GVR Report cover Bone Grafts And Substitutes Market Size, Share & Trends Report

Bone Grafts And Substitutes Market Size, Share & Trends Analysis Report By Material Type (Allograft, Synthetic), By Application (Spinal Fusion, Foot & Ankle, Joint Reconstruction), By Region, And Segment Forecasts, 2022 - 2030

  • Report ID: GVR-1-68038-154-2
  • Number of Pages: 150
  • Format: Electronic (PDF)
  • Historical Range: 2017 - 2020
  • Industry: Healthcare

Report Overview

The global bone grafts and substitutes market size was valued at USD 2.91 billion in 2021 and is expected to expand at a compound annual growth rate (CAGR) of 6.2% from 2022 to 2030. One of the key factors fueling the growth of the market is the rising incidence of bone and joint disorders. According to the CDC report, the global incidence rate of hip fracture is expected to rise by 240% in women and 310% in men. Osteoporosis is estimated to affect around 200 million women worldwide. Moreover, the rising demand for dental bone grafts is expected to drive the market for bone grafts and substitutes over the forecast period.

U.S. bone grafts & substitutes market size, by application, 2020 - 2030 (USD Million)

Bone grafts are widely adopted for orthopedic surgeries. These surgeries are classified as elective surgeries and most of the elective surgeries were postponed or canceled during the COVID-19 pandemic. This resulted in drastically decreasing demand for devices required for orthopedic surgeries, including bone graft and substitutes. Furthermore, extended factory closures by market players in various nations slowed down the production of the devices. However, since the last quarter of 2020, the infection rate is expected to decline, which will slowly restore the production cycles, hence increasing the production of bone grafts and substitutes.

Additionally, many countries have started to ease their lockdown by lifting certain restrictions related to healthcare facilities. This is expected to boost the demand for orthopedic surgeries, hence restoring the growth of the market. The launch of biocompatible synthetic grafts is also expected to fuel the growth of the market. Market players are investing in the development of such grafts to gain a stronger foothold. For instance, in October 2019, McGill University developed a biocompatible and toughened multilayered bone graft for the treatment of large bone defects, which was anticipated to provide a competitive edge over other players in the market.

Moreover, rising requirements for dental bone grafts and technological advancements are boosting the market growth. Minim Invasive Surg in 2018, stated that minimally invasive procedures are being adopted for the treatment of a varied range of bone disorders in the year. It also stated that about 400,000 spinal fusion cases were done in the U.S. annually. Such factors are likely to positively impact the market growth in the years to come. Moreover, increasing demand for developing biocompatible bone grafts to reduce adverse reactions is fueling market growth. Various players in the industry are continuously making investments for the development of new products with better bioactivity, biocompatibility, and suitable mechanical properties.

Application Insights

The spinal fusion segment held the largest revenue share of over 60.0% in 2021. Based on application, the market is classified into long bone, spinal fusion, foot and ankle, joint reconstruction, craniomaxillofacial, and dental. The growth can be attributed to the rising adoption of bone graft materials for spondylosyndesis. Moreover, the rising geriatric population prone to orthopedic ailments is pushing the need for corrective surgical treatment, thereby anticipated to boost the market growth in the near future. According to the World Health Organization, the geriatric population is expected to double from 12% to 22% from 2015 to 2050.

Increasing usage of grafts for dental procedures is estimated to provide lucrative opportunities for the segment to grow through the forecast period. The grafts are usually used as a scaffold and filler in order to facilitate bone formation and promote healing. Growing acceptance of dental implant surgical procedures along with advanced techniques such as bone regeneration and bone grafts is anticipated to boost the market growth. In addition to this, increasing success rates of dental implants are resulting in the growing demand for bone grafts and substitutes in the market. As per Trend Statistics, the number of dental implant procedures in 2019 has increased by 6.3% since the previous year.

The joint reconstruction segment is expected to witness steady growth over the forecast period owing to the increasing number of knee replacement and hip replacement procedures. According to the center for orthopedic and neurological care and research, the number of total knee replacement surgeries is estimated to increase by 673% to 3.5 million procedures annually, by 2030. The long bone segment is anticipated to witness significant growth in the years to come. Injuries and trauma to extremities due to road accidents and sports injuries are among the factors boosting the adoption of bone grafts and substitutes in long bone surgeries. Major players operating in this segment include Baxter, Stryker, and Medtronic, among others.

Material Type Insights

The allograft segment led the market and accounted for over 55.0% share of the global revenue in 2021. The allograft segment is further divided into the demineralized bone matrix and others. The adoption of allografts is increasing due to their properties, such as immediate structural support and osteoconductivity. Additionally, they do not require another surgery bone, which triggers fast wound healing and decreases the surgery time. These are commonly used in spine, hip, and knee areas. Demineralized bone matrices are easily available in various sizes and shapes, such as chips, pellets, and granules. In addition, they demonstrate both osteoinductive as well as osteoconductive properties, which increases their popularity, hence boosting the market growth.

Global bone grafts & substitutes market share, by material type, 2021 (%)

The synthetic segment is anticipated to witness significant growth over the forecast period. This growth is due to the products’ better biocompatibility, lesser risk of disease transmission, and better acceptance among patients as compared to allografts. The synthetic segment is further classified into composites, ceramics, polymers, and BMP. The ceramics segment dominated the market in 2021 and is further sectioned into HAP, ß-TCP, α-TCP, bi-phasic calcium phosphates (BCP), and others. Ceramic material gets easily reabsorbed in a patient’s body, which maintains the position of their bone and has a reduced risk of infection or disease transmission. Furthermore, the segment is securing popularity owing to its smaller time period of surgery, controlled blood loss, and reduced pain involved in the procedure performed.

Regional Insights

North America dominated the market with over 40.0% share of the global revenue in 2021. Growing awareness related to the commercially accessible innovative products, accessibility of a well-developed healthcare structure, and higher healthcare expenditure of 16.9% in 2018 is the major aspects contributing to the regional market growth. The market in the U.S. is leading the North American as well as global market by generating the maximum demand for bone grafts and substitutes because of the growing number of trauma-related injuries as well as cases of orthopedic disease.

Asia Pacific is estimated to witness lucrative growth during the forecast period. This growth can be attributed to rising medical tourism and favorable government initiatives. On the other hand, stringent regulatory guidelines restrict the adoption in a few nations. For instance, in South Korea, the product has to be approved before marketing by the Korean Food and Drug Administration (KFDA). In Australia, the products are regulated by the Therapeutic Goods Administration (TGA). The stringent regulatory outlook in Japan restricts the entry of foreign players into the country. Though, with the latest approval of DBM in Japan in 2019, the allograft market is set to record lucrative growth in the Asia Pacific over the next decade.

Key Companies & Market Share Insights

The industry is marked by the presence of various large and small businesses operators. The market is characterized by intense competition and is dominated by key participants. Key players are focusing on executing innovative strategies like mergers and acquisitions, market penetration, partnerships, and distribution agreements to intensify their revenue. For instance, in February 2021, NuVasive acquired Simplify Medical to enhance its cervical portfolio and extend growth opportunities. Some prominent players in the global bone grafts and substitutes market include:

  • AlloSource

  • DePuySynthes, Inc.

  • Baxter

  • Nuvasive, Inc.

  • Smith & Nephew

  • Medtronic

  • Orthofix Holdings, Inc.

  • TBF Tissue Engineering

  • OST Devloppement

  • Zimmer Biomet

  • Wright Medical Group N.V.

  • GeistlichPharma AG

  • Stryker Corporation

  • Biobank

Bone Grafts And Substitutes Market Report Scope

Report Attribute


Market size value in 2022

USD 3.06 billion

Revenue forecast in 2030

USD 4.94 billion

Growth Rate

CAGR of 6.2% from 2022 to 2030

Base year for estimation


Historical data

2017 - 2020

Forecast period

2022 - 2030

Quantitative units

Revenue in USD million/billion & CAGR from 2022 to 2030

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Material type, application, region

Regions covered

North America; Europe; Asia Pacific; Latin America; MEA

Country Scope

U.S.; Canada; U.K.; Germany; Italy; France; Spain; Japan; China; India; South Korea; Brazil; Mexico; South Africa

Key companies profiled

Allo Source; Baxter; DePuy Synthes, Inc.; Medtronic; Nuvasive, Inc.; Orthofix Holdings, Inc.; Smith & Nephew, Inc.; Stryker Corporation; Wright Medical Group N.V.; OST Devloppement; Zimmer Biomet; GeistlichPharma AG; TBF Tissue Engineering; Biobank

Customization scope


Free report customization (equivalent to up to 8 analysts’ working days) with purchase. Addition or alteration to country, regional & segment scope.

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Segments Covered in the Report

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2017 to 2030. For the purpose of this report, Grand View Research has segmented the global bone grafts and substitutes market report on the basis of material type, application, and region:

  • Material Type Outlook (Revenue, USD Million, 2017 - 2030)

    • Allograft

      • Demineralized Bone Matrix

      • Others

    • Synthetic

      • Ceramics

        • HAP

        • β-TCP

        • α-TCP

        • Bi-phasic Calcium Phosphates (BCP)

        • Others

      • Composites

      • Polymers

      • Bone Morphogenic Proteins (BMP)

  • Application Outlook (Revenue, USD Million, 2017 - 2030)

    • Craniomaxillofacial

    • Dental

    • Foot & Ankle

    • Joint Reconstruction

    • Long Bone

    • Spinal Fusion

  • Regional Outlook (Revenue, USD Million, 2017 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

      • France

      • Italy

      • Spain

    • Asia Pacific

      • China

      • India

      • Japan

      • South Korea

    • Latin America

      • Brazil

      • Mexico

    • MEA

      • South Africa

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