Bone Graft And Substitutes Market Size, Share & Trends Report

Bone Graft And Substitutes Market Size, Share & Trends Analysis Report By Product (Allograft, Synthetic), By Application (Dental, Spinal Fusion), By Region (APAC, North America), And Segment Forecasts, 2020 - 2027

  • Published Date: Nov, 2020
  • Base Year for Estimate: 2019
  • Report ID: GVR-1-68038-154-2
  • Format: Electronic (PDF)
  • Historical Data: 2016 - 2018
  • Number of Pages: 145

Report Overview

The global bone graft and substitutes market size was estimated at USD 2.68 billion in 2019 and it is expected to grow at a compound annual growth rate (CAGR) of 5.1% during the forecast period. Rising incidences of bone & joint disorders are the key driver of this market. Moreover, the rising demand for dental bone grafts is expected to drive the market.

The U.S. bone graft & substitutes market size

The advent of biocompatible synthetic grafts is also expected to fuel market growth. For instance, in October 2019, McGill University developed a biocompatible and toughened multilayered bone graft for the treatment of large bone defects. The implants were capable of sustaining mechanical loads while being temporary fillers with bone void regrowth.

In addition, the rising adoption of dental bone grafts and technological advancements are boosting the market growth. The higher success rate associated with dental bone grafts is boosting their demand. Minim Invasive Surg in 2018, stated that minimally invasive procedures were adopted for the treatment of a varied range of bone disorders in the year. It also stated that about 400,000 spinal fusion cases were done in the U.S. annually. Such factors positively impact market growth.

Bone grafts are widely adopted in orthopedic surgeries. These surgeries are classified as elective surgeries and most of the elective surgeries were postponed or canceled during the Covid-19 pandemic. This resulted in a drastically decreasing demand for devices required for orthopedic surgeries, including bone graft & substitutes. Furthermore, extended factory closures by market players in various nations also slowed down the production of the devices.

However, since the infection rate is expected to decline from last quarter 2020, the production cycles are expected to restore to normalcy, thereby boosting the market growth. In addition, many countries have also started to ease their lockdown by lifting certain restrictions related to healthcare facilities as well. This is expected to boost the demand for orthopedic surgeries, hence restoring the growth of the market.

Product Insights

The allograft segment led the global market and accounted for more than 58% share of the global revenue in 2019. The allograft segment is further divided into the demineralized bone matrix and others. The adoption of allografts is increasing due to its properties, such as immediate structural support and osteoconductivity. Moreover, it negates the second bone surgery, which reduces the time and triggers rapid wound healing. These are commonly used in spine, hip, and knee areas.

The synthetic product segment is anticipated to show significant growth over the forecast period. This growth is due to the products’ better biocompatibility, lesser risk of disease transmission, and better acceptance among patients as compared to allografts. The synthetic segment is further segmented into ceramic, composite, BMP, and polymers. The ceramic products led the synthetic segment dominated the market in 2019 and it is further sectioned into ß-TCP, HAP, bi-phasic calcium phosphates (BCP), α-TCP, and others.

Ceramic material gets easily reabsorbed in a patient’s body, which maintains the position of their bone, and it also has a reduced risk of infection or disease transmission. Furthermore, lesser time of surgery, controlled blood loss, and reduced pain offered by the procedure drive the segment.

Application Insights

The spinal fusion segment led the market and accounted for over 60% of the global revenue share in 2019. The growth can be attributed to the rising geriatric population. According to the World Health Organization, the geriatric population is expected to double from 12% to 22% from 2015 to 2050. Increasing usage of grafts for dental procedures is estimated to provide lucrative opportunities for the segment to grow through the forecast period. The grafts are usually used as a scaffold and filler to facilitate bone formation as well as to promote healing.

Global bone graft & substitutes market share

Increasing adoption of dental implant surgical procedures coupled with advanced techniques, such as bone regeneration and bone grafts, is anticipated to promote market growth. Furthermore, rising success rates of dental implants are also resulting in a rising demand for bone grafts & substitutes in the market. According to Trend Statistics, the number of dental implant procedures in 2019 has increased by 6.3% since the previous year. The joint reconstruction segment is also expected to demonstrate significant growth owing to the increasing number of knee and hip replacement procedures. According to the center for orthopedic & neurological care & research, the number of total knee replacement surgeries is estimated to increase by 673% to 3.5 million procedures annually, by 2030.

Regional Insights

North America led the global market in 2019 and accounted for over 41% share of the overall revenue. Growing awareness about the commercially available advanced products, rising healthcare expenditure, and accessibility of a well-developed healthcare structure are the major aspects contributing to the region’s growth. The U.S. is the top revenue-generator in the North American regional market due to high product demand on account of the rising incidence rate of orthopedic diseases and trauma-related injuries.

Asia Pacific is anticipated to register the fastest CAGR during the forecast period. This growth can be attributed to rising medical tourism and favorable government initiatives. On the other hand, stringent regulatory guidelines restrict the adoption in a few nations. For instance, in South Korea, the product has to be approved before marketing by the Korean Food and Drug Administration (KFDA). In Australia, the products are regulated by the Therapeutic Goods Administration (TGA). The stringent regulatory outlook in Japan restricts the entry of foreign companies in the country. Though, with the latest approval of DBM in Japan in 2019, the allograft market is set to record lucrative growth in the Asia Pacific over the next decade.

Key Companies & Market Share Insights

The market leaders are involved in product launch, partnership, and acquisitions to sustain the competition. Established organizations as well as small-scale companies are investing in product development to gain a competitive edge. For instance, in November 2019, NuVasive, Inc. received FDA approval for the CoRoent Small Interlock system, which is used to treat adult patients suffering from spinal instability or cervical disc degeneration. This will help the company expand its product portfolio.

In September 2019, DePuy Synthes-a subsidiary of Johnson & Johnson Medical Devices Companies-introduced a CONDUIT interbody platform-a 3D printed implant with EIT cellular titanium technology-for spine surgery. After the launch, the company is expected to expand its offerings to treat degenerative spine disease.

Bone Graft And Substitutes Market Report Scope



The market size value in 2020

USD 2.7 billion

Revenue forecast in 2027

USD 3.9 billion

Growth rate

CAGR of 5.1% from 2020 to 2027

Base year for estimation


Actual estimates/Historical data

2016 - 2018

Forecast period

2020 - 2027

Quantitative units

Revenue in USD million/billion and CAGR from 2020 to 2027

Report coverage

Revenue forecast, company share, competitive landscape, growth factors, and trends

Segments covered

Product, application, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S.; Canada; U.K.; Germany; France; Italy; Spain; Japan; China; India; South Korea; Brazil; Mexico; South Africa

Key companies profiled

AlloSource; Baxter; DePuy Synthes, Inc.; Medtronic PLC; Nuvasive, Inc.; Orthofix Holdings, Inc.; Smith & Nephew, Inc.; Stryker Corp.; Wright Medical Group N.V.; OST Developpement; Zimmer Biomet; Geistlich Pharma AG; TBF Tissue Engineering; Biobank

Customization scope

Free report customization (equivalent up to 8 analysts’ working days) with purchase. Addition or alteration to country, regional & segment scope.

Pricing and purchase options

Avail of customized purchase options to meet your exact research needs. Explore purchase options

Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2016 to 2027. For the purpose of this study, Grand View Research has segmented the global bone graft and substitutes market report on the basis of product, application, and region:

  • Product Outlook (Revenue, USD Million, 2016 - 2027)

    • Allograft

      • Demineralized Bone Matrix (DBM)

      • Others

    • Synthetic

      • Ceramics

        • HAP

        • β-TCP

        • α-TCP

        • Bi-phasic Calcium Phosphates (BCP)

        • Others

      • Composites

      • Polymers

      • Bone Morphogenic Proteins (BMP)

  • Application Outlook (Revenue, USD Million, 2016 - 2027)

    • Craniomaxillofacial

    • Dental

    • Foot & Ankle

    • Joint Reconstruction

    • Long Bone

    • Spinal Fusion

  • Regional Outlook (Revenue, USD Million, 2016 - 2027)

    • North America

      • U.S.

      • Canada

    • Europe

      • U.K.

      • Germany

      • France

      • Italy

      • Spain

    • Asia Pacific

      • China

      • Japan

      • India

      • South Korea

    • Latin America

      • Brazil

      • Mexico

    • Middle East & Africa

      • South Africa

Frequently Asked Questions About This Report

Pricing & Purchase Options

Service Guarantee

  • Insured Buying

    This report has a service guarantee. We stand by our report quality.

  • Confidentiality

    We are in compliance with GDPR & CCPR norms. All interactions are confidential.

  • Custom research service

    Design an exclusive study to serve your research needs.

  • 24/5 Research support

    Get your queries resolved from an industry expert.

Buy Chapters or Sections

Avail customized purchase options to meet your exact research needs:

  • Buy sections of this report
  • Buy country level reports
  • Request for historical data
  • Request discounts available for Start-Ups & Universities