Perfusion System Market Analysis By Technology (Hypothermic Machine Perfusion, Normothermic Machine Perfusion), By Organ Type (Heart, Lung, Kidney, Liver), And Segment Forecasts, 2018 - 2025

Industry Insights

The global perfusion system market size was valued at USD 87.05 million in 2016 and is expected to witness a CAGR of 8.7% during the forecast period. Increasing incidence of organ failures is expected to accelerate the demand for transplantation procedures over the forecast period.

The major problem in these procedures is organ supply. To curb this problem, two preservation methods are used, Machine Perfusion (MP) and Static Cold Storage (SCS). Although SCS is a highly adopted process for preservation, it is inefficient to maintain high-risk organs. Hypothermic Machine Perfusion (HMP) has emerged as an effective solution to curb such problems.

U.S. perfusion system market, by technology, 2014 - 2025 (USD million)

Rising demand of transplantation due to increasing incidence of chronic diseases is the key contributing factor for market growth. Moreover, growing number of organ failures is contributing further toward the growing demand for cost-effective solutions for preservation. According to the statistics published by the National Institute of Diabetes and Digestive and Kidney Diseases (NIH), approximately 661,000 people are affected by kidney failures in the U.S and the number is expected to increase over the forecast period.

Transplantation is an effective treatment for end-stage organ failure. The demand for organs has increased significantly due to high success rates of such treatments in the recent years. According to statistics by the Centre for Disease Control (CDC), in 2014, 75,000 people were waiting for organ donations, however only 8,000 actual deceased donations were performed that year.

However, unavailability of donors in order to meet the increasing demand has resulted in an unexpected shortage. As per the National Kidney Foundation, there are 121,678 people waiting for transplantations in the U.S. as of 1st November 2016. This has resulted in increased mortality, which thereby surges the demand for perfusion systems to improve the viability of the organ.

Most of the times, donated organs are not available during surgical procedures due to lack of preservation and transport facilities. These technologies provide enhanced preservation, thereby increasing its shelf life, which increases the patient outcome. Thus, the above mentioned factors are responsible for boosting the overall market growth.

Technology Insights

HMP held a dominant share of MP technologies as of 2016, owing to associated benefits with its usage. It is a well-established alternative for cold storage in kidney preservation as it offers viability of grafts before transplantation procedure. In a kidney transfer surgery, it helps in increasing patient survival rate and improving the quality of a graft. In addition, it also offers a platform for recovery of grafts before surgery.

Research activities are being conducted to check the viability of HMP for transplantation of other organs such as the liver. It provides a continuous flow of antioxidants and metabolic substrates and helps in flushing proteins, toxins, and cytokines from the liver. This attenuates the reperfusion damage that occurs in a statically stored liver.

Normothermic MP techniques are expected to gain popularity in the coming years to curb the rising demand for warm blood perfusion. Perfusion at Normal Body Temperature (NMP) is applicable in both ex-situ and in-situ regional perfusion methods.

Liver transplantation from the diseased donor results in reperfusion lesions that increase the risk of hepatocellular carcinoma recurrence after transplantation. NMP with Extracorporeal Membrane Oxygenation (ECMO) prevent the risk of reperfusion of lesions and help reduce the risk associated with cancer recurrence. These aforementioned benefits with the use of NMP are expected to act as a growth propeller in the near future.

Organ Type Insights

Transplantation of kidney held a dominant share as kidney failure rates are high due to increasing incidence of Chronic Kidney Disease (CKD). The MP devices introduced until now are most commonly used to preserve kidney, hence, this segment dominated the market as of 2016.

The most commonly used MP system for a kidney is LifePort Kidney Transporter by Organ Recovery Systems Inc., WAVES RM3 by Waters Medical Systems, and Airdrive hypothermic kidney perfusion transport system.

MP for the heart transplant is anticipated to witness lucrative growth over the forecast period due to rising R&D to develop cost-effective and viable solutions for transplantation procedures. Research is being undertaken for the development of novel technologies for the heart, which is expected to serve this industry with growth potential.

MP procedures for lungs, liver, pancreas, etc., are expected to be implemented during the forecast period as the demand is increasing. The available MP devices for lungs are OCS Lungs by Organ Care Systems, Vivoline LS1, and Lung Assist by Organ Assist B.V. and Xvivo Systems.

Regional Insights

North America held the dominant share of organ perfusion systems as of 2016 owing to increasing demand for transplant surgery. According to the U.S. Department of Health and Human Services, there are more than 119,000 people waiting for transplantations & only 2,555 donors are available as of April 2017 and the number is expected to grow in the coming years

The growing disparity between demand and supply is a major public health crisis. In order to satisfy this unmet need, increasing initiatives to promote donations are necessary. In the U.S., various initiatives are being undertaken by the government to promote donation. For example, in 2016, the Organ Summit was organized by the White House to spotlight the actions to be taken for reducing the waiting list for transplantation.

Global perfusion system market revenue, by region, 2016 (%)

The Asia Pacific regional market for MP is anticipated to grow at the fastest CAGR owing to rising incidence of chronic diseases coupled with the demand for organ donation. The government of developed as well as developing nations is encouraging people to help transplant surgery by promoting organ donation. For instance, The Ministry of Health & Family Welfare, Government of India has taken series of measures to promote donation. The government has implemented the National Organ Transplant Programme in the country to promote donation.

Moreover, the government has agreed to provide financial assistance for the establishment of Regional Organ and Tissue Transplant Organizations. Presence of nonprofit organizations such as Donate Life America in the U.S., which promotes organ donation in collaboration with the American Hospital Association is also a high impact rendering factor for perfusion systems market.

Competitive Insights

The market participants are XVIVO Perfusion AB; Organ Assist B.V.; Organ Recovery Systems; Organ Transport Systems; Waters Medical Systems; Paragonix Technologies, Inc.; TransMedics, Inc.; OrganOx Limited; and Bridge to Life Ltd.

This industry is witnessing a significant boost owing to growing demand for transplantation. This has attracted several local and international players to the market. The key factor contributing to this growth is rising demand for technologically advanced products that aid in enhanced ex vivo perfusion.

The market is competitive in nature with key players involved in continuous product development and partnership alliances to aid market penetration. Rising number of distributors and dealers for MP systems are expected to elevate industry rivalry in the near future.

Industry players are involved in extensive R&D activities. Many products under clinical trials in the U.S. and Europe are expected to gain approval during the forecast period. Owing to the aforementioned factors, competitive rivalry for the market is expected to be high over the forecast period.

Report Scope

Segments covered in the report

This report forecasts revenue growth at global, regional, & country levels and provides an analysis of the industry trends in each of the sub segments from 2014 to 2025. For the purpose of this study, Grand View Research has segmented the global perfusion system market on the basis of technology, organ type, and region:

• Technology Outlook (Revenue, USD Million, 2014 - 2025)

  • Hypothermic

  • Normothermic

• Organ Type Outlook (Revenue, USD Million, 2014 - 2025)

  • Heart

  • Lung

  • Kidney

  • Liver

  • Others

• Regional Outlook (Revenue, USD Million, 2014 - 2025)

  • North America

    • U.S.

    • Canada

  • Europe

    • UK

    • Germany

  • Asia Pacific

    • Japan

    • China

  • Latin America

    • Brazil

    • Mexico

  • The Middle East and Africa

    • South Africa