GVR Report cover Idiopathic Pulmonary Fibrosis Treatment Market Size, Share & Trends Report

Idiopathic Pulmonary Fibrosis Treatment Market Size, Share & Trends Analysis Report By Drug Class (MAPK Inhibitors, Tyrosine Kinase Inhibitors, Autotaxin Inhibitors), By Region, And Segment Forecasts, 2019 - 2026

  • Report ID: GVR-3-68038-119-1
  • Number of Report Pages: 70
  • Format: PDF, Horizon Databook
  • Historical Range: 2014 - 2017
  • Forecast Period: 2019 - 2025 
  • Industry: Healthcare

Industry Insights

The global idiopathic pulmonary fibrosis treatment market size was valued at USD 2.00 billion in 2018 and is estimated to expand at a CAGR of 12.7% over the forecast period. Increasing prevalence of idiopathic pulmonary fibrosis (IPF) and increasing geriatric population are the key drivers of the market. Rising number of cigarette smoking people, leading to a high prevalence of IPF, is also projected to fuel the growth.

Aging is considered as the greatest risk factor for development. Hence, the fact that the global base of geriatric population is anticipated to grow over the forecast period and is expected to serve this market as a high impact rendering driver. According to the World Population Aging Report 2015 by United Nations, the number of elderly people aged 60 years and above is expected to grow by 56%, i.e., from 901 million in 2015 to 1.4 billion in 2030. In addition, the number of elderly people aged 80 and over is projected to triple by 2050 and will reach 434 million.

U.S. IPF treatment market

Increasing prevalence of IPF is anticipated to propel the market. According to the National Institutes of Health (NIH), nearly 30,000 to 40,000 new cases of IPF are diagnosed each year and 100,000 people are affected in the U.S. Furthermore, commercialization of novel drugs and surge in cigarette smoking population are some of the other key factors expected to boost the market growth over the forecast period.

The presence of a strong pipeline is likely to have a positive impact on the IPF treatments market. For instance, GLPG1690, an autotaxin inhibitor is developed by Galapagos and is currently in phase III trials in the U.S. and Europe and is expected to be commercialized in 2022. Moreover, there are nearly 20 drugs in phase II clinical trials with a novel mechanism of action. The new approaches to treatment include combination therapy and third-line therapy in patients who have failed Ofev and Esbriet.

Drug Class Insights

On the basis of drug class, the idiopathic pulmonary fibrosis treatment market is segmented into MAPK inhibitors, tyrosine kinase inhibitors, and autotaxin inhibitors. Esbriet (MAPK Inhibitor) by F. Hoffman La Roche and Ofev (Tyrosine Kinase Inhibitor) by Boehringer Ingelheim International GmbH are the only drugs approved by the Food and Drug Administration (FDA) for the treatment of IPF. Both these drugs slow down the rate of functional decline in patients with IPF.

MAPK Inhibitors (Esbriet) led the market in 2018 and is estimated to expand at a CAGR of 8.9% over the forecast period. Esbriet will have first mover advantage for years as it was the first drug approved in 2011 in Europe for treating mild to moderate IPF and in 2014 in the U.S. for IPF. The drug has a well-established safety profile and expected to gain high market share due to patients switching from off label and non-pharmacological therapies.

Tyrosine Kinase Inhibitors (OFEV) is expected to expand at a lucrative CAGR over the forecast period. OFEV was designated as a breakthrough therapy and was granted fast track, priority review by the FDA. The drug has gained maximum share in the U.S., whereas usage in Europe and Japan continues to be much lower due to Esbriet’s first mover advantage.

Regional Insights

North America led the IPF treatments market in 2018 owing to high market penetration and increasing prices of the drugs. The market is growing rapidly due to accelerated approvals of two drugs in the U.S. in 2014. Moreover, the increasing prevalence of IPF is one of the major factors anticipated to boost the market.

Manufacturers offer various programs to improve access among patients. For instance, F. Hoffman La-Roche, Ltd (Genentech) offer Genentech Access to Care Foundation and Esbriet Co-Pay Card Program that covers the out of pocket expenses and provides Esbriet free of charge for certain household income thresholds. Boehringer Ingelheim offers similar free access and co-pay assistance programs.

Global IPF treatment market

Europe was estimated to be the second-largest market in 2018 owing to the increasing prevalence of IPF. For instance, according to the European Idiopathic Pulmonary Fibrosis Foundation, 30,000 to 35,000 new cases of IPF are diagnosed every year. Moreover, between 80,000 to 111,000 people are living with IPF in Europe. The average life expectancy of patients diagnosed with IPF is 2-5 years.

Idiopathic Pulmonary Fibrosis Treatment Market Share Insights

Some of the key market players are F. Hoffman La-Roche Ltd; Boehringer Ingelheim International GmbH; Galapagos; FibroGen, Inc.; Prometic Life Sciences Inc.; Bristol-Myers Squibb Company; MediciNova, Inc.; Merck & Co., Inc.; Novartis AG; and Merck & Co.

Major players undertake strategies such as acquisitions, new product development, and product enhancement to gain market share. For instance, in September 2017, F. Hoffman-La Roche Ltd announced positive results of a six-month study that combined Esbriet and Nintedanib. The study showed a similar safety profile for the combination of two drugs to that expected for each drug alone.

Report Scope



Base year for estimation


Actual estimates/Historical data

2014 - 2017

Forecast period

2019 - 2026

Market representation

Revenue in USD Million & CAGR from 2018 to 2026

Regional scope

North America, Europe, Asia Pacific, Latin America & MEA

Country scope

U.S., Canada, U.K., Germany, Spain, Italy, France, Japan, China, Brazil, Argentina, South Africa

Report coverage

Revenue forecast, company share, competitive landscape, growth factors and trends

15% free customization scope (equivalent to 5 analyst working days)

If you need specific information, which is not currently within the scope of the report, we will provide it to you as a part of customization

Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest market trends in each of the sub-segments from 2014 to 2026. For the purpose of this study, Grand View Research has segmented the idiopathic pulmonary fibrosis treatment market on the basis of drug class and region:

  • Drug Class Outlook (Revenue, USD Million, 2014 - 2026)

    • MAPK Inhibitors

      • Esbriet

    • Tyrosine Inhibitors

      • Ofev

    • Autotaxin Inhibitors

      • GLPG 1690

  • Regional Outlook (Revenue, USD Million, 2014 - 2026)

    • North America

      • The U.S.

      • Canada

    • Europe

      • Germany

      • The U.K.

      • France

      • Italy

      • Spain

    • Asia Pacific

      • China

      • Japan

    • Latin America

      • Brazil

      • Argentina

    • MEA

      • South Africa

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