G-Protein Coupled Receptors (GPCRs) Market Size, Share & Trends Report

G-Protein Coupled Receptors (GPCRs) Market Size, Share & Trends Analysis Report By Product (Cell Lines, Detection Kits), By Assay Type, By Application (Cancer Research, Inflammation Research), And Segment Forecasts, 2019 - 2026

  • Published Date: Jul, 2019
  • Base Year for Estimate: 2018
  • Report ID: GVR-3-68038-224-2
  • Format: Electronic (PDF)
  • Historical Data: 2015 - 2017
  • Number of Pages: 135

Industry Insights

The global G-protein coupled receptors market size was estimated at USD 2.60 billion in 2018 and is projected to expand further at a CAGR of 6.7% from 2019 to 2026. GPCRs respond to a wide range of external stimulus and a part of several disease etiologies. Wide application of techniques, such as High-Throughput Screening (HTS), combinatorial chemistry, and medicinal chemistry, has led to the identification of ligands that modulate the target's activity.

This, in turn, has resulted in the effective identification of pharmaceutically relevant drug candidates, which drives the adoption of these receptors in the drug discovery processes. Presence of large number approved drugs and drugs under clinical and preclinical studies, which target these receptors, boost the demand for GPCR screening assays in drug development. Moreover, an increasing number of allosteric modulators, biological drugs, and biased agonists that target these receptors accelerate the demand for associated assays.

U.K. G-Protein Coupled Receptors market

Advancements in the computational approaches to streamline receptor structure contribute to the development ofeffective drug discovery methods. Researchers from the University of Southern California, the Skolkovo Institute of Science & Technology, and the Moscow Institute of Physics & Technology designed a thermally stable GPCR by a computational method for the formulation of new drugs.

Companies in the market focus more on research to explore the novel biological functions of the approved and withdrawn drug candidates, so that these can be used for other indications as well. A research based on custom-designed oligonucleotide GPCR chip by Arena Pharmaceuticals has identified a relative expression of more than seven hundred receptors of high therapeutic importance. This research would be further utilized for the discovery of small molecules.

Product Insights

The availability of an extensive range of cell lines for the assays resulted in the largest revenue share of cell lines in 2018. Cell lines play a major role in the cellular impedance assays for the detection of GPCR targets thus attributing to the estimated revenue share. Detection kits have gained popularity in recent years, as they are an easy-to-use, robust, and highly sensitive products to evaluate the activity through different pathways. Moreover, the advent of new detection strategies based on nonlabelled systems, such as resonance wave-guide grating or impedance-based sensors, is anticipated to support the growth of the segment.

Assay Type Insights

Owing to the fact that cyclic Adenosine Monophosphate (cAMP) is an important intracellular second messenger in GPCR signal transduction, cAMP assays accounted for the largest revenue share in 2018. Presence of a broad product portfolio, in terms of reagent kits for the measurement of the cAMP messenger levels, is further driving the segment. Calcium functional assays segment is expected to witness the fastest CAGR from 2019 to 2026 on account of the advantages associated with the use of calcium flux assays, such as high sensitivity, ease in the estimation of calcium flux, and user configurability.

Application Insights

A substantial number of applications are associated with G-protein coupled receptor activity for the treatment of several disorders. Majority of tumor angiogenesis and immunotherapy related detections are associated with GPCR activity. The ubiquitously expressed protein is involved in intercellular communication that paves the path for the development of potential therapeutics.

Global G-Protein Coupled Receptors market

Implementation of GPCR assays in cancer research generates substantial revenue. Several studies have proved that the GPCR activity reveals the tumor proliferation, invasiveness, angiogenesis, metastasis, and drug resistance in cancer patients. As per the research, each type of cancer cell/tumor is found to express a common set of GPCR. It has also been observed that >150 different GPCRs are expressed by some types of cell, out of which one is expressed at a comparatively high level.

This pronounces the biomarker-based research in the sector thus leading to development of lead candidate targeting GPCRs. The role of this receptor has evolved in the inflammation research area over recent years. G-protein coupled receptor kinases regulate the signaling pathways, such as nuclear factor κ-B signaling pathway, which is related to different inflammatory processes. Thus, these signaling pathways act as a potential therapeutic target in various inflammatory diseases.

Regional Insights

North America led the global G-protein coupled receptors market in 2018 due to the strategic investments in cancer research, approval of GPCR-targeted drugs, and increased focus on drug discovery & development activities. In November 2017, 134 GPCR targets for drugs were approved in U.S. or European Union and 128 targets were listed in the FDA orange book. Asia Pacific is anticipated to be the fastest-growing regional market over the forecast years due to the presence of several emerging companies, such as Sosei Heptares, HD Biosciences Co., Ltd., and NB Health Laboratory. The number of growth initiatives undertaken by the companies to improve their market presence drives regional growth.

G-Protein Coupled Receptors Market Share Insights

Some key participants operating in the GPCRs market include Thermo Fisher Scientific, Inc.; Eurofins Scientific; QIAGEN; WuXi AppTec(HD Biosciences Co. Ltd); Promega Corporation; Abcam plc; Perkin Elmer Inc.(Cisbio Bioassays); Enzo Biochem Inc.; Merck KGaA; and Becton-Dickinson and Company.

Mergers, acquisitions, and licensing deals for the R&D activities are the key strategies undertaken by these companies to maintain their market presence. Moreover, they are integrating automation and innovative technologies with drug development screening procedures to improve their capabilities in therapeutic production.

Report Scope

Attribute

Details

Base year for estimation

2018

Actual estimates/Historical data

2015 - 2017

Forecast period

2019 - 2026

Market representation

Revenue in USD Million and CAGR from 2019 to 2026

Regional scope

North America, Europe, Asia Pacific, Latin America, and MEA

Country scope

U.S., Canada, Germany, U.K., China, India, Japan, Brazil, and South Africa

Report coverage

Revenue forecast, company share, competitive landscape, growth factors and trends

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Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2015 to 2026. For the purpose of this study, Grand View Research has segmented the global G-protein coupled receptors market report on the basis of product, assay type, application, and region:

  • Product Outlook (Revenue, USD Million, 2015 - 2026)

    • Cell Lines

    • Detection Kits

    • Cell Culture Reagents

    • Ligands

  • Assay Type Outlook (Revenue, USD Million, 2015 - 2026)

    • cAMP Functional Assays

    • Calcium Functional Assays

    • β-Arrestin Functional Assays

    • Radioligand Binding and GTPγS Functional Assays

    • Internalization Assays

    • Trafficking Assays

    • Other Assays

  • Application Outlook (Revenue, USD Million, 2015 - 2026)

    • Cancer Research

    • CNS Research

    • Metabolic Research

    • Cardiovascular Research

    • Respiratory Research

    • Inflammation Research

    • Other Application

  • Regional Outlook (Revenue, USD Million, 2015 - 2026)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

    • Asia Pacific

      • China

      • India

      • Japan

    • Latin America

      • Brazil

    • Middle East and Africa (MEA)

      • South Africa

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