GVR Report cover Bone Grafts And Substitutes Market Size, Share & Trends Report

Bone Grafts And Substitutes Market Size, Share & Trends Analysis Report By Material Type (Allograft, Synthetic), By Application (Craniomaxillofacial, Dental, Foot & Ankle, Joint Reconstruction), By Region, And Segment Forecasts, 2023 - 2030

  • Report ID: GVR-1-68038-154-2
  • Number of Pages: 150
  • Format: Electronic (PDF)
  • Historical Range: 2017 - 2021
  • Industry: Healthcare

Report Overview

The global bone grafts and substitutes market size was valued at USD 2.80 billion in 2022 and is estimated to grow at a compound annual growth rate (CAGR) of 6.3% from 2023 to 2030. The increasing demand for synthetic substitutes and rising number of product approvals by various regulatory authorities are anticipated to fuel market growth during the forecast period. For instance, In July 2020, Baxter received U.S. FDA clearance for its Altapore Shape Bioactive Bone Graft. This expanded the company’s Altapore bone graft substitute lineup. Furthermore, various benefits and advantages from bone grafts and substitutes, such as biocompatibility, safety, and osteoconductivity to fractured bones, have propelled the adoption of these products in recent years.

U.S. bone grafts & substitutes market size and growth rate, 2023 - 2030

Increasing demand for developing biocompatible bone grafts to reduce adverse reactions is driving the market. Also, increasing use of synthetic grafts with Hydroxyapatite (HAp) and Tricalcium Phosphate (TCP), which has shown better biocompatibility as compared to others, is another factor facilitating the adoption of biocompatible bone grafts.

In addition, supportive regulatory framework, and growing efforts from market participants to develop new products with better bioactivity, biocompatibility, and suitable mechanical properties is further escalating market expansion. For instance, in October 2020, Graftys received Medical Device Single Audit Program (MDSAP) certification for its Sterile Calcium Phosphate Resorbable Bone Void Fillers and related delivery systems in Australia, Brazil, Canada, and the U.S. Similarly, in March 2022, Molecular Matrix, Inc. announced the commercial launch of Osteo-P Synthetic Bone Graft Substitute for use in the musculoskeletal system. This product is developed by using HCCP technology that is very beneficial in bone regeneration and repair.

Moreover, the rising adoption of minimally invasive procedures is further escalating the demand for bone grafts and substitutes. Surgeons are choosing minimally invasive procedures instead of open or traditional approaches owing to various benefits associated with MIS such as quick procedure, less recovery time, shorter hospital stays and less incisions. According to data from the American Academy of Orthopedic Surgeons (AAOS), the number of minimally invasive orthopedic procedures performed in the United States has been increasing steadily over the years. Some of the commonly performed minimally invasive orthopedic procedures in the U.S. are, arthroscopy, spine surgeries, fracture repair and joint replacement procedures. Thus, the rising number of MIS is anticipated to drive the market at significant pace.

The COVID-19 pandemic has had a significant impact on the market. Like many other industries, the bone grafts and substitutes market has experienced disruptions in supply chains, manufacturing, and distribution due to the pandemic. One of the major impacts of COVID-19 on market has been a decline in elective procedures. In order to conserve hospital resources and reduce the risk of COVID-19 transmission, many hospitals and clinics had postponed elective surgeries. This has led to a decrease in demand for grafts and substitutes, which are often used in elective procedures such as joint replacements.

In addition, the pandemic severely disrupted global supply chains, including those that produce the raw materials needed to manufacture bone grafts and substitutes. This has led to shortages of some products and increased costs for others. But, after the COVID-19 pandemic, the market has started to gain momentum and is anticipated to grow at a significant pace in the coming years.

Material Type Insights

The allograft segment held the largest revenue share of 57.3% in 2022 in the material type segment and is anticipated to witness robust growth opportunities during the forecast period. The allograft adoption is significantly increasing owing to its properties such as osteoconductivity, and immediate structural support. In addition, positive patient outcomes with allograft products and various recent launches of allografts have supported the segment expansion. Also, allografts do not require other surgery to harvest bone, which turns in rapid wound healing, lesser surgery time, and higher success rates. For instance, according to a study published by NCBI in February 2022, bone fusion with allograft showed a success rate between the range of 87% and 94.3%.

Global bone grafts & substitutes market share and size, 2022

The synthetic segment is projected to exhibit significant growth over the forecast period. The robust growth of the segment is owing to the products’ lesser risk of disease transmission, better biocompatibility, and better acceptance among patients when compared to allografts. The synthetic segment is further classified into ceramic, composite, polymers, and BMP. The segment is also expected to be driven by the rising burden of orthopedic disorders coupled with increasing demand for synthetic products in developed countries.

Application Insights

In the application segment, the spinal fusion sub-segment held the largest market share of about 60.31% in 2022. The increasing adoption of bone graft materials for spondylosyndesis and the rising geriatric population prone to a number of orthopedic ailments are responsible for the higher revenue share of the segment. The geriatric population is steadily increasing. According to the U.S. Census Bureau, in 2022, the country had a geriatric population of around 56 million, accounting for 16.9% of the country’s total population, and this number is projected to surpass 73.1 million in 2030. This indicates that more than one in five people will be of retirement age. Thus, the high number of elderly populations is fueling the demand for orthopedic solutions.

The rising adoption of grafts for dental procedures is likely to provide lucrative opportunities for the dental segment throughout the forecast period. The grafts are usually used as scaffolds and fillers in order to facilitate bone formation as well as to promote healing. The increasing acceptance of dental implant surgical procedures along with advanced techniques such as bone grafts and bone regeneration is projected to boost the market growth. Moreover, the rising success rates of dental implants is also resulting into the high demand for bone grafts & substitutes in the market.

Regional Insights

North America dominated the global market in 2022 with a share of 41.8% and is projected to be the leading revenue contributor during the forecast period. The rising geriatric population and increasing incidence of sports injuries & fatal accidents are among the key factors boosting the demand for bone grafts and substitutes in North America. In addition, the presence of well-established healthcare infrastructure, supportive reimbursement policies, and presence of large number of orthopedic surgeons performing surgeries with bone grafts are further fueling the adoption of such products in the region. For instance, according to Definitive Healthcare, LLC, U.S. currently has 24,350 orthopedic surgeons.

Bone Grafts & Substitutes Market Trends, by Region, 2023 - 2030

However, APAC is projected to exhibit a robust growth rate during the forecast period. the presence of a larger patient pool with a range of orthopedic conditions, and rising investments by market participants to expand their presence in the region are expected to drive the APAC market. For instance, in October 2021, CoreBone raised USD 3.7 million in investment for expanding its activity in China and commercializing bioactive bone graft material for orthopedic and dental treatments.

Key Companies & Market Share Insights

The industry is marked by the presence of various large and small business operators. It is competitive and dominated by participants such as Orthofix, Stryker, Nuvasive, Medtronic, DePuy Synthes, and Wright Medical, among others. Key players are emphasizing on executing innovative strategies like market penetration, mergers and acquisitions, partnerships, and distribution agreements to bolster their revenue. For instance, in In October 2021, the company announced the launch of AlloMend Extra Large Acellular Dermal Matrix, increasing its AlloMend product line. Some of the key players in the bone grafts & substitutes market include:  

  • AlloSource

  • DePuy Synthes (Johnson & Johnson)

  • Baxter

  • NuVasive, Inc.

  • Smith + Nephew

  • Medtronic

  • Orthofix Medical, Inc.

  • TBF

  • OST Laboratories

  • Zimmer Biomet

  • Geistlich Pharma AG

  • Stryker

  • Biobank

Bone Grafts And Substitutes Market Report Scope

Report Attributes


The market size value in 2023

USD 3.0 billion

The revenue forecast in 2030

USD 4.53 billion

Growth rate

CAGR of 6.3% from 2023 to 2030

Base year for estimation


Actual estimates/Historical data

2017 - 2021

Forecast period

2023 - 2030

Report updated

April 2023

Quantitative units

Revenue in USD million & CAGR from 2023 to 2030

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Material type, application

Regions covered

North America; Europe; Asia Pacific; Latin America; MEA

Country Scope

U.S.; Canada; UK; Germany; Italy; France; Spain; Denmark, Norway, Sweden, Japan; China; India; South Korea; Australia, Brazil; Mexico; Argentina, South Africa, Saudi Arabia, UAE, Kuwait

Key companies profiled

AlloSource; Baxter; DePuy Synthes; Medtronic; NuVasive, Inc.; Orthofix Medical, Inc.; Smith + Nephew; Stryker.; OST Laboratories; Zimmer Biomet; Geistlich Pharma AG; TBF; Biobank

Customization scope

Free report customization (equivalent up to 8 analysts’ working days) with purchase. Addition or alteration to country, regional & segment scope.

Pricing and purchase options

Avail customized purchase options to meet your exact research needs. Explore purchase options


Global Bone Grafts And Substitutes Market Report Segmentation

This report forecasts revenue growth at the regional & country level and provides an analysis of the latest trends and opportunities in each of the sub-segments from 2017 to 2030. For this study, Grand View Research has segmented the bone grafts and substitutes market on the basis of products and region:

Global Bone Grafts & Substitutes Market Report Segmentation

  • Material Type Outlook (Revenue, USD Million, 2017 - 2030)

    • Allograft

      • Demineralized Bone Matrix

      • Others

    • Synthetic

      • Ceramics

        • HAP

        • β-TCP

        • α-TCP

        • Bi-phasic Calcium Phosphates (BCP)

        • Others

      • Composites

      • Polymers

      • Bone Morphogenic Proteins (BMP)

  • Application Outlook (Revenue, USD Million, 2017 - 2030)

    • Craniomaxillofacial

    • Dental

    • Foot & Ankle

    • Joint Reconstruction

    • Long Bone

    • Spinal Fusion

  • Regional Outlook (Revenue, USD Million, 2017 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

      • France

      • Italy

      • Spain

      • Denmark

      • Sweden

      • Norway

    • Asia Pacific

      • China

      • India

      • Japan

      • South Korea

      • Australia

    • Latin America

      • Brazil

      • Mexico

      • Argentina

    • MEA

      • South Africa

      • Saudi Arabia

      • UAE

      • Kuwait

Frequently Asked Questions About This Report

gvr icn


gvr icn

This FREE sample includes market data points, ranging from trend analyses to market estimates & forecasts. See for yourself.

gvr icn


We can customize every report - free of charge - including purchasing stand-alone sections or country-level reports, as well as offer affordable discounts for start-ups & universities.

Contact us now to get our best pricing.

esomar icon

ESOMAR certified & member

D&B icon

Leading SME award by D&B

We are GDPR and CCPA compliant! Your transaction & personal information is safe and secure. For more details, please read our privacy policy.

great place to work icon