Oligonucleotide Synthesis Market Size, Share & Trends Analysis Report By Product & Service (Oligonucleotides, Equipment/Synthesizer), By Application (PCR Primers, PCR Assays & Panels), By Region, And Segment Forecasts, 2024 - 2030

Research Methodology

A three-pronged approach was followed for deducing the oligonucleotide synthesis market estimates and forecasts. The process has three steps: information procurement, analysis, and validation. The whole process is cyclical, and steps repeat until the estimates are validated. The three steps are explained in detail below:

Information procurement: Information procurement is one of the most extensive and important stages in our research process, and quality data is critical for accurate analysis. We followed a multi-channel data collection process for oligonucleotide synthesis market to gather the most reliable and current information possible.

• We buy access to paid databases such as Hoover’s and Factiva for company financials, industry information, white papers, industry journals, SME journals, and more.
• We tap into Grand View’s proprietary database of data points and insights from active and archived monitoring and reporting.
• We conduct primary research with industry experts through questionnaires and one-on-one phone interviews.
• We pull from reliable secondary sources such as white papers and government statistics, published by organizations like WHO, NGOs, World Bank, etc., Key Opinion Leaders (KoL) publications, company filings, investor documents, and more.
• We purchase and review investor analyst reports, broker reports, academic commentary, government quotes, and wealth management publications for insightful third-party perspectives.

Analysis: We mine the data collected to establish baselines for forecasting, identify trends and opportunities, gain insight into consumer demographics and drivers, and so much more. We utilized different methods of oligonucleotide synthesis market data depending on the type of information we’re trying to uncover in our research.

• Market Research Efforts: Bottom-up Approach for estimating and forecasting demand size and opportunity, top-down Approach for new product forecasting and penetration, and combined approach of both Bottom-up and Top-down for full coverage analysis.

• Value-Chain-Based Sizing & Forecasting: Supply-side estimates for understanding potential revenue through competitive benchmarking, forecasting, and penetration modeling.

• Demand-side estimates for identifying parent and ancillary markets, segment modeling, and heuristic forecasting.

• Qualitative Functional Deployment (QFD) Modelling for market share assessment.

Market formulation and validation: We mine the data collected to establish baselines for forecasting, identify trends and opportunities, gain insight into consumer demographics and drivers, and so much more. We utilize different methods of data analysis depending on the type of information we’re trying to uncover in our research.

• Market Formulation: This step involves the finalization of market numbers. This step on an internal level is designed to manage outputs from the Data Analysis step.

• Data Normalization: The final market estimates and forecasts are then aligned and sent to industry experts, in-panel quality control managers for validation.

• This step also entails the finalization of the report scope and data representation pattern.

• Validation: The process entails multiple levels of validation. All these steps run in parallel, and the study is forwarded for publishing only if all three levels render validated results.

Oligonucleotide Synthesis Market Categorization:

The oligonucleotide synthesis market was categorized into three segments, namely product & service (Oligonucleotides, Equipment/Synthesizer, Reagents, Services), application (PCR Primers, PCR Assays & Panels, Sequencing, DNA Microarrays, Fluorescence In Situ Hybridization, Antisense Oligonucleotides), and regions (North America, Europe, Asia Pacific, Latin America, Middle East & Africa).

Segment Market Methodology:

The oligonucleotide synthesis market was segmented into product & service, application, and regions. The demand at a segment level was deduced using a funnel method. Concepts like the TAM, SAM, SOM, etc., were put into practice to understand the demand. We at GVR deploy three methods to deduce market estimates and determine forecasts. These methods are explained below:

Market research approaches: Bottom-up

• Demand estimation of each product across countries/regions summed up to from the total market.

• Variable analysis for demand forecast.

• Demand estimation via analyzing paid database, and company financials either via annual reports or paid database.

• Primary interviews for data revalidation and insight collection.

Market research approaches: Top-down

• Used extensively for new product forecasting or analyzing penetration levels.

• Tool used invoice product flow and penetration models Use of regression multi-variant analysis for forecasting Involves extensive use of paid and public databases.

• Primary interviews and vendor-based primary research for variable impact analysis.

Market research approaches: Combined

• This is the most common method. We apply concepts from both the top-down and bottom-up approaches to arrive at a viable conclusion.

Regional Market Methodology:

The oligonucleotide synthesis market was analyzed at a regional level. The global was divided into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa, keeping in focus variables like consumption patterns, export-import regulations, consumer expectations, etc. These regions were further divided into twenty-three countries, namely, the U.S.; Canada; Germany; the UK.; France; Spain; Italy; Denmark; Sweden; Norway; China; Japan; India; South Korea; Australia; Thailand; Brazil; Argentina; Mexico; South Africa; Saudi Arabia; UAE; Kuwait.

All three above-mentioned market research methodologies were applied to arrive at regional-level conclusions. The regions were then summed up to form the global market.

Oligonucleotide synthesis market companies & financials:

The oligonucleotide synthesis market was analyzed via companies operating in the sector. Analyzing these companies and cross-referencing them to the demand equation helped us validate our assumptions and conclusions. Key market players analyzed include:

• Thermo Fisher Scientific, Inc. - Thermo Fisher Scientific, Inc. manufactures & provides laboratory reagents, equipment, analytical instruments, consumables, & diagnostic products. The company operates through numerous brands like Thermo Scientific, Applied Biosystems, Fisher Scientific, Invitrogen, and Unity Lab Services. It operates through four reportable segments: specialty diagnostics, life sciences solutions, analytical instruments, and laboratory products & services. The life sciences solutions segment includes four businesses: clinical Next-generation Sequencing (NGS), biosciences, bioproduction, and genetic sciences. The company provides services to pharmaceutical & biotechnology companies, clinical diagnostics laboratories, hospitals, government agencies, and research institutes.

• Merck KGaA - Merck KGaA is a pioneering multinational science and technology company. With a global presence across 60+ countries, it operates in three primary sectors: healthcare, life sciences, and performance materials/electronics. Its healthcare division focuses on pharmaceuticals and biopharmaceuticals, contributing to advancements in oncology, neurology, and fertility treatments. The life sciences sector provides vital products and services for scientific research and pharmaceutical manufacturing. Meanwhile, the performance materials/electronics division specializes in cutting-edge chemicals for industries like displays, cosmetics, and electronics.

• Danaher Corporation - Danaher is a prominent global innovator in life sciences and diagnostics, dedicated to leveraging science and technology to enhance human health. Collaborating with clients worldwide, Danaher tackles intricate challenges, designing solutions that translate scientific advancements into tangible improvements. The company focuses on life sciences, diagnostics, biotechnology, and other domains. It has prominent subsidiaries such as Cytiva and Integrated DNA Technologies (IDT) in the oligonucleotide synthesis space.

• Dharmacon Inc. - Dharmacon is a leader in RNA synthesis and has introduced 2’- ACE chemistry. It is a leader in RNA interference. Acquiring Open Biosystems expanded its RNAi portfolio, strengthening it with genome-wide vector-based shRNA tools. Today, Dharmacon is a key player in CRISPR-Cas9 gene editing and offers the industry's first synthetic guide RNAs & a comprehensive CRISPR gene editing toolkit, showcasing its commitment to innovative tools for the global genomics research community.

• Agilent Technologies - Agilent empowers customers globally in cancer treatment, ensuring food, water, air, & medicine quality and advancing drug discovery. With a comprehensive product portfolio, Agilent's innovations include analytical, research, and diagnostic solutions. Its international teams, including CrossLab, offer expertise and support, optimizing laboratories for impactful scientific endeavors.

• Kaneka Eurogentec S.A. - Eurogentec, a biotechnology supplier in Belgium and part of Kaneka Corporation, specializes in genomics & proteomics. Established in 1985, the ISO 9001 and ISO 13485 certified company, approved by the U.S. FDA, serves the life sciences, biotech, diagnostic, and pharmaceutical markets. With three business units, it offers genomics and proteomics solutions, including oligonucleotides, Polymerase Chain Reaction (PCR)/qPCR kits, peptides, antibodies, and assay kits. The In Vitro Diagnostics (IVD) unit supports GMP oligonucleotide and Taq DNA polymerase manufacturing for molecular diagnostic applications. The biomanufacturing unit focuses on GMP biomanufacturing, adhering to FDA and EMA requirements, for proteins, plasmids, & vaccines in preclinical, clinical, and commercial contexts.

• LGC Biosearch Technologies - Laboratory of the Government Chemist (LGC) is a prominent global life sciences tools company, delivering vital components and solutions in crucial areas of human healthcare and applied markets. With a focus on high-growth applications, LGC offers a premium product portfolio integral to genomic analysis and quality assurance. These tools are embedded in customer products and workflows, recognized for their performance, quality, & versatility. The company plays a pivotal role in customer workflows from discovery to commercial manufacturing, and its tools contribute to bringing new diagnostics & therapies to market, advancing research & development, optimizing food production, and ensuring the continuous monitoring & enhancement of food, environment, & consumer product quality.

• Biolegio - Biolegio, a prominent oligonucleotide synthesis company in Europe, specializes in producing custom oligos for global use in the biological industry. Universities and hospitals widely utilize its products and contribute to fundamental research on genetically determined diseases. DNA research employing its products aids in developing devices for faster and more accurate diagnoses using patient DNA material, supporting advancements in medical practices.

• Twist Bioscience - Twist Bioscience, based in South San Francisco, is a synthetic biology company with a proprietary silicon-based process for synthetic DNA production. Serving diverse fields like medicine, agriculture, and data storage, it provides synthetic genes, oligo pools, and NGS target enrichment to researchers aiming for positive global impact. Uniquely positioned, Twist accelerates efforts by offering precision, overcoming DNA synthesis and sequencing inefficiencies.

• Bio-Synthesis - Bio-Synthesis, based in Lewisville, Texas, is a contract manufacturer in biology specializing in high-quality nucleic acids, peptides, and molecular biology products. Operating an ISO 9001-certified facility, the company complies with regulatory standards for research, diagnostic, and therapeutic industries. As peptide specialists, the company offers premium products, including API polypeptides and peptide arrays, with expertise in both liquid & solid-phase Fmoc peptide synthesis. Bio-Synthesis is also a pioneer in oligonucleotide synthesis, introducing third-generation nucleic acid analogs like Bridged Nucleic Acid (BNA) for enhanced binding affinity and stability. Its solutions contribute to drug discovery and biomedical research advancement.

Value chain-based sizing & forecasting

Supply Side Estimates

• Company revenue estimation via referring to annual reports, investor presentations, and Hoover’s.

• Segment revenue determination via variable analysis and penetration modeling.

• Competitive benchmarking to identify market leaders and their collective revenue shares.

• Forecasting via analyzing commercialization rates, pipelines, market initiatives, distribution networks, etc.

Demand side estimates

• Identifying parent markets and ancillary markets

• Segment penetration analysis to obtain pertinent

• revenue/volume

• Heuristic forecasting with the help of subject matter experts

• Forecasting via variable analysis

Oligonucleotide Synthesis Market Report Objectives:

• Understanding market dynamics (in terms of drivers, restraints, & opportunities) in the countries.

• Understanding trends & variables in the individual countries & their impact on growth and using analytical tools to provide high-level insights into the market dynamics and the associated growth pattern.

• Understanding market estimates and forecasts (with the base year as 2023, historic information from 2018 to 2023, and forecast from 2024 to 2030). Regional estimates & forecasts for each category are available and are summed up to form the global market estimates.

Oligonucleotide Synthesis Market Report Assumptions:

• The report provides market value for the base year 2023 and a yearly forecast till 2030 in terms of revenue/volume or both. The market for each of the segment outlooks has been provided on region & country basis for the above-mentioned forecast period.

• The key industry dynamics, major technological trends, and application markets are evaluated to understand their impact on the demand for the forecast period. The growth rates were estimated using correlation, regression, and time-series analysis.

• We have used the bottom-up approach for market sizing, analyzing key regional markets, dynamics, & trends for various products and end-users. The total market has been estimated by integrating the country markets.

• All market estimates and forecasts have been validated through primary interviews with the key industry participants.

• Inflation has not been accounted for to estimate and forecast the market.

• Numbers may not add up due to rounding off.

• Europe consists of EU-8, Central & Eastern Europe, along with the Commonwealth of Independent States (CIS).

• Asia Pacific includes South Asia, East Asia, Southeast Asia, and Oceania (Australia & New Zealand).

• Latin America includes Central American countries and the South American continent

• Middle East includes Western Asia (as assigned by the UN Statistics Division) and the African continent.

Primary Research

GVR strives to procure the latest and unique information for reports directly from industry experts, which gives it a competitive edge. Quality is of utmost importance to us, therefore every year we focus on increasing our experts’ panel. Primary interviews are one of the critical steps in identifying recent market trends and scenarios. This process enables us to justify and validate our market estimates and forecasts to our clients. With more than 8,000 reports in our database, we have connected with some key opinion leaders across various domains, including healthcare, technology, consumer goods, and the chemical sector. Our process starts with identifying the right platform for a particular type of report, i.e., emails, LinkedIn, seminars, or telephonic conversation, as every report is unique and requires a differentiated approach.

We send out questionnaires to different experts from various regions/ countries, which is dependent on the following factors:

• Report/Market scope: If the market study is global, we send questionnaires to industry experts across various regions, including North America, Europe, Asia Pacific, Latin America, and MEA.

• Market Penetration: If the market is driven by technological advancements, population density, disease prevalence, or other factors, we identify experts and send out questionnaires based on region or country dominance.

The time to start receiving responses from industry experts varies based on how niche or well-penetrated the market is. Our reports include a detailed chapter on the KoL opinion section, which helps our clients understand the perspective of experts already in the market space.