Circulating Tumor Cells (CTC) Market Size, Share & Trends Report

Circulating Tumor Cells (CTC) Market Size, Share & Trends Analysis Report By Technology (Enrichment, Detection, Analysis, Negative Selection, Microchips), By Application, And Segment Forecasts, 2012 - 2022

  • Published Date: Mar, 2018
  • Base Year for Estimate: 2016
  • Report ID: 978-1-68038-287-7
  • Format: Electronic (PDF)
  • Historical Data: 2012 - 2016
  • Number of Pages: 130

Industry Insights

The global circulating tumor cells (CTC) market size was estimated at USD 4.99 billion in 2016 and is expected to grow at a double-digit growth rate during the forecast period. Increasing demand for preventive medicine, thus influencing the demand for CTC tests is a key factor that is expected to boost the market growth.

Germany CTC market

Circulating tumor cells are significantly useful in determining the status of disease progression rate and projection of therapy needed for tumor eradication. Further development of various tumor markers that can be used along with companion diagnostics to diagnose or monitor various forms of cancer are expected to boost usage rates of CTC tests in the coming years.

Circulating tumor cell detection test possesses the ability to detect, quantify, and analyze tumor cells in the blood of cancer patients. It includes enrichment, detection and analysis of the detected circulating tumor cells. Circulating tumor cells tests are applicable in the characterization of tumor cells through biochemical marker analysis. CTC isolation, detection, and molecular characterization systems find investigational application in prostate, breast, colon, head, neck, skin, lung, and pancreatic cancer

Growing incidences oncology diseases and the introduction of novel biotechnological methods that enable the isolation and quantitation of circulating tumor cells. Furthermore, other factors like early disease diagnosis, cost savings on multiple treatments, drug safety, patient compliance, and optimization of therapies are attributive for rising demand for the preventive medicine, thus influencing the demand for CTC tests.

On course of the forecast period it is expected that over 150 companion diagnostic on-label combinations and a range of personalized therapeutic drugs under clinical trials and development pipelines based on companion diagnostics. The level of adoption of companion diagnostics is expected to significantly increase after these obtain complete FDA approval and are commercialized fully.

Technology Insights

Based on technology, the market is categorized into ex-vivo positive selection technology, in-vivo positive selection, negative selection, microchips & single spiral micro channel. CTC enrichment methods have occupied a market revenue share of over 45.0% of the total market it is anticipated that it shall witness lucrative growth over the forecast period and these techniques for CTC detection include enrichment using magnetic beads, centrifugal force, filtration, and other physical properties such as size, density, deformity, and electric charges.

Development of enriched CTCs enables their functional characterization which is critical for disease interrogation and target therapy thus leading to rise in growth of demand for enrichment technology. The enrichment process can be broadly categorized into positive selection, negative depletion, and combination of both the techniques. High usage rates of enrichment methodology for CTC detection in biotechnology research establishments and high accuracy exhibited by this technology are some key factors expected to drive market growth in the forecast period.

Application Insights

The detection of CTC has become robust and reproducible with the introduction of novel technology such as capturing CTC clusters from the unprocessed blood using molecular biology techniques. Standardization in methodology, which is instrumental for the facilitation of multicenter trials, has led the elevated clinical utility of CTC. Research initiatives led by various organizations to discover efficient and high yielding CTC collection techniques is also set to help the market grow in the forecast years.

Global CTC market

Other applications such as CTC analysis hold much greater potential for market growth as this helps real time monitoring of the disease progression, and response to administered therapy. Biomarker development, use of screencell technology, tumorigenesis research might add to the revenue generation for the market growth in the forecast period.

Regional Insights

North America has had the dominating market share in the global market. It held the share of over 48% in 2016. Presence of key players, sophisticated healthcare infrastructure, high patient awareness levels, and high R&D investment pertaining to drug discovery are some of the factors responsible for its large share. Moreover, constant technological developments followed by new discoveries of specific antigens and biomarkers are responsible for estimated growth of CTC market testing.

Asia Pacific is estimated to witness a significant growth over the next decade with a CAGR of around 13.4%, owing to the increasing incidences of cancer among the developing countries in the region that can be attributed to the aging population and changing lifestyle associated with increasing disposable income and epidemiologic transition. Growth is mainly led by the technologically advanced countries like Japan & China, which are effectively pushing for better techniques to detect and monitor cancer.

Circulating tumor cells market Share Insight

Some major participants in the circulating tumor cells market include Janssen Diagnostics, Advanced Cell Diagnostics, Aviva Biosciences, Biocept Inc., Biofluidica Inc., CellTraffix Inc., Clearbridge BioMedics Pte Ltd, Epic Sciences Inc., Fluxion Biosciences Inc., ScreenCell, Silicon Biosystems, Sysmex Corporation, and Greiner Bio-One GmbH.

Other players include AdnaGen AG, Apocell Inc., Biocep Ltd, Canopus Bioscience Ltd, Creatv Microtech Inc., Ikonisys Inc., IV Diagnostics Inc., Miltenyi Biotech GmbH, Nanostring Technologies Inc., Rarecells Diagnostics., and Vitatex Inc.

Report Scope



Base year for estimation


Actual estimates/Historical data

2012 - 2016

Forecast period

2017 - 2022

Market representation

Revenue in USD Billion and CAGR from 2017 to 2025

Regional scope

North America, Europe, Asia Pacific, Latin America, Middle East & Africa

Country scope

U.S., Canada, Germany, France, UK, China, Japan, Brazil, South Africa

Report coverage

Revenue forecast, company share, competitive landscape, growth factors and trends

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Segments covered in the report

This report forecasts revenue growth at global, regional & country levels and provides an analysis on the industry trends in each of the sub-segments from 2012 to 2022. For this study, Grand View Research has segmented the global circulating tumor cells market report based on technology, applications and region:

  • Technology Outlook (Revenue, USD Billion; 2012 - 2022)

    • CTC Enrichment

      • Ex-vivo positive selection

      • In-vivo positive selection

      • Negative selection

      • Microchips

      • Single spiral micro channel

    • CTC Detection

      • Immunocytochemical technologies

      • Molecular(RNA) based technologies

      • EPISPOT functional in-vitro cell culture

      • Functional in-vitro cell invasion assay

      • Xenotransplantation models

    • CTC Analysis

  • Application Outlook (Revenue, USD Billion; 2012 - 2022)

    • Tumorigenesis research

    • EMT biomarkers development

    • Cancer stem cell research

    • Others

  • Regional Outlook (Revenue, USD Billion; 2012 - 2022)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • France

      • UK

    • Asia Pacific

      • China

      • Japan

    • Latin America

      • Brazil

    • MEA

      • South Africa

Key questions answered by the report
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