Single-cell sequencing methods offer the highest-resolution understanding of cellular heterogeneity. Due to their decreasing cost and rapid growth, these methods are widely accessible to researchers globally. These technologies facilitate the analysis of a large number of cells, making them potent tools to characterize rare cell types and improve understanding of various cell states. Moreover, single-cell application in biomedical sciences helps unravel disease outcomes and pathogenesis mechanisms.
The rapid growth in users, technologies, and applications of NGS and third-generation sequencing has been a key factor in introducing genomic analysis to the single-cell level. Furthermore, Cancer is progressively known as a single-cell disease, which means that studying the genome of single cells can deliver information inaccessible to traditional molecular assays. The single-cell analysis also permits the detection of circulating tumor cells (CTCs) in liquid biopsies. Another significant area for these technology is the preimplantation diagnostics of embryos created by IVF. This application is distinguished by small sample sizes, signifying the need for single-cell exactness. For instance, in October 2022, BioSkryb Genomics announced an agreement with Cooper Genomics to license BioSkryb’s patented genomic amplification technology. Cooper Genomics will use the technology by BioSkryb to improve their preimplantation genetic testing (PGT) abilities and allow clinicians and researchers to unlock deeper understandings of the genome to evaluate embryonic viability.
Another remarkable trend is the advent of multi-omics. This approach improves the data quality and efficiency through the study of multiple analytes concurrently, for instance, splitting samples, combined analysis, or altering one class of analytes into another. An example of such a multi-omics approach is the cellular indexing of epitopes and transcriptomes by sequencing (CITE-seq by Illumina). This method combines the sequencing and capturing of RNA inside the cell by using barcoded antibodies that interact with the epitopes on the cell surface.
The market is segmented on product type, application, end-user, and region. The product type segment includes single-cell genomics, single-cell transcriptomics, single-cell proteomics, and single-cell metabolomics. The application segment is further segmented into oncology, cell biology, neurology, and immunology. The end-user segment is further segmented into pharmaceutical & biotechnology companies, academic and research organizations, hospital and diagnostic laboratories, and others.
In the next years, the market is anticipated to grow rapidly. Several factors drive this growth:
The advent of high-throughput and automated platforms
Increasing need for studying heterogeneous cell systems
Growing demand for noninvasive tests in oncology
Upsurge in funding through the single-cell core facilities
Large-scale research initiatives
Additionally, in a rapidly growing field of research, single-cell omics are vital for those working in neuroscience, oncology, and immunology. Improvements in the sector have led to substantial scientific breakthroughs. For instance, in June 2021, Cellenion and SCIENION launched the cellenCHIP 384 for single-cell omics sample preparation. The cellenCHIP 384, with its nanowell format, options for customization, and accessory range, extends the automated abilities of the cellenONE for high throughput workflows and miniaturization. Furthermore, in October 2020, Mission Bio, Inc. launched Tapestri Single-cell Multi-omics Solution. The company is also partnering with BioLegend to develop antibody panels for single-cell protein detection with the novel device.
Pharmaceutical & Biotechnology Companies
Academic and Research Organizations
Hospital and Diagnostic Laboratories
North America (U.S., Canada),
Europe (UK, Germany, France, Italy, Spain, Denmark, Sweden, Norway)
Asia Pacific (Japan, China, India, Australia, Thailand, South Korea)
Latin America (Brazil, Mexico, Argentina),
Middle East & Africa (Saudi Africa, South Arabia, UAE, Kuwait)
Major companies operating in the market include 1Cellbio, 10x Genomics Inc.; Angle PLC; Aviva Biosciences; Illumina Inc; Bio-Rad Laboratories; Dolomite Bio; Hifibio and others.
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