of long Oligonucleotide with higher precision and better yield to cater the growing need for custom oligos.

Availability of regulatory environment that supports the progress of genomics is the key factor contributing to the large revenue share of North America. Local presence of key players with a well-established distribution network across the region further strengthens the oligonucleotide synthesis market.

Product Insights

The services segment held the highest market share of 30% in 2022 and is expected to witness the highest growth during the forecast period. Certain factors such as growing use of molecular diagnostic tests coupled with the higher adoption of oligonucleotide therapeutics are expected to contribute to market growth. Moreover, key players are also involved in broadening their offerings by entering new markets or by the acquisition of service providers in different countries.

Furthermore, the oligonucleotide segment is anticipated to project considerable growth in the coming years. With the increase in the number of genomic studies being carried out, such as gene expression analysis and genetic testing, can be attributed to a substantial revenue share. In addition, the introduction of biochips (DNA chips) for parallel analysis of a large number of clinical samples is anticipated to contribute considerably to the markets’ revenue. With growing usage of antisense oligonucleotide in clinical trials for various conditions such as cancer, cardiac disorders, and ocular dysfunctions, the segment is anticipated to witness lucrative growth in the near future. Increasing use of technologies such as PCR, sequencing, and DNA microarrays for genetic testing and biological sample analysis further boosts the revenue growth.

Application Insights

The PCR primers segment registered the highest market share of 23.4% in 2022. Primers are the most widely used oligonucleotide in PCR. They are part of sequences complementary to the 5’ end of the targeted sequence and are used for sequencing or amplification application. The adoption of primers for gene sequencing experiments is increasing. Their use in fluorescent detection and target amplification has led to the development of various primer designs with different probe- and primer-based detection chemistries. With advances in technology, PCR has evolved and has resulted into RT-PCR, qPCR, and digital PCR. PCR assays and panels are designed for detecting and measuring gene expression. Need for primers to suit the application of these enhanced systems for uses such as accurate quantification of gene expression is anticipated to fuel market growth.

PCR assays and panels segment is anticipated to witness lucrative CAGR of 13.65% during 2023-2030. PCR panels and assays are designed and developed for the detection and measurement of gene expressions in biologically related genes. These assays are preconfigured to increase the range of canonical pathways, signaling, diseases, and other cellular processes. For instance, PCR assays for glycogen metabolism genes, IL-12 signaling pathways, and protein groups such as growth factors are easily available commercially.

End-user Insights

The academic research institutes segment held the highest market share of 42.9% in 2022 owing to the extensive genomic research being conducted by universities and academic research institutes either in collaboration with private investors or with government support. Huge investment by developed countries for genomic research to compete and lead the global market has extended financial support to academic research.

Global oligonucleotide synthesis Market share and size, 2022

Furthermore, the pharmaceuticals and biotechnology companies’ segment is projected to witness significant CAGR of 13.3% during 2023-2030. Pharmaceutical companies generate significant demand for oligonucleotide synthesis for the development of oligonucleotide-based drugs along with their use in target screening and identification. High adoption of oligo sequences for investigating their clinical pharmacology, study drug-drug interaction, immunogenicity, and renal impairment has made a significant contribution to the segment growth. Advances in oligonucleotide therapeutics with their success in initial phases of clinical trials can be attributed to the segment growth.

Regional Insights

North America dominated the global market with a revenue share of over 32.3% in 2022. The large share is mainly attributed to the presence of a large number of companies as well as research institutes creating high demand for oligonucleotides. For instance, in April 2021, DNAScript collaborated with Moderna along with a USD 5 million grant from the U.S. Defense Advanced Research Projects Agency. This collaboration was intended for the development of a prototype for robust manufacturing of therapeutics and vaccines as part of the global nucleic acids on-demand program.

Asia Pacific is poised to witness the fastest CAGR of 14.91% during 2023-2030. This is due to the growing interest of key players in emerging markets in gaining higher profits. Players have adopted various strategies such as acquisitions, collaborations, and distribution agreements to gain higher market share by increasing their revenue generation.

Oligonucleotide Synthesis Market Trends, by Region, 2023 - 2030

Groundbreaking innovations such as CRISPR and NGS in biotechnology have led to developments in genomics as well as the healthcare sector. Increase in use of oligonucleotides in therapeutics and molecular diagnostics drives its demand in developed countries. In addition, adoption of advanced diagnostic tools and focus on precision medicine in developed countries also drives the demand for oligonucleotide synthesis.

Key Companies & Market Share Insights

Key entities in the market are undertaking several strategic initiatives such as new product launches, partnerships, geographical expansion, strategic collaborations, mergers and acquisitions to strengthen the market presence. For instance, in February 2023, CPI, Novartis, AstraZeneca and the University of Manchester announced a partnership to expand patient access to life-saving oligonucleotide therapeutics. This partnership is aimed to revolutionize oligonucleotide-based therapeutics in the treatment of various life-threatening diseases. Some of the prominent players in the oligonucleotide synthesis market include:

  • Thermo Fisher Scientific, Inc.

  • Merck & Co., Inc.

  • GE Healthcare

  • Dharmacon Inc.

  • Agilent Technologies

  • Bio-synthesis

  • Kaneka Eurogentec S.A

  • Integrated DNA Technologies, Inc.

  • BioAutomation

  • Biolegio

  • Twist Bioscience

Oligonucleotide Synthesis Market Report Scope

Report Attribute


Market size value in 2023

USD 3.70 billion

Revenue forecast in 2030

USD 8.83 billion

Growth rate

CAGR of 13.22% from 2023 to 2030

Base year for estimation


Historical data

2018 - 2021

Forecast period

2023 - 2030

Quantitative units

Revenue in USD million and CAGR from 2023 to 2030

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Product, application, end-user, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S.; Canada; Germany; UK; France; Italy; Spain; Denmark; Sweden; Norway; China; Japan; India; South Korea; Australia; Thailand; Brazil; Mexico, Argentina; South Africa; Saudi Arabia, UAE; Kuwait

Key companies profiled

Thermo Fisher Scientific, Inc.; Merck & Co., Inc.; GE Healthcare; Dharmacon Inc.; Agilent Technologies; Bio-synthesis; Kaneka Eurogentec S.A.; Integrated DNA Technologies, Inc.; BioAutomation; Biolegio; Twist Bioscience

Customization scope

Free report customization (equivalent up to 8 analyst’s working days) with purchase. Addition or alteration to country, regional & segment scope.

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Global Oligonucleotide Synthesis Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For the purpose of this report, Grand View Research has segmented the global oligonucleotide synthesis market report on the basis of product, application, end-user, and region.

Global Oligonucleotide Synthesis Market Report Segmentation

  • Product Outlook (Revenue, USD Million, 2018 - 2030)

    • Oligonucleotides

      • Oligonucleotides, By Product Type

        • Column-based Oligos

        • Array-based Oligos

      • Oligonucleotides, By Nucleic Acid Type

        • DNA

        • RNA

    • Equipment/Synthesizer

    • Reagents

    • Services

      • Oligo Synthesis

        • 25 nmol

        • 50 nmol

        • 200 nmol

        • 1000 nmol

        • 10,000 nmol

    • Purification

    • Modification

  • Application Outlook (Revenue, USD Million, 2018 - 2030)

    • PCR Primers

    • PCR Assays and Panels

    • Sequencing

    • DNA Microarrays

    • Fluorescence In Situ Hybridization (FISH)

    • Antisense Oligonucleotides

    • Other Applications

  • End-use Outlook (Revenue, USD Million, 2018 - 2030)

    • Academic Research Institutes

    • Diagnostic Laboratories

    • Pharmaceutical - Biotechnology Companies

  • Regional Outlook (Revenue, USD Million, 2018 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • UK

      • France

      • Italy

      • Spain

      • Denmark

      • Sweden

      • Norway

    • Asia Pacific

      • Japan

      • China

      • India

      • South Korea

      • Thailand

      • Australia

    • Latin America

      • Brazil

      • Mexico

      • Argentina

    • Middle East and Africa (MEA)

      • South Africa

      • Saudi Arabia

      • UAE

      • Kuwait

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