GVR Report cover Bone Graft And Substitutes Market Size, Share & Trends Report

Bone Graft And Substitutes Market Size, Share & Trends Analysis Report By Material Type (Allograft, Synthetic), By Application (Craniomaxillofacial, Dental, Foot & Ankle), By Region, And Segment Forecasts, 2021 - 2028

  • Published Date: Feb, 2021
  • Base Year for Estimate: 2020
  • Report ID: GVR-1-68038-154-2
  • Format: Electronic (PDF)
  • Historical Data: 2016 - 2019
  • Number of Pages: 145

Report Overview

The global bone graft and substitutes market size was valued at USD 2.78 billion in 2020 and it is expected to expand at a CAGR of 5.8% from 2021 to 2028. Rising incidences of bone and joint disorders is the key driver of this market. According to a CDC report, the global incidence rate of hip fracture is expected to rise by 240% in women and 310% in men. Osteoporosis is estimated to affect around 200 million women worldwide in 2018. Moreover, the rising demand for dental bone grafts and substitutes is also expected to drive the market.

U.S. bone graft and substitutes market size, by material type, 2016 - 2028 (USD Million)

The launch of biocompatible synthetic grafts is also expected to fuel the growth in the market for bone graft and substitutes. Market players are investing in the development of such grafts to gain a stronger foothold. For instance, in October 2019, McGill University developed a biocompatible and toughened multilayered bone graft for the treatment of large bone defects, which was anticipated to provide a competitive edge over other players in the market.

Moreover, the rising requirements for dental bone grafts and technological advancements are also boosting the market growth. Minim Invasive Surg in 2018, stated that minimally invasive procedures are being adopted for the treatment of a varied range of bone disorders in the year. It also stated that about 400,000 spinal fusion cases were done in the U.S. annually. Such factors positively impact market growth.

Bone grafts are widely adopted for orthopedic surgeries. These surgeries are classified as elective surgeries and most of the elective surgeries were postponed or canceled during the COVID-19 pandemic. This resulted in a drastic decrease in demand for devices required for orthopedic surgeries, including bone graft and substitutes. Furthermore, extended factory closures by market players in various nations also slowed down the production of the devices.

 COVID19 bone graft and substitutes market impact: marginal growth of 3.6% from 2019 to 2020

Pandemic Impact

Post COVID Outlook

The bone grafts & substitutes market experienced a slight decrease in growth rate, which stood at 3.61% from 2019 to 2020 as compared to 4.0% as per earlier projections

The U.S. FDA released an updated notification in January 2021, according to which no known COVID-19 transmission by implantation, transplantation, infusion, or transfer of HCT/Ps. This will positively impact the market with a YoY growth of over 5% for the next few years.

Nuvasive reported a decrease in the revenue by 5.4% to USD 259.9 million in 2020 Q1 as compared to 274.8 million in 2019 Q1

By 2021, many companies reported recovery in sales with positive projections for the future. For instance, Stryker's spine segment revenue reported double-digit growth of 11.3% in 2021 Q1 as compared to 2020.

Stryker's gross profit decreased to 65.3% of sales in 2020 Q1 from 65.8% in 2019 Q1 primarily due to unfavorable results on account of deferred elective medical procedures as part of the COVID response

 


However, since the last quarter of 2020, the infection rate is expected to decline which will slowly restore the production cycles, hence increasing the production of bone grafts and substitutes as well. Additionally, many countries have also started to ease their lockdown by lifting certain restrictions related to healthcare facilities as well. This is expected to boost the demand for orthopedic surgeries, hence restoring the growth of the market for bone graft and substitutes.New expansion activities, product approvals, product launches, partnerships, and acquisitions have positively impacted the market in recent years. Furthermore, there has been a significant increase in the demand for bone grafts and substitutes due to the growing number of orthopedic surgeries which in turn is fueling the market growth.

Material Type Insights

The allograft segment led the market for bone graft and substitutes and accounted for the largest revenue share of over 57.0% in 2020. The allograft segment is further divided into the demineralized bone matrix and others. Adoption of allografts is increasing due to their properties such as immediate structural support and osteoconductivity. Also, they do not require another surgery bone, which triggers fast wound healing and decreases the surgery time. These are commonly used in spine, hip, and knee areas.

The synthetic segment is anticipated to show significant growth over the forecast period. This growth is due to the products’ better biocompatibility, lesser risk of disease transmission, and better acceptance among patients as compared to allografts. The synthetic segment is further classified into composite, ceramic, polymers, and BMP. The ceramic segment dominated the market in 2020 and it is further sectioned into HAP, ß-TCP, α-TCP, bi-phasic calcium phosphates (BCP), and others. Ceramic material gets easily reabsorbed in a patient’s body which maintains the position of their bone, and it also has a reduced risk of infection or disease transmission. Furthermore, the segment is securing popularity owing to its smaller time period of surgery, controlled blood loss, and reduced pain involved in the procedure performed.

Application Insights

The spinal fusion segment dominated the market for bone graft and substitutes and held the largest revenue share of more than 60.0% in 2020. The growth can be attributed to the rising adoption of bone graft materials for spondylosyndesis. Moreover, the rising geriatric population prone to orthopedic ailments is further pushing the need for corrective surgical treatment, thereby anticipated to boost the overall market in near future. According to the World Health Organization, the geriatric population is expected to double from 12% to 22% from 2015 to 2050.

Increasing usage of grafts for dental procedures is estimated to provide lucrative opportunities for the segment to grow through the forecast period. The grafts are usually used as a scaffold and filler in order to facilitate bone formation as well as to promote healing. The growing acceptance of dental implant surgical procedures along with advanced techniques such as bone regeneration and bone grafts is anticipated to boost the market growth. In addition to this, increasing success rates of dental implants are also resulting in a growing demand for bone grafts and substitutes. As per Trend Statistics, the number of dental implant procedures in 2019 has increased by 6.3% since the previous year.

Global bone graft and substitutesmarket share, by application, 2020 (%) 

The joint reconstruction segment is also expected to demonstrate steady growth owing to the increasing number of knee replacement and hip replacement procedures. According to the center for orthopedic and neurological care and research, the number of total knee replacement surgeries is estimated to increase by 673% to 3.5 million procedures annually, by 2030.

Regional Insights

North America dominated the bone graft and substitutes market and accounted for the largest revenue share of over 41.0% in 2020. Growing awareness related to the commercially accessible innovative products, accessibility of a well-developed healthcare structure, and higher healthcare expenditure of 16.9% in 2018 are the major aspects contributing towards its growth. In the U.S., the market for bone graft and substitutes is expected to grow well by generating the maximum demand for bone grafts and substitutes because of the growing number of trauma-related injuries as well as cases of orthopedic disease.

In Asia Pacific, the market for bone graft and substitutes is estimated to demonstrate lucrative growth during the forecast period. This growth can be attributed to rising medical tourism and favorable government initiatives. On the other hand, stringent regulatory guidelines restrict the adoption in a few nations. For instance, in South Korea, the product has to be approved before marketing by the Korean Food and Drug Administration (KFDA). In Australia, the products are regulated by the Therapeutic Goods Administration (TGA). The stringent regulatory outlook in Japan restricts the entry of foreign players into the country. Though, with the latest approval of DBM in Japan in 2019, the allograft market is set to record lucrative growth in the Asia Pacific over the next decade.

Key Companies & Market Share Insights

The market leaders are involved in product launches, partnerships, and acquisitions to sustain the competition. In March 2020, Orthofix International N.V acquired the FITBONE system. The transaction involves other applications such as the FITSPINE system for fusion less operation to treat scoliosis. Post this acquisition, Orthofix became the only orthopedic company to offer a complete range of external and internal fixation solutions for limb reconstruction.

Established organizations, as well as small players, are investing in product development to gain a competitive edge. For instance, in November 2019, NuVasive, Inc. received FDA approval for the CoRoent Small Interlock system, which is used to treat adult patients suffering from spinal instability or cervical disc degeneration. This will help the company expand its product portfolio.

Furthermore, in September 2019, DePuy Synthes-a subsidiary of Johnson & Johnson Medical Devices Companies-introduced a CONDUIT interbody platform-a 3D printed implant with EIT cellular titanium technology-for spine surgery. After the launch, the company is expected to expand its offerings to treat degenerative spine disease. Some of the prominent players in the bone graft and substitutes market include:

  • AlloSource

  • DePuy Synthes, Inc.

  • Baxter

  • Nuvasive, Inc.

  • Smith & Nephew,

  •  Medtronic

  • Orthofix Holdings, Inc.

  • TBF Tissue Engineering

  • OST Devloppement

  • Zimmer Biomet

  • Wright Medical Group N.V.

  • Geistlich Pharma AG

  • Stryker Corporation

  • Biobank

Bone Graft And Substitutes Market Report Scope

Report Attribute

Details

The market size value in 2021

USD 2.91 billion

Revenue forecast in 2028

USD 4.3 billion

Growth Rate

CAGR of 5.8% from 2021 to 2028

Base year for estimation

2020

Historical data

2016 - 2019

Forecast period

2021 - 2028

Quantitative units

Revenue in USD Million and CAGR from 2021 to 2028

Report coverage

Revenue forecast, company share, competitive landscape, growth factors, and trends

Regional scope

North America; Europe; Asia Pacific; Latin America; Middle East & Africa

Segments covered

Material type, application, region

Country Scope

U.S.; Canada; U.K.; Germany; France; Italy; Spain; Japan; China; India; South Korea; Brazil; Mexico; South Africa

Key companies profiled

AlloSource; Baxter; DePuy Synthes, Inc.; Medtronic; Nuvasive, Inc.; Orthofix Holdings Inc.; Smith & Nephew, Inc.; Stryker Corporation; Wright Medical Group N.V.; OST Devloppement; Zimmer Biomet; Geistlich Pharma AG; TBF Tissue Engineering; Biobank

Customization scope

Free report customization (equivalent to up to 8 analysts’ working days) with purchase. Addition or alteration to country, regional & segment scope.

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Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2016 to 2028. For the purpose of this study, Grand View Research has segmented the global bone graft and substitutes market report on the basis of material type, application, and region:

  • Material Type Outlook (Revenue, USD Million, 2016 - 2028)

    • Allograft

      • Demineralized Bone Matrix

      • Others

    • Synthetic

      • Ceramics

        • HAP

        • β-TCP

        • α-TCP

        • Bi-phasic Calcium Phosphates (BCP)

        • Others

      • Composites

      • Polymers

      • Bone Morphogenic Proteins (BMP)

  • Application Outlook (Revenue, USD Million, 2016 - 2028)

    • Craniomaxillofacial

    • Dental

    • Foot & Ankle

    • Joint Reconstruction

    • Long Bone

    • Spinal Fusion

  • Regional Outlook (Revenue, USD Million, 2016 - 2028)

    • North America

      • U.S.

      • Canada

    • Europe

      • U.K.

      • Germany

      • France

      • Italy

      • Spain

    • Asia Pacific

      • Japan

      • China

      • India

      • South Korea

    • Latin America

      • Brazil

      • Mexico

    • Middle East & Africa

      • South Africa

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