Amyotrophic Lateral Sclerosis Treatment Market Size, Share & Trends Report

Amyotrophic Lateral Sclerosis Treatment Market Size, Share & Trends Analysis Report By Treatment (Medication, Stem Cell Transplant), By Distribution Channel (Hospital Pharmacies, Retail Pharmacies), And Segment Forecasts, 2019 - 2026

  • Published Date: Oct, 2019
  • Base Year for Estimate: 2018
  • Report ID: GVR-4-68038-001-9
  • Format: Electronic (PDF)
  • Historical Data: 2015 - 2017
  • Number of Pages: 110

Report Overview

The global amyotrophic lateral sclerosis treatment market size was valued at USD 537.2 million in 2018 and is expected to grow at a compound annual growth rate (CAGR) of 5.8% from 2019 to 2026. Rising geriatric population, growing awareness about ALS, and increasing incidence rate are the factors driving this market. However, the high cost associated with ALS treatment may pose as an impediment for the market during the forecast period.

North America amyotrophic lateral sclerosis treatment market size

Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a progressive neurodegenerative disorder that damages nerve cells in the central nervous system responsible for controlling the voluntary muscles. Some of the common symptoms include muscle twitching, stiff muscles, and weakness due to decrease in the size of muscles of the legs or arms. Around half of the people suffering from ALS may lose the ability to swallow, breathe, speak, walk, and use their hands.

According to the National Institute of Neurological Disorders and Stroke (NINDS), following gradual paralysis, patients with ALS often die from respiratory failure within 3-5 years. It also states that between the two types of ALS, the sporadic type is the most common form, accounting for 90- 95% of all cases in the U.S. while the familial type accounts for the rest.

Familial ALS (FALS) is hereditary in nature, where there is a 50% chance of inheriting the genetic mutation for each offspring and eventually developing the disorder. In 25-40% of the people suffering from familial ALS, the defect is most commonly found in the C9ORF72 gene. Mutation in this gene also leads to a condition known as frontotemporal dementia (FTD), which may develop along with ALS as a comorbidity referred to as ALS-FTD.

Although there is no cure for ALS, treatments such as medications and stem cell therapies can help in the management of the symptoms, prevention of unnecessary complications, and slows down the disease progression. Adoption of sedentary lifestyle increases the risk of developing the disorder among the geriatric population, which creates a demand for novel therapeutics approaches and targeted treatment options. These factors are expected to further drive the amyotrophic lateral sclerosis treatment market.

Treatment Insights

The treatment segment has been divided into medications, stem cell therapies and others. Among the treatments, the medication segment is anticipated to dominate the global ALS treatment market through the forecast period. There are only two drugs approved for the treatment of ALS, Rilutek (riluzole) and Radicava (edaravone). Another drug, Nuedexta (dextromethorphan/quinidine) has received FDA approval for the treatment pseudobulbar affect (PBA), a comorbidity of ALS.

Stem cell therapy is expected to show the highest CAGR due to the increasing demand of new approaches and advanced treatment options. Several initiatives have been taken by the government authoritative bodies and the Collaborative ALS Drug Discovery Initiative (CADDI) to fast-track development of novel drugs and treatments. This is expected to further boost the number of clinical trials and launch of pipeline drugs during the forecast period.

Distribution Channel Insights

The distribution channel segment has been divided into hospital pharmacies, retail pharmacies and others. Hospital pharmacies accounted for the largest market share in 2018 and is expected to retain the leading position through the forecast period. The requirement for several hospital stays and visits during the course of ALS treatment facilitates the growth of this segment. There is high patient preference for hospital pharmacies as well as retail pharmacies. This can be attributed to the easy and rapid access to a broad range of drugs and adequate products in the stock offered by these distribution channels.

Europe amyotrophic lateral sclerosis treatment Market share

Other distribution channels in the amyotrophic lateral sclerosis treatment market include online pharmacies, diagnostics laboratories, and clinics. Online Pharmacies are also gaining prominence due to the growing popularity of eCommerce channels that offer a wide range of options along with in-depth drug information.

Regional Insights

Among the regions, North America accounted for the largest market share in 2018 and is estimated to retain its leading position over the forecast period.High healthcare expenditure, favorable reimbursement policies, huge demand for ALS drugs, and established healthcare infrastructure are the factors driving the market. According to the data published in the Centers for Disease Control and Prevention (CDC) Morbidity and Mortality Weekly Report, in 2015 around 16,583 cases of amyotrophic lateral sclerosis were identified in the U.S.

Asia Pacific is expected to exhibit the fastest growth rate of all regions over the forecast period. The industry is witnessing an increasing revenue generation from riluzole generic manufacturers in this region, especially in India and China. Some of the key factors propelling the market growth in this region include growing R&D investment in the healthcare sector, plenty of unexplored opportunities, and promising initiatives by the manufacturers as well as the governments.

Key Companies & Market Share Insights

Mitsubishi Tanabe Pharma Corporation held the largest market share in 2018. 

However, the patent for Rilutek, which was launched in 1995, expired in 2013, giving rise to the production of cheap generic versions of the drug. Companies are adopting various strategies such as new product development, expansion into emerging counties, and strategic partnerships to gain a competitive advantage. Some of the prominent players in the amyotrophic lateral sclerosis treatment market include:

  • Mitsubishi Tanabe Pharma Corporation

  • Otsuka Pharmaceutical Co., Ltd.

  • BrainStorm Therapeutics

  • Biogen Inc.

  • Corestem

  • AB Science

  • F.Hoffmann-La Roche AG

  • Biohaven Pharmaceutical

  • Sun Pharmaceutical

  • Ionis Pharmaceuticals, Inc.

Amyotrophic Lateral Sclerosis Treatment Market Report Scope

Report Attribute

Details

Market size value in 2020

USD 647.9 million

Revenue forecast in 2026

USD 885.5 million

Growth Rate

CAGR of 5.8% from 2019 to 2026

Base year for estimation

2018

Historical data

2015 - 2017

Forecast period

2019 - 2026

Quantitative units

Revenue in USD million and CAGR from 2019 to 2026

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Treatment, distribution channel, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S.; Canada; Germany; UK; France; Italy; Spain; Russia; Japan; China; India; Australia; South Korea; Singapore; Brazil; Mexico; Argentina; South Africa; Saudi Arabia; UAE

Key companies profiled

Mitsubishi Tanabe Pharma Corporation; Otsuka Pharmaceutical Co., Ltd.; BrainStorm Therapeutics; Biogen Inc.; Corestem; AB Science; F.Hoffmann-La Roche AG; Biohaven Pharmaceutical; Sun Pharmaceutical; Ionis Pharmaceuticals, Inc.

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Segments covered in the report

This report forecasts revenue growth at global, regional, & country levels, and provides an analysis of the industry trends in each of the sub-segments from 2015 to 2026. For the purpose of this study, Grand View Research has segmented the global amyotrophic lateral sclerosis treatment market report on the basis of treatment, distribution channel, and region:

  • Treatment Outlook (Revenue, USD Million, 2015 - 2026)

    • Medication

    • Stem Cell Therapy

    • Others

  • Distribution Channel Outlook (Revenue, USD Million, 2015 - 2026)

    • Hospital Pharmacies

    • Retail Pharmacies

    • Others

  • Regional Outlook (Revenue, USD Million, 2015 - 2026)

    • North America 

      • U.S.

      • Canada

    • Europe 

      • UK

      • Germany

      • France

      • Italy

      • Spain

      • Russia

    • Asia Pacific 

      • Japan

      • China

      • India

      • South Korea

      • Singapore

      • Australia

    • Latin America 

      • Brazil

      • Mexico

      • Argentina

    • Middle East & Africa

      • South Africa

      • Saudi Arabia

      • UAE

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