The global gene therapy market size is expected to reach USD 10.0 billion by 2028 registering a CAGR of 20.4% during the forecast period, according to a new report by Grand View Research, Inc. The market growth is attributed to the increasing prevalence of cancer coupled with the lack of effective treatment for the disease. Constant expansion of cancer genetic studies has deciphered relevant information about cancer-related molecular signatures.
This has driven the clinical trials for advanced cancer therapeutics, thereby driving the market growth. In addition, expansion of this mode of treatment in non-cancer applications with approval of therapies, such as approval of Bluebird Bio’s Zynteglo in June 2019 for β-thalassemia and others, demonstrates the shift in the preferences of companies towards other unsaturated segments.
Various universities and institutes are observed to exhibit a broad portfolio in the pipeline, which is anticipated to boost revenue generation in the future. The market is anticipated to witnesses a short-term revenue slowdown due to a shift in focus and delay in product launches. However, initiatives for developing novel trial designs, improving the regulatory environment, and managing the supply chain are expected to play a critical role in minimizing the impact of the current global crisis.
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Viral vectors have proven their efficiency as a method for effective gene deliveries. As a result, a substantial number of research communities and biotechnology companies have designed their gene therapy programs based on viral vectors
Moreover, most of currently FDA-secured products involve the use of viral vectors, which contributes to the dominance of the viral vectors segment
Due to the approval and huge success of lentivirus-based Kymriah and retrovirus-based Yescarta, retrovirus and lentivirus are also among the key revenue-generating segments
Cancer has led the revenue flow in the market over the past few years and is expected to maintain its dominance in the forecast period
The presence of approved products for various cancer forms including Large B-cell lymphoma, Acute Lymphoblastic Leukemia (ALL), and melanoma has resulted in the dominance of this segment
The U.S. is recognized as the hub for clinical trials related to gene therapy. This has significantly impacted the revenue growth of the North America market
Also, the success of Yescarta and Kymriah in the U.S. as the first approved CAR-t therapy programs has driven huge investments by various government agencies, sponsors, and key companies in this region
Major market participants are partnering with other key stakeholders via signing licensing, commercialization, and development deals to enhance their worldwide business operations
For instance, in June 2020, uniQure announced a license agreement with CSL Behring for the commercialization of hemophilia B gene therapy
Grand View Research has segmented the global gene therapy market on the basis of indication, vector type, and region:
Gene Therapy Indication Outlook (Revenue, USD Million, 2017 - 2028)
Acute Lymphoblastic Leukemia (ALL)
Inherited Retinal Disease
Large B-cell Lymphoma
Head & Neck Squamous Cell Carcinoma
Peripheral Arterial Disease
Spinal Muscular Atrophy (SMA)
Gene Therapy Vector Type Outlook (Revenue, USD Million, 2017 - 2028)
Retrovirus & gamma Retrovirus
Modified Herpes Simplex Virus
Non-viral Plasmid Vector
Gene Therapy Regional Outlook (Revenue, USD Million, 2017 - 2028)
Rest of the World
List of Key Players of Gene Therapy Market
Oxford BioMedica plc
Dimension Therapeutics, Inc.
Bristol-Myers Squibb Company
Applied Genetic Technologies Corporation
F. Hoffmann-La Roche Ltd.
Bluebird Bio, Inc.
Taxus Cardium Pharmaceuticals Group, Inc. (Gene Biotherapeutics)
Sangamo Therapeutics, Inc.
Gilead Lifesciences, Inc.
Benitec Biopharma Ltd.
Sibiono GeneTech Co., Ltd.
Shanghai Sunway Biotech Co., Ltd.
Gensight Biologics S.A.
Epeius Biotechnologies Corp.
Astellas Pharma, Inc.
American Gene Technologies
BioMarin Pharmaceuticals, Inc.
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