Nucleotide Market Size, Share & Trends Analysis Report By Product (Deoxy Nucleotides), By Technology (TaqMan Allelic Discrimination, Gene Chips & Microarrays), By Application, By Region, And Segment Forecasts, 2023 - 2030

Nucleotide Market Size & Trends

The global nucleotide market size was valued at USD 788.8 million in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 7.12% from 2023 to 2030. The rising application scope of nucleotides in various end-use industries such as pharmaceuticals, food & beverage additives, animal feed additives, and diagnostics research will likely augment the growth. With rising consumer awareness related to the ill effects of savory ingredients, the demand for nucleotide-based flavor enhancers is anticipated to drive industry demand.

The rising application scope of the product in industries, including pharmaceuticals, particularly in the U.S. and Canada, is expected to have a positive impact on industry growth. Globally rising demand from the livestock industry for animals and increased animal health concerns have raised the demand for food additives. For instance, Gilead Sciences developed Remdesivir (GS-5734) with the help of the U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).

The rapidly expanding usage of nucleotides in diagnostics research for determining and testing diseases, including the presence of various viral infections, or certain forms of cancer, is expected to propel demand over the next few years. In addition, favorable government policies worldwide are expected to propel demand over the forecast period. According to the National Center for Biotechnology Information (NCBI), pyrimidine metabolism (PyM) is a complex process involving different enzymes in the cells. It includes recycling nucleosides, making new nucleotides from scratch, and breaking down pyrimidines. In regular cells, these processes work together smoothly. However, cancer cells depend heavily on making new nucleotides from scratch (de novo pathway) to fuel their fast and uncontrolled growth.

The growing use of nucleotide in nutraceutical products owing to factors such as poor diet or stress will help optimize the immune system's function, which is expected to propel industry growth. Furthermore, increasing pressure from various health and safety organizations regarding human health and safety is expected to promote product demand over the coming years.

The COVID-19 pandemic had a positive impact on the market for nucleotides. Nucleotides are used in the treatment of viral diseases, and the increased demand for nucleotides for COVID-19 has boosted the market. In addition, the rising application of nucleotides in drug discovery has also propelled market growth. There has been a surge in demand for nucleotides to develop new antiviral drugs. Nucleotides are also used to treat other viral diseases, such as hepatitis B and C, HIV, and influenza.

In addition to the demand for nucleotides in the pharmaceutical industry, there is also a growing demand for nucleotides in the food and animal feed industries. Nucleotides are added to food and animal feed to improve palatability, boost immunity, and promote growth. According to the UN Food and Agricultural Organization (FAO), a 60% increase in food production is expected by 2050, and the production of animal protein will grow even more as meat production will double, dairy production will triple, and fish production will almost triple.

Technology Insights

The major technological processes in the industry include TaqMan allelic discrimination, gene chips & microarrays, and SNP by pyrosequencing, among others. Among these key processes, the TaqMan allelic discrimination segment dominated the global market in 2022, followed by SNP by pyrosequencing. TaqMan allelic discrimination contributed significantly to the overall revenue in 2022 and is expected to witness strong growth in the near future, owing to the increasing demand from diagnostic research facilities.

The Asia Pacific region is expected to witness a considerable growth in demand for the TaqMan allelic discrimination technology, owing to the prevalence of chronic diseases. The technology of SNP by pyrosequencing is expected to witness brisk growth over the forecast years, owing to its high demand from major end-use industries and various advantages such as it being easy to read and share and offering true sequence information.

Application Insights

The diagnostics research segment dominated the global market for nucleotides in 2022. The fast-developing use of the product in diagnostics research for determining and testing diseases, including the presence of various viral infections or certain forms of cancer, is expected to propel segment demand over the next few years.

On the other hand, the food & beverage additive segment is expected to advance substantially through 2030, on account of the rising global demand for flavor enhancers, particularly in Asia Pacific, Europe, and North America. The previously mentioned versatile health benefits associated with nucleotides make them suitable for use in food & beverage items and medical purposes, which is likely to propel market growth over the forecast period.

Product Insights

The deoxy nucleotides (dNTPs) segment dominated the global nucleotide market in 2022 with a revenue share of 47.49% and is furthermore likely to expand with the fastest CAGR of 7.34% over the forecast period. The increasing use of (dNTPs) in various applications such as DNA sequencing, DNA synthesis, gene therapy, vaccine development, and cancer research is driving the segment’s substantial expansion.

The product segment is further divided into deoxy nucleotides, dideoxynucleotides, nucleotides for RNA Synthesis (rNTP), and labeled nucleotides. The dominance of the deoxy nucleotides segment in the overall nucleotides market is due to a combination of factors, including their stability, availability, and affordability. These factors will likely continue to drive the growth of the nucleotide industry during the forecast period.

Regional Insights

North America was the largest market for nucleotides in 2022, accounting for 39.09% of the global revenue share. The region is anticipated to dominate the industry over the forecast period due to the growing interest of regional consumers in nutritional food products. In addition, increasing self-medication, coupled with rising awareness regarding health safety, is likely to propel product demand over the forecast period.

Europe accounted for the second-largest revenue share of 23.94% of the global market in 2022, owing to the large-scale use of chemicals in the regional pharmaceutical sector over the past few years. The rising application scope in nutraceutical products, owing to its help in raising the resistance to bacterial infections in humans and animals, is expected to fuel demand for nucleotides.

Asia Pacific is likely to advance at the fastest CAGR of 7.81% over the forecast period. The increasing industrialization of nucleotides, growing demand for functional foods, and increasing prevalence of chronic diseases in the region are driving the market's growth. As a prerequisite for sustained social and economic development, the Chinese government released Healthy China 2030, a blueprint outlining its ongoing commitment to health. Nucleotides are expected to be in high demand in the region during the forecast period due to the growing pharmaceutical research initiatives in the country.

Key Companies & Market Share Insights

The market has a large number of manufacturers accounting for a majority of the market share. Product launches, approvals, strategic acquisitions, and innovations are just a few of the important business strategies market participants use to maintain and expand their global reach. For instance, in January 2023, Thermo Fisher Scientific Inc. acquired The Binding Site Group, a leading company for diagnostics globally. This acquisition is aimed at providing early diagnosis and accurate decisions for the appropriate treatment of patients.

In another instance, in January 2023, Agilent Technologies Inc. collaborated with Quest Diagnostics, one of the largest diagnostic information service companies globally. This collaboration will facilitate patients and providers in the U.S. to have extended access to the ‘Agilent Resolution ctDx FIRST’ liquid biopsy NGS test. Following are some of the major participants in the global nucleotide market:

• CJ CheilJedang Corp.

• Star Lake Bioscience Co., Inc.

• Thermo Fisher Scientific Inc.

• MEIHUA HOLDINGS GROUP CO., LTD.

• F. Hoffmann-La Roche Ltd.

• Biorigin

• DSM Nutritional Products AG

• Promega Corporation

• Agilent Technologies Inc.

• Lallemand Inc.

• Nanjing Biotogether Co., Ltd.

• NuEra Nutraceuticals Inc.

• Ohly

Nucleotide Market Report Scope

Global Nucleotide Market Report Segmentation

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For the purpose of this study, Grand View Research has segmented the global nucleotidemarket report based on product, technology, application, and region:

• Product Outlook (Revenue, USD Million, 2018 - 2030)

  • Deoxy Nucleotides

    • By Production Method

      • Enzyme Sourced

      • Chemical Synthesis

  • Dideoxynucleotides

  • Nucleotides for RNA Synthesis (rNTP)

  • Labelled Nucleotides

• Technology Outlook (Revenue, USD Million, 2018 - 2030)

  • TaqMan Allelic Discrimination

  • Gene Chips & Microarrays

  • SNP By Pyrosequencing

  • Other

• Application Outlook (Revenue, USD Million, 2018 - 2030)

  • Pharmaceuticals

  • Diagnostics Research

  • Food & Beverage Additive

  • Animal Feed Additive

  • Others

• Regional Outlook (Revenue, USD Million, 2018 - 2030)

  • North America

    • U.S.

    • Canada

  • Europe

    • UK

    • Germany

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • Asia Pacific

    • Japan

    • China

    • India

    • Australia

    • Thailand

    • South Korea

  • Latin America

    • Brazil

    • Mexico

    • Argentina

  • Middle East and Africa

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait