The U.S. liver cancer diagnostics market size is expected to reach USD 4.44 billion by 2033, exhibiting a CAGR of 3.74% from 2025 to 2033, according to a new report by Grand View Research, Inc. This growth is attributable to the increasing prevalence of liver cancer, rising prevalence of risk factors for liver cancer, and technological advancements. The significant prevalence of liver cancer in the country highlights the need for its prevention, detection, and treatment. For instance, liver and intrahepatic bile duct cancer accounted for 2.2% of all new cancer cases in 2022.
Moreover, the growing number of government programs and collaborative efforts to transform cancer prevention, detection, treatment, and research in the country through substantial investments, data-driven approaches, and nationwide collaborations are further expected to propel market growth. For instance, the Translational Liver Cancer (TLC) Consortium, established by the National Cancer Institute’s (NCI) Division of Cancer Prevention, aims to advance translational research specifically focused on improving surveillance, early detection, and risk stratification of liver cancer.
The Cancer Moonshot initiative initiated in February 2022 highlights the importance of collaborative efforts in advancing cancer research, treatment, and patient care. A significant investment of USD 240 million in the Cancer Moonshot supports new ways to prevent, detect, treat, and survive cancer. This funding is likely channeled through the Advanced Research Projects Agency for Health (ARPA-H) to researchers and innovators working on cancer-related projects. The investment includes initiatives such as developing tools for early cancer detection, innovative approaches for visualizing cancer cells during surgery, novel treatment methods like using bacteria to target cancer cells and designing devices for more effective tumor treatment.
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In terms of end-use, the hospitals and diagnostic laboratories segment dominated the market with the highest share of 49.26% in 2024. This high share is attributable to the significant presence of hospitals across the country.
Based on test type, Laboratory testing remains the largest contributor, accounting for 39.98% of revenue in 2024, supported by serum biomarker panels, immunoassays, and blood-based monitoring.
In Jan 2023, Amy Kim and her team from Johns Hopkins Medicine developed a new screening test for liver cancer, which uses urine to isolate complementary tumor DNA for cancer detection.
Grand View Research has segmented the U.S. liver cancer diagnostics market based on the test type, and end use
U.S. Liver Cancer Diagnostics Test type Outlook (Revenue, USD Million, 2021 - 2033)
Laboratory Tests
Biomarkers
Oncofetal and Glycoprotein Antigens
Enzymes and Isoenzymes
Growth Factors and Receptors
Molecular Markers
Pathological Biomarkers
Blood Tests
Imaging
Endoscopy
Biopsy
U.S. Liver Cancer Diagnostics End use Outlook (Revenue, USD Million, 2021 - 2033)
Hospitals & Diagnostic Laboratories
Academic & Research Institutes
Pharmaceutical & CRO Laboratories
List of Key Players in U.S. Liver Cancer Diagnostics Market
Abbott Laboratories
Thermo Fisher Scientific, Inc.
F. Hoffmann-La Roche Ltd.
Qiagen N.V.
Siemens Healthineers
Becton, Dickinson & Company
Illumina, Inc.
Epigenomics AG
Koninklijke Philips N.V.
Fujifilm Medical Systems U.S.A., Inc.
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