Controlled Release Drug Delivery Market Size, Share & Trends Analysis Report, By Technology (Targeted Delivery, Transdermal), By Release Mechanism, By Application, By Region, And Segment Forecasts, 2023 - 2030

Report Overview

The global control release drug delivery market size was valued at USD 49.46 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 10.6% from 2023 to 2030. Changing prescription pattern of physicians preferring controlled release drug delivery over conventional systems owing to the benefits such as high-therapeutic efficacy, better patient compliance, and reduced treatment cost are expected to contribute towards the growth of the market over the forecast period. Moreover, being a part of a highly competitive and fragmented market, pharmaceutical companies are pro-active with the changing market requirements and are continuously investing on developing controlled release drug delivery system, thereby significantly driving the demand.

Constantly rising R&D expenditure by pharmaceutical development companies that are focused on development of efficient therapy for chronic and non-communicable complications such as cancer, diabetes, and hypertension are expected to boost the market growth over the forecast period. For instance, Taris an R&D based biomedical company’s pipeline product TAR-200 (Gemcitabine) indicated for the treatment of bladder cancer includes a controlled release drug delivery system. Furthermore, it is expected that Johnson & Johnson will complete the acquisition of Taris Biomedical in 2020. It’s lead investigational product TAR-200 is reported to be one of the main reasons behind the acquisition.

Rising geriatric and pediatric population globally is one of the major factors contributing towards the market growth, largely due to the non-adherence to the medicine regimen as it is very common among these age-groups. Geriatric populations suffer from compromised physical, mental and biological functions that affect their medicine intake. Also, their body cannot tolerate high doses and harsh side-effects of drugs. Thus, the demand for controlled release drug delivery system is expected to grow with steeply rising patient population.

Controlled release drug delivery allows significant reduction in dose and dosage frequency, prevent abnormal fluctuations of plasma drug levels, improves efficacy, enhance patient compliance and achieve uniform drug effect of the administered drug. In comparison to traditional delivery systems, the control releases drug delivery systems achieve a prolonged therapeutic effect, delivering drug at the target site at a pre-determined that too at a predictable drug release kinetics. Thus, with several added benefits offered by the controlled release delivery system, their adoption is expected to increase at a notable rate over the forecast period.

Technology Insights

Targeted delivery held the largest market share of more than 23.72% in 2022 as a large number of market participants have a strong portfolio for the technology.

Targeted delivery offers preferred site of action and can aid in allowing drugs to be away from sites that might lead to drug toxicity. Since these systems provide increased bioavailability, targeted technologies provide localization of drug, which leads to improved absorption, reduced fluctuation in circulating drug levels, and low risk of side-effects it’s a commonly preferred drug delivery technology.

The rising demand to improve the shelf-life and achieve controlled drug release of highly complex and unstable molecules such as proteins, vitamins, and antioxidants is expected to foster the growth of the microencapsulation segment over the forecast period. For instance, vitamin A is characterized by poor water solubility and chemical stability, but when microencapsulated the shelf life of product increases, concomitantly helping in achieving controlled drug release.

Implantable systems provide improved efficiency, reduced side-effects, convenience, and ensure linear delivery of drugs over a specified period. Coacervates represent a novel class of drug delivery vehicles, developed as carriers of small molecule drugs and proteins. These include heparin-based coacervates holding synthetic polycations for controlled delivery of growth factor. With an increasing usage of these systems, they are anticipated to command considerable share in the control release drug delivery market in near future.    

Release Mechanism Insights

Feedback regulated drug delivery systems accounted for a large share of 26.84% in 2022 owing to their therapeutic efficiency in treatment of disorders such as diabetes. Additionally, with increasing R&D activities being conducted to exploit the potential of feedback regulated controlled drug delivery systems as antidotes is expected to aid to the market growth.

Chemically activated systems consist of pH activated, hydrolysis activated, and enzyme activated systems. The ability to respond promptly and specifically to the metabolite of interest that results in improved drug therapy is the factor driving the growth of the segment. For instance, optimum and controlled release of insulin is established in hyperglycemic patients using an enzyme activated release mechanism.

In recent past, chemically activated delivery systems have gaining tremendous popularity. Market players are also investing in the segment in order to strengthen their portfolio. For instance, LYRICA Pregabalin and QuilliChew ER chewable tablets, marketed by Pfizer, Inc., are chemically activated delivery systems that offer controlled release. The segment is projected to represent sizeable share in the controlled release drug delivery market throughout the forecast horizon. 

Application insights

The oral controlled segment accounted for the largest share of 2022 with share of 36.04% owing to its frequent usage and availability.  Metered dose inhaler is another lucrative segment that is expected to grow at a significant rate over the forecast period. Rising prevalence of respiratory disorders, frequent product and technological advancements are the factors expected to drive the growth of the segment in long run. For instance, Gofire Inc, a medical technology company introduced a metered dose inhaler in 2019, that features a unique dose completion alert signal assuring accurate dosing. Furthermore, Aradigm Corporation’s current product pipeline consists of three drugs for treatment of bronchiectasis, cystic fibrosis, and smoking cessation that make use of metered dose inhalers as they are a relatively easy way to administer drugs.

Injectables held a considerable share in the market in 2022 owing to a wide product diversity and usage in treatment of various diseases. Long acting injectables are preferred to conventional forms of delivery as they offer several advantages, including predictable drug release profile during a definite period of time, enhanced patient compliance, improved systemic availability of drugs, ease of application, and thus an overall reduction on medical costs incurred.

Regional Insights

In 2022, North America was the leading regional market in the global arena with 42.53% market share. Supportive government initiatives taken for the development of controlled release drug delivery and growing investments in R&D are expected to propel the market growth in the region. Besides this, presence of prominent market players is promoting the adoption of controlled release drug delivery systems. Increasing burden of chronic diseases such as cancer, diabetes, and cardiac disorders is aiding the market growth. Spiraling utilization of controlled release drug delivery systems for treatment of hypertension is one of the key trends escalating the growth of regional market.

Europe accounted for the second largest share in 2022 owing to increasing research and developmental activities and presence of major pharmaceutical companies in the region. With significant rise in patients suffering from chronic diseases such as cancer, diabetes, and COPD, the regional market is poised to tread along a healthy growth track over the coming years.

Asia Pacific is likely to witness the highest CAGR during the forecast period. The region has been gaining global attention due to increasing development in the pharmaceutical industry. Rapid expansion in the Indian and Chinese pharmaceutical industry is positively affecting the market in the region. Presence of large geriatric population in Japan is another major factor triggering product adoption.

Key Companies & Market Share Insights

Various companies make use of a wide range of technologies that ensure controlled release. Major pharmaceutical companies are also indulged in implementing controlled release to increase consumer base and product penetration. Thus, the market consists of various players facing intense competition from other players and new entrants.

In addition, key participants are indulged in mergers and acquisitions to expand their existing product portfolios. For instance, in January 2016, Capsugel announced completion of acquisition of Xcelience and Powdersize, which aided the company to expand its existing resources with respect to its dosage form solutions business segment.

Major players are also engaged in development of novel of controlled release drug delivery technologies. For instance, in October 2015, Capsugel announced launch of enTRinsic drug delivery technology that provides complete enteric protection along with targeted release into upper gastrointestinal tract for a variety of compounds.

The market is highly fragmented as several developers are engaged in development of drugs that cater to specific patient requirements. Key players of control release drug delivery market include:

• Orbis Biosciences, Inc.

• Merck and Co., Inc.

• Alkermes plc

• Johnson and Johnson

• Coating Place, Inc.

• Corium International, Inc.

• Depomed, Inc.

• Pfizer, Inc

• Aradigm Corporation

• Capsugel.

Controlled Release Drug Delivery Systems Market Report scope

Global Controlled Release Drug Delivery Market Report Segmentation

This report forecasts revenue growth at global, regional & country levels and provides an analysis on the industry trends in each of the sub-segments from 2018 to 2030. For the purpose of this study, Grand View Research has segmented the global controlled release drug delivery market on the basis of technology, release mechanism, application. and region:

• Technology Outlook (Revenue in USD Million, 2018 - 2030)

  • Wurster Technique

  • Coacervation

  • Micro Encapsulation

  • Implants

  • Transdermal

  • Targeted Delivery

  • Others (Microelectromechanical Technology, Liposomes)

• Release Mechanism Outlook (Revenue, USD Million, 2018 - 2030)

  • Polymer Based Systems

  • Micro Reservoir Partition Controlled Drug Delivery Systems

  • Feedback Regulated Drug Delivery Systems

  • Activation-modulated Drug Delivery Systems

    • Osmotic Pressure Activated

    • Hydrodynamic Pressure Activated

    • Vapor Pressure Activated

    • Mechanically Activated

    • Magnetically Activated

  • Chemically Activated

    • pH Activated

    • Hydrolysis Activated

    • Enzyme Activated

• Application Outlook (Revenue, USD Million; 2018 - 2030)

  • Metered Dose Inhalers

  • Injectable

  • Transdermal and Ocular Patches

  • Infusion Pumps

  • Oral Controlled-drug delivery Systems

  • Drug Eluting Stents

• Regional Outlook (Revenue, USD Million, 2018 - 2030)

  • North America

    • U.S.

    • Canada

  • Europe

    • Germany

    • UK

    • France

    • Italy

    • Spain

    • Netherland

    • Switzerland

    • Russia

    • Belgium

    • Sweden

  • Asia Pacific

    • China

    • Japan

    • India

    • Thailand

    • South Korea

    • Indonesia

    • Philippines

    • Vietnam

    • Singapore

    • Malaysia

  • Latin America

    • Brazil

    • Mexico

    • Argentina

    • Colombia

    • Chile

  • Middle East & Africa

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait

    • Israel