GVR Report cover Mixed Mode Chromatography Resin Market Size, Share & Trends Report

Mixed Mode Chromatography Resin Market Size, Share & Trends Analysis Report By Technique (Ion Exchange-Hydrophobic, Hydroxyapatite), By End-use (Pharmaceutical & Biotechnology), And Segment Forecasts, 2018 - 2025

  • Report ID: GVR-2-68038-543-4
  • Number of Pages: 79
  • Format: Electronic (PDF)

Report Overview

The global mixed-mode chromatography resin market size was valued at USD 75.4 million in 2017 and is anticipated to grow at a revenue-based compound annual growth rate (CAGR) of 7.1% from 2018 to 2025 on account of an increase in healthcare expenditure all around the world, coupled with rising use of mixed-mode resin for therapeutic drug treatment. The rise in the number of contract manufacturing organizations (CMOs) and contract research organizations (CROs) is also expected to drive the market from 2017 to 2025.

Mixed Mode Chromatography Resin Market size, by technique

Demand in the market has been on a rise thanks to ongoing developments in drug discovery processes by leading pharmaceutical companies, particularly to find a cure for widespread diseases such as Ebola, Zika, and H1N1. Big and established pharma and biopharma companies now outsource most biopharmaceutical drug discovery and development activities.

Chromatography helps companies develop and manufacture biological pharmaceutical tools to achieve safety and quality. Currently, chromatography is applied like a valued technique for purification, separation, and analysis of compounds present in complex mixtures and used in pharmaceutical, chemical, biochemistry, and environmental science.

The high cost of raw material, coupled with the need for a highly-skilled workforce to perform these techniques has resulted in increasing the overall cost of chromatography. This high cost compared to other separation techniques is expected to act as a restraint for the market over the forecast period.

Mixed Mode Chromatography Resin Market Trends

Biosimilars are the world's fastest-growing biologics market. Due to the expiration of patents in the market, many companies are encouraged to participate in biosimilars. One of the most important bio-separation techniques utilized in the production of biosimilar antibodies is chromatography. During the forecast period, rising demand for generic medicines is expected to increase the use of chromatographic resins. Other chronic diseases for which biosimilars are developed include meningitis, cancer, adult T-cell leukemia, obesity, hypertension, and influenza E. This factor is expected to drive market growth during the forecast period.

The COVID-19 pandemic has affected several industries and businesses experiencing losses as lockdowns were imposed and supply lines were interrupted. The market, on the other hand, had seen a rise in demand as a result of the pandemic. This is because one of the key applications of these resins is the generation of antibodies. This is being used by medicinal companies to create medicines that fight and lessen the severity of COVID-19 as well as other disorders in general.

The cost of raw materials has increased in parallel with the need for highly specialized workers, increasing the overall cost of chromatography. The higher cost compared to other separation processes is expected to hamper the market over the forecast period.

The key driver for the market is the increase in the number of manufacturing and research companies. The rise of drug discovery procedures by major pharmaceutical companies for diseases like Zika, Ebola, and H1N1 is also propelling the market forward. The development of biopharmaceutical drugs as a result of advances in pharmaceutical and biopharma is another opportunity for the market to flourish.

Technique Insights

The market is segmented by technique into ion exchange - hydrophobic and hydroxyapatite. Ion exchange - hydrophobic resin emerged as the dominant segment in the mixed-mode chromatography resin market in 2017 owing to rapid growth in drug discovery activities in developed as well as developing economies. The segment is also expected to grow at the fastest CAGR during the forecast period in terms of both revenue and volume.

End-use Insights

The use of chromatography in the pharmaceutical sector as per the U.S. FDA regulations is witnessing growth, which is favorably influencing the market. The European Medical Agency’s (EMA) initiative to ensure drug safety is likely to trigger the growth of the global market.

Increasing demand for therapeutic antibodies for the treatment of patients is also a major driver that is triggering industry growth. The trend of replacing conventional separation techniques such as filtration and distillation with chromatography has also driven innovation for the application of chromatography in various new segments.

Regional Insights

North America is expected to remain a key region in the global market, driven primarily by the U.S. The country has been enjoying robust growth due to strong government spending in research and development activities.

Mixed Mode Chromatography Resin Market Trends by Region

Demand in the Asia Pacific is expected to grow at an exponential rate. This development can be credited to many initiatives by Chinese and Indian governments to boost their biotechnology and pharmaceutical sectors. The Asia Pacific is anticipated to continue as the fastest-growing regional market during the forecast period.

High healthcare expenditure, increasing disposable in emerging economies, and high availability of cheap and skilled workforce is expected to boost the biotechnology sector in emerging economies of Asia Pacific, which will in turn propel the overall market.

Key Companies & Market Share Insights

GE Healthcare Lifesciences, Merck KGaA, Tosoh Corp, Purolite Corp, Danaher Corp, and Bio-Rad Labs are some of the major market players. In November 2015, Sigma-Aldrich was acquired by Merck KGaA and this allowed Merck to foray into the chromatography market. Extensive R&D in the global resin industry has driven the development of novel resin products that have better productivity compared to conventional resins.

Recent Developments

  • In September 2022, Purolite announced a strategic partnership with PharmNXT Biotech to bring its Praesto agarose-based Protein A and  Ion Exchange chromatography resins to South Korea and Singapore. The partnership will enhance the supply and distribution support of the Praesto range in South Korea.

  • In September 2022, Tosoh Bioscience LLC, a provider of chromatographic solutions, launched the Octave BIO Multi-Column Chromatography (MCC) system to develop pre-clinical processes. It has a unique modular design that can accommodate a wide range of resins.

  • In June 2022, Bio-Rad Laboratories, Inc. launched EconoFit Chromatography Column Packs to support screening experiments of resins. It provides a wide selection of resins prepacked with mixed-mode, cation, and anion resin columns allowing customers to select the optimal chemistry for different target molecules.

  • In June 2022, Tosoh Bioscience GmbH, a supplier of chromatographic solutions, announced the introduction of SkillPak 50 and 200 pre-packed columns. These columns are used for the development of antibody fragments, viruses, ADCs, monoclonal antibodies, and oligonucleotides.

Mixed Mode Chromatography Resin Market Report Scope

Report Attribute


Revenue forecast in 2025

USD 130.3 million by 2025

Growth Rate

7.1% from 2018 to 2025

Forecast period

2018 - 2025

Base year for estimation


Segments Covered

Technique, End-use, Regional

Key Companies Profiled

GE Healthcare Lifesciences, Merck KGaA, Tosoh Corp, Purolite Corp, Danaher Corp, and Bio-Rad Labs

Market representation

Volume in Thousand Liters; Revenue in USD Million, and CAGR from 2018 to 2025

Regional scope

North America, Europe, Asia Pacific

Country scope

U.S., U.K., Germany, France, China, India, Japan, South Korea.

Report coverage

Revenue forecast, competitive landscape, growth factors and trends

Pricing and purchase options

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Global Mixed Mode Chromatography Resin Market Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2014 to 2025. For this study, Grand View Research has segmented the global mixed-mode chromatography resin market report based on technique, end-use, and region:

Global Mixed Mode Chromatography Resin Market Segmentation

  • Technique Outlook (Volume, Thousand Liters; Revenue, USD Million, 2014 - 2025)

    • Ion exchange - Hydrophobic

    • Hydroxyapatite

    • Others

  • End-use Outlook (Volume, Thousand Liters; Revenue, USD Million, 2014 - 2025)

    • Pharmaceutical and Biotechnology

  • Regional Outlook (Volume, Thousand Liters; Revenue, USD Million, 2014 - 2025)

    • North America

      • The U.S.

    • Europe

      • U.K.

      • Germany

      • France

    • Asia Pacific

      • China

      • India

      • Japan

      • South Korea

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