GVR Report cover Tangential Flow Filtration Market Size, Share & Trends Report

Tangential Flow Filtration Market Size, Share & Trends Analysis Report By Product (Single-use, Membrane Filters), By Technology (Ultrafiltration, Microfiltration), By Application, By End-user, By Region, And Segment Forecasts, 2022 - 2030

  • Report ID: GVR-4-68039-997-3
  • Number of Pages: 200
  • Format: Electronic (PDF)
  • Historical Range: 2018 - 2020
  • Industry: Healthcare

Report Overview

The global tangential flow filtration market size was valued at USD 1.88 billion in 2021 and is expected to expand at a compound annual growth rate (CAGR) of 11.53% from 2022 to 2030. The market is majorly driven by the rising adoption of tangential flow filtration technology to meet the growing demand for biopharmaceuticals for treating various disorders and degenerative diseases such as diabetes, cancer, and rheumatoid arthritis. In addition, the advantages of tangential flow filtration (TFF) such as high performance and reproducible operations and increasing investments for the development of novel TFF products by companies are influencing the growth of the market.

Japan tangential flow filtration market size, by technology, 2020 - 2030 (USD Million)

The COVID-19 pandemic has positively impacted industry growth as there was a rise in the manufacturing of vaccines and viral vectors to tackle the SARS-CoV-2 infection. The rise in the production of COVID-19 treatment therapeutics also increased downstream processing, which further requires filtration and separation techniques. For example, in a research article published in August 2021, scientists from Brazil and the U.S. evaluated the production process of COVID-19 adenoviral vector vaccines. During the downstream process, the scientists employed two steps of ultrafiltration-diafiltration by employing TFF systems having 300kDa membrane for recovery and concentration of the adenoviral vectors. Such research studies along with the mass manufacturing of COVID-19 vaccines and the influx of investments for expanding the production have paved the growth path for the market.

Furthermore, the continuous investments by industry players and supportive government initiatives have resulted in facility expansions and intensive R&D for the development of new equipment and technologies, which are employed for the manufacturing of biopharmaceuticals. The growing demand for biopharmaceuticals and the COVID-19 vaccine mass production has created a wave of new opportunities for key players. Moreover, the rising adoption of single-use bioprocessing systems for the manufacturing of biopharmaceuticals has boosted the use of single-use TFF systems among the end-users. For instance, in January 2021, a total of USD 114 million was invested by Pall Corporation for production capacity expansion to meet the increased demand for single-use technologies needed for COVID-19 vaccine manufacturing. The firm has added capacity at its facilities in Ilfracombe and Newquay (the U.K.), Hoegaarden (Belgium), Medemblik (Netherlands), Bad Kreuznach (Germany), Fajardo (Puerto Rico), and Pensacola (the US).

Additionally, the advantages of TFF over normal flow filtration attribute to the high usage rate and further influence the growth. Increased flow rate, lower product build-up, elimination of filter aids, deceased cleaning, and change of filters are a few of the advantages of TFF systems. Furthermore, as TFF is a continuous filtration process, it reduces the operation time and technological advancements have allowed automation. Automated filtration systems further boost the productivity and robustness of the process and reduce membrane fouling, which eventually increases the membrane shelf-life. Owing to these benefits, TFF systems have found their application in biopharmaceutical manufacturing. Multiple players have also advanced their market presence and developed novel technology. For example, in June 2021, Repligen Corporation was granted a patent for its Tangential Flow Depth Filtration (TFDF) filter, which provides a single-use solution with low hold-up volume and high flux. Such developments and innovations in this space are expected to propel the industry growth over the forecast period.

Product Insights

Membrane filters held the largest share of over 30.0% in 2021. The continuous adoption of filtration systems by various industries, the advantages of the TFF system over dead-end or normal flow filtration, and accessibility to different filter types such as PES, PVDF, PCTE, and PTFE are contributing to the segment growth. Furthermore, the flexibility to scale up and down due to the availability of different membrane pore sizes and filtration areas for the intended process fuels revenue generation.

Single-use TFF systems will observe the fastest growth rate of 12.26% during the forecast period. The high adoption rate of single-use technologies by multiple companies, contract organizations, and research settings will bolster the growth of the market. Several benefits such as smaller footprints, reduced process time, and elimination of cross-contamination have driven the market for single-use TFF systems. Additionally, the launch of new single-use TFF systems contributes to the expected growth. For example, in September 2021, ABEC, Inc. announced the launch of its new single-use TFF system. With this product launch, the company aims to increase downstream productivity by offering high flow rates and reduced processing time.

Technology Insights

The microfiltration segment held the largest share of over 30.0% in 2021. High use of microfiltration technology during cell separation processes majorly contributes to the revenue generation of this segment. In addition, the challenges such as protein fractionation, microbial removal, and pretreatment of other membranes are solved by microfiltration membranes, thus bolstering the growth. Moreover, as these membranes have pore sizes in the range of 0.1 to 10 µm, this technology offers optimized flux, reduces the fouling tendency, and helps in the separation of suspended particles.

The nanofiltration segment is expected to witness the fastest growth from 2022 to 2030. With membrane pore size in the range of 1 to 10 nm, nanofiltration technology is highly employed in the end-stage sterilization process and selective ion separation. Furthermore, these membranes produce high flux at lower pressures and even require lesser energy. Nanofiltration membranes remove multivalent ions, microbes, proteins, and organic compounds, and only allow water and some salts to pass through, thus this technology is widely adopted in drug formulation and filling, water purification, feed water stream management, and water pollution control, thereby driving the future demand for this segment.

Application Insights

Protein purification dominated the market with over 25.0% in 2021. The rapidly growing industry of recombinant proteins is the key factor driving the market. The increased production of therapeutic proteins employs TFF stage during the manufacturing due to its added advantages. Also, in many biomanufacturing industries, TFF has eliminated the use of centrifugation. For instance, Pall Corporation confirmed that its StaxmAx Clarification equipment has been employed by Dr. Reddy’s Laboratories, an Indian pharmaceutical MNC, for multiple monoclonal antibodies harvesting processes.  In addition, this separation technology has been used over years to desalt and concentrate proteins and peptides, recover and purification of antibodies, and many more such processes. Thus, the industry trend of adopting recombinant protein-based therapeutics will fuel the growth of tangential flow filtration applications.

The vaccine and viral vectors segment are anticipated to exhibit the fastest CAGR during the forecast period. Owing to the worldwide demand for COVID-19 vaccines for preventative treatment during the pandemic, the use of TFF technology in the downstream process is estimated to contribute to the growth. The automation in TFF systems allows an increase in the speed and easy scale-up of vaccine manufacturing processes. Additionally, the use of single-use TFF systems offers facility flexibility, low hold-up volume, increased product recovery, faster output with reduced process times, and elimination of cross-contamination, which is crucial when mass-producing vaccines.

End-user Insights

Pharmaceutical and biotechnology companies held the largest share of over 40.0% in 2021. This is owing to the increased drug discovery programs, multiple therapeutic product pipelines, and rising investments by companies to support the R&D efforts. Moreover, the presence of numerous TFF product offerings by key players allows manufacturers to employ these products for various applications. For instance, Sartorius AG offers ready-to-use TFF cassettes in single and reusable types, which can be used in laboratories and industries. Vast applications such as harvesting cells, concentration or fractionation of molecules, recovery of viral vectors, and clarifications of broths have also increased the usage of TFF systems. In addition, the COVID-19 vaccine production by pharmaceutical and biotechnological companies contributed to this segment’s revenue generation.

Global tangential flow filtration market share, by end-user, 2021 (%)

The contract research organizations (CROs) and contract manufacturing organizations (CMOs) segment is expected to witness the fastest growth over the forecast period. Rising demand for biopharmaceuticals, increased investments, and huge adoption of single-use technologies will contribute to segment growth. TFF systems offer CROs and CMOs the required flexibility, reduced operating time, and productivity and efficiency in the manufacturing process. This further allows these entities to produce biopharmaceutical products with faster speed for commercialization.

Regional Insights

North America held the largest revenue share of over 40.0% in 2021. The increase in bioprocessing operations to meet the demand for biotherapeutics, increasing incidence of chronic diseases and genetic disorders, rising awareness regarding the safety of treatments, and the developed healthcare settings have boosted regional growth. In addition, the presence of a supportive government fuels development. For example, the Government of Canada committed about USD 0.7 billion (CAD 1 billion) in funding in budget 2021 for developing life sciences and bio-manufacturing firms. This funding is for over seven years and through SIF (Strategic Innovation Fund). Through this fund, Biovectra, a CDMO enhanced its Nova Scotia biologics facility and opened a new facility in Prince Edward Island, which aims to boost Canada’s domestic demand for therapeutics and vaccines.

Tangential Flow Filtration Market Trends by Region

Asia Pacific (APAC) is expected to emerge as the fastest-growing regional market over the forecast period. Key factors such as increasing demand for biologics and drugs, a significant influx of investments by domestic and international companies, and the rise of CMOs in emerging countries such as China, Japan, and South Korea are contributing to the industry growth. Moreover, the focus on the modernization of treatments, developing healthcare infrastructure, and demand for low-cost therapeutics will support the growth of the TFF market in APAC.

Key Companies & Market Share Insights

The market is growing endlessly for the past few years owing to its advantages and high adoption rate by bio-manufacturers. The increased application in protein purification techniques, immunology, and microbiology fields has created worthwhile opportunities for key players in the TFF marketplace. Moreover, a vast filtration product portfolio for numerous applications has resulted in high revenue generation. To gain a competitive advantage, players are employing various strategic initiatives such as acquisitions, partnerships, collaborations, and new product launches.

For instance, in November 2021, Donaldson Company, Inc. acquired Solaris Biotechnology Srl, an Italy-based bioprocessing equipment manufacturer, for USD 40.3 million (EUR 41 million). The acquisition expanded the company’s access to biopharma and life science customers as Solaris’s portfolio included bioreactors, TFF systems, and fermenters. Such business initiatives will boost the product portfolio, increase the adoption of TFF products in bioprocessing operations, and intensify the market competition, thereby driving the marketplace. Some prominent players in the global tangential flow filtration market include:

  • Danaher Corporation

  • Sartorius AG

  • Parker-Hannifin Corporation

  • Alfa Laval AG

  • Merck KGaA

  • Repligen Corporation

  • ABEC, Inc.

  • Sterlitech Corporation

  • Synder Filtration, Inc.

  • Meissner Filtration Products, Inc.

Tangential Flow Filtration Market Report Scope

Report Attribute


Market size value in 2022

USD 2.08 billion

Revenue forecast in 2030

USD 4.98 billion

Growth rate

CAGR of 11.53% from 2022 to 2030

Base year for estimation


Historical data

2018 - 2020

Forecast period

2022 - 2030

Quantitative units

Revenue in USD million/billion and CAGR from 2022 to 2030

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Product, technology, application, end-user, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S.; Canada; Germany; U.K.; France; Italy; Spain; Japan; China; India; Australia; South Korea; Brazil; Mexico; South Africa; Saudi Arabia; UAE

Key companies profiled

Danaher Corporation; Alfa Laval AG; Merck KGaA; Repligen Corporation; ABEC, Inc.; Sartorius AG; Parker-Hannifin Corporation; Sterlitech Corporation; Synder Filtration, Inc.; Meissner Filtration Products, Inc.

Customization scope

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Global Tangential Flow Filtration Market Segmentation

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2018 to 2030. For the purpose of this report, Grand View Research has segmented the global tangential flow filtration market report on the basis of product, technology, application, end-user, and region:

  • Product Outlook (Revenue, USD Million, 2018 - 2030)

    • Single-use Tangential Flow Filtration Systems

    • Reusable Tangential Flow Filtration Systems

    • Membrane Filters

      • Polyethersulfone (PES)

      • Polyvinylidene Difluoride (PVDF)

      • Polytetrafluoroethylene (PTFE)

      • Mixed Cellulose Ester & Cellulose Acetate

      • Polycarbonate Tracked Etched (PCTE)

      • Regenerated Cellulose

      • Others

    • Filtration Accessories

  • Technology Outlook (Revenue, USD Million, 2018 - 2030)

    • Ultrafiltration

    • Microfiltration

    • Nanofiltration

    • Others

  • Application Outlook (Revenue, USD Million, 2018 - 2030)

    • Protein Purification

    • Vaccine And Viral Vectors

    • Antibody Purification

    • Raw Material Filtration

    • Others

  • End-user Outlook (Revenue, USD Million, 2018 - 2030)

    • Pharmaceutical & Biotechnology Companies

    • Contract Research Organizations & Contract Manufacturing Organizations

    • Academic Institutes & Research Laboratories

  • Regional Outlook (Revenue, USD Million, 2018 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • U.K.

      • Germany

      • France

      • Italy

      • Spain

    • Asia Pacific

      • Japan

      • China

      • India

      • South Korea

      • Australia

    • Latin America

      • Brazil

      • Mexico

    • Middle East & Africa

      • South Africa

      • Saudi Arabia

      • UAE

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