Bone Grafts and Substitutes Market Size, Share & Trends Report

Bone Grafts and Substitutes Market Size, Share & Trends Analysis Report By Material Type (Natural, Synthetic), By Application Type (Spinal Fusion, Craniomaxillofacial, Long Bone), By Region, And Segment Forecasts, 2018 - 2025

  • Published Date: Jun, 2018
  • Base Year for Estimate: 2016
  • Report ID: GVR-1-68038-154-2
  • Format: Electronic (PDF)
  • Historical Data: 2014 - 2015
  • Number of Pages: 87

Industry Insights

The global bone grafts and substitutes market size was valued at USD 2.4 billion in 2016 and is expected to register a CAGR of 5.5% over the forecast period. Growing target population base is driving market growth. 

In addition, availability of advanced products in a variety of shapes and sizes providing high osteoconductive and osteoinductive properties is supporting its demand. Constantly rising geriatric population is one of the primary factors responsible for increased cases of osteoarthritis and lower of bone density. Furthermore, a paradigm shift toward minimally invasive procedures is augmenting market growth globally.

U.S. bone grafts and substitutes market

Bone grafts and substitutes are widely used in orthopedic surgeries for numerous applications. Rising cases of orthopedic problems casued due to weakened bones is projected to fuel demand. According to the Department of Economic and Social Affairs, United Nations, Population Division, the number of people aged over 60 was 841 million in 2013 and is expected to reach 2 billion in 2050. Thus, the number of orthopedic surgeries is expected to grow with rising geriatric population who is more prone to orthopedic ailments. Thus, the market is anticipated to witness a significant demand during the forecast period.

However, risk of disease transmission and immune response are major factors challenging market growth. In addition, high cost of advanced products and stringent regulatory pathway involved are further limiting market development. Furthermore, ethical issues associated with bone harvesting are restraining market growth in some regions.

Material Type Insights

Based on material, the market is segmented into natural and synthetic. The natural segment is further segmented into autografts and allografts. The allografts segment includes demineralized bone matrix and others, whereas the synthetic segment is further broken down into ceramic, composite, polymers, and Bone Morphogenic Proteins (BMP). Increasing prevalence of orthopedic diseases and growing awareness regarding various applications of bone graft substitutes are expected to boost segment growth.

The natural segment led the global bone grafts and substitutes market owing to availability of safety and risk data. Natural bone grafts are harvested from a patient’s or donor’s body. Companies such as Zimmer Biomet and TBF Tissue Engineering offer natural bone grafts (xenografts). Autografts are considered as a gold standard for bone grafting procedures owing to lower risk of immune response and disease transmission.

However, wounds at bone harvesting and grafting sites prolong healing process and result in longer hospital stay. Healthcare facilities are actively adopting novel methods to reduce hospital stay. Thus, disadvantages associated with autografts are driving the adoption of allografts and synthetic grafts. In addition, products with natural origin and osteoconductive and osteoinductive properties are commercially available. Therefore, growth of the autografts segment is anticipated to be limited during the forecast period.

Adoption of allografts over autografts is swiftly increasing owing to properties such as immediate structural support and osteoconductivity. Moreover, allografts do not require another surgery to harvest the bone, which results in reduced surgery time and wound healing. Thus, the growth of this segment is higher.

Application Insights

Major applications include craniomaxillofacial, dental, foot and ankle, joint reconstruction, long bone, and spinal fusion. Improving reimbursement coverage and presence of a large geriatric patient population are some of the factors supporting market growth.

Global bone grafts and substitutes market

Spinal fusion accounts for the largest revenue share. Spinal fusion is a procedure used to correct defects in small bones (vertebrae) in the spine. It is primarily used for immobilization of spinal column. The total number of spinal fusion procedures performed in the age group of 45 to 65 years were 1,95,235 in 2012, as per CDC. Rising geriatric population, which is more prone to spondylolisthesis and degeneration of disc, and increasing number of trauma cases due to road accidents and sports injuries are driving the product demand in this segment.

Regional Insights

North America captured the largest revenue share in 2016. High awareness regarding the commercially available products, higher healthcare expenditure, and availability of advanced healthcare infrastructure are the major factors contributing toward its growth. U.S., in particular, is leading the global market by generating the maximum product demand on account of high prevalence of orthopedic diseases and trauma-related injuries.

Developing economies in Asia Pacific, such as China, Japan, India, and Hong Kong, are expected to contribute to the market growth in the region. Booming medical tourism industry offering advanced healthcare services at affordable costs is the key factor driving the market in Asia Pacific.

Bone Grafts and Substitutes Market Share Insights

Some of the key market players are DePuy Synthes; Medtronic PLC; Nuvasive, Inc.; Orthofix Holdings, Inc.; Wright Medical Group N.V.; AlloSource, Inc.; and Stryker Corp. Most of these key companies adopt strategies such as partnerships, collaborations, mergers and acquisitions to strengthen their market position. New product development and launch is also one of the commonly adopted strategies.

For instance, in August 2017, AlloSource, Inc. introduced a new product—AlloFuse Select CM—an addition to the AlloFuse product line. The AlloFuse line extension was launched with the aim to enhance AlloFuse portfolio of demineralized bone fiber, putty, and gel allografts and to provide surgeons with premium AlloSource cellular allografts to meet various needs of patients.

Report Scope



Base year for estimation


Actual estimates/Historical data

2014 - 2015

Forecast period

2017 - 2025

Market representation

Revenue in USD Million & CAGR from 2017 to 2025

Regional scope

North America, Europe, Asia Pacific, Latin America & MEA

Country scope

U.S., Canada, U.K., Germany, China, Japan, Brazil, Mexico, & South Africa

Report coverage

Revenue, company share, competitive landscape, growth factors, trends

15% free customization scope (equivalent to 5 analysts working days)

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Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis on latest industry trends and opportunities in each of the sub-segments from 2014 to 2025. For the purpose of this study, Grand View Research has segmented the global bone grafts and substitutes market report on the basis of material, application, and region:

  • Material Type Outlook (Revenue, USD Million, 2014 - 2025)

    • Natural

      • Autografts

      • Allografts

        • Demineralised Bone Matrix

        • Others

    • Synthetic

      • Ceramic

      • Composite

      • Polymer

      • Bone Morphogenetic Proteins (BMP)

  • Application Type Outlook (Revenue, USD Million, 2014 - 2025)

    • Spinal Fusion

    • Dental

    • Joint Reconstruction

    • Craniomaxillofacial

    • Foot and Ankle

    • Long Bone

  • Regional Outlook (Revenue, USD Million, 2014 - 2025)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

    • Asia Pacific

      • Japan

      • China

    • Latin America

      • Mexico

      • Brazil

    • MEA

      • South Africa

Key questions answered by the report
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