Gene Synthesis Market (2026 - 2033)

Gene Synthesis Market Summary

The global gene synthesis market size was valued at USD 2.7 billion in 2025 and is projected to grow from USD 3.1 billion in 2026 to USD 9.3 billion by 2033, growing at a CAGR of 16.7% from 2026 to 2033. North America dominated the market, accounting for the largest global share of 37.5% in 2025. The growth of the market is attributed to factors such as favorable government policies relating to synthetic biology. Investors have been more focused on synthetic biology research during the past few years.

Source: Grand View Research, IR Documents, Primary Interviews, Paid Databases

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The COVID-19 outbreak has benefited the gene synthesis market by creating significant growth opportunities. Researchers are exploring untapped possibilities in the gene synthesis field, which is helping to boost market growth in terms of revenue generation. For instance, researchers at the National Institute of Standards and Technology have developed synthetic SARS-CoV-2 gene fragments to assist researchers to develop accurate and reliable diagnostic tests for the disease. Synthetic DNA technological advancements are getting significant traction as a viable method to address concerns associated with the increasing number of emerging viruses and the potential threats of the next global pandemic. The SARS-CoV-2 pandemic along with pandemics involving other novel diseases in the near future can be rapidly addressed with the help of this promising technique to quickly replicate and analyze genes of interest.

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Targeted therapy has gained significant interest from the biotechnology and pharmaceutical industry and researchers. It has become an important technique of disease management. Targeted therapy in combination with immunotherapy and chemotherapy is anticipated to witness significant growth in the coming years. This would open up lucrative opportunities for both established and emerging players in the gene synthesis market.

The lack of skilled professionals in the field of gene synthesis and biotechnology is one of the main factors which could hinder the market growth, as the companies operating in this market would require trained and experienced staff at their facilities. Therefore, companies are entering into several strategic collaborations with universities to offer staff online workshops, on-site training, and sponsored projects to develop the right professionals. This would further help to drive the gene synthesis market growth.

Market Dynamics

The gene synthesis market is witnessing robust growth, driven by the increasing demand for synthetic genes in applications such as drug discovery, vaccine development, synthetic biology, and genetic engineering. Rising investments in genomics research, expanding adoption of personalized medicine, and growing use of gene synthesis in biopharmaceutical production are further supporting market growth. In addition, continuous advancements in DNA synthesis technologies, declining synthesis costs, and increasing research activities in cell and gene therapies are expected to support market expansion over the forecast period.

Analyst Perspective

The gene synthesis market is expected to witness strong growth, driven by increasing applications in synthetic biology, genetic engineering, vaccine development, and cell & gene therapy research. Rising demand for customized DNA constructs in drug discovery, protein engineering, and genomics research is accelerating the adoption of gene synthesis technologies. Technological advancements in DNA synthesis platforms, coupled with declining synthesis costs and growing investments in precision medicine and biotechnology research, are expected to support long-term market expansion. Market participants are focusing on automation, faster turnaround times, and high-fidelity synthesis solutions to strengthen their competitive position and address evolving research requirements.

Method Insights

Based on method, the solid-phase synthesis segment held the largest revenue share of over 35.1% in 2025. owing to the increasing adoption rate during the past few years. The segment held around 35.87% of the revenue share in 2022. This is a prominent technology for applications in several fields and for various research purposes, since it may be used to create modified & canonical polymers of nucleic acids, specifically RNA or DNA.

Most companies currently offering commercial services for gene synthesis utilize a solid-phase synthesis process, using various synthesis platforms made available by companies such as Agilent technology, Blue Heron Biotech, and Sloning BioTechnology, among others.

The PCR-based enzyme segment is expected to register the fastest CAGR during the forecast period. Certain factors such as its precision, ease of use, and reasonably priced technology are the factors estimated to accelerate segment growth by 2033. It is an effective method to produce the A+T-rich malaria genome.

Moreover, PCR-based gene synthesis provides a simple solution to the issue of producing significant amounts of labeled protein for NMR spectroscopy, when the gene encoding the protein is difficult or unavailable to express effectively. Thus, the aforementioned applications of this technique are contributing to segment growth.

Service Insights

Based on services, the antibody DNA synthesis segment held the largest revenue share of over 60.9% in 2025. The presence of several market players offering services for antibody DNA synthesis has contributed to the gene synthesis market dominance in 2022. Companies are providing services to research institutions and biotech/ pharma companies to allow cloning and synthesis of antibody chain sequences into any vector.

In April 2022, Twist Bioscience Corporation announced the launch of a high-throughput antibody production platform. Customers can convert digital DNA (dDNA) sequences into purified IgG antibodies using the antibody production workflow. In June 2022, Codex DNA, Inc. presented automated synthetic biology technologies to accelerate discovery workflows at the conference on antibody engineering and therapeutics in Europe.

Viral gene synthesis is projected to witness the fastest growth rate owing to the growing virus vector-related R&D activities. Furthermore, companies are involved in the synthesis of all structural and non-structural gene fragments or protein genes of the SARS-CoV-2. In February 2022, Eleven Therapeutics and Twist Bioscience Corporation developed a replicon tool, which can be used to examine viral genome replication and antiviral drug screening, along with therapeutic & vaccine development.

Application Insights

Based on application, the gene & cell therapy development segment held the largest revenue share of over 35.2% in 2025. This is anticipated to expand the advanced therapies pipeline for the treatment of chronic diseases. These therapies are gaining significant acceptance among therapy developers due to their efficiency in treating diseases that were not treatable using the traditional mode of treatment.

Several initiatives have been undertaken by biotechnology and pharmaceutical companies to promote cell and gene therapy treatments. In January 2022, Century Therapeutics entered into a collaboration with Bristol Myers Squibb Company to develop iPSC-derived allogeneic cell therapies.

Disease diagnosis is anticipated to witness the fastest growth rate in the coming years owing to the growing disease burden worldwide and a rising need for enhancement in medical diagnostics. Synthetic biology provides bio-molecular engineering strategies that can go beyond the limitations of traditional antibody-based diagnostics platforms, which are usually slow, expensive, and not appropriate for the testing of emerging pathogens or rare diseases.

Moreover, the increasing adoption of advanced techniques for driving scientific advancements, such as the production of designer cells that can employ synthetic gene circuits for surveying disease biomarkers and aiding in disease diagnosis, is also contributing to the segment’s growth.

End-use Insights

Based on end-use, the academic and government research institutes segment held the largest revenue share of over 54.4% in 2025, and it is expected to grow with the fastest CAGR over the forecast period. In 2022, the segment held around 54.30% share of revenue globally. The research institutes are entering into collaborations with service providers to speed up their research programs that require the characterization and synthesis of gene fragments.

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For instance, in February 2021, Medicines Manufacturing and Innovation Centre collaborated with Exactmer, Novartis, UK Research & Innovation, and AstraZeneca. This collaboration aims to develop a sustainable, scalable, and cost-effective manufacturing process for oligonucleotides.

Biotechnology and pharmaceutical companies are projected to witness significant growth in the coming years. Key players are also focusing on the development and launch of new platforms that can enhance the gene synthesis process. For instance, in August 2020, Codex DNA launched BioXp 3250 system for synthetic biology workflow. This platform aims to accelerate the development of new biologics and vaccines. It allows researchers to generate large DNA fragments of up to 7kb at high speed without compromising accuracy. These factors would further contribute to the segment’s growth.

Regional Insights

North America dominated the gene synthesis market with the largest revenue share of 37.5% in 2025. This can be attributed to the presence of several key market players offering gene synthesis services, increasing interest of major biotechnology & pharmaceutical companies in gene & cell therapy development, the expanding field of synthetic biology in the region, and increasing interest in gene synthesis in the molecular biology arena.

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Furthermore, the presence of a high number of contract research organizations (CROs) providing gene synthesis services is expected to increase revenue in the region. For instance, GenScript has established a significant presence across the North American region. It offers a broad range of services, including antibody drug development services and custom gene synthesis services

Asia Pacific is projected to witness the fastest growth rate during the forecast period due to increasing research activities for the development of effective therapeutics, coupled with increasing interest in synthetic biology research. In addition, there is a growing incidence of diseases due to lifestyle changes. Improving healthcare infrastructure, entry of large biotechnology organizations, and growing R&D activities are also expected to contribute to market growth.

Key Companies & Market Share Insights

Key players operating in the market are taking several strategic initiatives such as entering into collaborations, partnerships, and geographical expansions in favorable regions. Companies are introducing novel products to strengthen their product portfolio in the market. For instance, in March 2022, ProteoGenix launched XtenCHO Transient CHO Expression System.

This product simplifies recombinant protein production, further accelerating early-phase drug screening. Similarly, in February 2022, Integrated DNA Technologies, Inc. announced the introduction of Alt-R HDR Donor Blocks, which enables research professionals to edit the Homology-directed Repair (HDR) genome for developing treatments. Some of the prominent companies in the global gene synthesis market include:

Key Edge Analytics Companies

The following key companies have been profiled for this study on the gene synthesis market.

• GenScript

• Brooks Automation, Inc. (GENEWIZ)

• Boster Biological Technology

• Twist Bioscience

• ProteoGenix, Inc

• Biomatik

• ProMab Biotechnologies, Inc.

• Thermo Fisher Scientific, Inc.

• Integrated DNA Technologies, Inc.

• OriGene Technologies, Inc.

Global Gene Synthesis Market Segmentation

This report forecasts revenue growth at global, regional, and country levels along with provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global gene synthesis market report based on the method, service, application, end-use, and region:

• Method Outlook (Revenue, USD Million, 2021 - 2033)

  • Solid-phase Synthesis

  • Chip-based Synthesis

  • PCR-based Enzyme Synthesis

• Services Outlook (Revenue, USD Million, 2021 - 2033)

  • Antibody DNA Synthesis

  • Viral DNA Synthesis

  • Others

• Application Outlook (Revenue, USD Million, 2021 - 2033)

  • Gene & Cell Therapy Development

  • Vaccine Development

  • Disease Diagnosis

  • Others

• End-use Outlook (Revenue, USD Million, 2021 - 2033)

  • Biotechnology & Pharmaceutical Companies

  • Academic & Government Research Institutes

  • Contract Research Organizations

• Regional Outlook (Revenue, USD Million, 2021 - 2033)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • Germany

    • U.K.

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • Asia Pacific

    • China

    • India

    • Japan

    • South Korea

    • Australia

    • Thailand

  • Latin America

    • Brazil

    • Argentina

  • Middle East & Africa

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait

Research Methodology

The gene synthesis market figures in this report are based on a proven research process that combines executive interviews with secondary research from proprietary databases, company filings, and recognized regulatory and institutional sources. Market size is built through value-chain sizing-reconciling supply-side and demand-side estimates-and triangulated with bottom-up and top-down approaches. Every estimate passes multiple levels of expert validation before publication, with each gene synthesis segment quantified using the revenue-capture definitions in the table below.

Delivered Customizations

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