GVR Report cover Isothermal Nucleic Acid Amplification Technology Market Size, Share & Trends Report

Isothermal Nucleic Acid Amplification Technology Market Size, Share & Trends Analysis Report By Product, By Technology (NASBA, HDA, LAMP, SDA, SPIA, NEAR, TMA, RCA, RPA, SMAP2), And Segment Forecasts, 2018 - 2025

  • Published Date: Aug, 2017
  • Base Year for Estimate: 2016
  • Report ID: GVR-1-68038-588-5
  • Format: Electronic (PDF)
  • Historical Data: 2014 - 2016
  • Number of Pages: 150

Industry Insights

The global Isothermal Nucleic Acid Amplification Technology market size was valued at USD 1.6 billion in 2016. Increasing demand for INAAT as a molecular testing technique and the rising prevalence of infectious diseases is expected to drive the market over the forecast period.

According to NCBI, there are over 9.5 million deaths due to infectious diseases every year, of which the majority occur in developing nations. Respiratory viral infections, diarrhea, and pneumonia are some of the leading causes of mortality, mostly in infants. The rise in the aging population across the globe and the increase in the adoption of INAAT over other molecular diagnostic techniques are few key factors driving the market. Furthermore, increasing demand for user-friendly, rapid, and disease-specific kits is also anticipated to boost the adoption of this technology.

Global INAAT market

INAAT is widely used in the U.S., primarily for diagnosis of infectious diseases such as HIV-AIDS, H. influenzae, S. pneumonia (respiratory tract infections), N. gonorrhoeae, C. trachomatis (genital infections), and TB. According to the CDC, over 2.8 million new cases of chlamydia occur in the U.S. each year and more than 2% of the young population already suffers from the infection.

Continuous improvements in existing amplification products along with the introduction of new technologies such as Strand Displacement Amplification (SDA), Single Primer Isothermal Amplification (SPIA), & Recombinase Polymerase Amplification (RPA), and changing regulatory scenarios for the same are expected to boost the market. The SMART2 technique is one of the major technological advancements from 2010 to 2013. There is an increase in the number of strategic partnerships between companies that manufacture kits and manufacturers of isothermal NAAT diagnostics for the development of novel techniques, and this is likely to boost the growth of this segment.

Product Insights

The products segment comprises of instruments and reagents. The reagents segment held the largest share in 2016 owing to extensive usage in hospitals and primary healthcare settings, and are also expected to witness substantial growth over the forecast period.

Consumables and reagents are used more extensively as compared to instruments and witness regular demand owing to increasing R&D. However, the instruments segment is expected to grow at a significant rate due to the introduction of devices that are advanced in terms of accuracy, speed, and portability.

Technology Insights

Some of the technologies in the market include SPIA, SDA, Nucleic Acid Sequence Based Amplification (NASBA), Helicase-Dependent Amplification (HDA), Loop-Mediated Isothermal Amplification (LAMP), and Transcription-Mediated Amplification (TMA). Global demand for INAAT has increased due to rising awareness among customers. TMA was the largest revenue-generating technology segment in the diagnostic market in 2016, as it is the first INAAT introduced in the market. It was developed by Hologic (Gen probe).

The increasing population suffering from cancer and infectious diseases has boosted demand for low-cost diagnostics such as INAAT. Other amplification technologies such as Polymerase Chain Reaction (PCR) are not able to fulfill the need for low-cost diagnosis. Novel technologies, which include LAMP and HDA, are anticipated to exhibit steady growth over the forecast period. Non-PCR technologies such as INAAT are gaining significance due to customization features offered by them.

Global Isothermal Nucleic Acid Amplification Technology (INAAT) market

Application Insights

Isothermal amplification is mostly used for the detection of infectious diseases. This, along with the introduction of more specific kits, increasing incidence of diseases such as HIV, hepatitis A & B, & STDs that include chlamydia and gonorrhea are key factors expected to drive the isothermal nucleic acid amplification technology market. Moreover, the increasing need for rapid testing for the detection of infectious diseases to prevent them from spreading, especially in low-income countries, is expected to propel growth.

Blood screening is also an important application segment owing to the increasing number of blood transfusions across the globe. INAAT is widely used for screening of transfused blood for infectious organisms to limit their dissemination and prevent epidemics. Several companies have been undertaking extensive R&D for the usage of INAAT in the detection of cancer-specific molecular biomarkers and the development of drugs specific to these biomarkers.

End-Use Insights

Hospitals dominated the segment with the largest market share in 2016. Development of wireless communication and miniaturized point of care INAAT instruments aids hospital-based analysis by providing single-level access to diagnostic results throughout the hospital. Automation, a large number of samples for the detection of infectious diseases, and demand for accurate results are factors expected to boost dominance.

As per the end-user analysis, the reference labs segment is expected to exhibit growth due to an increasing number of reference laboratories and high adoption of novel & accurate molecular diagnostic techniques. Various public funding bodies such as CDC, NIH, as well as private investors, such as Wellcome Trust and Bill & Melinda Gates Foundation, encourage the development of advanced technologies for rapid analysis of specific infectious diseases.

Regional Insights

North America dominated the regional segment for the INAAT market with the highest revenue in 2016. Economies in the region, including the U.S. and Canada, have exhibited high growth owing to established research infrastructure and rising research initiatives. Growth in the isothermal diagnostics market can be attributed to growing demand and investments from foreign players, which has led to increased competitive rivalry.

The Asia Pacific is anticipated to be the fastest-growing region over the forecast period. China has witnessed rapid urbanization owing to strong economic growth. An increase in disposable income in developing economies, a large population, an increase in investments in healthcare facilities, and unmet clinical needs are factors anticipated to drive the adoption of INAAT devices. Demand for cost-effective diagnosis and preventive medicine is also expected to boost the market.

Isothermal Nucleic Acid Amplification Technology Market Share Insights

The INAAT market is highly competitive and concentrated. Some of the key players accounting for the largest share in 2016 are Alere, Inc.; bioMerieux SA; Eiken Chemical Co. Ltd.; Hologic, Inc. (Gen-Probe); Lucigen; QIAGEN; Quidel Corporation; Thermo Fisher Scientific; and Becton, Dickinson & Company.

Customized products and applications are expected to boost competitiveness. Players are likely to undertake mergers & acquisitions to diversify their product portfolios and gain market share.

Report Scope



Base year for estimation


Actual estimates/Historical data

2014 - 2016

Forecast period

2017 - 2025

Market representation                                      

Revenue in USD Million and CAGR from 2017 to 2025

Regional scope

North America, Europe, Asia Pacific, Central & South America, Middle East & Africa

Country scope

U.S., Canada, U.K., Germany, China, Japan, India, Brazil, Mexico, South Africa

Report coverage          

Revenue forecast, company share, competitive landscape, growth factors and trends

15% free customization scope (equivalent to 5 analyst working days)

If you need specific market information, which is not currently within the scope of the report, we will provide it to you as a part of customization

Segments Covered in the Report

This report forecasts revenue growth at global, regional & country levels and provides an analysis of the industry trends in each of the sub-segments from 2014 to 2025. For the purpose of this study, Grand View Research has segmented the global Isothermal Nucleic Acid Amplification Technology market on the basis of product, technology, application, end-use, and region:

  • By Product Outlook (Revenue, USD Million, 2014 - 2025)

    • Instrument

    • Reagent

  • By Technology Outlook, (Revenue, USD Million, 2014 - 2025)

    • NASBA

    • HDA

    • LAMP

    • SDA

    • SPIA

    • NEAR

    • TMA

    • RCA

    • RPA

    • SMAP2

    • Others

  • By Application Outlook (Revenue, USD Million, 2014 - 2025)

    • Blood screening

    • Infectious disease diagnostics

    • Cancer

    • Others

  • By End-use Outlook (Revenue, USD Million, 2014 - 2025)

    • Hospitals,

    • Central and reference labs

    • Others

  • Regional Outlook (Revenue, USD Million, 2014 - 2025)

    • North America

      • The U.S.

      • Canada

    • Europe

      • The U.K.

      • Germany

    • Asia Pacific

      • China

      • India

      • Japan

    • Central & South America

      • Brazil

      • Mexico

    • Middle East & Africa

      • South Africa

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