GVR Report cover Amniotic Membrane Market Size, Share & Trends Report

Amniotic Membrane Market Size, Share & Trends Analysis Report By End Use (Hospitals, ASCs), By Product (Cryopreserved, Dehydrated), By Application (Ophthalmology, Surgical Wounds), And Segment Forecasts, 2022 - 2030

  • Report ID: GVR-2-68038-657-8
  • Number of Pages: 120
  • Format: Electronic (PDF)
  • Historical Range: 2017 - 2020
  • Industry: Healthcare

Report Overview

The global amniotic membrane market size was estimated at USD 2.9 billion in 2021 and is estimated to grow at a compound annual growth rate (CAGR) of 14.8% during the forecast period. The amnion membrane is majorly used for wound healing owing to its bacteriostatic and pain reduction properties. Increasing awareness in the recent past has led to a rise in the number of transplants leading to increasing demand for these tissue-based products. This awareness has also led to a surge in the number of donations, thus, fueling the market growth. Typically, amniotic membranes are used for indications including reconstruction of the conjunctiva surface, pterygium excisions, surgical wounds, corneal ulcers, pressure and venous leg ulcers, limbal stem cell deficiency, and regenerative medicine among others.

Germany amniotic membrane market size, by application, 2020 - 2030 (USD Million)

Therefore, factors, such as increasing research in the field of stem cell and regenerative medicine, heavy R&D investments, and a rise in the number of surgeries performed worldwide, are expected to influence the market growth. The COVID-19 pandemic has caused enormous disruption in the supply chain of the overall medical device industry. The pandemic considerably transformed the functioning of healthcare systems. Disruptions across supply and demand chains, production capacities, and sales and revenue cycles were observed resulting in restrictions of economic activity.

However, major market players are undertaking initiatives to overcome the challenges posed by this pandemic. Initiatives, such as increasing investments, a surge in partnerships and collaborations, and innovative product development strategies, are anticipated to accelerate the market growth over the forecast period. Amniotic membranes are typically used in two categories, as a surgical graft or as a biological bandage for treating and managing wounds. The usage of these membranes facilitates re-epithelization acting as a scaffold when used as a graft.

Its anti-inflammatory and anti-scarring properties are especially vital in case of burn injuries, reducing intensified inflammation and discomfort in patients. Hence, increasing awareness about these benefits is anticipated to propel market growth. Moreover, they are widely used in the treatment of eye surface disorders, such as in the treatment of bacterial keratitis, corneal ulcers, cataract, glaucoma, bullous keratopathy, corneal degeneration, ocular dystrophy, eyelid reconstruction, and various others. The rise in the geriatric population worldwide has spurred the number of ophthalmology surgeries, creating a huge demand for these tissue-based products.

Product Insights

Based on the product, the market is classified into dehydrated and cryopreserved amniotic membranes. Cryopreserved amniotic membrane held the largest revenue share of more than 58.5% in 2021 due to its high effectiveness and adoption rates globally. This kind of cryopreserved membrane is usually stored in a cell culture medium that contains 50% glycerol at a temperature of -80 °C. The amniotic membrane is well-preserved in cryopreserved amniotic membranes with its histological and biological properties. Thus, cryopreserved membranes are majorly used in visual surgeries aiding in reduced eye inflammation and enhanced recovery. Hence, this segment is anticipated to grow at a lucrative growth rate during the forecast period.

Dehydrated amniotic membranes are typically used for the treatment of various surgical wounds, reconstruction procedures, and venous and pressure leg ulcers. Usually, these are used as biological bandages to promote healing. PalinGen, FlōGraft, AmbioDisk, and AmnioFix are some examples of commercially available dehydrated amniotic membranes. In addition, these membranes are widely used in the treatment and management of surgical wounds and incisions, owing to properties such as their ability to maintain a watertight seal, inhibit inflammatory responses, and prevent disease transmissions. Thus, the rising usage of dehydrated membranes is anticipated to fuel the segment growth.

Application Insights

On the basis of application, the market is segmented into ophthalmology, surgical wounds, and others. The surgical wounds segment accounted for the maximum revenue share of more than 36% in 2021. Owing to the rising number of chronic and infectious diseases, a global rise in the number of surgeries has been witnessed boosting the market potential. These products are most often used in ophthalmic surgeries to initiate faster recovery and reduce inflammation. In addition, these membranes are used in reconstructive surgeries to promote healing and reduce scarring. According to the American Society of Plastic Surgeons, in 2017, around 17.5 million surgical cosmetic surgeries were performed across the U.S. These facts are indicative of the rising number of individuals undergoing surgery to enhance their aesthetic appeal.

The usage of amniotic membranes facilitates reduced scarring and promotes faster healing with a reduced risk of infections. Thus, the increasing number of cosmetic surgeries is creating a huge demand for these products, significantly aiding the market growth. These products are also used in the reconstruction of burn cases, propelling their demand. The usage of amniotic membranes in such cases helps in enabling epithelialization and rapid wound healing. It is also proven to reduce pain, facilitating easy movement of the affected area. As the usage of this method proves to be cheaper than allografts and xenografts, it is highly preferred and increasingly being used in developing regions, which is anticipated to accelerate the market growth.

End-use Insights

Based on end-use, the market is segmented into hospitals, Ambulatory Surgical Centers (ASCs), specialty clinics, and research and academic institutes. The hospital segment held the largest market share of more than 38% in 2021. This is mainly due to frequent visits by patients as hospitals are the primary care settings facilitating easy treatment for a wide range of diseases. The rising usage of amniotic membranes in ASCs is another factor expected to enhance market growth. The use of these products is easy and effective and also facilitates recovery of the wound without frequent visits to hospitals or clinics. This supports the segment growth.

Global amniotic membrane market share, by end use, 2021 (%)

Specialty clinics that are taken into consideration in the study are burn centers, plastic surgery clinics, dermatology clinics, and others. As most of these require methods to prevent infections and promote effective wound healing, the use of amniotic membranes is frequently seen in these settings, facilitating segment growth. Research and academic institutes also hold a significant share in the global market owing to increasing R&D investments by major market players and hospitals to understand the possible applications of the products. The amniotic membrane provides a substrate for stem cells that can be used in various other applications, propelling increasing research on the subject.

Regional Insights

North America dominated the market in 2021 with a revenue share of more than 31%. Well-established healthcare facilities and the presence of leading market players in North America are the major factors responsible for regional market growth. Increased focus on alternative technologies along with the adoption of advanced technologies in this region is expected to further boost the market growth during the forecast period. The Europe region accounted for the second-highest revenue share and is expected to grow at a steady CAGR from 2022 to 2030. The healthcare system in the European region is publicly funded and some countries have adopted universal healthcare systems, thereby increasing the product demand. An increasing number of patients suffering from chronic diseases is expected to boost the adoption of amniotic membranes among healthcare professionals.

According to the WHO, non-communicable diseases, such as cardiovascular diseases, chronic respiratory diseases, diabetes, and cancer, together account for over 86% of deaths and 77% of the disease burden in Europe. Thus, a high prevalence of chronic diseases and a rise in surgical interventions are anticipated to accelerate market growth. Asia Pacific is predicted to grow at a significant CAGR over the forecast period. Most of the countries in this region are developing economically and the disposable income is steadily increasing. Several multinational companies are heavily investing in this region. In addition, large unmet needs along with developing healthcare infrastructure, especially in Japan and India, are the major factors anticipated to enhance the market growth.

Key Companies & Market Share Insights

The market constitutes a large number of global as well as local players. The majority of the market players have strong collaborations with tissue banks and hospitals to ensure placental donations. Almost all of the key players are accredited by the American Association of Tissue Banks (AATB) to provide quality and sterile products. These factors are anticipated to aid in the growth of the market during the forecast period. Moreover, key players are mainly involved in developing and marketing membranes solely focused on specific areas of application. For instance, AmnioFix, developed by MiMedx Group Inc., is a dehydrated amniotic membrane that is used particularly for surgical incisions as it acts as a barrier membrane and reduces scar tissue formations. Some of the key players operating in the global amniotic membrane market are:

  • Alliqua BioMedical Inc.

  • Amnio Technology, LLC

  • Applied Biologics LLC

  • Human Regenerative Technologies, LLC

  • DermaSciences

  • Katena Products, Inc.

  • MiMedx Group Inc.

  • Skye Biologics, Inc.

  • Amniox Medical Inc.

  • Organogensis, Inc.

Amniotic Membrane Market Report Scope

Report Attribute


Market size value in 2022

USD 3.23 billion

Revenue forecast in 2030

USD 8.5 billion

Growth rate

CAGR of 14.8% from 2022 to 2030

Base year for estimation


Historical data

2017 - 2020

Forecast period

2022 - 2030

Quantitative units

Revenue in USD million/billion and CAGR from 2022 to 2030

Report coverage

Revenue forecast, company share, competitive landscape, growth factors & trends

Segments covered

Product, application, end-use, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S.; Canada; U.K.; Germany; France; Italy; Spain; Japan; China; India; Thailand; Australia; Brazil; Mexico; Argentina; Colombia; South Africa; Saudi Arabia; UAE

Key companies profiles

Alliqua BioMedical Inc.; Amnio Technology, LLC; Applied Biologics LLC; Human Regenerative Technologies, LLC; DermaSciences, Katena Products, Inc.; MiMedx Group Inc.; Skye Biologics, Inc.; Amniox Medical Inc.; Organogensis, Inc.

Customization scope

Free report customization (equivalent up to 8 analysts working days) with purchase. Addition or alteration to country, regional, and segment scope

Pricing and purchase options

Avail customized purchase options to meet your exact research needs. Explore purchase options


Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2017 to 2030. For the purpose of this study, Grand View Research has segmented the global amniotic membrane market report based on product, application, end-use, and region:

  • Product Outlook (Revenue, USD Million, 2017 - 2030)

    • Cryopreserved

    • Dehydrated

  • Application Outlook (Revenue, USD Million, 2017 - 2030)

    • Surgical Wounds

    • Ophthalmology

    • Others

  • End-use Outlook (Revenue, USD Million, 2017 - 2030)

    • Hospitals

    • Ambulatory Surgical Centers (ASCs)

    • Specialty Clinics

    • Research and Academic Institutes

  • Regional Outlook (Revenue, USD Million, 2017 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

      • France

      • Italy

      • Spain

    • Asia Pacific

      • Japan

      • China

      • India

      • Australia

      • Thailand

    • Latin America

      • Brazil

      • Mexico

      • Argentina

      • Colombia

    • MEA

      • South Africa

      • Saudi Arabia

      • UAE

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