PNH Treatment Market Size Worth $5.8 Billion by 2025 | CAGR: 11.2%

October 2018 | Report Format: Electronic (PDF)

The global paroxysmal nocturnal hemoglobinuria (PNH) treatment market size is expected to reach USD 5.8 billion by 2025 at a 11.2% CAGR during the forecast period, according to a new report by Grand View Research, Inc. Several factors such as rise in number of blood and bone marrow related disorders, increase in geriatric population, wider adoption of novel therapeutics, and emergence of biologics are driving the market.

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired, chronic hematologic disorder. It is an ultra-rare disease with approximately 8,000 to 10,000 cases reported in North America and Europe. The life-threatening disease often manifests in three forms: thrombosis, persistent intravascular hemolysis, and pancytopenia. Although information on its prevalence is scarce, PNH is estimated to affect more than 20,000 people worldwide with an incidence of about 1.3 per million annually and a prevalence of around 16 per million. PNH affects men and women equally. Although physical symptoms can begin at any age, they usually develop between 30-40 years of age.

Novel treatments including monoclonal antibodies, recombinant proteins, and cyclic peptides are gaining penetration in developed markets. However, high cost of therapy with Soliris and other emerging pipeline drugs presents a barrier in adoption in developing regions. Blood transfusion and supportive care are anticipated to lose momentum during the forecast period due to adverse side effects and sub-optimal efficacy.

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Further key findings from the report suggest:

  • An estimated 5,000 - 6,000 people in U.S. suffer from PNH, with approximately 450 new cases being reported annually

  • U.S. dominated the global PNH treatment market with more than 35% share in 2017 due to high cost of treatment in U.S., potential approval of a range of pipeline drugs, and adoption of novel therapeutics

  • Treatment with medication dominated the PNH market with a share of more than 75% in 2017. Apart from drugs, the stem cell transplant segment is projected to witness double-digit growth through the forecast period

  • Alexion, Akari, Apellis, Amgen, CinnaGen, Ra Pharmaceuticals, Alnylam, Achillion, Novartis, Roche, and Regeneron Pharmaceuticals are some of the key players in this market

  • Currently, 16 products are under clinical evaluation for PNH treatment in various stages of development. Promising pipeline candidates such as ALXN1210, Coversin, APL2, and RA101495 offer significant commercial potential post regulatory approval.

Grand View Research has segmented the global paroxysmal nocturnal hemoglobinuria (PNH) treatment market based on treatment and major markets:

Paroxysmal Nocturnal Hemoglobinuria (PNH) Treatment Outlook (Revenue, USD Million; 2017 - 2025)

  • Medication

  • Stem Cell Transplant

  • Blood Transfusion

Paroxysmal Nocturnal Hemoglobinuria (PNH) Treatment Country Outlook (Revenue, USD Million, 2017 - 2025)

  • U.S.

  • Japan

  • U.K.

  • Germany

  • France

  • Spain

  • Italy

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