Protein Purification and Isolation Market Analysis By Technology (Ultrafiltration, Precipitation, Chromatography, Electrophoresis), By Application, And Segment Forecasts, 2018 - 2025

Industry Insights

The global protein purification & isolation market size was valued at USD 4.7 billion in 2016, growing at CAGR of 8.1% during forecast period. Increased research in the fields of biotechnology and pharmaceuticals for development of drug candidates is a key contributing factor for its growth. Moreover, increasing R&D investments by pharmaceutical companies is estimated to propel growth.

The growing need for rapid purification kits to screen, purify, prepare, and concentrate the samples in less time is also anticipated to propel the market growth. There is an increasing demand for advanced techniques owing to the increasing need for accurate identification of numerous new protein molecules and to purify & isolate the functional proteins with least amount of contaminants. 

Increase in investment by pharmaceutical and biotechnological companies along with various governments across the globe have resulted in an increase in the growth of R&D. The pharmaceutical industry is one of the most profitable industries, with huge funds being spent on the identification and development of biomarker specific drugs. Accurate isolation of proteins with high volume of purified substrate is an important part of preclinical drug development phase.

Constant technological advancements and innovations are expected in the market. There has been a technological shift from the adoption of agarose beads and other resins to magnetic and protein beads and tagging ligand system for the purifying specific proteins from different samples. Moreover, high adoption of automated protein purification analyzers by many end users is also expected to boost growth.

Product Insights

Segmentation of the market is done on the basis of products into instruments and consumables categories. Kits, reagents, columns, magnetic beads, and resins are the commonly used consumables for protein isolation and purification. In 2016, the reagents segment held the highest share. High usage, increasing commercialization of more advanced resins, and extensive usage of the same are some factors responsible for dominance. 

Reagents are also used to eliminate guesswork and ensure accurate results, thereby making them the fastest growing segment of the market. On the other hand, the instruments segment is expected to witness stable growth over the forecast period owing to increasing advancements on the basis of accuracy, sensitivity, and portability.

Technology Insights

In 2016, the chromatography segment dominated with a largest revenue. Chromatography is considered as one of the sensitive and accurate methods for protein purification and isolation as compared to other techniques. Market players also focus on the commercialization of new products based on this technology to increase their share. For example, in 2016, Bio-Rad Laboratories launched a new software for the purification of proteins with NGC chromatography systems. 

The chromatography segment is also growing at the fastest CAGR of 8.3%. Different chromatography techniques such as hydrophobic interaction chromatography, affinity chromatography, reversed-phase chromatography, bead-based chromatography, and ion exchange chromatography help the end users in deciding the purification technique based on their applications. Other techniques used for protein purification and isolation such as western blotting, precipitation, and ultrafiltration find applications in primary protein purification in academic research.

Application Insights

In 2016, the protein-protein interaction segment held the largest share owing to increasing initiatives for structural protein-based studies coupled with high usage of these techniques for deriving highly purified and specific proteins. Protein biomarkers help in detection of many chronic disorders and are further used as target in development of specific drugs by many biopharmaceuticals companies. 

Drug screening is identified as the fastest growing segment with CAGR of 8.9% over the forecast period. Drug screening is highly used for discovering novel drugs with various applications. Drug screening includes development of drugs with higher efficacy and lesser adverse effects than conventional drugs.

End-use Insights

This is segmented into hospitals, academic & research institutes, pharmaceutical & biotechnological companies, and CROs. Academic and research institutes dominated the market in 2016. Increasing research initiatives in academic institutes for protein-protein interaction, structural & functional proteomics, and detailed kinetic analysis are some of the factors contributing toward largest share.

On the other hand, CROs are identified as the fastest growing segment due to the increased number of preclinical trials outsourced by drug development companies to these contract research organizations and high amount of R&D investment associated with it.

Regional Insights

In 2016, North America held a significant revenue of over 45.0% due to the established research infrastructure, high funding for basic life science research, and presence of major market players. Moreover, increase in initiatives for biopharmaceutical drug development in this region is estimated to influence growth. 

Asia Pacific is anticipated to showcase commercial growth with fastest CAGR in 2016. Governments of developing countries such as China, India, South Africa, and Brazil are anticipated to offer high potential growth platform for this industry by providing funds for the development of novel purification and isolation methods.

Competitive Insights

Some of the major key players in this market include Thermo Fisher Scientific, Merck KGaA, Sigma-Aldrich Co., QIAGEN, Bio-Rad Laboratories, Inc., Agilent Technologies, Promega Corporation, GE Healthcare, Norgen Biotek Corporation, and Abcam plc. 

Key players are focusing on expanding their businesses in developing regions to increase their market share. Various other strategies were implemented by these companies which include strategic collaborations, FDA approvals, and mergers & acquisitions. For instance, in 2015, Merck, one of the leading companies in protein purification and isolation products completed the acquisition of Sigma-Aldrich, another major player in this market. This strategic collaboration has led to the formation of one of the leaders in the life sciences segment.

Report Scope

Segments Covered in the Report

This report forecasts revenue growth and provides an analysis on the market trends in each of the sub-markets from 2014 to 2025. For the purpose of this study, Grand View Research has segmented the protein purification and isolation market on the basis of product, technology, application, end use, and region:

• Product Outlook (Revenue, USD Million; 2014 - 2025)

  • Instruments

  • Consumables

    • Kits

    • Reagents

    • Columns

    • Magnetic beads

    • Resins

    • Others

• Technology Outlook (Revenue, USD Million; 2014 - 2025)

  • Ultrafiltration

  • Precipitation

  • Chromatography

    • Ion exchange chromatography

    • Affinity chromatography

    • Reversed phase chromatography

    • Size exclusion chromatography

    • Hydrophobic interaction chromatography

  • Electrophoresis

    • Gel electrophoresis

    • Isoelectric focusing

    • Capillary electrophoresis

  • Western Blotting

  • Others

• Application Outlook (Revenue, USD Million; 2014 - 2025)

  • Drug screening

  • Biomarker discovery

  • Protein-protein interaction studies

  • Diagnostics

• End-use Outlook (Revenue, USD Million; 2014 - 2025)

  • Academic and research institutes

  • Hospitals

  • Pharmaceutical and biotechnological companies

  • CROs

• Regional Outlook (Revenue, USD Million; 2014 - 2025)

  • North America

    • U.S.

    • Canada

  • Europe

    • Germany

    • UK

  • Asia Pacific

    • China

    • Japan

    • India

  • Latin America

    • Mexico

    • Brazil

  • MEA

    • South Africa