GVR Report cover Protein Purification And Isolation Market Size, Share & Trends Report

Protein Purification And Isolation Market Size, Share & Trends Analysis Report By Product (Instruments, Consumables), By Technology, By Application, By End Use, By Region, And Segment Forecasts, 2022 - 2030

  • Report ID: GVR-1-68038-881-7
  • Number of Pages: 185
  • Format: Electronic (PDF)
  • Historical Range: 2017 - 2020
  • Industry: Healthcare

Report Overview

The global protein purification and isolation market size was valued at USD 7.7 billion in 2021 and is expected to expand at a compound annual growth rate (CAGR) of 10.6% from 2022 to 2030. Growing research in the areas of pharmaceutical and biotechnology for the development of novel drugs drives the demand for protein purification and isolation. Furthermore, rising investments in R&D by pharmaceutical manufacturers are projected to drive the market. The unexpected COVID-19 outbreak prompted the implementation of lockdown rules across the globe, causing delays in protein purification and isolation import and export. The pandemic also lowered the availability of funds from private investors and governments around the world. Purification and isolation of proteins refer to a set of procedures for isolating a specific protein from a complicated combination of cells, organisms, or tissues.

U.S. protein purification and isolation market size, by product, 2020 - 2030 (USD Billion)

Protein research requires these techniques to separate, concentrate, stabilize, and eliminate contaminants including endotoxins, viruses, and nucleic acid. They involve determining material and maintaining a purification table to track the enzyme's development. They are mostly used to classify a protein's function, structure, and interactions. Affinity chromatography, immunoprecipitation, proteomics, and enzyme assay are some of the regularly utilized methods of protein purification and separation. Over the pandemic, the disruption in the process had a negative impact on the market, but increased government funding for R&D is enabling the market to recover, and the market is expected to grow during the forecast period.

Governments are increasingly investing in R&D and undertaking initiatives that promote the development and growth of the pharmaceutical and biotechnology markets. They also provided added benefits via tax incentives, grants, and investment-friendly regulations among others. Pharmaceutical is a highly lucrative industry for protein purification and isolation solutions owing to significant investments in the development of biomarker-specific molecules. Precise isolation of proteins with a significant amount of purified substrate is a vital component of the preclinical drug development phase.

Ongoing technological advancements further drive the market for protein purification and isolation solutions. Magnetic and protein beads and ligand tagging systems are increasingly preferred over traditional methods such as agarose beads and other resins. Furthermore, the rising usage of automated analyzers is projected to drive the demand for purification and isolation solutions.

The rising significance of discovering novel ligands, such as protein-based therapeutic compounds, is a major factor fueling the market expansion. Additionally, rising demand for purification kits in rapid screen tests, a shift towards technologically advanced instrumentation for protein purification, growth of the proteomics market, and increasing R&D in pharmaceutical and biotechnological fields are expected to propel the market growth. However, instruments that result in a reduced acceptance rate, the difficulty of maintaining purification kits that fit all proposes, and high tool costs are acting as hurdles to market growth. In addition, the protein purification and isolation industry is benefiting from untapped growth markets and protein therapies.

Product Insights

Consumables captured the largest revenue share of over 60.0% in 2021. Columns, reagents, kits, resins, and magnetic beads are the most commonly used consumables. In 2021, kits dominated the consumables product segment as they are convenient and offer several benefits. For instance, they can be effectively used for the isolation of GST-tagged protein from the crude or cleared lysate. Based on product, the market is categorized into consumables and instruments.

The growth of the reagents segment can be attributed to the high usage and a rise in the commercialization of advanced resins. Reagents also help remove ambiguity and ensure precise results. The instruments segment is likely to witness steady growth over the forecast period due to the development of accurate, sensitive, and portable instruments.

Technology Insights

Chromatography held the largest revenue share of over 25.0% in 2021 and is projected to witness significant growth through the forecast period. Chromatography is one of the most accurate and sensitive techniques for the isolation and purification of proteins when compared to its counterparts. Various companies are hence focusing on commercializing new products based on this technology in order to expand their product portfolio.

For instance, in 2018, Bio-Rad commercialized ChromLab Software, a novel software for the purification of proteins using NGC chromatography systems. The availability of various types of chromatography techniques makes them suitable for a range of applications, further driving the segment.

Application Insights

Protein-protein interaction studies grabbed the largest revenue share of over 30.0% in 2021 and are projected to witness substantial growth over the forecast period. High adoption of these techniques for deriving highly purified proteins and an increasing number of studies based on structural protein is contributing to the segment growth.

The drug screening segment is estimated to register the highest growth rate over the forecast period. It is extensively used for discovering innovative drugs with different applications. Drug screening comprises the development of drugs with higher efficacy than conventional drugs as well as fewer side effects. Moreover, increasing R&D investments by manufacturers for the screening of novel drugs through structure-based studies and protein-protein interaction are projected to drive the segment.

End-use Insights

Academic and research institutes accounted for the largest revenue share of over 35.0% in 2021. Growing research initiatives in academic institutes for structural and functional proteomics, detailed kinetic analysis, and protein-protein interaction are contributing to the demand for protein purification and isolation solutions. On the basis of end-use, the market for protein purification and isolation has been segmented into academic and research institutes, hospitals, contract research organizations (CROs), and pharmaceutical and biotechnological companies.

Global protein purification and isolation market share, by end use, 2021 (%)

The CROs segment is estimated to witness significant growth over the forecast period owing to the rise in the number of preclinical trials outsourced by drug development companies and significant R&D investments associated with it. These organizations conduct more precise R&D functions for the pharmaceutical industry, along with offering a range of services for clinical trial activities, further driving the segment over the forecast period.

Regional Insights

North America held the largest revenue share of over 45.0% in 2021, followed by Europe. This can be attributed to high funding for life science research, established research infrastructure, and the presence of key players. Furthermore, the rise in biopharmaceutical drug development is estimated to drive the regional market over the forecast period.

The Asia Pacific is estimated to witness the fastest growth over the forecast period. Initiatives undertaken by the governments of developing countries such as India and China for the development of healthcare infrastructure are estimated to drive the demand for protein purification and isolation solutions in this region. Moreover, these governments are providing funds for the development of novel purification and isolation methods.

Key Companies & Market Share Insights

Market players are adopting various strategies such as product development, geographic expansion, mergers, acquisitions, and collaborations to increase their market share. For instance, in December 2021, GE Healthcare Life Sciences announced that it has completed its acquisition of BK Medical, from Altaris Capital Partners, LLC for an upfront cash payment of USD 1.45 billion in September 2021.

Additionally, Thermo Fisher Scientific and Symphogen announced in March 2022 that they would continue the collaboration to provide biopharmaceutical research and development laboratories and platform workflows for quality monitoring and simplified characterization of complex therapeutic proteins. This will help it maintain Thermo Fisher Scientific's leadership position in the protein purification and separation sector. Some prominent players in the global protein purification and isolation market include:

  • Merck KGaA

  • Thermo Fischer Scientific, Inc.

  • GE Healthcare Life Sciences

  • Qiagen N.V.

  • Sigma-Aldrich Corporation

  • Agilent Technologies

  • Bio-Rad Laboratories, Inc.

  • Promega Corporation

  • Abcam

  • Norgen Biotek Corporation

Protein Purification And Isolation Market Report Scope

Report Attribute


Market size value in 2022

USD 8.4 billion

Revenue forecast in 2030

USD 19.1 billion

Growth Rate

CAGR of 10.6% from 2022 to 2030

Base year for estimation


Historical data

2017 - 2020

Forecast period

2022 - 2030

Quantitative units

Revenue in USD million and CAGR from 2022 to 2030

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Product, technology, application, end-use, region

Regional scope

North America; Europe; Asia Pacific; Latin America; Middle East & Africa

Country scope

U.S.; Canada; U.K.; Germany; France; Spain; Italy; Japan; China; India; South Korea; Mexico; Brazil; Colombia; Chile; South Africa; UAE

Key companies profiled

Merck KGaA; Thermo Fischer Scientific, Inc.; GE Healthcare Life Sciences; Qiagen N.V.; Sigma-Aldrich Corporation; Agilent Technologies; Bio-Rad Laboratories, Inc.; Promega Corporation; Abcam

Customization scope

Free report customization (equivalent up to 8 analysts working days) with purchase. Addition or alteration to country, regional & segment scope.

Pricing and purchase options

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Segments Covered in the Report

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2017 to 2030. For the purpose of this study, Grand View Research has segmented the global protein purification and isolation market report on the basis of product, technology, application, end-use, and region:

  • Product Outlook (Revenue, USD Million, 2017 - 2030)

    • Instruments

    • Consumables

      • Kits

      • Reagents

      • Columns

      • Magnetic Beads

      • Resins

      • Others

  • Technology Outlook (Revenue, USD Million, 2017 - 2030)

    • Ultrafiltration

    • Precipitation

    • Chromatography

      • Ion Exchange Chromatography

      • Affinity Chromatography

      • Reversed-Phase Chromatography

      • Size Exclusion Chromatography

      • Hydrophobic Interaction Chromatography

    • Electrophoresis

      • Gel Electrophoresis

      • Isoelectric Focusing

      • Capillary Electrophoresis

    • Western Blotting

    • Others

  • Application Outlook (Revenue, USD Million, 2017 - 2030)

    • Drug Screening

    • Biomarker Discovery

    • Protein-protein Interaction Studies

    • Diagnostics

  • End-use Outlook (Revenue, USD Million, 2017 - 2030)

    • Academic and Research Institutes

    • Hospitals

    • Pharmaceutical and Biotechnological Companies

    • CROs

  • Regional Outlook (Revenue, USD Million, 2017 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

      • France

      • Spain

      • Italy

    • Asia Pacific

      • Japan

      • China

      • India

      • South Korea

    • Latin America

      • Brazil

      • Mexico

      • Colombia

      • Chile

    • Middle East and Africa (MEA)

      • South Africa

      • UAE

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