Organ Preservation Market (2026 - 2033)

Organ Preservation Market Summary

The global organ preservation market size was valued at USD 291.2 million in 2025 and is projected to grow from USD 311.1 million in 2026 to USD 516.9 million by 2033, at a CAGR of 7.5% from 2026 to 2033. North America dominated the market, accounting for the largest global share of 45.3% in 2025. Market growth is driven by rising demand for organ transplants, technological advancements, an aging population, and proactive government initiatives. 

According to the U.S. Census Bureau, it is projected that 20% of the U.S. population will be aged 65 and older by 2024, leading to a higher incidence of age-related diseases necessitating organ transplants. This significant increase in the elderly population will intensify the demand for effective preservation solutions, particularly for kidney, liver, and heart transplants, as more elderly patients require these critical procedures. Government initiatives further bolster the organ preservation market by enhancing organ donation rates through awareness campaigns and funding. For instance, in February 2023, the Indian Express reported that the Brihanmumbai Municipal Corporation (BMC) allocated approximately USD 924 million to improve healthcare services and raise awareness of organ donation. Such governmental support is vital in driving the need for efficient preservation methods, particularly in emerging markets such as the Asia Pacific, where healthcare expenditures are rising. This convergence of factors is preparing the organ preservation industry for substantial growth in the coming years.

One of the major growth drivers for the market is the increasing adoption of advanced preservation technologies such as hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP). These technologies are increasingly preferred over traditional preservation methods because they help reduce ischemic injury, improve organ assessment, extend preservation time, and increase the utilization of marginal donor organs. The transition from static cold storage to dynamic machine perfusion systems is transforming transplant procedures globally and improving organ transport efficiency.

Advanced perfusion systems are especially gaining traction in heart, liver, and lung transplantation procedures, where maintaining organ functionality during transportation is critical. In 2024, TransMedics Group reported continued expansion in the clinical adoption of its Organ Care System (OCS) platforms for heart, lung, and liver transplantation across transplant centers in the U.S., highlighting the growing acceptance of portable organ perfusion technologies.

Growing government initiatives and organ donation awareness campaigns are also contributing significantly to market expansion. Several countries are strengthening organ donation infrastructure and implementing public awareness programs to reduce transplant waiting lists and improve donor organ availability. In the UK, NHS Blood and Transplant continues to promote nationwide organ donation campaigns and improve transplant logistics infrastructure to enhance donor organ utilization and reduce organ discard rates. Similarly, the U.S. government and United Network for Organ Sharing (UNOS) have expanded efforts focused on improving organ procurement efficiency and transplantation accessibility across the country.

The market is also benefiting from the increasing use of donation after circulatory death (DCD) organs and the growing focus on expanding the donor organ pool. Advanced preservation technologies are enabling transplant centers to successfully preserve and assess marginal donor organs that were previously considered unsuitable for transplantation. In 2025, Mayo Clinic highlighted ongoing advancements in ex vivo organ perfusion and donor organ rehabilitation technologies to improve preservation times and increase transplantation success rates for high-risk donor organs. Such developments are expected to improve donor organ utilization and support long-term market growth.

Market Dynamics

Organ preservation solutions and technologies are gaining significant traction as they enable transplant centers, hospitals, organ procurement organizations (OPOs), and healthcare providers to maintain organ viability, improve transplant success rates, and optimize patient outcomes through advanced preservation platforms. These solutions integrate technologies such as static cold storage systems, hypothermic machine perfusion, normothermic machine perfusion, oxygenated perfusion platforms, organ monitoring sensors, and digitally connected preservation management systems to provide real-time control over temperature regulation, oxygen delivery, metabolic support, perfusion parameters, and organ viability assessment. Organ preservation technologies help healthcare providers address the growing global demand for organ transplantation by extending preservation times, reducing ischemia-reperfusion injury, improving donor organ utilization rates, and enabling the transportation of organs across greater geographic distances. Furthermore, the increasing adoption of ex vivo organ perfusion systems, advancements in preservation solutions, expansion of transplant infrastructure, and growing focus on improving graft survival and post-transplant outcomes are accelerating the integration of next-generation organ preservation technologies across the global transplant ecosystem.

Market Concentration & Characteristics

The organ preservation market is moderately consolidated, with major companies such as XVIVO, TransMedics, Paragonix Technologies, and Bridge to Life holding significant market shares. These companies offer advanced organ preservation technologies, including hypothermic machine perfusion systems, normothermic perfusion devices, organ transport solutions, and preservation fluids designed to improve organ viability and transplantation outcomes. Their product portfolios support the preservation and transportation of kidneys, livers, hearts, lungs, and other organs, helping healthcare providers reduce organ wastage, extend preservation time, and improve transplant success rates and patient outcomes.

The industry is witnessing a high degree of innovation driven by the growing demand for advanced organ transport and perfusion technologies that improve organ viability, extend preservation time, and enhance transplant success rates. Companies are also integrating advanced sensors, automated monitoring systems, and data-driven preservation platforms to support safer and more efficient organ transportation during transplantation procedures. For instance, in September 2025, OrganOx received FDA approval to operate its metra liver perfusion system during air transport, enabling improved long-distance donor liver transport and expanding access to transplant procedures.

The market is witnessing a significant rise in partnerships and collaborations as medical device companies, transplant centers, healthcare organizations, and research institutes work together to accelerate innovation and improve organ transplantation outcomes. Strategic collaborations are increasingly focused on expanding access to advanced machine perfusion technologies, improving organ transport systems, strengthening clinical research programs, and enhancing the efficiency of organ preservation during transplantation procedures. For instance, in July 2025, XVIVO Perfusion collaborated with leading U.S. transplant centers through its PRESERVE CAP study to support continued clinical evaluation of its Heart Assist Transport device aimed at improving heart preservation and transportation outcomes.

The organ preservation market operates within a highly regulated framework governed by agencies such as the U.S. Food and Drug Administration, the European Medicines Agency, and other global healthcare authorities that focus on device safety, organ viability, sterility, transport conditions, clinical effectiveness, and transplant outcomes. Regulatory oversight has increased significantly due to the growing adoption of advanced machine perfusion systems, portable organ transport technologies, and oxygenated preservation devices used in organ transplantation procedures. Regulatory agencies are placing stronger emphasis on clinical validation, quality control, real-time monitoring capabilities, and safe transportation standards to improve transplant success rates and reduce organ wastage.

The organ preservation industry faces growing competition from alternative preservation approaches such as static cold storage solutions, emerging regenerative medicine technologies, bioengineered organs, and advanced ex-vivo organ support systems, which are increasingly being explored to improve transplant efficiency and reduce dependency on conventional preservation methods. Traditional cold storage techniques remain widely used due to their lower cost and simpler operational requirements, particularly in smaller healthcare facilities and developing regions. In addition, ongoing advancements in artificial organ development, organ regeneration research, and xenotransplantation technologies are creating potential alternatives to conventional donor organ preservation systems.

The industry is witnessing significant regional expansion as manufacturers and transplant technology providers strengthen their presence across emerging healthcare markets in Asia-Pacific, Latin America, the Middle East, and Eastern Europe to meet the growing demand for organ transplantation procedures. Rising cases of chronic diseases leading to organ failure, improvements in healthcare infrastructure, increased awareness of organ donation, and expanded transplant programs are encouraging companies to establish strategic partnerships, distribution networks, and clinical collaborations in high-growth regions. In addition, governments and healthcare organizations across developing countries are investing in advanced transplant facilities and modern organ-preservation technologies to improve transplant success rates and reduce organ waste.

Analyst Perspective

The global organ preservation market is driven by rising demand for organ transplantation, growing cases of end-stage organ failure, and the persistent shortage of donor organs. Increasing adoption of advanced preservation technologies is helping healthcare providers extend organ viability, improve graft quality, and enhance transplant outcomes. Technologies such as hypothermic and normothermic machine perfusion, oxygenated preservation systems, and real-time organ monitoring are gaining traction across hospitals, transplant centers, and organ procurement organizations. These innovations help reduce ischemia-reperfusion injury, extend preservation windows, improve organ assessment, and increase donor organ utilization and transplant success rates.

Solution Insights

Based on solution, the University of Wisconsin (UW) segment led the market with the largest revenue share of 36.0% in 2025. The growth is primarily attributed to the widespread clinical adoption of the UW solution for preserving critical organs, such as the liver, kidney, and pancreas, during transplantation procedures. UW solution has long been considered the gold standard in organ preservation owing to its superior ability to minimize cellular swelling, reduce ischemic injury, maintain intracellular balance, and extend organ viability during cold storage. Recent industry developments continue to reinforce the dominance of the UW solution segment. In October 2025, Bridge to Life received FDA 510(k) clearance for its multi-sourced Belzer UW and MPS organ preservation solutions with expanded labeling across all abdominal organs. This regulatory milestone strengthened the commercial adoption of UW-based preservation technologies and highlighted the increasing demand for reliable preservation systems in transplantation medicine.

The perfadex segment is expected to post the fastest CAGR of 8.4% over the forecast period, driven by the rising number of lung transplantation procedures and the growing demand for advanced lung-specific preservation solutions. Perfadex is a low-potassium dextran-based extracellular preservation solution specifically developed for donor lung flushing, cold storage, and transportation during transplantation. According to XVIVO Perfusion, PERFADEX Plus has been used in more than 90,000 lung transplantations globally and is utilized by over 90% of lung transplantation clinics worldwide. The company also introduced ready-to-use formulations pre-supplemented with calcium ions and THAM to simplify clinical preparation procedures and reduce operational errors during transplantation. These clinical advantages have supported the growing adoption of Perfadex across transplant centers globally.

Organ Insights

Based on organ type, the kidneys segment led the market with the largest revenue share of 34.5% in 2025. The growth is primarily due to the rising global burden of chronic kidney disease (CKD) and the increasing number of kidney transplantation procedures worldwide. Kidneys represent the most commonly transplanted organs globally, which has significantly increased the demand for effective organ preservation solutions, perfusion systems, and transportation technologies. The growing prevalence of diabetes, hypertension, obesity, and aging populations has substantially contributed to the rising incidence of end-stage renal disease (ESRD), thereby accelerating the need for kidney transplantation and associated preservation technologies. Recent technological advancements are further supporting segment expansion. In May 2024, Paragonix Technologies announced that its KidneyVault Portable Renal Perfusion System was successfully used in multiple donor kidney transports across the U.S. The device was developed to improve the temperature-controlled preservation and transportation of donor kidneys, reflecting the industry's growing focus on enhancing transplant outcomes through advanced preservation technologies.

The heart segment is expected to witness the fastest CAGR over the forecast period, driven by the rising prevalence of cardiovascular diseases and the growing number of heart transplant procedures globally. Rising incidences of heart failure, coronary artery disease, congenital heart disorders, and cardiomyopathies have significantly increased the demand for donor hearts and advanced preservation technologies. According to the World Health Organization (WHO), cardiovascular diseases remain the leading cause of death globally, accounting for nearly 17.9 million deaths annually, which continues to accelerate the need for heart transplantation and effective organ preservation systems. Recent clinical and commercial developments continue to support segment growth. In September 2024, TransMedics Group announced strong utilization growth of its Organ Care System (OCS) Heart platform across the U.S., supported by increasing adoption among transplant centers of extended-criteria donor heart preservation and DCD heart transplantation procedures. The OCS Heart system enables normothermic perfusion of donor hearts outside the body, helping clinicians assess organ function prior to transplantation and significantly improving transplant logistics.

Preservation Technique Insights

Based on preservation technique, the static cold storage segment led the market with the largest revenue share of 45.1% in 2025. Static cold storage is widely used to preserve kidneys, livers, hearts, and pancreases by reducing organ metabolism under hypothermic conditions, thereby slowing cellular degradation and minimizing ischemic injury. The technique remains highly preferred across transplant centers due to its cost-effectiveness, operational simplicity, ease of transportation, and established clinical reliability compared to more complex perfusion-based preservation methods. Static cold storage remains the most commonly used preservation approach, particularly in kidney and liver transplantation, because it allows safe preservation during clinically accepted transportation periods while requiring relatively limited infrastructure. In addition, the increasing demand for donor organ sharing across regions and countries has further strengthened the importance of reliable cold storage systems and preservation solutions.

The normothermic machine perfusion segment is anticipated to grow at a significant rate over the forecast period. Unlike traditional cold storage methods, normothermic machine perfusion preserves organs at near-physiological temperatures by continuously supplying oxygen and nutrients via circulating perfusate. This approach helps maintain normal cellular metabolism, enables functional assessment of donor organs prior to transplantation, and significantly reduces ischemia-reperfusion injury. These advantages are driving the growing clinical preference for NMP systems in liver, heart, kidney, and lung transplantation procedures. The rising shortage of donor organs and the increasing use of marginal or extended-criteria donor organs are major factors driving the demand for normothermic perfusion technologies. NMP systems enable clinicians to assess, repair, and preserve organs that may otherwise be discarded under conventional static cold-storage methods. The ability of normothermic perfusion systems to extend preservation time and improve post-transplant graft function is also encouraging wider adoption among transplant centers and healthcare institutions.

Regional Insights

North America dominated the organ preservation market with the largest revenue share of 45.3% in 2025. The growth of the market in the region is driven by the increasing number of organ transplant procedures, strong healthcare infrastructure, and rising awareness regarding organ donation. The presence of advanced transplant centers, favorable government support, and high adoption of advanced organ preservation technologies further support market growth. In addition, increasing investments by leading healthcare companies and research organizations in improving organ storage and transportation solutions are contributing to the expansion of the market. The U.S. remains the major contributor to regional growth due to the high demand for kidney, liver, heart, and lung transplantation procedures, along with the growing focus on reducing organ wastage and improving transplant success rates.

U.S. Organ Preservation Market Trends

The organ preservation market in the U.S. held the largest share in the North America region in 2025. With around 40,000 organ transplants conducted each year, advances in preservation technologies and robust public awareness campaigns significantly boost the demand for effective preservation solutions, ultimately ensuring improved outcomes for transplant recipients and enhancing the overall efficiency of the transplantation process.

Europe Organ Preservation Market Trends

Theorgan preservationindustry in Europeis being reshaped by the growing number of organ transplant procedures, increasing awareness about organ donation, and continuous advancements in preservation technologies. Countries are investing in advanced healthcare infrastructure and transplant programs to improve organ availability and transplantation success rates. The market is also benefiting from supportive government initiatives, rising research activities, and the adoption of modern organ preservation systems that help extend organ viability during storage and transportation. In addition, collaborations between hospitals, research institutes, and medical device companies are supporting innovation and improving overall transplant outcomes across the region.

The UK organ preservation industry is steadily growing due to the increasing number of organ transplant procedures, rising awareness about organ donation, and strong support from the healthcare system for transplant programs. The country has well-established transplant centers and advanced medical infrastructure, which support the adoption of modern organ preservation technologies. In addition, ongoing research activities, government initiatives to increase organ donation rates, and growing investments in healthcare innovation are driving market growth. The increasing focus on improving organ storage, transportation, and transplant success rates is further driving demand for advanced organ preservation solutions in the country.

The organ preservation industry in Germany is expected to grow in the forecast period. The country has experienced an increase in organ transplant procedures, bolstered by government initiatives that promote organ donation. Furthermore, advancements in preservation techniques are significantly enhancing the viability of donated organs, thereby improving transplantation outcomes.

Asia Pacific Organ Preservation Market Trends

Theorgan preservationindustry in the Asia Pacific is witnessing the rising number of organ failure cases, increasing demand for organ transplantation, and improving healthcare infrastructure across countries. Growing awareness regarding organ donation, supportive government initiatives, and increasing investments in advanced medical technologies are further supporting market expansion. In addition, the presence of a large patient population and the growing adoption of advanced organ preservation solutions by hospitals and transplant centers are helping improve transplant success rates and driving the overall growth of the regional market.

The China organ preservation industry is benefiting from the rapid expansion of healthcare infrastructure, the increasing number of organ transplant procedures, and the growing government support for organ donation programs. Rising cases of chronic diseases such as kidney and liver disorders are increasing the demand for organ transplantation and advanced preservation solutions. In addition, the country is witnessing higher investments in medical technology, research activities, and transplant facilities, which are supporting the adoption of modern organ preservation systems. Growing awareness about organ donation and the increasing focus on improving transplant success rates are further contributing to the growth of the market in China.

The organ preservation industry in India is expected to register the fastest growth in the Asia Pacific market over the forecast period. Government initiatives to enhance healthcare services and promote organ transplantation are pivotal in driving market growth. Moreover, improvements in preservation techniques are increasing the viability of organs during transport, effectively addressing the rising demand for successful transplant outcomes within the country.

Latin America Organ Preservation Market Trends

The organ preservationindustry in the Latin America is an emerging market and is expected to grow at a significant rate due to the increasing prevalence of chronic diseases leading to organ failure, rising demand for organ transplantation procedures, and improving healthcare infrastructure. Growing awareness about organ donation and increasing government efforts to strengthen transplant programs are also supporting market growth. In addition, rising investments in healthcare facilities, expanding access to advanced medical technologies, and the gradual adoption of modern organ preservation solutions by hospitals and transplant centers are contributing to the development of the market across the region.

The Brazil organ preservation industry is growing steadily, supported by the increasing number of organ transplant procedures, improving healthcare infrastructure, and rising awareness regarding organ donation. The country has one of the largest public transplant programs, which is driving the demand for effective organ preservation solutions to improve transplant success rates. In addition, growing government support, increasing investments in hospitals and transplant centers, and the adoption of advanced preservation technologies are contributing to market growth.

Middle East & Africa Organ Preservation Market Trends

Theorgan preservationindustry in the Middle East and Africais growing steadily, owing to the rising number of organ failure cases, increasing demand for organ transplantation procedures, and improving healthcare infrastructure across the region. The region is focusing on strengthening transplant services and expanding access to advanced healthcare technologies. In addition, growing awareness of organ donation, supportive government initiatives, and increased investments in hospitals and transplant centers are driving the adoption of advanced organ preservation solutions and supporting overall market growth in the region.

The Saudi Arabia organ preservation industry is experiencing notable growth, supported by the expansion of healthcare infrastructure, an increasing number of organ transplant procedures, and a strong government focus on improving healthcare services under national healthcare development programs. Rising awareness regarding organ donation and the growing prevalence of chronic diseases such as kidney and liver disorders are increasing the demand for advanced organ preservation solutions. In addition, investments in modern hospitals, transplant centers, and advanced medical technologies are helping improve organ storage and transportation capabilities, which further support the growth of the market in the country.

Key Organ Preservation Company Insights

The organ preservation market is highly competitive, with key players focusing on strengthening their market position through technological advancements, strategic collaborations, and global expansion initiatives. Companies are increasingly investing in advanced organ preservation technologies such as normothermic machine perfusion systems, portable organ transport devices, oxygenated perfusion solutions, and real-time organ monitoring platforms to improve organ viability, reduce ischemic injury, and enhance transplant success rates across organ transplantation procedures.

Key Organ Preservation Companies

The following key companies have been profiled for this study on the organ preservation market.

• XVIVO

• TransMedics, Inc.

• 21st Century Medicine

• Bridge to Life Ltd.

• Preservation Solutions, Inc.

• Global Transplant Solutions

• Organ Recovery Systems

• CryoLife, Inc. (Artivion, Inc)

• Paragonix Technologies, Inc (Getinge)

Competitive Benchmarking

Recent Development

• In September 2025, OrganOx received FDA approval for the operation of its metra liver perfusion system during air transport. This development is expected to improve long-distance donor liver transportation, expand access to transplant procedures, and enhance the efficiency of organ preservation during transit.

• In September 2025, Paragonix Technologies announced the successful use of its KidneyVault Portable Renal Perfusion System to preserve and transport a donor kidney for more than 46 hours before transplantation. The development highlighted the growing role of advanced hypothermic machine perfusion technologies in expanding donor organ utilization and improving transplant outcomes.

• In November 2024, XVIVO completed enrollment for the PRESERVE clinical trial, evaluating their heart technology’s safety and effectiveness, achieving this milestone five months ahead of schedule with 141 patients transplanted.

• In October 2024, Bridge to Life and ULS Coimbra announced a collaboration to enhance liver preservation for transplantation, launching case studies to highlight innovative procedures at ULS Coimbra’s liver transplant program.

Organ Preservation Market Report Scope

Global Organ Preservation Market Report Segmentation

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. Forthis study, Grand View Research has segmented the global organ preservation market report based on solution, organ, preservation technique, and region:

• Solution Outlook (Revenue, USD Million, 2021 - 2033)

  • University of Wisconsin (UW)

  • Custodiol HTK

  • Perfadex

  • Others

• Organ Type Outlook (Revenue, USD Million, 2021 - 2033)

  • Kidneys

  • Liver

  • Lung

  • Heart

  • Others

• Preservation Technique Outlook (Revenue, USD Million, 2021 - 2033)

  • Static Cold Storage

  • Hypothermic Machine Perfusion

  • Normothermic Machine Perfusion

  • Others

• Regional Outlook (Revenue, USD Million, 2021 - 2033)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • UK

    • Germany

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • Asia Pacific

    • Japan

    • China

    • India

    • Australia

    • South Korea

    • Thailand

  • Latin America

    • Brazil

    • Argentina

  • Middle East & Africa

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait

Research Methodology

The organ preservation market figures in this report are based on a proven research process that combines executive interviews with secondary research from proprietary databases, company filings, and recognized regulatory and institutional sources. Market size is built through value-chain sizing - reconciling supply-side and demand-side estimates - and triangulated with bottom-up and top-down approaches. Every estimate passes multiple levels of expert validation before publication, with each organ preservation segment quantified using the revenue-capture definitions in the table below.

Segment Definition

Estimation Model

Delivered Customizations

This report has been delivered with the following In-depth customizations