The global myasthenia gravis (MG) treatment market size was estimated at USD 1.16 billion in 2018 and is anticipated to grow at a CAGR of 7.5% over the forecast period. The key factors driving this market include the rising adoption of immunotherapies, the approval of promising drugs, the emergence of biologics, and increasing awareness of rare diseases.
Myasthenia gravis (MG) is a chronic, progressive, and rare neuromuscular disorder that is characterized by weakness of the head, limb, spinal, eye, and respiratory muscles. In this autoimmune disorder, antibodies are produced against the acetylcholine receptor (AchR) that impedes the normal transmission of electrical signals from nerves to muscles.
According to the National Organization for Rare Disorders (NORD), in the U.S. around 14-40 per 100,000 individuals suffer from myasthenia gravis. Reports suggest that the frequency of the disorder is on the rise over the last several decades. This can be attributed to the better identification of patients and the increasing prevalence of autoimmune disorders in general across the world.
Myasthenia gravis occurs more frequently in females than in males, and although symptoms may appear at any age, its onset usually peaks in men in their 50s or 60s and women during their 20s or 30s. There is no proven cure for myasthenia gravis, however, patients can be treated with medications and surgery for the management of the symptoms.
At present, research is focused on a better understanding of the specifics of the autoimmune problems associated with MG and improving their diagnosis and treatment. Additionally, the market is observing a paradigm shift in the area of research from suppressing the immune system to rebalancing it. Another important area of research is the physiology of the neuromuscular junction (NMJ), aimed at improvement in its function regardless of probable immune system attacks.
Among the treatments, medication held the largest market share and is expected to maintain its leading position through the forecast period. This is because medications can dramatically inhibit the immune system and largely manage the associated symptoms. Medications include immunotherapies such as Soliris (eculizumab), corticosteroids, and immunosuppressive drugs such as Prograf (tacrolimus) and Neoral/Sandimmune (cyclosporine). The other major treatment alternative, surgery, is the most invasive in nature and usually involves a thymectomy (thymus removal). The thymus deteriorates with age (thymic involution), however complete loss of the thymus in such manner will significantly weaken a patient’s immune system.
The myasthenia gravis treatment market is witnessing an upsurge in the number of pipeline studies for drug development that is expected to drive the market. Recently, Alexion Pharmaceuticals’ Soliris (eculizumab) received approval by both the U.S. FDA and the European Commission for the treatment of adult patients with generalized myasthenia gravis who are anti-AchR antibody-positive. Soliris is the first and only complement inhibitor approved for this disorder. The increasing use of monoclonal antibodies and immunosuppressants is aimed at the reduction of lifelong exposure to corticosteroids and improvement in long-term results.
Based on end-use, the myasthenia gravis treatment market has been segmented into hospitals, clinics, and others. The hospital segment held the largest market share in 2018 and is expected to grow at the highest CAGR over the forecast period. This can be attributed to access to a large patient pool and high demand for advanced equipment for MG treatment in hospital settings. There has been an increase in the number of patient visits for diagnosis and treatment of MG due to the availability of a broad range of treatment options in such facilities. Furthermore, one of the major factors contributing to its large share is the increased investment in state-of-the-art healthcare infrastructures.
The clinic segment held the second-largest share in 2018 and is expected to retain the position through the forecast period. Currently, with the growing need for specialized treatments, a lot of patients are preferring specialty clinics for rapid diagnosis and effective MG treatment. A large segment of the end-users also depends on eCommerce channels for obtaining therapeutics for myasthenia gravis. These segments are significantly contributing to the growth of myasthenia gravis treatment market.
Among all the regions, North America had the largest market share in 2018 and is projected to lead the market over the forecast period. This can be attributed to the high adoption of immunotherapies and monoclonal antibodies, increasing healthcare expenditure, presence of established research and development facilities, and favorable reimbursement scenario.
Asia Pacific is anticipated to grow at the fastest CAGR through the forecast period due to the increase in revenue generation from medications such as immunosuppressants and monoclonal antibodies in this region. Other factors propelling the growth are the initiatives associated with increasing investments in the healthcare sector by the governments and manufacturers in the region.
Some of the key companies operating in this space include Alexion Pharmaceutical Inc., Grifols SA, Avadel Pharmaceuticals plc. Novartis AG, Pfizer, Inc., AbbVie Inc., F. Hoffmann-La Roche Ltd., GlaxoSmithKline plc, Bausch Health Companies Inc., and Shire plc. Alexion Pharmaceuticals and Astellas Pharma hold the largest market shares due to the strong sales of their flagship products including Soliris and Prograf.
However, generic competition is a major hindrance to market growth, due to patent loss of several marketed products and the availability of low-priced substitutes to branded drugs in the market. To gain an advantage against competitors, companies are adopting strategies such as expansion in the emerging countries, new product development, spreading awareness, and getting into collaborations.
Report Attribute |
Details |
Market size value in 2020 |
USD 1.8 billion |
Revenue forecast in 2026 |
USD 2.06 billion |
Growth Rate |
CAGR of 7.5% from 2019 to 2026 |
Base year for estimation |
2018 |
Historical data |
2015 - 2017 |
Forecast period |
2019 - 2026 |
Quantitative units |
Revenue in USD Million and CAGR from 2019 to 2026 |
Report coverage |
Revenue forecast, company share, competitive landscape, growth factors and trends |
Segments covered |
Treatment, end-use, region |
Regional scope |
North America; Europe; Asia Pacific; Latin America; MEA |
Country scope |
U.S., Canada, Germany, UK, France, Italy, Spain, Russia, Japan, China, India, Australia, South Korea, Singapore, Brazil, Mexico, Argentina, South Africa, Saudi Arabia, UAE |
Key companies profiled |
Alexion Pharmaceutical Inc.; Grifols SA; Avadel Pharmaceuticals plc. Novartis AG; Pfizer; Inc.; AbbVie Inc.; F. Hoffmann-La Roche Ltd.; GlaxoSmithKline plc; Bausch Health Companies Inc.; Shire plc. |
Customization scope |
Free report customization (equivalent up to 8 analysts working days) with purchase. Addition or alteration to country, regional & segment scope. |
Pricing and purchase options |
Avail customized purchase options to meet your exact research needs. Explore purchase options |
This report forecasts revenue growth at global, regional, & country levels, and provides an analysis of the industry trends in each of the sub-segments from 2015 to 2026. For the purpose of this study, Grand View Research has segmented the global myasthenia gravis treatment market report on the basis of treatment, end-use, and region:
Treatment Outlook (Revenue, USD Million, 2015 - 2026)
Medication
Surgery
Others
End-Use Outlook (Revenue, USD Million, 2015 - 2026)
Hospitals
Clinics
Others
Regional Outlook (Revenue, USD Million, 2015 - 2026)
North America
The U.S.
Canada
Europe
UK
Germany
France
Italy
Spain
Russia
Asia Pacific
Japan
China
India
South Korea
Singapore
Australia
Latin America
Brazil
Mexico
Argentina
Middle East & Africa
South Africa
Saudi Arabia
UAE
b. The global myasthenia gravis market size was estimated at USD 1.7 billion in 2019 and is expected to reach USD 1.8 billion in 2020.
b. The global myasthenia gravis market is expected to grow at a compound annual growth rate of 7.2% from 2019 to 2026 to reach USD 2.7 billion by 2026.
b. North America dominated the myasthenia gravis market with a share of 48.4% in 2019. This is attributable to the high adoption of novel therapies, increasing research and development investments, and favorable reimbursement scenario.
b. Some key players operating in the myasthenia gravis market include Alexion Pharmaceutical Inc., Grifols SA, Avadel Pharmaceuticals plc. Novartis AG, Pfizer, Inc., AbbVie Inc., F. Hoffmann-La Roche Ltd., GlaxoSmithKline plc, Bausch Health Companies Inc., and Shire plc.
b. Key factors that are driving the market growth include rising adoption of immunotherapies, approval of promising drugs, emergence of biologics, and increasing awareness of rare diseases.
GET A FREE SAMPLE
This FREE sample includes market data points, ranging from trend analyses to market estimates & forecasts. See for yourself.
NEED A CUSTOM REPORT?
We can customize every report - free of charge - including purchasing stand-alone sections or country-level reports, as well as offer affordable discounts for start-ups & universities.
Contact us now to get our best pricing.
ESOMAR certified & member
Leading SME award by D&B
We are GDPR and CCPA compliant! Your transaction & personal information is safe and secure. For more details, please read our privacy policy.
"The quality of research they have done for us has been excellent."
Multiple therapeutic regimens are being followed across the globe in attempts to come up with a reliable treatment for Covid-19. One line of treatment includes the use of hydroxychloroquine, while a second treatment line focuses to use antiviral drugs used in the disease management of HIV. Both these approaches have surged demand from advanced antivirals and antimalarial drugs. This impacts the drug manufacturers as an off label indication for these drug classes has to be worked upon. At the moment, the WHO has not prescribed any of these approaches, neither they have commented if one is better than the other. The report will account for Covid19 as a key market contributor.
We value your investment and offer free customization with every report to fulfil your exact research needs.