Upstream Bioprocessing Market To Reach $59.24 Billion By 2030

Upstream Bioprocessing Market Growth & Trends

The global upstream bioprocessing market size is expected to reach USD 59.24 billion by 2030, registering a CAGR of 14.3% from 2024 to 2030, according to a new report by Grand View Research, Inc. Commercial success and wide acceptance of biopharmaceuticals have provided lucrative growth avenues to several in house as well as contract manufacturing biopharmaceutical companies. Furthermore, a confluence of factors, such as high demand for biosimilars and biologics, launch of improved cost-effective technologies, and growing acceptance of single-use systems have driven the revenue performance of the market.

Start-ups and new market entrants often face budget constraints while establishing new biomanufacturing plants. Thus, these entities expand their biotherapeutics portfolio by outsourcing the production process to contract services, thereby aiding in revenue growth for upstream bioprocessing services.

Continuous upstream bioprocessing has greatly benefited the bioprocessing industry. Rising implementation of methods, such as acoustic wave technology and continuous centrifugation, for clarification of bioreactor cultures tends to minimize the clarification burden. This, in turn, increases the cell-culture densities, consequently resulting in efficient upstream processes.

Ongoing advancements in cell line productivity with respect to protein expression and clone screening are expected to result in the fastest CAGR of cell culture products over the forecast period. Cell culture is considered as the most challenging and crucial step in upstream bioprocessing, and thus demands more attention with respect to technological intricacies, resulting in the largest share in the upstream bioprocessing market.

Factors such as multi-use systems incur one-time investment, are applicable for larger bioprocessing volumes and maintain the pH and oxygen accurately resulting in high usage rate of these systems. However, a paradigm shift from conventional stainless-steel bioreactors to single-use bioreactor systems has attributed to the lucrative growth of the single-use segment.

Key market players are adopting strategic initiatives, such as novel product developments, mutually beneficial partnerships, agreements, and geographical expansion to reinforce their market presence. For instance, in February 2019, Danaher Corporation signed an agreement to acquire the Biopharma business of GE Life Sciences. The acquisition broadened Danaher’s market presence with the addition of GE Biopharma’s cell culture media, single-use technologies, development instrumentation, and consumables to its existing portfolio.

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Upstream Bioprocessing Market Report Highlights

• High availability of bioreactors and continuous launches of single-use bioreactors by the key market players can be attributed to the remarkable revenue share of the bioreactors segment

• Presence of well-established biopharmaceutical manufacturing firms capable of performing in-house bioproduction has led to the maximum revenue share of this segment

• The outsourced segment is expected to grow at the highest CAGR over the forecast period, owing to increase in investments and expansion of manufacturing capabilities through the integration of single-use systems in the plants by CMOs

• North America dominated the market and accounted for a share of 36.2% in 2023 as a result of the continuous innovations in biotechnology and rising preferences for biopharmaceuticals in the region. Moreover, the presence of substantial in-house biopharmaceutical manufacturers coupled with numerous investments in the U.S. biologics market has driven the growth

• Asia Pacific is expected to be the fastest-growing region in the market and is expected to grow at a CAGR of 17.4% during the forecast period due to growing awareness about the rapid analytical methods that can be used for in-process control during the upstream workflows

Upstream Bioprocessing Market Segmentation

Grand View Research has segmented the upstream bioprocessing market on the basis of on product, workflow, use type, mode, and region:

Upstream Bioprocessing Product Outlook (Revenue, USD Million, 2018 - 2030)

• Bioreactors/Fermenters

• Cell Culture Products

• Filters

• Bioreactors Accessories

• Bags & Containers

• Others

Upstream Bioprocessing Workflow Outlook (Revenue, USD Million, 2018 - 2030)

• Media Preparation

• Cell Culture

• Cell Separation

Upstream Bioprocessing Use Type Outlook (Revenue, USD Million, 2018 - 2030)

• Multi-use

• Single-use

Upstream Bioprocessing Mode Outlook (Revenue, USD Million, 2018 - 2030)

• In-house

• Outsourced

Upstream Bioprocessing Regional Outlook (Revenue, USD Million, 2018 - 2030)

• North America

  • U.S.

  • Canada

• Europe

  • Germany

  • UK

  • France

  • Italy

  • Spain

  • Denmark

  • Norway

  • Sweden

• Asia Pacific

  • Japan

  • China

  • India

  • Australia

  • Thailand

  • South Korea

• Latin America

  • Brazil

  • Mexico

  • Argentina

• MEA

  • South Africa

  • Saudi Arabia

  • UAE

  • Kuwait

List of Key Players in the Upstream Bioprocessing Market

• Thermo Fisher Scientific, Inc.

• Merck KGaA

• Corning Incorporated

• Sartorius AG

• Eppendorf AG

• Danaher

• Boehringer Ingelheim GmbH

• Applikon Biotechnology

• PBS Biotech, Inc.

• Lonza

• VWR International, LLC

• Meissner Filtration Products, Inc.

• Repligen Corporation

• Entegris

• Kuhner AG