Upstream Bioprocessing Market Size, Share & Trends Report

Upstream Bioprocessing Market Size, Share & Trends Analysis Report By Product, By Workflow (Media Preparation, Cell Culture, Cell Separation), By Use Type (Multi-Use, Single-Use), By Mode, By Region, And Segment Forecasts, 2023 - 2030

  • Report ID: GVR-3-68038-592-2
  • Number of Pages: 145
  • Format: Electronic (PDF)
  • Historical Range: 2018 - 2021
  • Industry: Healthcare

Research Methodology

A three-pronged approach was followed for deducing the upstream bioprocessing market estimates and forecasts. The process has three steps: information procurement, analysis, and validation. The whole process is cyclical, and steps repeat until the estimates are validated. The three steps are explained in detail below:

Information procurement: Information procurement is one of the most extensive and important stages in our research process, and quality data is critical for accurate analysis. We followed a multi-channel data collection process for upstream bioprocessing market to gather the most reliable and current information possible.

  • We buy access to paid databases such as Hoover’s and Factiva for company financials, industry information, white papers, industry journals, SME journals, and more.
  • We tap into Grand View’s proprietary database of data points and insights from active and archived monitoring and reporting.
  • We conduct primary research with industry experts through questionnaires and one-on-one phone interviews.
  • We pull from reliable secondary sources such as white papers and government statistics, published by organizations like WHO, NGOs, World Bank, etc., Key Opinion Leaders (KoL) publications, company filings, investor documents, and more.
  • We purchase and review investor analyst reports, broker reports, academic commentary, government quotes, and wealth management publications for insightful third-party perspectives.

Analysis: We mine the data collected to establish baselines for forecasting, identify trends and opportunities, gain insight into consumer demographics and drivers, and so much more. We utilized different methods of upstream bioprocessing market data depending on the type of information we’re trying to uncover in our research.

  • Market Research Efforts: Bottom-up Approach for estimating and forecasting demand size and opportunity, top-down Approach for new product forecasting and penetration, and combined approach of both Bottom-up and Top-down for full coverage analysis.

  • Value-Chain-Based Sizing & Forecasting: Supply-side estimates for understanding potential revenue through competitive benchmarking, forecasting, and penetration modeling.

  • Demand-side estimates for identifying parent and ancillary markets, segment modeling, and heuristic forecasting.

  • Qualitative Functional Deployment (QFD) Modelling for market share assessment.

Market formulation and validation: We mine the data collected to establish baselines for forecasting, identify trends and opportunities, gain insight into consumer demographics and drivers, and so much more. We utilize different methods of data analysis depending on the type of information we’re trying to uncover in our research.

  • Market Formulation: This step involves the finalization of market numbers. This step on an internal level is designed to manage outputs from the Data Analysis step.

  • Data Normalization: The final market estimates and forecasts are then aligned and sent to industry experts, in-panel quality control managers for validation.

  • This step also entails the finalization of the report scope and data representation pattern.

  • Validation: The process entails multiple levels of validation. All these steps run in parallel, and the study is forwarded for publishing only if all three levels render validated results.

Upstream Bioprocessing Market Categorization:

The upstream bioprocessing market was categorized into four segments, namely product (Bioreactors/Fermenters, Cell Culture Products, Filters,Bioreactors Accessories, Bags & Containers), workflow (Media Preparation, Cell Culture, Cell Separation), use type (Multi-use, Single-use), mode (In-house, Outsourced), and regions (North America, Europe, Asia Pacific, Latin America, Middle East & Africa).

Segment Market Methodology:

The upstream bioprocessing market was segmented into product, workflow, use type, mode, and regions. The demand at a segment level was deduced using a funnel method. Concepts like the TAM, SAM, SOM, etc., were put into practice to understand the demand. We at GVR deploy three methods to deduce market estimates and determine forecasts. These methods are explained below:

Market research approaches: Bottom-up

  • Demand estimation of each product across countries/regions summed up to from the total market.

  • Variable analysis for demand forecast.

  • Demand estimation via analyzing paid database, and company financials either via annual reports or paid database.

  • Primary interviews for data revalidation and insight collection.

Market research approaches: Top-down

  • Used extensively for new product forecasting or analyzing penetration levels.

  • Tool used invoice product flow and penetration models Use of regression multi-variant analysis for forecasting Involves extensive use of paid and public databases.

  • Primary interviews and vendor-based primary research for variable impact analysis.

Market research approaches: Combined

  • This is the most common method. We apply concepts from both the top-down and bottom-up approaches to arrive at a viable conclusion.

Regional Market Methodology:

The upstream bioprocessing market was analyzed at a regional level. The globe was divided into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa, keeping in focus variables like consumption patterns, export-import regulations, consumer expectations, etc. These regions were further divided into twenty-three countries, namely, the U.S.; Canada; UK.; Germany; France; Italy; Spain; Denmark; Sweden; Norway; Japan; China; India; Australia; South Korea; Thailand; Brazil; Mexico; Argentina; Saudi Arabia; South Africa; UAE; Kuwait

All three above-mentioned market research methodologies were applied to arrive at regional-level conclusions. The regions were then summed up to form the global market.

Upstream bioprocessing market companies & financials:

The upstream bioprocessing market was analyzed via companies operating in the sector. Analyzing these companies and cross-referencing them to the demand equation helped us validate our assumptions and conclusions. Key market players analyzed include:

  • GE Healthcare -GE Healthcare offers medical technologies and solutions to healthcare entities worldwide. Its specialties are cardiology, orthopedics, and ambulatory surgery centers. It offers products for bone health, EP recording, clinical parameters & accessories, computed tomography, advanced visualization, diagnostic cardiology, hemodynamic recording, metabolic health, patient monitoring, healthcare IT, mammography, interventional image-guided systems, life sciences, perioperative care, radiography & fluoroscopy, magnetic resonance imaging, molecular imaging, nuclear imaging agents, perinatal care, respiratory care, surgical imaging, and ultrasound. Its FlexFactory platform is a bioprocess platform that uses single-use technology for mAbs production.

  • Thermo Fisher Scientific, Inc. -Thermo Fisher Scientific, Inc. is a publicly held biotechnology company established after collaboration between Thermo Electron and Fisher Scientific. Thermo Fisher provides products in life science, industrial & applied science, and clinical diagnostics. The company has operations in over 50 countries. It offers products through the following brands: Unity Lab Services, Invitrogen, Thermo Scientific, Fisher Scientific, and Applied Biosystems.

  • Merck KGaA - Merck KGaA is a German multinational company that provides healthcare solutions and materials. It operates across three sectors: healthcare, life science, and performance materials. It has global operations, including North America, Europe, Asia, Latin America, Oceania, and Africa.

  • Corning, Inc. - Corning, Inc. is a publicly held company involved in delivering solutions for drug discovery and cell culture. This company has research centers located in North America, Europe, and Asia. It offers products for life sciences and pharmaceutical technologies. Its life sciences product portfolio covers bioprocess solutions, including single-use technology.

  • Sartorius AG -Sartorius AG offers products for pharmaceuticals and laboratory equipment. Sartorius Group companies operate under Sartorius AG. Its business is segmented into two divisions: bioprocess solutions and lab products & services. Its bioprocess solutions business offers products for process control, fluid management, media & buffers, bioreactors & fermentors, and configurable single-use system. Through its lab products & services business, it offers products for weighing, lab water purification, liquid handling filtration/purification, quality control, and cell cultivation.

  • Eppendorf AG - Eppendorf AG is a life sciences company involved in manufacture of consumables, instruments, and services for sample, liquid, and cell handling in laboratories worldwide. The company’s offerings include pipettes, automated pipetting systems, dispensers, centrifuges, mixers, spectrometers, DNA amplification equipment, ultra-low temperature freezers, fermenters, bioreactors, CO2 incubators, shakers, and cell manipulation systems. The consumables offered by the company include pipette tips, test tubes, microtiter plates, and single-use bioreactor vessels.

  • Danaher - Danaher’s diagnostic and life science businesses collectively offer products & solutions in disease treatment & life sciences research. Its life science companies are involved in developing products for clinical research facilities, government agencies, and academic institutions. It offers filtration, separation, and purification technologies for biopharmaceutical industry.

  • Boehringer Ingelheim International GmbH - Boehringer Ingelheim International GmbH is involved in R&D of medications for humans and animals. The company operates in various therapeutic areas of respiratory diseases, diseases of the central nervous system, cardiovascular diseases, metabolic diseases, oncological diseases, and viral diseases. Boehringer Ingelheim BioXcellence is a subsidiary of the parent group that provides contract manufacturing services to pharmaceutical and biotechnology companies. The company offers a portfolio of technologies for production of non-antibody scaffolds, antibodies, Fab fragments, recombinant proteins, and pDNA from either microbial fermentation systems or mammalian cell culture.

  • Applikon Biotechnology B.V. - Applikon Biotechnology B.V. is a privately held company, which designs and commercializes the bioreactor system for production of vaccines, biopharmaceuticals, nutraceuticals, antibodies, tissues, and biosimilars in the pharmaceutical industry. The company supports pharmaceutical and industrial microbiology industry for upstream procedures by incorporating scalable platforms. It provides bioreactors that range from small, mini-bioreactors to large-volume cultivation systems.

  • PBS Biotech, Inc. - PBS Biotech, Inc. is a privately held company that develops and supplies single-use bioreactors for biopharmaceutical companies. The company develops these systems with patented air and liquid mixing technology. It offers cost-effective single-use bioreactors to facilitate cell culture process ranging from R&D to clinical to cGMP production level. It serves different aspects of biopharmaceutical industry including cell therapies, therapeutic proteins, and vaccines. The company employs vertical wheel technology, single-use assembly, and embedded controller technology.

Value chain-based sizing & forecasting

Supply Side Estimates

  • Company revenue estimation via referring to annual reports, investor presentations, and Hoover’s.

  • Segment revenue determination via variable analysis and penetration modeling.

  • Competitive benchmarking to identify market leaders and their collective revenue shares.

  • Forecasting via analyzing commercialization rates, pipelines, market initiatives, distribution networks, etc.

Demand side estimates

  • Identifying parent markets and ancillary markets

  • Segment penetration analysis to obtain pertinent

  • revenue/volume

  • Heuristic forecasting with the help of subject matter experts

  • Forecasting via variable analysis

Upstream Bioprocessing Market Report Objectives:

  • Understanding market dynamics (in terms of drivers, restraints, & opportunities) in the countries.

  • Understanding trends & variables in the individual countries & their impact on growth and using analytical tools to provide high-level insights into the market dynamics and the associated growth pattern.

  • Understanding market estimates and forecasts (with the base year as 2022, historic information from 2018 to 2021, and forecast from 2023 to 2030). Regional estimates & forecasts for each category are available and are summed up to form the global market estimates.

Upstream Bioprocessing Market Report Assumptions:

  • The report provides market value for the base year 2022 and a yearly forecast till 2030 in terms of revenue/volume or both. The market for each of the segment outlooks has been provided on region & country basis for the above-mentioned forecast period.

  • The key industry dynamics, major technological trends, and application markets are evaluated to understand their impact on the demand for the forecast period. The growth rates were estimated using correlation, regression, and time-series analysis.

  • We have used the bottom-up approach for market sizing, analyzing key regional markets, dynamics, & trends for various products and end-users. The total market has been estimated by integrating the country markets.

  • All market estimates and forecasts have been validated through primary interviews with the key industry participants.

  • Inflation has not been accounted for to estimate and forecast the market.

  • Numbers may not add up due to rounding off.

  • Europe consists of EU-8, Central & Eastern Europe, along with the Commonwealth of Independent States (CIS).

  • Asia Pacific includes South Asia, East Asia, Southeast Asia, and Oceania (Australia & New Zealand).

  • Latin America includes Central American countries and the South American continent

  • Middle East includes Western Asia (as assigned by the UN Statistics Division) and the African continent.

Primary Research

GVR strives to procure the latest and unique information for reports directly from industry experts, which gives it a competitive edge. Quality is of utmost importance to us, therefore every year we focus on increasing our experts’ panel. Primary interviews are one of the critical steps in identifying recent market trends and scenarios. This process enables us to justify and validate our market estimates and forecasts to our clients. With more than 8,000 reports in our database, we have connected with some key opinion leaders across various domains, including healthcare, technology, consumer goods, and the chemical sector. Our process starts with identifying the right platform for a particular type of report, i.e., emails, LinkedIn, seminars, or telephonic conversation, as every report is unique and requires a differentiated approach.

We send out questionnaires to different experts from various regions/ countries, which is dependent on the following factors:

  • Report/Market scope: If the market study is global, we send questionnaires to industry experts across various regions, including North America, Europe, Asia Pacific, Latin America, and MEA.

  • Market Penetration: If the market is driven by technological advancements, population density, disease prevalence, or other factors, we identify experts and send out questionnaires based on region or country dominance.

The time to start receiving responses from industry experts varies based on how niche or well-penetrated the market is. Our reports include a detailed chapter on the KoL opinion section, which helps our clients understand the perspective of experts already in the market space.

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