GVR Report cover Gastroesophageal Reflux Disease Therapeutics Market Size, Share & Trends Report

Gastroesophageal Reflux Disease Therapeutics Market Size, Share & Trends Analysis Report By Drug Type (Antacids, Proton Pump Inhibitors, H2 Receptor Blocker, Pro-Kinetic Agents), By Region, And Segment Forecasts, 2018 - 2025

  • Report ID: GVR-1-68038-778-0
  • Number of Pages: 80
  • Format: Electronic (PDF)
  • Historical Range: 2014 - 2016
  • Industry: Healthcare

Report Overview

The global Gastroesophageal Reflux Disease (GERD) therapeutics market size was valued at USD 5.66 billion in 2016 and is expected to witness a decline in its revenue to USD 4.34 billion by 2025, shrinking at a CAGR of 2.9%. Patent expiry of blockbuster drugs prescribed for the treatment of acid reflux disorders is majorly attributable for the downfall of this market.

U.S. GERD therapeutics market size

Rife with patent litigations and strong clinical pipelines, the market landscape continues to experience substantial changes. Proton pump inhibitors and histamine H2 receptor antagonists hold prominence in the current market scenario.

U.S. GERD therapeutics market, by drug type, 2014 - 2025 (USD Million)

Upon loss of patent protection of previously dominant branded drugs, low-priced generic molecules can consume up to 90% sales of branded molecules. Growing number of companies worldwide increasingly being subjected to price scrutiny coupled with shift in government focus on promoting consumer accessibility will engender further drug price reductions. Although expiry of major patents has affected the market turnover, the demand for acid-reducing drugs, owing to the rising incidence of heartburn across the globe, is expected to escalate in the coming years.

While GERD devices serve as an alternative approach to managing heartburn, these devices have struggled owing to their low success rates and failed clinical trials. Hence, limited acceptance of GERD management devices have contributed to the increasing demand for acid neutralizing drugs as the major therapy approach.

However, GERD devices for minimally invasive procedures to address underlying anatomical defects are steadily gaining traction with growing supportive clinical evidence for devices to perform procedures, such as transoral fundoplication, which prevent reflux of acid and non-acid contents altogether. To further reinforce its adoption in the U.S., a new CPT code (43210) was established to facilitate the reimbursement process in 2016.

Drug Type Insights

Antacids held the dominant market share in the year 2016 and are to retain their top position throughout the forecast period. Antacids are preferred as first-line therapy for mild and infrequent symptoms as they neutralize gastric acid secretions immediately. Convenient over-the-counter availability of antacids in various forms such as tablets, powders, and syrups is responsible for their excessive adoption. In addition, the American Hospital Formulary, among other countries, enlists over 120 antacid preparations to advocate their use.

PPIs accounted for the second largest segment in 2016 as they are the most commonly prescribed medication type for heartburn. Inflow of generics following the loss of exclusivity of popular drugs, including Nexium and Prilosec, has affected the sales of branded PPIs. A further decline is looming large with the awaited expiration of other patent-protected therapeutics, such as Dexilant.

Regional Insights

North America was identified as the largest regional segment in terms of market share for GERD therapeutics in the year 2016. In the U.S., every year, more than 80 million people experience GERD symptoms, of which, 25 million people suffer from heartburn or acid reflux daily and 60 million people on a monthly basis.

In addition, the number of outpatient clinic visits related to GERD in the U.S. has been increasing in the last few years stemming from the fact that the geriatric population is more prone to developing heartburn and acid reflux. Nearly 18% of the American population will be aged 65 and more by 2025.

On the other hand, the Asia Pacific region is projected to showcase the fastest growth rate over the forecast period. The rising geriatric population and lifestyle & dietary risk factors such as obesity & high fat diet, respectively, is expected to drive the market growth in this region. In developing countries, such as India and China, the trend of self treatment is rapidly growing due to the availability and affordability of OTC antacids.

Global GERD therapeutics market, by Region, 2016 (USD Million)

Global GERD therapeutics market share

Competitive Insights

A highly competitive generics-driven market is creating downward pressure on drug prices with lowered retail sales, which will engender stagnant growth in the coming years. The competition between the companies manufacturing these drugs ranges from medium to high. AstraZeneca PLC; Eisai Co., Ltd.; GlaxoSmithKline PLC; Takeda Pharmaceutical Co., Ltd.; and Johnson & Johnson account for the top players in the market. Moreover, Daewoong Pharmaceutical Co., Ltd.; Ironwood Pharmaceuticals, Inc.; SRS Pharmaceuticals Pvt. Ltd.; and SFJ Pharmaceuticals Group are some of the emerging companies in this industry.

Amongst others in this space, Ironwood Pharmaceuticals, Inc. and RaQualia Pharma, Inc. are focusing on developing new generic molecules involving existing and novel drug mechanisms as part of their strategy to invade the market. This space is also marked by numerous generic players vying to capture a larger market share through copycat versions to replace the expired blockbuster drugs.

Gastroesophageal Reflux Disease Therapeutics Market Report Scope

Report Attribute


Market size value in 2020

USD 4.6 billion

Revenue forecast in 2025

USD 3.2 billion

Growth Rate

CAGR of 2.3% from 2017 to 2025

Base year for estimation


Historical data

2014 - 2016

Forecast period

2017 - 2025

Quantitative units

Revenue in USD Million and CAGR from 2017 to 2025

Report coverage

Revenue forecast; company share; competitive landscape; growth factors and trends

Segments covered

Drug type, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S., Canada, UK, Germany, Japan, China, Brazil, South Africa

Key companies profiled

AstraZeneca PLC; Eisai Co., Ltd.; GlaxoSmithKline PLC; Takeda Pharmaceutical Co., Ltd.; and Johnson & Johnson.

Customization scope

Free report customization (equivalent up to 8 analysts working days) with purchase. Addition or alteration to country; regional & segment scope.

Pricing and purchase options

Avail customized purchase options to meet your exact research needs. Explore purchase options

Segments Covered in the Report

This report forecasts revenue growth and provides an analysis of the market trends in each of the sub-markets from 2014 to 2025. For the purpose of this study, Grand View Research has segmented the GERD therapeutics market on the basis of drug type and region:

  • Drug Type Outlook (Revenue, USD Million; 2014 - 2025)

    • Antacids

    • H2 Receptor Blockers

    • Proton Pump Inhibitors (PPIs)

    • Pro-kinetic agents

  • Regional Outlook (Revenue, USD Million; 2014 - 2025)

    • North America

      • U.S.

      • Canada

    • Europe

      • UK

      • Germany

    • Asia Pacific

      • Japan

      • China

    • Latin America

      • Brazil

    • MEA

      • South Africa

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