AAV Contract Development And Manufacturing Organizations Market To Reach $3,490.3 Million By 2033

AAV Contract Development And Manufacturing Organizations Market Growth & Trends

The global AAV contract development and manufacturing organizations market size is estimated to reach USD 3,490.3 million by 2033, expanding at a CAGR of 16.5% from 2025 to 2033, according to a new report by Grand View Research, Inc. The main drivers of this market are the robust pipeline of adeno-associated virus (AAV) for gene therapies & vaccines, technological advancements in manufacturing of adeno-associated viral vectors, and a highly competitive market with various strategies undertaken by key market players. For instance, in September 2022, Rocket Pharmaceuticals, Inc. acquired Renovacor, Inc., a biotechnology company, focused on offering precision medicines. This acquisition is in line with the company's aim to strengthen its position as a pioneer in adeno-associated virus (AAV)-based gene therapy for cardiac illness.

AAV-mediated gene therapy products that address fatal and severely disabling diseases have proliferated in recent years, with investment in academic startups, and several products entering clinical trials by major pharmaceutical companies. AAV vector has become a highly effective treatment for cardiovascular, neurological, and immunological illnesses as well as cancer. Due to these factors, market participants and CDMOs implement strategies like M&A, expansions, product launches, collaborations, and partnerships.

Significant advancements have been made in the use of viral vectors within the gene therapy & gene-modified cell therapy fields over the past 10 years. Vendors have innovated existing technologies as part of the industry's ongoing improvement efforts to support the special needs of viral vector manufacturing. These developments include the introduction of iCELLis technology for adherent cell culture and the creation of chromatographic resins for the production of viral vectors. Furthermore, next-generation analytics such as Droplet Digital Polymerase Chain Reaction (ddPCR), Analytical Ultracentrifugation (AUC), Size-Exclusion Chromatography-Multi-Angle Light Scattering (SEC-MALS), and Capillary Electrophoresis-Sodium Dodecyl Sulphate (CE-SDS) facilitate accurate & precise quantification.

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AAV Contract Development And Manufacturing Organizations Market Report Highlights

• The downstream processing segment dominated the market with a revenue share of 54.9% in 2024. The main driver of this market is the small size of AAV capsids and they are very stable as compared to other viruses, so purification of AAV vectors is relatively easy

• Based on culture type, the market is segregated into adherent culture and suspension culture. The adherent culture segment dominated the market in 2024. As they require less specialized bioengineering knowledge than three-dimensional platforms

• Based on end user, The pharmaceutical and biopharmaceutical companies segment held the largest market share in 2024 and is also anticipated to show the highest growth over the forecast period

• Asia Pacific AAV contract development and manufacturing organizations industry is anticipated to witness the fastest CAGR over the forecast period. The large patient base, lower overall costs, skilled workforce, and changes in the regulatory scenario are the key factors driving the market growth

AAV Contract Development And Manufacturing Organizations Market Segmentation

Grand View Research has segmented the global AAV contract development and manufacturing organizations market based on workflow, culture, application, end use, and region:

AAV Contract Development And Manufacturing Organizations Workflow Outlook (Revenue, USD Million, 2021 - 2033)

• Upstream Processing

  • Vector Amplification & Expansion

  • Vector Recovery & Harvesting

• Downstream Processing

  • Purification

  • Fill Finish

AAV Contract Development And Manufacturing Organizations Culture Outlook (Revenue, USD Million, 2021 - 2033)

• Adherent Culture

• Suspension Culture

AAV Contract Development And Manufacturing Organizations Application Outlook (Revenue, USD Million, 2021 - 2033)

• Cell & Gene Therapy Development

• Vaccine Development

• Biopharmaceutical and Pharmaceutical Discovery

• Biomedical Research

AAV Contract Development And Manufacturing Organizations End Use Outlook (Revenue, USD Million, 2021 - 2033)

• Pharmaceutical and Biopharmaceutical Companies

• Academic & Research Institutes

AAV Contract Development And Manufacturing Organizations Regional Outlook (Revenue, USD Million, 2021 - 2033)

• North America

  • U.S.

  • Canada

  • Mexico

• Europe

  • UK

  • Germany

  • France

  • Italy

  • Spain

  • Denmark

  • Norway

  • Sweden

• Asia Pacific

  • Japan

  • China

  • India

  • Australia

  • South Korea

  • Thailand

• Latin America

  • Brazil

  • Argentina

• Middle East and Africa (MEA)

  • South Africa

  • Saudi Arabia

  • UAE

  • Kuwait

  • Oman

  • Qatar

List of Key Players in AAV Contract Development And Manufacturing Organizations Market

• Thermo Fischer Scientific, Inc.

• Creative Biogene

• Catalent Inc.

• Charles River Laboratories International, Inc.

• Danaher (Aldevron)

• Forge Biologics

• Genezen

• ViroCell Biologics

• Merck KGaA

• VIRALGEN

• Biovian Oy

• Esco Lifesciences (Esco Aster Pte. Ltd.)

• GenScript ProBio

• Porton Advanced Solution Ltd

• Ask Bio

• Showa Denko

• Takara Bio, Inc.

• ABL Manufacturing

• Oxford Biomedica

• Belief Biomed, Inc.

• Beijing Anlong Biomedicine Co., Ltd

• Forecyte Bio Limited

• Gene Pharma, Inc.

• Skyline Therapeutics

• TFBS Bioscience, Inc.