Gene Synthesis Market Size, Share & Trends Analysis Report By Method (Solid-phase Synthesis, Chip-based Synthesis, PCR-based Enzyme Synthesis), By Service, By Application, By End-use, By Region, And Segment Forecasts, 2023 - 2030

Research Methodology

A three-pronged approach was followed for deducing the gene synthesis market estimates and forecasts. The process has three steps: information procurement, analysis, and validation. The whole process is cyclical, and steps repeat until the estimates are validated. The three steps are explained in detail below:

Information procurement: Information procurement is one of the most extensive and important stages in our research process, and quality data is critical for accurate analysis. We followed a multi-channel data collection process for gene synthesis market to gather the most reliable and current information possible.

• We buy access to paid databases such as Hoover’s and Factiva for company financials, industry information, white papers, industry journals, SME journals, and more.
• We tap into Grand View’s proprietary database of data points and insights from active and archived monitoring and reporting.
• We conduct primary research with industry experts through questionnaires and one-on-one phone interviews.
• We pull from reliable secondary sources such as white papers and government statistics, published by organizations like WHO, NGOs, World Bank, etc., Key Opinion Leaders (KoL) publications, company filings, investor documents, and more.
• We purchase and review investor analyst reports, broker reports, academic commentary, government quotes, and wealth management publications for insightful third-party perspectives.

Analysis: We mine the data collected to establish baselines for forecasting, identify trends and opportunities, gain insight into consumer demographics and drivers, and so much more. We utilized different methods of gene synthesis market data depending on the type of information we’re trying to uncover in our research.

• Market Research Efforts: Bottom-up Approach for estimating and forecasting demand size and opportunity, top-down Approach for new product forecasting and penetration, and combined approach of both Bottom-up and Top-down for full coverage analysis.

• Value-Chain-Based Sizing & Forecasting: Supply-side estimates for understanding potential revenue through competitive benchmarking, forecasting, and penetration modeling.

• Demand-side estimates for identifying parent and ancillary markets, segment modeling, and heuristic forecasting.

• Qualitative Functional Deployment (QFD) Modelling for market share assessment.

Market formulation and validation: We mine the data collected to establish baselines for forecasting, identify trends and opportunities, gain insight into consumer demographics and drivers, and so much more. We utilize different methods of data analysis depending on the type of information we’re trying to uncover in our research.

• Market Formulation: This step involves the finalization of market numbers. This step on an internal level is designed to manage outputs from the Data Analysis step.

• Data Normalization: The final market estimates and forecasts are then aligned and sent to industry experts, in-panel quality control managers for validation.

• This step also entails the finalization of the report scope and data representation pattern.

• Validation: The process entails multiple levels of validation. All these steps run in parallel, and the study is forwarded for publishing only if all three levels render validated results.

Gene Synthesis Market Categorization:

The gene synthesis market was categorized into four segments, namely method (Solid-phase Synthesis, Chip-based Synthesis, PCR-based Enzyme Synthesis), services (Antibody DNA Synthesis, Viral DNA Synthesis,), application (Gene & Cell Therapy Development, Vaccine Development, Disease Diagnosis), and regions (North America, Europe, Asia Pacific, Latin America, Middle East & Africa).

Segment Market Methodology:

The gene synthesis market was segmented into method, services, application, and regions. The demand at a segment level was deduced using a funnel method. Concepts like the TAM, SAM, SOM, etc., were put into practice to understand the demand. We at GVR deploy three methods to deduce market estimates and determine forecasts. These methods are explained below:

Market research approaches: Bottom-up

• Demand estimation of each product across countries/regions summed up to from the total market.

• Variable analysis for demand forecast.

• Demand estimation via analyzing paid database, and company financials either via annual reports or paid database.

• Primary interviews for data revalidation and insight collection.

Market research approaches: Top-down

• Used extensively for new product forecasting or analyzing penetration levels.

• Tool used invoice product flow and penetration models Use of regression multi-variant analysis for forecasting Involves extensive use of paid and public databases.

• Primary interviews and vendor-based primary research for variable impact analysis.

Market research approaches: Combined

• This is the most common method. We apply concepts from both the top-down and bottom-up approaches to arrive at a viable conclusion.

Regional Market Methodology:

The gene synthesis market was analyzed at a regional level. The globe was divided into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa, keeping in focus variables like consumption patterns, export-import regulations, consumer expectations, etc. These regions were further divided into twenty-three countries, namely, the U.S.; Canada; Germany; UK.; France; Italy; Spain; Denmark, Sweden, Norway, China; Japan; India; Australia; Thailand; South Korea, Brazil; Mexico; Argentina; South Africa; Saudi Arabia; UAE; Kuwait

All three above-mentioned market research methodologies were applied to arrive at regional-level conclusions. The regions were then summed up to form the global market.

Gene synthesis market companies & financials:

The gene synthesis market is analyzed via companies operating in the sector. Analyzing these companies and cross-referencing them to the demand equation helped us validate our assumptions and conclusions. Key market players analyzed include:

• GenScript -GenScript is involved in life sciences research & application services. The company has four major platforms: Contract Research Organization (CRO) platform, Contract Development and Manufacturing Organization (CDMO) platform, integrated global cell therapy platform, and industrial synthetic products platform. The cell therapy platform provides solutions for refractory diseases, such as inflammatory diseases and cancer. The industrial synthetic platform develops feed & food processing and other industrial products. The CDMO platform provides discovery and development services to various governments, pharmaceutical & biotech companies, and academic customers.

• GENEWIZ (Brooks Automation, Inc.)–GENEWIZ is one of the leading global providers of genomics R&D services. Key services offered by the company include clinical & GLP regulatory services, bioinformatics, next-generation sequencing, molecular biology, gene synthesis, and DNA sequencing. The company has a broad network of laboratories in the U.S. across Seattle, San Francisco, Los Angeles, San Diego, Washington, Boston, and Research Triangle Park, NC. In addition, the company has a global footprint across Japan (Tokyo), the UK (Takeley), and China (Guangzhou, Tianjin, Suzhou, & Beijing).

• ProteoGenix, Inc.- ProteoGenix, Inc. is a life sciences company that offers services in immunology and molecular biology. It is involved in polyclonal & monoclonal antibody development, gene & peptide synthesis, and recombinant protein purification & expression. Its product portfolio includes proteins, ELISA kits, tissue microarray, molecular biology products, and chimera RNAi.

• OriGene Technologies, Inc. - OriGene Technologies, Inc. is involved in the development of products for academic, pharmaceutical, and biotechnology research. The company’s product portfolio includes more than 35,000 human TrueORF cDNA clones and 40,000 human full-length TrueClone DNA cDNA collection. It had developed full-length proteins from MVPro proteins, which are expressed in mammalian cells from TrueORF cDNA clones. It has also initiated several projects, such as the TrueMAB project, which is involved in the development of mouse monoclonal antibodies against protein antigens.

• Integrated DNA Technologies, Inc. - Integrated DNA Technologies, Inc. develops, manufactures, and markets nucleic acid products in the areas of biotechnology, agriculture, pharmaceuticals, academic research, & medical diagnostics. The company has developed propriety technologies, such as next-generation sequencing, qPCR, RNA interference, and CRISPR genome editing. Its primary business is the production of custom oligonucleotides.

• ProMab Biotechnologies, Inc. - ProMab Biotechnologies, Inc. is involved in the development & manufacture of antibodies, engineered cell lines, and recombinant proteins by using immunology, microbiology, bioinformatics, protein expression, gene cloning, and molecular biology. The company aims to improve human health by focusing on the field of immunotherapy, especially T/NK technologies. Its specialties include antibody engineering, CAR T-cell products & services, bispecific antibodies, T-cell activation beads, peptide synthesis, CAR-NK cell products, and recombinant protein expression in mammalian, insect, & bacterial systems.

• Biomatix - Biomatix has a vast portfolio of products & services, which includes protein production, ELISA kits, antibody production, and antibody sequencing services. Its product portfolio includes more than 22,000 ELISA kits, 15,000 proteins, 300 biochemicals, and 26,000 antibodies. Services offered by the company include gene synthesis, peptide synthesis, antibody production, and protein expression. The company works in close association with R&D & production departments, and has more than 35 distributors around the world. It aims to provide customizable solutions and quality research products.

• Thermo Fisher Scientific, Inc. - Thermo Fisher Scientific, Inc. is a U.S.-based publicly held biotechnology company established after the collaboration of Thermo Electron and Fisher Scientific Company. Thermo Fisher provides products in life sciences, industrial & applied sciences, and clinical diagnostics. The company has operations in over 50 countries. Thermo Fisher offers products through the following brands: Applied Biosystems, Thermo Scientific, Invitrogen, Unity Lab Services, and Fisher Scientific.

• Twist Bioscience - Twist Bioscience works in the field of agriculture, industrial chemicals, medicine, and data storage using synthetic DNA tools. The company has developed a synthetic DNA manufacturing process based on a semiconductor. This process features a high throughput silicon platform that miniaturizes the chemistry required for DNA synthesis and enables the synthesis of 9,600 genes on a single silicon chip. The miniaturization has helped in increasing the throughput by a factor of 1,000 and reduction in the reaction volume by a factor of 1,000,000.

• Boster Biological Technology - Boster Biological Technology was established in 1993 in the U.S. The company specializes in antibody manufacturing of Western Blotting/Immunohistochemistry (WB/IHC) assays and highly sensitive & specific ELISA kits. The antibodies are validated by flow cytometry, WB, ELISA, and IHC. The company’s products and technologies have been cited in more than 29,000 publications. Its Picokine ELISA kits are highly sensitive and give a little background. The kits are validated against blood plasma, cell culture supernatants, and biologically relevant matrices. The company also offers a variety of services for the scientific community. The services include antigen production to antibody purification & validation, antigen design, custom assay development, CRO service for ELISA, WB, and IHC.

Value chain-based sizing & forecasting

Supply Side Estimates

• Company revenue estimation via referring to annual reports, investor presentations, and Hoover’s.

• Segment revenue determination via variable analysis and penetration modeling.

• Competitive benchmarking to identify market leaders and their collective revenue shares.

• Forecasting via analyzing commercialization rates, pipelines, market initiatives, distribution networks, etc.

Demand side estimates

• Identifying parent markets and ancillary markets

• Segment penetration analysis to obtain pertinent

• revenue/volume

• Heuristic forecasting with the help of subject matter experts

• Forecasting via variable analysis

Gene Synthesis Market Report Objectives:

• Understanding market dynamics (in terms of drivers, restraints, & opportunities) in the countries.

• Understanding trends & variables in the individual countries & their impact on growth and using analytical tools to provide high-level insights into the market dynamics and the associated growth pattern.

• Understanding market estimates and forecasts (with the base year as 2022, historic information from 2018 - 2021, and forecast from 2023 to 2030). Regional estimates & forecasts for each category are available and are summed up to form the global market estimates.

Gene Synthesis Market Report Assumptions:

• The report provides market value for the base year 2022 and a yearly forecast till 2030 in terms of revenue/volume or both. The market for each of the segment outlooks has been provided on region & country basis for the above-mentioned forecast period.

• The key industry dynamics, major technological trends, and application markets are evaluated to understand their impact on the demand for the forecast period. The growth rates were estimated using correlation, regression, and time-series analysis.

• We have used the bottom-up approach for market sizing, analyzing key regional markets, dynamics, & trends for various products and end-users. The total market has been estimated by integrating the country markets.

• All market estimates and forecasts have been validated through primary interviews with the key industry participants.

• Inflation has not been accounted for to estimate and forecast the market.

• Numbers may not add up due to rounding off.

• Europe consists of EU-8, Central & Eastern Europe, along with the Commonwealth of Independent States (CIS).

• Asia Pacific includes South Asia, East Asia, Southeast Asia, and Oceania (Australia & New Zealand).

• Latin America includes Central American countries and the South American continent

• Middle East includes Western Asia (as assigned by the UN Statistics Division) and the African continent.

Primary Research

GVR strives to procure the latest and unique information for reports directly from industry experts, which gives it a competitive edge. Quality is of utmost importance to us, therefore every year we focus on increasing our experts’ panel. Primary interviews are one of the critical steps in identifying recent market trends and scenarios. This process enables us to justify and validate our market estimates and forecasts to our clients. With more than 8,000 reports in our database, we have connected with some key opinion leaders across various domains, including healthcare, technology, consumer goods, and the chemical sector. Our process starts with identifying the right platform for a particular type of report, i.e., emails, LinkedIn, seminars, or telephonic conversation, as every report is unique and requires a differentiated approach.

We send out questionnaires to different experts from various regions/ countries, which is dependent on the following factors:

• Report/Market scope: If the market study is global, we send questionnaires to industry experts across various regions, including North America, Europe, Asia Pacific, Latin America, and MEA.

• Market Penetration: If the market is driven by technological advancements, population density, disease prevalence, or other factors, we identify experts and send out questionnaires based on region or country dominance.

The time to start receiving responses from industry experts varies based on how niche or well-penetrated the market is. Our reports include a detailed chapter on the KoL opinion section, which helps our clients understand the perspective of experts already in the market space.