GVR Report cover Antifungal Drugs Market Size, Share & Trends Report

Antifungal Drugs Market Size, Share & Trends Analysis Report By Drug Class (Azoles, Echinocandins, Polyenes, Allylamines), By Indication (Dermatophytosis, Aspergillosis, Candidiasis), By Region, And Segment Forecasts, 2022 - 2030

  • Report ID: GVR-1-68038-293-8
  • Number of Pages: 100
  • Format: Electronic (PDF)
  • Historical Range: 2018 - 2020
  • Industry: Healthcare

Report Overview

The global antifungal drugs market size was valued at USD 14.8 billion in 2021 and is projected to witness a compound annual growth rate (CAGR) of 3.7% from 2022 to 2030. The growing prevalence of fungal infections such as aspergillosis and candidiasis is one of the key factors propelling the market. Fungal infections encompass both systemic and superficial infections including infections of the skin, eye, mouth, and vagina. Antifungal products with fungicidal activity are mostly used to treat a wide array of diseases, such as athlete's foot, ringworm, and fungal meningitis, caused by fungal agents. Moreover, mounting cases of patients suffering from hospital-acquired or nosocomial infections and infectious diseases are poised to propel the growth of the market during the forecast period.

 U.S. antifungal drugs market, by drug class, 2020 - 2030 (USD Billion)

Fungal diseases are a public health problem as they can affect any individual. However, there is a severe threat of fungal infections to people with weak immune responses such as patients with AIDS. There is a high possibility of the development of opportunistic fungal infections in these patients. According to statistics published by the Centers for Disease Control and Prevention in 2016, every year, nearly 220,000 new individuals are affected by cryptococcal meningitis, which is a brain infection and has resulted in 181,000 deaths per year around the world. Most of the deaths are reported in sub-Saharan Africa, as the prevalence of HIV/AIDS is more in these countries.

The COVID-19 outbreak is predicted to restrain the market for antifungal drugs over the forecast period. The COVID-19 virus has spread to nearly all countries on the earth since its discovery in December 2019, causing the World Health Organization (WHO) to announce it as a public medical emergency. In the pneumonia cases, COVID-19, a novel coronavirus, was confirmed as the causative culprit. This virus quickly spread over the globe, killing a great number of individuals. The WHO declared COVID-19 a global pandemic in March 2020, and strict measures to halt the disease's spread were suggested. The pandemic has slowed the development of the healthcare industry and disturbed the supply chain since then.

The market for antifungal medications was impacted by flight limitations during the first quarter of 2020. The antifungal medicine business has been affected by supply chain disruption and strict social distancing rules. The unblocking of economies during the 2nd quarter of 2020, however, has resurrected the market for antifungal drugs, which had been stalling. Moreover, in order to stem the spread of COVID-19, government authorities in a majority of countries have ordered nationwide lockdowns. Similarly, health systems in a number of countries around the world were having trouble maintaining their supply chains. The slowness of the supply chain has also impacted the demand for antifungal medications.

The ongoing public-private partnership agreements in the pharmaceutical industry for the development of novel therapeutics are projected to offer tremendous growth opportunities to the market for antifungal drugs. For example, CARB-X, an international public-private partnership, is anticipated to provide around USD 350 million in the coming five years to boost the R&D pipeline. Partners involved are the U.S. Department of Health and Human Services, Antimicrobial Resistance Centre in England, and Boston University School of Law. A considerably large range of antifungal preparations, both topical and oral agents such as creams, sprays, tablets, and injections, are commercially available in the market for antifungal drugs. The rising popularity of over-the-counter antifungal drugs for dermal infections is further escalating market growth. However, the expiration of patents on branded therapeutics and the availability of counterfeit drugs are estimated to impede the growth of the market for antifungal drugs over the forecast period.

Drug Class Insights

The Azoles drug class segment dominated the market for antifungal drugs and accounted for a revenue share of 47.4% in 2021 with leading therapeutic agents such as Noxafil, Vfend, Diflucan, and Cresemba. The dominance of the market can be attributed to broad-spectrum activity delivered by Azoles. These agents support fungistatic activities by inhibiting fungal enzymes. Azoles are used in the treatment of candidemia, blastomycosis, systemic candidiasis, and ocular fungal infections. Azoles are also used in the treatment of systemic fungal infections, classified into triazoles and imidazoles. They offer a wide spectrum of activity and enhanced safety levels. Triazoles have fewer adverse effects, less serious drug interactions, and improved absorption and distribution properties. The aforementioned benefits of the use of azoles are contributing to the growth of the segment.

Increasing drug resistance among Aspergillus and Candida species, specifically to azoles, is expected to restrict the growth of the market for antifungal drugs. Allylamines are synthetic fungicidal agents that are anticipated to register a CAGR of over 2.2% during the forecast period. These drugs are prescribed for nail infections, jock itch, athlete foot, and ringworms. Lamisil is the most commonly prescribed topical antifungal medication after fluconazole for the treatment of systematic antifungals by dermatologists. Thus, the rising prevalence of dermatological diseases is likely to further boost the growth of the segment.

Indication Insights

Candidiasis, which is the most commonly occurring systemic fungal infection, is expected to exhibit the fastest CAGR over the forecast period. It is a yeast infection caused by genus Candida. Its treatment has evolved over time. Some of the changes include appropriate usage of echinocandins and broad-spectrum azoles for treatment of candidemia, mucosal candidiasis, and invasive candidiasis. Increasing number of patients, who are more susceptible to fungal infections, is a key driver for the segment. In addition, growing awareness among patients and healthcare professionals is poised to spur the growth of the antifungal drugs market.

 Global antifungal drugs market share, by indication, 2021 (%)

The dermatophytosis segment is anticipated to hold a sizeable share in the market during the forecast period due to the rising incidence of skin infections in children. In the recent decade, the incidence of this infection has considerably increased due to an unhealthy lifestyle. This has raised concerns for immunocompromised patients, who are susceptible to extensive lesions and atypical manifestations due to fungi.

The others segment of indications includes invasive pulmonary aspergillosis, rhinocerebral mucormycosis, and endocarditis. The availability of a limited number of therapeutics for the treatment of invasive fungal infections as compared to bacterial infections is one of the major problems faced by clinicians. Only a few classes of drug molecules have been developed over the past 30 years. Players are focusing on the development of effective therapeutic agents for the treatment of systemic fungal infections in immunocompromised patients. Various public-private partnership agreements for the development of novel therapeutics are projected to provide the market with tremendous growth opportunities.

Regional Insights

North America dominated the market for antifungal drugs and accounted for a revenue share of 41.5% in 2021. The growth of the region can be attributed to the increasing incidence of infectious diseases. Rise in prevalence has raised clinical urgency to increase the usage of these drugs and has boosted the development of innovative drugs with fast-track approvals by the FDA. In addition, the presence of established pharmaceutical companies, which are consistently striving for extensive commercialization of their drugs and enhancing their geographical reach, is anticipated to be a key factor escalating the growth of the regional market.

In the Asia Pacific, the market for antifungal drugs is estimated to exhibit the highest CAGR during the forecast period. The presence of a huge base of target population, growing disposable income and availability of drugs, and high unmet clinical needs are contributing to the growth of the regional market. Thus, global players are focusing on high R&D investment as well as commercializing branded drugs at a relatively lower price in the region. Japan held a substantial share in the APAC market in 2021, owing to an increasing medical expenditure and greater insurance coverage.

Key Companies & Market Share Insights

Key players are adopting competitive strategies, such as product development and collaborative agreements, to capture a greater market share. For instance, in June 2016, Merck entered into definitive agreement to acquire Afferent Pharmaceuticals. In addition, in July 2018, Sato Pharmaceutical Co., Ltd. and Eisai Co., Ltd. announced release of NAILIN oral antifungal tablets in Japan for the treatment of onychomycosis. The competition among generics is strong in the market, forming more than 60.0% of the overall industry. This can impede market penetration of newly-developed products over the forecast period. Therefore, to survive the competition, manufacturers need to engage in product diversification strategies. Some of the prominent players in the antifungal drugs market include:

  • Novartis AG

  • Pfizer, Inc.

  • Bayer AG

  • Sanofi

  • Merck & Co., Inc.

  • GlaxoSmithKline plc

  • Abbott

  • Glenmark

  • Enzon Pharmaceuticals, Inc.

  • Astellas Pharma, Inc.

Antifungal Drugs Market Report Scope

Report Attribute

Details

Market size value in 2022

USD 15.3 billion

Revenue forecast in 2030

USD 20.5 billion

Growth Rate

CAGR of 3.7% from 2022 to 2030

Base year for estimation

2021

Historical data

2018 - 2020

Forecast period

2022 - 2030

Quantitative Units

Revenue in USD million and CAGR from 2018 to 2030

Report coverage

Revenue forecast, company share, competitive landscape, growth factors and trends

Segments covered

Drug class, indication, region

Regional scope

North America; Europe; Asia Pacific; Latin America; Middle East & Africa

Country scope

U.S.; Canada; Germany; U.K.; Japan; China; India; Brazil; Mexico; South Africa

Key Companies profiled

Novartis AG; Pfizer, Inc.; Bayer AG; Sanofi; Merck & Co., Inc.; GlaxoSmithKline plc; Abbott; Glenmark; Enzon Pharmaceuticals, Inc.; Astellas Pharma, Inc.

Customization scope

Free report customization (equivalent to up to 8 analyst’s working days) with purchase. Addition or alteration to country, regional, and segment scope

Pricing and purchase options

Avail customized purchase options to meet your exact research needs. Explore purchase options

 

Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For the purpose of this study, Grand View Research has segmented the global antifungal drugs market report on the basis of drug class, indication, and region:

  • Drug Class Outlook (Revenue, USD Million, 2018 - 2030)

    • Azoles

      • Voriconazole (Vfend)

      • Posaconazole (Noxafil)

      • Clotrimazole (Canesten)

      • Isavuconazole (CRESEMBA)

      • Others

    • Echinocandins

      • Caspofungin (Cancidas)

      • Micafungin (Mycamine/ Funguard)

      • Others

    • Polyenes

      • Amphotericin (AmBisome)

      • Others

    • Allylamines

      • Terbinafine (Lamisil)

      • Others

    • Others

  • Indication Outlook (Revenue, USD Million, 2018 - 2030)

    • Dermatophytosis

    • Aspergillosis

    • Candidiasis

      • Invasive Candidiasis

      • Vulvovaginal Candidiasis (VVC)

      • Mouth/Throat/Esophageal Candidiasis

      • Other Candida Infections

    • Others

  • Regional Outlook (Revenue, USD Million, 2018 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • U.K.

      • Germany

    • Asia Pacific

      • Japan

      • China

      • India

    • Latin America

      • Brazil

      • Mexico

    • Middle East & Africa

      • South Africa

Frequently Asked Questions About This Report

pdf

GET A FREE SAMPLE

bck

This FREE sample includes market data points, ranging from trend analyses to market estimates & forecasts. See for yourself.

cog

NEED A CUSTOM REPORT?

We can customize every report - free of charge - including purchasing stand-alone sections or country-level reports, as well as offer affordable discounts for start-ups & universities.

Contact us now to get our best pricing.

BBB icon gvr sidebar D&B icon gvr sidebar

We are GDPR and CCPA compliant! Your transaction & personal information is safe and secure.