Plasmid DNA Contract Manufacturing Market Size, Share & Trends Report

Plasmid DNA Contract Manufacturing Market Size, Share & Trends Analysis Report By Application (Cell & Gene Therapy, Immunotherapy), By Therapeutic Area (Cancer, Infectious Diseases), By End-user, By Region, And Segment Forecasts, 2023 - 2030

Report ID: GVR-4-68040-004-2
Number of Pages: 275
Format: Electronic (PDF)

Historical Range: 2018 - 2021
Industry: Healthcare

Market Segmentation

Plasmid DNA Contract Manufacturing Application Outlook (Revenue, USD Million, 2018 - 2030)
- Cell & Gene Therapy
- Immunotherapy
- Others
Plasmid DNA Contract Manufacturing Therapeutic Area Outlook (Revenue, USD Million, 2018 - 2030)
- Cancer
- Infectious Diseases
- Autoimmune Diseases
- Cardiovascular Diseases
- Others
Plasmid DNA Contract Manufacturing End-user Outlook (Revenue, USD Million, 2018 - 2030)
- Pharmaceutical and Biotechnology Companies
- Research Institutes
Plasmid DNA Contract Manufacturing Regional Outlook (Revenue, USD Million, 2018 - 2030)
- North America
  - North America Plasmid DNA Contract Manufacturing Market, By Application
    - Cell & Gene Therapy
    - Immunotherapy
    - Others
  - North America Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
    - Cancer
    - Infectious Diseases
    - Autoimmune Diseases
    - Cardiovascular Diseases
    - Others
  - North America Plasmid DNA Contract Manufacturing Market, By End-user
    - Pharmaceutical and Biotechnology Companies
    - Research Institutes
  - U.S.
    - U.S. Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - U.S. Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - U.S. Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Canada
    - Canada Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Canada Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Canada Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
- Europe
  - Europe Plasmid DNA Contract Manufacturing Market, By Application
    - Cell & Gene Therapy
    - Immunotherapy
    - Others
  - Europe Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
    - Cancer
    - Infectious Diseases
    - Autoimmune Diseases
    - Cardiovascular Diseases
    - Others
  - Europe Plasmid DNA Contract Manufacturing Market, By End-user
    - Pharmaceutical and Biotechnology Companies
    - Research Institutes
  - U.K.
    - U.K. Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - U.K. Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - U.K. Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Germany
    - Germany Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Germany Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Germany Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - France
    - France Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - France Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - France Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Italy
    - Italy Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Italy Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Italy Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Spain
    - Spain Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Spain Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Spain Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Denmark
    - Denmark Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Denmark Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Denmark Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Sweden
    - Sweden Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Sweden Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Sweden Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Norway
    - Norway Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Norway Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Norway Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Rest of EU
    - Rest of EU Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Rest of EU Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Rest of EU Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
- Asia Pacific
  - Asia Pacific Plasmid DNA Contract Manufacturing Market, By Application
    - Cell & Gene Therapy
    - Immunotherapy
    - Others
  - Asia Pacific Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
    - Cancer
    - Infectious Diseases
    - Autoimmune Diseases
    - Cardiovascular Diseases
    - Others
  - Asia Pacific Plasmid DNA Contract Manufacturing Market, By End-user
    - Pharmaceutical and Biotechnology Companies
    - Research Institutes
  - Japan
    - Japan Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Japan Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Japan Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - China
    - China Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - China Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - China Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - India
    - India Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - India Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - India Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Australia
    - Australia Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Australia Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Australia Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Thailand
    - Thailand Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Thailand Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Thailand Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - South Korea
    - South Korea Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - South Korea Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - South Korea Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Rest of APAC
    - Rest of APAC Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Rest of APAC Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Rest of APAC Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
- Latin America
  - Latin America Plasmid DNA Contract Manufacturing Market, By Application
    - Cell & Gene Therapy
    - Immunotherapy
    - Others
  - Latin America Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
    - Cancer
    - Infectious Diseases
    - Autoimmune Diseases
    - Cardiovascular Diseases
    - Others
  - Latin America Plasmid DNA Contract Manufacturing Market, By End-user
    - Pharmaceutical and Biotechnology Companies
    - Research Institutes
  - Brazil
    - Brazil Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Brazil Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Brazil Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Mexico
    - Mexico Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Mexico Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Mexico Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Argentina
    - Argentina Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Argentina Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Argentina Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Rest of LATAM
    - Rest of LATAM Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Rest of LATAM Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Rest of LATAM Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
- Middle East & Africa
  - Middle East & Africa Plasmid DNA Contract Manufacturing Market, By Application
    - Cell & Gene Therapy
    - Immunotherapy
    - Others
  - Middle East & Africa Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
    - Cancer
    - Infectious Diseases
    - Autoimmune Diseases
    - Cardiovascular Diseases
    - Others
  - Middle East & Africa Plasmid DNA Contract Manufacturing Market, By End-user
    - Pharmaceutical and Biotechnology Companies
    - Research Institutes
  - South Africa
    - South Africa Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - South Africa Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - South Africa Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Saudi Arabia
    - Saudi Arabia Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Saudi Arabia Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Saudi Arabia Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - UAE
    - UAE Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - UAE Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - UAE Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Kuwait
    - Kuwait Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Kuwait Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Kuwait Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes
  - Rest of MEA
    - Rest of MEA Plasmid DNA Contract Manufacturing Market, By Application
      - Cell & Gene Therapy
      - Immunotherapy
      - Others
    - Rest of MEA Plasmid DNA Contract Manufacturing Market, By Therapeutic Area
      - Cancer
      - Infectious Diseases
      - Autoimmune Diseases
      - Cardiovascular Diseases
      - Others
    - Rest of MEA Plasmid DNA Contract Manufacturing Market, By End-user
      - Pharmaceutical and Biotechnology Companies
      - Research Institutes

Plasmid DNA Contract Manufacturing Market Dynamics

Driver: Increasing Prevalence of Chronic Diseases

Lifestyle diseases share risk factors with prolonged exposure to three modifiable lifestyle behaviors: unhealthy diet, smoking, and physical inactivity resulting in chronic diseases such as chronic obstructive pulmonary disease, heart disease, obesity, diabetes, stroke, metabolic syndrome, & several types of cancer. Formerly known as Western diseases or diseases of affluence or diseases of industrialized nations, these conditions are already referred to as chronic diseases & non-communicable, which are a subgroup of degenerative diseases. In addition to placing a substantial financial burden on healthcare, chronic disease can lead to loss of independence, years of infirmity, or even death. 17.9 million people annually-die from cardiovascular diseases, followed by cancer (9.3 million), chronic respiratory disorders (4.1 million), and diabetes (2.0 million, including renal disease fatalities due by diabetes). Cardiovascular diseases are the leading cause of death globally. The majority of cardiovascular disease fatalities occur in low- and middle-income nations. The use of plasmid DNA as a delivery system for gene therapies and DNA vaccines against hereditary diseases infectious, such as cancer and COVID-19, has gained popularity in recent years. Plasmids are additionally utilized to create viral particles for viral gene and oncolytic therapy. The recent development of artificial gene synthesis techniques has made it easier than ever to put together new plasmids. A range of therapeutic targets, vaccination antigens, therapeutic antibodies, shRNA molecules, CRSPR/Cas9 system components, viral vector components, etc., can be encoded via plasmids. In addition, it is now simple to modify expression cassettes, optimize codons for higher & more precise expression, and decrease bacterial backbones for safer & more effective plasmid synthesis.

Driver: Growing Popularity of Gene Therapy

Researchers are shifting their focus to gene therapy as a potential treatment for cancer and other rare diseases than in past years. The increase in the percentage of clinical studies, including gene therapy was observed as compared to previous years. This shift is expected to boost the market growth in coming years. The next generation of cell and gene therapies would eventually be able to act as an alternate treatment or customized medication. Furthermore, these treatments have a better success rate than small-molecule therapies as Cell & Gene Therapy (CGT) focuses on illness causes rather than general targets like small-molecule therapy. The size and sophistication of enterprises entering the market are both growing significantly. Small biotechnology startups accounted for a large portion of early adopters in this sector. Most large-sized pharmaceutical companies are now investing in CGT. For instance, in December 2021, Novartis reached an acquisition deal with Gyroscope Therapeutics, a startup that specializes in ocular gene therapy. With this acquisition, Novartis would be better positioned to offer gene therapy for ocular diseases. By 2025, the FDA estimated that 10 to 20 new BLAs for cell therapy products would be approved annually in the U.S. alone. In recent years, the U.S. FDA enhanced the clearance process for CGT. For instance, Penn Medicine's CAR T Cell Therapy, which was designed for the treatment of people with relapsed or resistant follicular lymphoma, received its third FDA approval in May 2022. There would likely be a surge in interest in CGT research because of these approvals. Cell & gene therapy has become more significant in the treatment of COVID-19 in addition to cancer. With 10 to 20 cell and gene therapy approvals yearly over the following 5 years, the market is expected to grow dramatically. The first two treatments using this technique to be approved were Spinraza and Onpattro.

Restraint: Quality Issues Associated with Contract Manufacturing

The gene therapy has seen substantial progress in recent years; despite this, various CAR-T and gene therapies have been licensed in the U.S. and the European Union; it is still a very young industry. The lack of well-established and functional manufacturing platforms, along with the limited availability of some essential raw materials & high cost of development, are some of the current market problems. In 2021, according to Pharma’s Almanac report, sponsors have hurried some of these early products to market, which has resulted in the adoption of non-optimal, ineffective processes as well as the requirement for several post-approval obligations. Reproducibility, repeatability, comparability, and scalability have all become very real challenges from quality and regulatory perspectives. The manufacturers face few unique challenges that include constant evolution of technology; scaling out versus scaling up a manufacturing process while ensuring process consistency and product quality, variability, & availability of raw materials; and the reliance on extensive manual manipulations in a cleanroom environment. However, the industry is still attempting to come up with solutions to handle these many difficulties. Thus, these abovementioned factors may hinder growth of the plasmid DNA contract manufacturing market.

What Does This Report Include?

This section will provide insights into the contents included in this plasmid DNA contract manufacturing market report and help gain clarity on the structure of the report to assist readers in navigating smoothly.

Plasmid DNA contract manufacturing market qualitative analysis

Industry overview
Industry trends
Market drivers and restraints
Market size
Growth prospects
Porter’s analysis
PESTEL analysis
Key market opportunities prioritized
Competitive landscape
- Company overview
- Financial performance
- Product benchmarking
- Latest strategic developments

Plasmid DNA contract manufacturing market quantitative analysis

Market size, estimates, and forecast from 2018 to 2030
Market estimates and forecast for product segments up to 2030
Regional market size and forecast for product segments up to 2030
Market estimates and forecast for application segments up to 2030
Regional market size and forecast for application segments up to 2030
Company financial performance

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