Scleroderma Therapeutics Market Size, Share & Trends Report

Scleroderma Therapeutics Market Size, Share & Trends Analysis Report By Drug Class (Immunosuppressors, ERA, CCBs, PA), By Indication (Systemic, Localized), By Region (North America, Europe), And Segment Forecasts, 2019 - 2026

  • Published Date: Jul, 2019
  • Base Year for Estimate: 2018
  • Report ID: GVR-3-68038-219-8
  • Format: Electronic (PDF)
  • Historical Data: 2014 - 2017
  • Number of Pages: 70

Industry Insights

The global scleroderma therapeutics market size was valued at USD 1.60 billion in 2018 and is estimated to expand at a CAGR of 6.0% from 2019 to 2026. The market is mainly driven by the off-label use of drugs approved for its symptomatic indications, such as rheumatoid arthritis. Lack of curative therapies and high prevalence of off-label drug use are underlying factors spurring interest in rare disease markets.

This is expected to fuel the development of targeted biologics and small molecule combination therapies. Increasing prevalence of scleroderma and rising incidences of genetic mutations coupled with drastic changes in the environment are also expected to be the key factors driving the market. In addition, increasing disposable income levels, enabling a higher spending capacity, and presence of well-defined regulatory framework supporting emergence of effective therapies in developed regions fuel the market growth.

U.S. scleroderma therapeutics market

The emergence of first-in-class curatives that are currently undergoing clinical development will also boost market growth over the forecast period. Furthermore, supplemental approvals for existing treatment options will reinforce growth.

Comorbidities associated with this disease account for the involvement of a wide range of drug classes prescribed in first- and second-line treatment of the condition. Among the indications, Pulmonary Arterial Hypertension (PAH) garnered the maximum sales. Medication for this comorbidity includes more than one drug class and several branded drugs. In addition, the two approved drugs in this market, bosentan, and iloprost are used to target PAH.

Drug Class Insights

On the basis of drug class, the market is segmented into immunosuppressors, Phosphodiesterase 5 Inhibitors - PHA, endothelin receptor antagonists, prostacyclin analogues, calcium channel blockers, analgesics, and others. Without a curative therapy for this disease, an expansive range of drug classes are prescribed to provide symptomatic relief. Immunosuppressants hold prominence as this class contains several biologics from established players such as Roche. Biologics and small molecule immunosuppressants are a growing segment with several pipeline drugs for scleroderma focusing on this class.

Novel therapies including Lenabasum and Ofev are expected to enter within the forecast period that are classed under ‘other drug classes’. PDE-5 inhibitors market by drug classes are facing headwinds due to patent expiration of Revatio that bring down the revenue. ERAs remain in focus as this class of drugs mostly includes branded therapies and due to their use in the treatment of the indication with high incidence i.e. PAH.

Indication Insights

Based on indication, the scleroderma therapeutics market is categorized into localized and systemic scleroderma. The indications falling under systemic scleroderma include SSc-induced symptoms and conditions that range from interstitial lung disease to pulmonary arterial hypertension. Systemic indications account for majority of share due to use of high-priced immunosuppressants.

Localized scleroderma currently holds a small share in this market but is expected to grow over the forecast period with the expected launch of a first-in-class therapy, FCX-013 by Fibrocell. Fibrocell’s FCX-013 holds orphan drug and fast track designation and if approved, it would be the first gene therapy for localized scleroderma. This treatment aims to arrest the fibrosis in the early stages of the disease. Lenabasum by Corbus Pharmaceuticals is the first oral therapy with high curative potential targeting diffuse cutaneous systemic sclerosis that is associated with a high burden of comorbidities.

Regional Insights

North America was the dominance regional market in 2018. Access to recently developed immunosuppressants coupled with favorable reimbursement scenario is the key revenue driver. Europe trails with a lower share as compared to U.S. majorly due to higher use of generics and biosimilars for off-label treatment of scleroderma.

Global scleroderma therapeutics market

In developing regions, generics and OTC drugs are the mainstay therapy for scleroderma and its symptoms. The Japan market although experiencing price cuts has faster access to new orphan therapies. Expected increase in access to biosimilar and generic immunosuppressants will drive growth in Latin America and MEA regions.

Scleroderma Therapeutics Market Share Insights

Some of the key companies in the market are F. Hoffman La-Roche Ltd.; Bristol-Myers Squibb Company; Celgene Corp.; arGentis Pharmaceuticals, LLC; Bayer AG; Boehringer Ingelheim International GmbH; Akashi Therapeutics; Prometic Life Sciences, Inc.; Emerald Health Pharmaceuticals; Kadmon Holdings, Inc.; Seattle Genetics, Inc.; Cytori Therapeutics, Inc.; Fibrocell Science, Inc.; Chemomab; Corbus Pharmaceuticals Holdings, Inc.; and Genkyotex.

The market is highly fragmented with Roche leading with a commanding market position. Roche’s Cellcept, Actemra, Rituxan, and Esbriet drew the highest revenue in 2018. The underlying factor is high preference for immunosuppressants in the treatment of scleroderma induced PAH and ILD. With growth in penetration of this class of drugs and their improved efficacy in comparison to existing alternatives - cyclophosphamide, methotrexate, and mycophenolate mofetil - these therapies will reign until the launch of curatives that are undergoing clinical development.

Report Scope

Attribute

Details

Base year for estimation

2018

Actual estimates/Historical data

2014 - 2017

Forecast period

2019 - 2026

Market representation

Revenue in USD Million and CAGR from 2019 to 2026

Regional scope

North America, Europe, Asia Pacific, Latin America, and MEA

Country scope

U.S., Canada, U.K., Germany, Spain, France, Italy, China, Japan, India, Hong Kong, Singapore, Australia, South Korea, Brazil, Mexico, Argentina, South Africa, Saudi Arabia, UAE, and Qatar

Report coverage

Revenue forecast, company share, competitive landscape, growth factors and trends

15% free customization scope (equivalent to 5 analyst working days)

If you need specific information, which is not currently within the scope of the report, we will provide it to you as a part of customization


Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2014 to 2026. For the purpose of this study, Grand View Research has segmented the global scleroderma therapeutics market report on the basis of drug class, indication, and region:

  • Drug Class Outlook (Revenue, USD Million, 2014 - 2026)

    • Immunosuppressors

    • Phosphodiesterase 5 Inhibitors - PHA

    • Endothelin Receptor Antagonists

    • Prostacyclin Analogues

    • Calcium Channel Blockers

    • Analgesics

    • Others

  • Indication Outlook (Revenue, USD Million, 2014 - 2026)

    • Systemic

    • Localized

  • Regional Outlook (Revenue, USD Million, 2014 - 2026)

    • North America

      • U.S.

      • Canada

    • Europe

      • U.K.

      • Germany

      • Spain

      • France

      • Italy

    • Asia Pacific

      • China

      • Japan

      • India

      • Hong Kong

      • Singapore

      • Australia

      • South Korea

    • Latin America

      • Brazil

      • Mexico

      • Argentina

    • MEA

      • South Africa

      • Saudi Arabia

      • UAE

      • Qatar

Key questions answered by the report
Request for Customization

Choose License Type

Single User - $5,950
Multi User (2-5) - $6,950
Enterprise Access - $8,950

Buy Chapters or Sections

Avail customized purchase options to meet your exact research needs:

  • Buy sections of this report
  • Buy country level reports
  • Request for historical data
  • Request discounts available for Start-Ups & Universities

Why Choose Us

  • Research support

    24/5 Research support

    Get your queries resolved from an industry expert.

  • Custom research service

    Custom research service

    Design an exclusive study to serve your research needs.

  • Quality assurance

    Quality assurance

    A testimonial for service in the form of BBB "A" Accreditation.

  • BBB Rating dandb
  • Information security

    Information security

    Your personal and confidential information is safe and secure.

  • grand view research PCI DSS complaint grand view research paypal verified