Kidney Preservation Market (2026 - 2033) Size, Share & Trends Analysis Report By Preservation Solution (University of Wisconsin Solution, Celsior Solution), By Technique (Static Cold Storage, Hypothermic Machine Perfusion), By Donor Type, By End Use, By Region, And Segment Forecasts

Kidney Preservation Market Summary

The global kidney preservation market size was valued at USD 66.6 million in 2025 and is projected to grow from USD 71.3 million in 2026 to USD 114.9 million by 2033, at a CAGR of 7.1% from 2026 to 2033. North America held the largest share of 37.3% of the global market in 2025. The growth is driven by multiple factors, including the increasing prevalence of chronic kidney disease (CKD) and end-stage renal disease (ESRD), rising demand for organ transplantation, and advancements in preservation technologies.

The growing number of patients awaiting kidney transplants is fueling the demand for effective preservation solutions. The aging global population further contributes to this demand, as kidney disease incidence rises with age, leading to a larger pool of potential transplant recipients. According to the World Health Organization (WHO), the global geriatric population is expected to increase from 1.2 billion in 2025 to around 2.1 billion in 2050. The growing awareness about kidney donation and transplantation is significantly influencing the kidney transplant organ preservation by expanding the donor pool and increasing transplant procedure volumes globally. Public health campaigns, media outreach, and advocacy by non-profits have contributed to increased understanding of the importance and safety of living and deceased kidney donation. For instance, in January 2024, a new campaign, "Make Your Mark," was launched to promote living kidney donation and save lives in the UK. The initiative, backed by Kidney Research UK, aimed to raise awareness about the benefits of living kidney donation and encouraged more people to consider donating. With over 7,000 people waiting for a kidney transplant in the UK, the campaign aimed to address the shortage of available kidneys. Such initiatives are expected to increase the kidney donation volumes over the forecast period. Hospitals and transplant centers are responding by adopting more reliable and advanced preservation technologies that ensure efficient organ viability during transport and storage.

The kidney transplant organ preservation is also driven by the rising global prevalence of chronic kidney disease (CKD), Stage Renal Disease (ESRD) and the subsequent increase in demand for kidney transplantation as the preferred treatment option for improved quality of life and survival rates compared to long-term dialysis. According to the American Kidney Fund, an estimated 35.5 million Americans have kidney disease, with about 815,000 living with kidney failure. Nearly 555,000 Americans are undergoing dialysis treatment. Moreover, the prevalence of kidney disease is on the rise, currently affecting more than 1 in 7 (or 14%) of American adults. Similarly, advancements in surgical techniques and immunosuppressive therapies have made transplantation a more viable and successful procedure, encouraging more patients and healthcare systems to choose kidney transplantation.

Below table indicates the cumulative annual kidney transplants in the U.S. (2018-2024):

Technological advancements and increased investment in the development of advanced kidney preservation technologies are also playing a crucial role in driving the kidney transplant organ preservation landscape. In February 2025, the National Kidney Foundation (NKF) Innovation Fund invested in NorthernLight, a medical device company, to advance next-generation kidney preservation technology. This investment aims to improve kidney transplantation outcomes by enhancing preservation techniques. NorthernLight's technology has the potential to increase the availability of transplantation of kidneys. The NKF Innovation Fund supports innovative solutions to improve kidney health and transplantation. Thus, the combination of technology, clinical utility, and financial backing is expected to drive innovation in the market, thereby fueling market growth.

Market Dynamics

Market Concentration & Characteristics

The industry exhibits notable concentration and is characterized by a growing demand for organ transplantation, driven by an increasing prevalence of chronic kidney disease. The market is also influenced by advancements in preservation technologies, such as hypothermic machine perfusion and normothermic machine perfusion.

The industry has witnessed a significant degree of innovation, driven by the increasing demand for improved transplant outcomes and extended organ viability. Traditionally reliant on static cold storage, the industry is transitioning toward more advanced methods such as hypothermic and normothermic machine perfusion. These technologies offer dynamic preservation environments that better mimic physiological conditions, significantly enhancing graft function and post-transplant outcomes. For instance, in January 2025, Paragonix Technologies announced the world's first in-human use of its KidneyVault renal perfusion system (FDA cleared in October 2024), a device designed to preserve kidneys for transplantation. The system aims to improve kidney preservation and reduce the risk of delayed graft function. According to the company, the KidneyVault system has shown promising results in maintaining kidney function during preservation.

The industry has witnessed a significant level of mergers and acquisitions (M&A) activity, driven by the need to consolidate technological capabilities and expand global market reach. Key players are acquiring firms with proprietary preservation solutions to strengthen their R&D pipelines and address the rising demand for viable donor kidneys. For instance, in August 2024, Getinge announced the acquisition of Paragonix to significantly enhance its global healthcare portfolio and address critical needs in solid organ transplantation. This strategic move aims to expand access to Paragonix's advanced organ preservation systems. Integration is expected to foster new innovations by combining organ containment and blood perfusion technologies, ultimately redefining market standards and improving patient outcomes worldwide.

Regulations play a crucial role in the industry, with a high level of impact across product development, clinical use, and market adoption. The regulatory oversight from agencies such as the FDA, EMA, and regional bodies is stringent owing to the industry’s reliance on biologically sensitive solutions and advanced preservation technologies. Moreover, compliance with Good Manufacturing Practices (GMP), ISO certifications, and post-market surveillance protocols adds to operational costs, significantly affecting smaller players. However, regulatory clarity can enhance innovation by establishing safety benchmarks.

The threat of substitutes is primarily from alternative organ preservation and transplant techniques, which could diminish the reliance on traditional static cold storage (SCS) and hypothermic machine perfusion (HMP) methods. One emerging substitute is normothermic machine perfusion (NMP), which mimics physiological conditions and offers extended preservation time, better assessment of organ viability, and potentially improved post-transplant outcomes. Additionally, advancements in regenerative medicine, such as bioengineered kidneys and xenotransplantation (e.g., genetically modified pig kidneys), can present long-term substitute threats. These alternatives, though currently in experimental or early clinical phases, could significantly reduce demand for conventional kidney preservation solutions.

The industry is undergoing significant regional expansion, driven by rising incidences of end-stage renal disease (ESRD), growing organ transplant programs, and advancements in preservation technologies. Moreover, the increasing awareness about kidney transplantation and organ donation in the emerging regions, owing to government-backed healthcare reforms and improved transplant logistics, is significantly driving market expansion. Additionally, regional partnerships and the entry of global players into these markets are enhancing access to advanced preservation solutions.

Preservation Solution Insights

The University of Wisconsin (UW) solution segment accounted for the largest market share of 75.3% in 2025, owing to its proven efficacy in maintaining organ viability during storage and transportation. The solution's unique composition, which includes a combination of antioxidants, energy substrates, and impermeable ions, helps to minimize cellular injury and maintain organ function during the preservation period. The solution's widespread adoption is also driven by its compatibility with a range of storage and transportation protocols, making it a versatile and reliable choice for kidney preservation.

The Institut Georges Lopez-1 (IGL-1) Solution is anticipated to experience significant growth due to its superior preservation capabilities and increasing adoption by transplant centers. IGL-1 Solution has been shown to reduce ischemia-reperfusion injury and improve graft function in kidney transplantation. The solution's ability to minimize cellular edema and maintain cellular homeostasis contributes to its growing popularity. Thus, the demand for IGL-1 Solution is expected to rise as transplant centers increasingly prioritize optimal organ preservation.

Technique Insights

The Normothermic Machine Perfusion (NMP) accounted for the largest revenue share in 2025 and is expected to witness the fastest growth owing to its ability to preserve kidneys at normal body temperature, thereby reducing ischemia-reperfusion injury. NMP allows for the assessment of kidney function and viability before transplantation, enabling better decision-making. As a result, NMP is expected to witness the fastest growth, driven by its potential to improve kidney transplant outcomes and increase the availability of donor kidneys. The increasing adoption of NMP can significantly contribute to the kidney preservation transplant industry, leading to better patient outcomes and improved graft survival rates.

The Static Cold Storage (SCS) segment is also expected to witness significant growth owing to its simplicity and cost-effectiveness. SCS involves cooling the kidney to a temperature of around 4°C, which slows down metabolic processes, reducing the demand for oxygen and nutrients. This technique has been widely adopted due to its ease of use and minimal requirement for specialized equipment. Moreover, the use of SCS also allows for a longer storage period, making it easier to transport kidneys over long distances, further increasing its demand for kidney preservation.

Donor Type Insights

The living donors segment accounted for the largest revenue share of 26.6% in 2025, owing to the increasing number of living donor kidney transplants, which have become a preferred treatment option for patients with end-stage renal disease (ESRD). The advantages of living donor kidney transplants, such as better graft survival rates and reduced waiting times, have contributed to their growing popularity. Moreover, advancements in surgical techniques and immunosuppressive therapies have made living donor kidney transplants a safer and more effective option. The increasing demand for kidney transplants, coupled with the shortage of deceased donor kidneys, has further driven the growth of living donor kidney transplants.

The Donation after Circulatory Death (DCD) segment is expected to witness the fastest growth in the donor type segment owing to the increasing awareness about DCD and its benefits, such as increased organ availability. DCD donors, also known as non-heart-beating donors, are individuals who have suffered cardiac arrest and are declared dead based on circulatory criteria, rather than brain death. The growing acceptance of DCD kidneys is driving the growth of this segment, as it provides an alternative source of kidneys for transplantation, thereby addressing the shortage of available organs.

End Use Insights

The transplant centers/hospitals segment accounted for the largest revenue share of 42.6% in 2025. This can be attributed to the complexity and specialized care required for kidney transplantation procedures. These centers have the necessary infrastructure, including trained personnel and equipment, to handle the complications of organ preservation and transplantation. The expertise and resources available at these centers enable them to effectively utilize kidney preservation technologies, thereby driving their dominance in the market.

The Organ Procurement Organizations (OPOs) segment is expected to witness the fastest growth owing to the increasing demand for organ transplants and the critical role OPOs play in managing the organ donation process. OPOs are responsible for coordinating organ donation, ensuring the quality of donated organs, and allocating them to transplant centers. The growing shortage of available kidneys for transplantation has led to an increased focus on optimizing organ procurement and preservation processes. Thus, OPOs are investing in advanced kidney preservation technologies to improve organ viability and increase transplant success rates, thereby fueling the segment growth.

Regional Insights

The North America kidney preservation market dominated the global industry and accounted for a 37.3% revenue share in 2025. The North American industry is driven by a combination of robust organ transplantation infrastructure, rising incidences of end-stage renal disease (ESRD), and a well-established reimbursement landscape. The region benefits from advanced healthcare systems, which heavily invest in organ transplant research and innovative preservation technologies such as hypothermic machine perfusion and normothermic perfusion, further fueling market growth.

U.S. Kidney Preservation Market Trends

The kidney preservation market in the U.S. held a significant share of North America in 2025. This can be attributed to the high incidence of end-stage renal disease (ESRD) and a significant rise in kidney transplant procedures across the country. The U.S. healthcare ecosystem, supported by strong transplant networks such as UNOS, has been instrumental in streamlining donor-recipient matching and enhancing organ utilization rates. Regulatory backing from the FDA has further enabled quicker adoption of innovative devices and solutions in clinical practice.

Europe Kidney Preservation Market Trends

The kidney preservation market in Europe is driven by the increasing prevalence of end-stage renal disease and a rising effort to enhance organ transplantation outcomes. Moreover, the aging population in the region is expected to increase the overall demand for kidney transplantation in the region, thereby fueling the market growth. Collaborative initiatives like the Consortium on Organ Preservation in Europe (COPE) are also playing a crucial role in developing and trialing advanced preservation strategies, demonstrating improved organ function and survival rates.

The UK kidney preservation market is witnessing significant growth, owing to the increased demand for transplants and significant technological innovations. Moreover, the high prevalence of diseases such as chronic kidney disease is further increasing the demand for kidney preservation in the country. For instance, according to the NHS England, among adults aged 35 and over, 78% had normal kidney function while 22% had chronic kidney disease (CKD), with a higher prevalence among women (24%) than men (20%); 11% had severe CKD (stages 3-5).

The kidney preservation market in Germany is experiencing notable growth, driven by an increasing demand for organ transplants and advancements in preservation technologies. Government initiatives aimed at increasing organ donation rates, coupled with the country's emphasis on healthcare innovation, are expected to enhance the adoption of advanced preservation solutions in both academic and clinical settings.

Asia Pacific Kidney Preservation Market Trends

The kidney preservation market in the Asia Pacific region is driven by rising incidences of end-stage renal disease (ESRD), expanding transplantation programs, and increasing adoption of advanced preservation technologies. The region's healthcare infrastructure is evolving, with countries investing in modernizing transplant facilities and training programs to enhance organ donation and transplantation rates. Moreover, the ongoing investments and policy initiatives aimed at enhancing transplantation outcomes and addressing the growing burden of kidney diseases are further expected to fuel the market growth over the forecast period.

The Japan kidney preservation market is poised for rapid growth, driven by advancements in preservation technologies and increasing demand for organ transplants owing to the rising burden of kidney disease. Moreover, the country’s aging population is further expected to increase the demand for kidney transplantation over the forecast period. For instance, the number of elderly people in Japan surged to 36.25 million, accounting for a record high 29.3 percent of the population, according to the figures released by the Ministry of Internal Affairs and Communications.

The kidney preservation market in China is driven by the country’s expanding organ transplantation programs and government-led reforms aimed at increasing donor availability. The establishment of the China Organ Transplant Response System (COTRS) has streamlined donor allocation, improving organ utilization efficiency. Rising incidences of chronic kidney disease and a growing elderly population have further increased the demand for kidney transplants, further driving investment in preservation technologies.

The India kidney preservation market is driven by the rising incidence of chronic kidney disease and expanding transplant programs. Moreover, India’s heavy burden of diabetic nephropathy and hypertension drives a growing demand for kidney transplants, pushing investment in preservation technologies. Moreover, increasing government focus on improving rural healthcare infrastructure is expanding access to transplant services beyond urban centers.

Latin America Kidney Preservation Market Trends

The kidney preservation industry in Latin America is driven by increasing organ transplant procedures and advancements in preservation technologies. Countries such as Brazil are at the forefront, with a significant number of transplantation centers and a growing adoption of machine perfusion methods. However, the region faces challenges, including disparities in healthcare infrastructure, limited access to advanced preservation technologies in rural areas, and the need for standardized protocols across countries. Addressing these issues through regional collaborations and investments in healthcare infrastructure is crucial for optimizing kidney preservation and transplantation outcomes in Latin America.

Brazil’s kidney preservation market is driven by the country’s efficient organ procurement and allocation network, led by state-run transplant coordination centers, significantly boosting the utilization of preserved kidneys. The country is also witnessing a rising burden of end-stage renal disease linked to widespread diabetes and hypertension, further intensifying the need for reliable kidney preservation.

Middle East And Africa Kidney Preservation Market Trends

The kidney preservation market in the Middle East & Africa is witnessing significant growth, driven by diverse regional dynamics and healthcare advancements. In the Middle East, there are significant investments in transplantation infrastructure, driven by rising incidences of chronic diseases such as diabetes and cardiovascular conditions. Similarly, in Africa, there is a significant increase in transplantation activities, supported by international collaborations and efforts to improve healthcare systems.

The Saudi Arabia kidney preservation market is anticipated to expand in the forecast period. This can be attributed to the government-backed healthcare expansion and targeted reforms in the transplant sector. The Ministry of Health’s Vision 2030 initiative prioritizes organ transplantation as part of broader healthcare modernization, resulting in increased funding for transplant centers and preservation technology. Moreover, the rise in lifestyle-related kidney diseases, particularly diabetic nephropathy, is pushing demand for reliable preservation techniques to ensure successful transplantation outcomes.

Key Kidney Preservation Company Insights

The scenario in the kidney preservation market is highly competitive, with several players competing to enhance their positions. The major companies are undertaking various organic as well as inorganic strategies such as new product development, collaborations, acquisitions, mergers, and regional expansion for serving the unmet needs of their customers.

Key Kidney Preservation Companies

The following key companies have been profiled for this study on the kidney preservation market.

• TransMedics Inc.

• XVIVO

• Bridge to Life Ltd.

• Paragonix Technologies Inc.

• OrganOx Limited

• Organ Recovery Systems

• Institut Georges Lopez (IGL)

• Preservation Solutions, Inc.

• Dr. Franz Köhler Chemie GmbH

• Essential Pharmaceuticals LLC

Competitive Benchmarking

Recent Developments

• In April 2025, the National Kidney Foundation (NKF) highlighted progress by Diatiro in advancing its Kidney Pod technology for kidney preservation during transplantation. Following prior FDA breakthrough designation, the company received FDA design approval and completed safety protocol requirements, supporting plans for FDA-approved clinical trials and future commercialization.

• In January 2025, Paragonix Technologies announced the launch of the world’s first-in-human use of its KidneyVault Portable Renal Perfusion System following FDA clearance received in October 2024. The system enables hypothermic perfusion with real-time remote monitoring capabilities aimed at improving kidney preservation and transplant workflow efficiency.

• In October 2024, Paragonix Technologies received FDA 510(k) clearance for its KidneyVault Portable Renal Perfusion System, a device designed to preserve kidneys for transplantation. The system aims to improve kidney preservation and transplantation outcomes. The clearance enables the use of the KidneyVault system in clinical settings.

Kidney Preservation Market Report Scope

Global Kidney Preservation Market Report Segmentation

This report forecasts revenue growth at the global, regional and country levels and provides an analysis on the latest industry trends and opportunities in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global kidney preservation market report on the basis of preservation solution, technique, donor type, end use, and region:

• Preservation Solution Outlook (Revenue, USD Million, 2021 - 2033)

  • University of Wisconsin

  • Histidin-Tryptophan-Ketoglutarat (HTK) Solution

  • Celsior Solution

  • Hypertonic Citrate Adenine (HC-A) Solution

  • Institute Georges Lopez (IGL-1) Solution

  • Others

• Technique Outlook (Revenue, USD Million, 2021 - 2033)

  • Static Cold Storage

  • Hypothermic Machine Perfusion

  • Normothermic Machine Perfusion

• Donor Type Outlook (Revenue, USD Million, 2021 - 2033)

  • Standard Criteria Donor (SCD)

  • Expanded Criteria Donor (ECD)

  • Donation after Brain Death (DBD)

  • Donation after Circulatory Death (DCD)

  • Living Donor

• End Use Outlook (Revenue, USD Million, 2021 - 2033)

  • Transplant Centers / Hospitals

  • Organ Procurement Organizations (OPOs)

  • Others

• Regional Outlook (Revenue, USD Million, 2021 - 2033)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • UK

    • Germany

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • Asia Pacific

    • Japan

    • China

    • India

    • Australia

    • South Korea

    • Thailand

  • Latin America

    • Brazil

    • Argentina

  • Middle East & Africa

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait

Delivered Customizations

This report has been delivered with the following In-depth customizations