Surgical Sealants And Adhesives Market (2026 - 2033) Size, Share & Trends Analysis Report By Type (Natural Or Biological, Synthetic And Semi Synthetic), By Application (Central Nervous System, General Surgery), By Indication (Tissue Engineering, Tissue Sealing), By Region, And Segment Forecasts

Surgical Sealants & Adhesives Market Summary

The global surgical sealants and adhesives market size was estimated at USD 2.73 billion in 2025 and is anticipated to reach USD 5.00 billion by 2033, growing at a CAGR of 8.0% from 2026 to 2033. The market is expected to witness lucrative growth over the next seven years owing to the increasing use of technologically advanced products and the rise in the number of surgical procedures worldwide.

Adhesives and sealants have evolved to become useful accompaniments in modern surgical procedures. They are widely preferred because of their safety, efficacy, and usability in repairing injured tissues and supporting wounds obtained during surgery. According to an article published by the National Library of Medicine in May 2023, approximately 234 million major surgical procedures are performed every year worldwide. Thus, the large number of surgeries conducted each year is expected to drive market growth from 2024 to 2030. 

Furthermore, the increase in the number of various surgeries, such as cosmetic surgery and cardiac surgery, is expected to support the market expansion. According to an article published by the American Society of Plastic Surgeons in September 2023, around 26.2 million surgical, minimally invasive reconstructive, and cosmetic procedures were performed in the U.S. in 2022, which is a 19% increase in cosmetic surgery procedures over 2019. Surgical procedures are generally accompanied by the risk of excessive bleeding, wound infection, or tissue damage. These risks associated with surgeries can help boost the demand for market products.

There is a rising trend in global road accidents and other catastrophic events. For instance, according to a 2023 WHO report, approximately 28% of worldwide road traffic fatalities took place in the WHO Southeast Asia Region, followed by 25% in the Western Pacific Region, 19% in the African Region, 12% in the Region of the Americas, 11% in the Eastern Mediterranean Region, and 5% in the European Region. The majority of these deaths, about nine in ten, occurred in low- and middle-income countries, where the fatality rates are notably higher relative to the number of vehicles and road infrastructure.

Moreover, the manufacturers and industry participants are focusing on developing advanced products in the market. For instance, in January 2023, Grifols, a major plasma medicine player, revealed a positive topline result from a phase 3b study of its fibrin sealant (FS) for treating bleeding in surgeries of pediatric patients. Such positive results from various studies and investigations undertaken by key manufacturers are expected to bring novel products to the market.

Market Concentration & Characteristics

The market growth stage is high, and the pace of the market growth is accelerating due to the presence of various well-established players such as Johnson & Johnson and numerous initiatives undertaken by these players.

Market growth stage is high, and the pace of the market growth is accelerating due to the development of advanced products and increased adoption of minimally invasive procedures. Companies are innovating continuously to offer better products. In addition, the regulatory bodies are also supporting innovative products by providing approvals for clinical trials and marketing. For instance, in December 2023, RevBio, the U.S.-based firm, obtained authorization from the Food and Drug Administration (FDA) to initiate a first-in-human (FIH) clinical trial for its bone adhesive, Tetranite, developed for cranial flap fixation. Tetranite is a synthetic, regenerative, self-setting, patented, osteoconductive, and injectable bone adhesive biomaterial. The regulatory support and advancement in materials of products are expected to drive innovation in the industry.

The market is also characterized by a moderate level of merger and acquisition (M&A) activity. This is due to several factors, including the desire to gain a competitive advantage in the industry and the need to consolidate in a rapidly growing market. Major industry participants are acquiring firms operating across the industry. For instance, in May 2022, a key industry player, Ethicon acquired the Netherlands-based company GATT Technologies. The company can use differentiated synthetic polymers to create hemostatic and sealant products with the acquisition.

Regulations are overseen by regulatory bodies such as the Food and Drug Administration (FDA) in the U.S. and similar agencies globally. The authorities have published a regulatory framework to assure product safety, effectiveness, and quality standards. In addition, the regulatory bodies are also involved in clinical trials and marketing approval of surgical sealants and adhesives. For instance, in June 2023, the U.S. Food and Drug Administration (FDA) authorized the Pre-Market Approval (PMA) of LiquiBandFix8, a device that consists of a Cyanoacrylate adhesive and can be used in hernia surgery.

Product substitutes in the surgical sealants and adhesives market are sutures, stitches, and Hemostats serve as substitutes.

Key market players such as Johnson & Johnson, Integra Life Sciences Corporation, Baxter, and Medtronic PLC hold substantial shares in the market. Their dominant presence is largely due to their financial position, well-established brands, extensive distribution networks, and product portfolio. For instance, Johnson & Johnson's offers diverse products for tissue sealing under its ENSEAL brand.

The market is experiencing robust global expansion due to the growing volume of surgical procedures performed and the increasing focus of industry participants on improving the accessibility of products in numerous countries. For instance, in 2021, BD acquired Tissuemed, a provider of surgical sealant solutions, to expand its offerings for surgeons outside the U.S.

Type Insights

The natural/biological sealants and adhesives segment accounted for the largest market in 2025 with a 65.0% share. The dominance of this segment can be due to the broad applications of various natural or biological sealants in medical practice.

Among the most widely used biological sealants are fibrin sealants, which mimic the final stage of the blood coagulation process to form a stable fibrin clot, ensuring effective hemostasis and tissue sealing. Collagen-based adhesives, derived from animal connective tissue, facilitate cell adhesion and tissue regeneration, proving valuable in vascular, neural, and reconstructive surgeries.

The synthetic & semi-synthetic adhesives & sealants segment shows the fastest CAGR over the forecast period. The growth of the segment can be attributed to the increasing demand for cyanoacrylates owing to their high-speed drying rate. Furthermore, the strong mechanical strength and ease of adhesion are anticipated to boost the adoption of cyanoacrylates in surgical practices worldwide.

Indication Insights

The tissue sealing segment accounted for USD 1.1 billion in 2025. This is due to the rise in surgical interventions and increasing product launches from major players. The key companies and manufacturers are launching tissue sealers that can help in surgeries. A prime example of innovation in this segment came in April 2025, when Baxter International Inc. launched the Hemopatch Sealing Hemostat with room temperature storage in Europe. This evolution enhances accessibility in operating rooms by eliminating refrigeration requirements, allowing immediate availability during critical procedures.

The tissue engineering segment is anticipated to witness the fastest CAGR over the forecast period, due to increasing demand for tissue regeneration in cases of burn or skin injuries. Furthermore, the rising cosmetic surgeries across the world are expected to support the growth of the tissue engineering segment.

Application Insights

The general surgery segment accounted for the largest market share of 22.9% in 2025. This is primarily due to the high volume of surgeries conducted annually. The need for these solutions is amplified by the growing clinical burden of gastrointestinal (GI) diseases. GI malignancies account for 26.0% of all cancer cases and nearly one-third of cancer-related deaths globally, underscoring the demand for safer and more effective surgical interventions. Meanwhile, the widespread use of screening procedures also drives complications requiring advanced sealant technologies. More than 15 million colonoscopies are performed annually in the U.S. alone, and while EMR and ESD are widely considered safe, the rising number of procedures has led to increased cases of delayed bleeding, intestinal wall perforation, and infection.

The cosmetic surgery segment is expected to witness the fastest CAGR over the forecast period. This is due to the increasing number of cosmetic procedures and the presence of numerous surgical sealants and adhesives that can be used in cosmetic surgeries. In addition, surgical adhesives are more beneficial in cosmetic procedures than other alternatives like stitches. For instance, according to the article published by SpecialChem in January 2022, skin grafts using cyanoacrylate adhesives can heal with much less scarring than those with stitches. Thus, such benefits associated with the market products are anticipated to propel the segment growth.

Regional Insights

North America surgical sealants and adhesives market dominated the overall global market in 2025 and accounted for a 49.7% revenue share. This is due to the high prevalence of chronic diseases such as cardiovascular disorders and cancer, which drive the demand for advanced medical solutions, including surgical adhesives and sealants, to manage surgical interventions effectively. For instance, according to the article published by the Mass General Brigham Incorporated in August 2023, over 900,000 cardiac surgeries, including coronary bypass surgeries, are performed in the U.S. every year. Thus, the large number of surgical procedures being conducted across the region is anticipated to support the regional market growth.

U.S. Surgical Sealants And Adhesives Market Trends

The U.S. surgical sealants and adhesives market accounted for a significant share of the North American market in 2025 due to its advanced healthcare infrastructure, presence of key players, and significant investments in research and development. The major market participants such as Baxter, CryoLife, Inc., Medtronic PLC, and Cardinal Health are present in the U.S. Moreover, the rising number of cosmetic surgeries in the U.S. is also anticipated to boost the market growth in the country.

Europe Surgical Sealants And Adhesives Market Trends

Europe surgical sealants and adhesives market was identified as a lucrative region in this industry due to the growing need for effective blood loss management in patients coupled with the large number of surgeries being performed every year. Moreover, the companies are launching several products in the UK. For instance, in May 2023, Olympus launched the POWERSEALTM Sealer/Divider in various regions including Europe.

The surgical sealants and adhesives market in the UK is expected to grow over the forecast period primarily due to the growing adoption of advanced surgical procedures that need efficient tissue sealing solutions. In addition, the presence of players like Olympus offering market products is expected to support the country's growth.

France surgical sealants and adhesives market is expected to grow over the forecast period due to the rising investment from companies operating in the country market, such as Tissium, for developing and expanding product portfolios of surgical sealants and adhesives. In addition, the growing geriatric population in the country is expected to propel the market growth as older people are at higher risk of injuries and chronic conditions.

The surgical sealants and adhesives market in the Germany is expected to grow over the forecast period due to the prevalence of chronic diseases and increased associated surgeries. The rise in surgeries is boosting the demand for surgical sealants and adhesives in Germany.

Asia Pacific Surgical Sealants And Adhesives Market Trends

The Asia Pacific region is expected to witness the fastest growth during the forecast period. This progress is driven by to increasing geriatric population, a rising prevalence of chronic diseases, and advancements in healthcare infrastructure. Moreover, the escalating number of surgical procedures and the growing awareness regarding the benefits of tissue sealing agents are contributing to the region's anticipated fastest growth rate during the forecast period.

Japan surgical sealants and adhesives market is expected to witness significant growth in the coming years. Japan has a robust regulatory environment for medical devices, which is anticipated to boost the development and adoption of surgical adhesives and sealants. Moreover, the country's aging population leads to a high demand for these medical devices, further driving the country's growth. According to an article published by the European Parliament in December 2020, around 28.7 % of the Japan individuals are 65 or older.

The surgical sealants and adhesives market in China is expected to grow over the forecast period, due to increasing surgical procedures, which demand the use of surgical adhesives and sealants. Moreover, the rising healthcare expenditure in developing countries, including China, is another factor contributing to this market expansion.

India surgical sealants and adhesives marketis expected to grow over the forecast period, due to a surge in surgical procedures, advancing healthcare infrastructure, and an increased focus on efficient wound management.

Middle East & Africa Surgical Sealants And Adhesives Market Trends

Surgical sealants and adhesives market in Middle East and Africa is growing as healthcare authorities in the MEA are committed to reducing injury rates & addressing chronic diseases in the region. To achieve this goal, governments are undertaking wound management initiatives and collaborating with various organizations to raise awareness about wound care. For instance, Wounds Group actively contributes by publishing the Diabetic Foot Journal, specifically for the Middle East. This journal aims to educate healthcare professionals and the public about the significance of diabetic foot care. Moreover, leading companies such as Ethicon (a Johnson & Johnson subsidiary) play a significant role in the surgical sealants and adhesives market across the Middle East and Africa.

Surgical sealants and adhesives market in Saudi Arabia is expected to grow over the forecast period due to due to rising older population of the country, which has led to an increased demand for advanced medical procedures and related equipment used in surgeries.

Kuwait surgical sealants and adhesives marketis expected to grow over the forecast period due to the increasing demand for effective blood loss management during surgeries and growing prevalence of chronic diseases, including cardiovascular and cancer, across the country.

Key Surgical Sealants And Adhesives Company Insights

The competitive scenario in the surgical sealants and adhesive market is driven by both established players and new entrants, with market expansion, partnerships, innovative product launches being key strategies. Companies are focusing on developing advanced products that provide superior performance and patient comfort. In addition, the rising investments are influencing the development of industry products.

Recent Developments

• In September 2025, B. Braun SE fully acquired True Digital Surgery (TDS), a Goleta-based expert in robotic-assisted 3D surgical microscopy, to advance digital microsurgery and strengthen its Aesculap AEOS platform. The move expands B. Braun’s presence in neurosurgery, spine, and ENT markets while positioning TDS as its innovation hub in California.

• In October 2024, NAMSA and Terumo formed a strategic outsourcing partnership to accelerate regulatory approval and commercialization of Terumo’s global medical device portfolio. The collaboration leverages NAMSA’s clinical, testing, and regulatory expertise to streamline development, reduce costs, and speed access to Terumo’s life-enhancing medical technologies worldwide.

• In November 2023, Ethicon, a Johnson & Johnson's MedTech division launched a hemostatic sealing patch, Ethizia, for controlling bleeding in surgeries.

• In November 2023, Pramand LLC, introduced the CraniSeal Dural Sealant System in the U.S. market. This system is used in cranial surgery.

• In March 2023, Animus Surgical introduced a new transparent, biodegradable, non-toxic hydrogel wound sealant.

Surgical Sealants And Adhesives Market Report Scope

Global Surgical Sealants And Adhesives Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global surgical sealants and adhesives market report based on type, indication, application, and region:

• Type Outlook (Revenue, USD Million, 2021 - 2033)

  • Natural or Biological Adhesives and Sealants

    • Fibrin Sealants

    • Collagen Based Adhesives

    • Gelatin Based Adhesives

  • Synthetic and Semi Synthetic Adhesives and Sealants

    • Cyanoacrylates

    • Polymeric Hydrogels

    • Urethane Based Adhesives

• Indication Outlook (Revenue, USD Million, 2021 - 2033)

  • Tissue Sealing

  • Tissue Engineering

  • Hemostasis

• Application Outlook (Revenue, USD Million, 2021 - 2033)

  • Central Nervous System

  • Cardiovascular

  • General surgery

  • Orthopedic

  • Cosmetic

  • Pulmonary

  • Urology

  • Ophthalmology

  • Others

• Regional Outlook (Revenue, USD Million, 2021 - 2033)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • Germany

    • UK

    • France

    • Italy

    • Spain

    • Norway

    • Sweden

    • Denmark

  • Asia Pacific

    • China

    • Japan

    • India

    • Thailand

    • South Korea

    • Australia

  • Latin America

    • Brazil

    • Argentina

  • MEA

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait