Gastrointestinal Therapeutics Market To Reach $51.45 Billion By 2033

Gastrointestinal Therapeutics Market Growth & Trends

The global gastrointestinal therapeutics market size is estimated to reach USD 51.45 billion by 2033, registering a CAGR of 2.2% from 2026 to 2033, according to a new report by Grand View Research, Inc. Unhealthy eating habits, coupled with a sedentary lifestyle, have led to the development of gastrointestinal diseases among consumers, which is expected to drive market growth. Moreover, the rising adoption of biologics for the treatment of GI disorders is also fueling growth. For instance, REMICADE (Infliximab) by Janssen Biotech, Inc., and other biological drugs have been approved for the treatment of Crohn’s disease and ulcerative colitis.

The increasing incidences of industry-academia collaborations to promote gastrointestinal research and develop novel therapies for patients with GI disorders will likely facilitate market expansion. For instance, in November 2020, Takeda Pharmaceutical Company Limited, Columbia University, and New York University formed a collaborative research alliance to advance gastroenterology research programs, to develop new therapeutics for gastrointestinal diseases.

Moreover, market growth is also anticipated to increase research & development initiatives by government and private organizations for the development of new gastrointestinal drugs. As of November 2022, according to the U.S. National Library of Medicine, there were 7,586 ongoing clinical studies (including observational studies, drug development, and others) related to gastrointestinal diseases, at various stages of development. Moreover, in May 2022, AbbVie Inc. announced positive topline results from a phase-3 study that is evaluating upadacitinib in adult patients with severe to moderate Crohn's disease, who were intolerant to biologic therapy.

The presence of government and non-profit organizations that support gastrointestinal research, offer to fund studies, and promote awareness about GI disorders, is anticipated to augment GI therapeutics market growth. For instance, the International Foundation for Gastrointestinal Disorders, GI- research foundation, and American Gastroenterological Association are some of the key organizations supporting research activities and increasing awareness about gastrointestinal diseases among people. These organizations also raise funds for ongoing GI research activities.

Furthermore, various strategic initiatives such as product launches, collaboration, mergers, and acquisitions undertaken by leading players are expected to offer lucrative opportunities for market growth. For instance, in July 2022, Eli Lilly announced a partnership with the Chinese drug 3D printing firm to develop and research 3D-printed oral drugs for the GI tract application.

In addition, in April 2020acquired global rights, excluding Canada, Europe, and Israel, of Movantik (naloxegol) by AstraZeneca, for the management of opioid-induced constipation. This acquisition is expected to strengthen the company’s position in the global gastrointestinal therapeutics industry.

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Gastrointestinal Therapeutics Market Report Highlights

• Based on drug type, the branded segment dominated the market with the largest revenue share of 66.68% in 2025, driven by strong adoption of patented biologics and specialty therapies for chronic gastrointestinal conditions.

• Based on drug class, the biologics and biosimilar segment dominated the market with the largest revenue share of 44.70% in 2025, supported by strong clinical effectiveness in inflammatory bowel diseases and other severe gastrointestinal disorders.

• Based on route of administration, the injectables segment dominated the market with the largest revenue share of 52.43% in 2025, due to increasing utilization of biologic therapies administered through intravenous and subcutaneous routes for severe gastrointestinal diseases.

• Based on application, the Crohn’s disease segment dominated the market with the largest revenue share of 33.54% in 2025, supported by rising global prevalence and strong demand for advanced biologic therapies required for long-term disease control.

• Based on distribution channel, the retail pharmacies segment dominated the market with the largest revenue share of 48.76% in 2025, due to extensive accessibility and convenience for patients requiring gastrointestinal medications.

• North America gastrointestinal therapeutics market held the largest share of 37.96% in 2025, due to the high prevalence of chronic digestive disorders and strong adoption of advanced biologic therapies.

Gastrointestinal Therapeutics Market Segmentation

Grand View Research has segmented the global gastrointestinal therapeutics market based on drug type, drug class, route of administration, application, distribution channel, and region:

Gastrointestinal Therapeutics Drug Type Outlook (Revenue, USD Million, 2021 - 2033)

• Branded

• Generics

Gastrointestinal Therapeutics Drug Class Outlook (Revenue, USD Million, 2021 - 2033)

• Aminosalicylates

• Digestive Enzymes

• Proton Pump Inhibitors

• Laxatives

• Anti-emetics

• H2 Antagonists

• Anti-diarrheals

• Biologics/ Biosimilar

• Others

Gastrointestinal Therapeutics Route of Administration Outlook (Revenue, USD Million, 2021 - 2033)

• Oral

• Injectables

• Others

Gastrointestinal Therapeutics Application Outlook (Revenue, USD Million, 2021 - 2033)

• Crohn's disease

• Ulcerative colitis

• GERD

• IBS

• Others

Gastrointestinal Therapeutics Distribution Channel Outlook (Revenue, USD Million, 2021 - 2033)

• Hospital Pharmacies

• Retail Pharmacies

• Online Pharmacies

Gastrointestinal Therapeutics Regional Outlook (Revenue, USD Million, 2021 - 2033)

• North America

  • U.S.

  • Canada

  • Mexico

• Europe

  • UK

  • Germany

  • France

  • Italy

  • Spain

  • Denmark

  • Sweden

  • Norway

• Asia Pacific

  • Japan

  • China

  • India

  • Australia

  • South Korea

  • Thailand

• Latin America

  • Brazil

  • Argentina

• Middle East & Africa

  • South Africa

  • Saudi Arabia

  • UAE

  • Kuwait

List of Key Players in the Gastrointestinal Therapeutics Market

• AbbVie Inc.

• AstraZeneca

• Salix Pharmaceuticals

• Takeda Pharmaceutical Company Limited

• Pfizer Inc.

• Bayer AG

• Abbott

• Janssen Pharmaceuticals NV

• Sun Pharmaceutical Industries Ltd.

• Cipla Inc.

• Gilead Sciences, Inc.