Oligonucleotide Synthesis Market To Reach $10.86 Billion By 2033

Oligonucleotide Synthesis Market Growth & Trends

The global oligonucleotide synthesis market size is expected to reach USD 10.86 billion by 2033, registering a 14.95% from 2026 to 2033, according to a new report by Grand View Research, Inc. The strong pipeline of oligonucleotide therapeutics in clinical trials, advancements in gene editing technologies, and increasing R&D spending by biotechnology companies are some of the major factors driving the market growth.

Oligonucleotide therapeutics participants are present in the late stages of clinical trials and are expected to be approved & commercialized over the forecast period. Companies have increased investments to develop oligonucleotide-based therapeutics. In October 2023, GSK plc and Arrowhead Pharmaceuticals announced a contract with Janssen Pharmaceuticals, Inc. (Janssen), a Johnson & Johnson company, to assign GSK exclusive worldwide rights to develop and commercialize JNJ-3989. Janssen initially in-licensed JNJ-3989 (previously ARO-HBV) from Arrowhead in 2018. Similar initiatives by well-established pharmaceutical companies are anticipated to drive market growth over the forecast period.

Government bodies, such as the Centers for Medicaid & Medicare Services for labs, the Federal Trade Commission for marketing, and the FDA for kits & information, have played a key role in the success of genomics, as they have been involved in monitoring the safe, appropriate, and accurate application of genomics & genetic tests. International funding bodies, such as NIH and Wellcome Trust, are engaged in providing funds for genetic studies, which is expected to fuel genomic studies in developed and emerging economies.

In May 2021, the UK government announced a funding of USD 43.4 million (GBP 37 million) for genomics research and data-driven initiatives, delivered via the UK Functional Genomics Initiative and Genome UK Implementation Plan, which was started in September 2019. The Genome UK strategy will be implemented with the help of the Genomics England project, which will receive USD 19.9 million (GBP 17 million) to investigate the potential value of newborn sequencing.

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Oligonucleotide Synthesis Market Report Highlights

• In 2025, the oligonucleotide synthesis industry was primarily driven by the increasing adoption of molecular diagnostics and oligonucleotide therapeutics, with the services segment contributing the largest share of 38.03% to the total revenue.

• PCR primers led the oligonucleotide synthesis market in 2025 with a 20.58% share, driven by their use in sequencing, amplification, and advanced PCR techniques such as qPCR, RT-PCR, and digital PCR, which boosted demand for specialized designs and accurate gene expression analysis.

• In 2025, academic research institutes dominated the oligonucleotide synthesis market with a share of 44.48%, due to the applications of oligonucleotides in PCR, gene editing, mutagenesis, and diagnostics.

• North America led the oligonucleotide synthesis market in 2025 with the share of 40.37%.

Oligonucleotide Synthesis Market Segmentation

Grand View Research has segmented the global oligonucleotide synthesis market on the basis of product & service, application, end-use, and region:

Oligonucleotide Synthesis Product & Service Scope Outlook (Revenue, USD Million, 2021 - 2033)

• Oligonucleotides

  • Product type

    • DNA

      • Technology

        • Column-based

        • Array-based

    • RNA

      • Technology

        • Column-based

        • Array-based

      • Type

        • Short RNA Oligos (<65 nt)

        • Long RNA Oligos (>65 nt)

        • CRISPR (sgRNA)

• Equipment/Synthesizer

• Reagents

• Services

  • DNA

    • Custom Oligo Synthesis Services

      • 25 nmol

      • 50 nmol

      • 200 nmol

      • 1000 nmol

      • 10000 nmol

    • Modification Services

    • Purification Services

  • RNA

    • Custom Oligo Synthesis Services

      • 25 nmol

      • 100 nmol

      • 1000 nmol

      • 10000 nmol

    • Modification Services

    • Purification Services

Oligonucleotide Synthesis Application Outlook (Revenue, USD Million, 2021 - 2033)

• PCR Primers

• PCR Assays and Panels

• Sequencing

• DNA Microarrays

• Fluorescence In Situ Hybridization (FISH)

• Antisense Oligonucleotides

• Other Applications

Oligonucleotide Synthesis End Use Outlook (Revenue, USD Million, 2021 - 2033)

• Academic Research Institutes

• Diagnostic Laboratories

• Pharmaceutical and Biotechnology Companies

Oligonucleotide Synthesis Regional Outlook (Revenue, USD Million, 2021- 2033)

• North America

  • U.S.

  • Canada

  • Mexico

• Europe

  • Germany

  • UK

  • France

  • Italy

  • Spain

  • Denmark

  • Sweden

  • Norway

• Asia Pacific

  • China

  • India

  • Japan

  • South Korea

  • Australia

  • Thailand

• Latin America

  • Brazil

  • Argentina

• Middle East and Africa (MEA)

  • South Africa

  • Saudi Arabia

  • UAE

  • Kuwait

List of Key Players of Oligonucleotide Synthesis Market

• Thermo Fisher Scientific Inc.

• Merck KGaA

• Danaher

• Revvity Discovery Limited

• Agilent Technologies, Inc.

• Bio-Synthesis, Inc.

• Kaneka Eurogentec S.A.

• LGC Biosearch Technologies

• Biolegio

• Twist Bioscience