GVR Report cover DNA Synthesis Market Size, Share & Trends Report

DNA Synthesis Market Size, Share & Trends Analysis Report By Service Type (Gene Synthesis, Oligonucleotide Synthesis), By Application (Research And Development, Therapeutics), By End-use, By Region, And Segment Forecasts, 2023 - 2030

  • Report ID: GVR-4-68040-009-7
  • Number of Pages: 125
  • Format: Electronic (PDF)
  • Historical Range: 2018 - 2021
  • Industry: Healthcare

Report Overview

The global DNA synthesis market was valued at USD 2.89 billion in 2022 and is expected to expand at a compound annual growth rate (CAGR) of 19.63% from 2023 to 2030. The growth of the market is attributed to factors such as the growing demand for DNA synthesis for its utility in modern applications in molecular biology, genetic engineering, and clinical diagnostics and therapeutics. The growing demand for research in drug discovery and personalized medicine is positively impacting the growth of the market. The COVID-19 pandemic situation has highlighted the utility of mRNA in research and vaccine production. The mRNA is essentially synthesized in the nucleus using the nucleotide sequence as a template. Moreover, synthetic nucleotides are being used for simulating reactions in the human body to gauge immunity profile, the development of vaccines, and the expansion of gene therapy techniques. For instance, in January 2022, Pfizer entered into a collaboration with Codex for the development of its nucleotide’s short-oligo ligation assembly-based novel enzymatic DNA synthesis technology for potential use by Pfizer in its biopharma products and mRNA-based vaccines.

U.S. DNA synthesis market size, by service type, 2020 - 2030 (USD Million)

Emerging advancements in genetic engineering have opened up new ventures for the appropriate engineering of biological systems. DNA writers are essentially genetically encoded devices used for targeted and recurring alterations of nucleotides in living cells. Many market players have developed novel DNA writers for use in nucleotide synthesis processes. The increasing demand for DNA synthesis across the globe is inspiring researchers to discover novel technologies for the same.

Gene synthesis facilitates researchers to choose a specifically desired sequence and design it. Further, gene synthesis is more precise, robust, and cost-effective than molecular cloning and mutagenesis. Moreover, the gene synthesis technique allows for codon optimization, which drastically enhances the efficacy of protein expression. For instance, in June 2022, researchers at the University of New York successfully created an artificial Hox gene that is intended to plan and re-direct the cells for the development of tissues, organelle, or organs using novel synthetic nucleotide technology and genomic engineering expertise in stem cells.

Enzymatic DNA synthesis offers seamless advantages in terms of accessibility and convenience, thereby enhancing the pace and control over iteration with drastically lowered environmental impact. As a result, market players are involved in collaborative efforts to create novel enzymatic DNA synthesis methods. For instance, in April 2022, Codexis, Inc. entered into a collaboration with Molecular Assemblies, Inc. to advance enzyme engineering technologies to deliver unique solutions for the enzymatic creation of nucleotides. The collaboration is intended to use highly evolved DNA polymerase to enable its Fully Enzymatic Synthesis technology.

Service Type Insights

The oligonucleotide DNA synthesis segment held the largest share of over 55.0% in 2022. Oligonucleotides are specifically designed with specific base pairs using a strand of nucleotide. They are most usually used as primers and probes for biological processes. The oligonucleotide synthesis technique is a rapid and inexpensive way of producing desired oligonucleotide sequences. Moreover, companies are entering into strategic initiatives to launch novel products, which is expected to drive the segment. For instance, in October 2022, Bachem signed into a collaboration with Eli-Lilly and Company for the development and manufacturing of APIs that are based on oligonucleotides. The collaboration is intended for Bachem to facilitate technical infrastructure and expertise to implement Lilly’s novel oligonucleotide manufacturing technology.

The gene DNA synthesis is anticipated to grow significantly during the forecast period. Custom gene synthesis overcomes the limitations of PCR-based processes. It yields reliable, safe, and cost-effective DNA constructs with verified sequences. Moreover, gene creation is a dependable, inexpensive method for creating highly precise, customized DNA constructs. DNA synthesis has transformed modern biology and is a powerful molecular biology tool that is gradually gaining over the research workflow.

Application Insights

The research and development segment held the largest share of over 40.0% in 2022. DNA is a fundamental tool for biotechnology-based research and trade. An estimate by Synbiobeta states that the global bio-engineering industry uses over 3 kg of nucleotide bases per year for vivid research applications. Synthetic DNA is also very widely used as the template for mRNA-based technologies for the production of vaccines for COVID-19 and cancers. For instance, in November 2021, DNAScript declares that it received a grant of USD 2.2 million from the National Human Genome Research Institute as a support fund for the development of next-generation printers that enzymatically print synthetic nucleotides.

The therapeutics segment is anticipated to grow significantly during the forecast period. Nucleotide synthesis is used to consistently support ongoing therapeutic research studies across the globe. Moreover, the availability of rapid, accurate DNA synthesis enables faster and more effective profiling of a wider range of targets from the capacity to develop synthetic gene circuits to developing and screening enzymes for therapeutic use.

End-use Insights

The biopharmaceutical companies segment held the largest share of over 40.0% in 2022 owing to a rise in the demand for biotechnology-based trade prospects across the globe. Moreover, synthetic nucleotides accelerate the developmental processes of enhanced bio-molecular therapies comprising enzymes, peptides, RNA catalysts, and aptamers. Moreover, companies can now synthesize DNA fragments more quickly, cheaply, and effectively due to the development of nucleotide production techniques and the focus on automation and autonomous technology. DNA synthesis is a fundamental molecular biology procedure that is crucial to many fields, including genetic engineering and clinical diagnosis and treatment. Such factors are expected to drive the segment.

Global DNA synthesis market share, by end-use, 2022 (%)

The academic and research institutes segment is anticipated to grow significantly during the forecast period. The synthesis of nucleotides consistently supports ongoing biological research studies across the globe for applications in fields such as genetic engineering and drug discovery.

Regional Insights

North America dominated the global market with a revenue share of over 40.0% in 2022. The demand for synthetic nucleotides in this region is growing due to numerous research initiatives in the region for emerging advancements in biotechnology including the rapid development of therapeutics and vaccines. For instance, in April 2021, DNAScript entered into a collaboration with Moderna along with a USD 5 million grant from the U.S. Defense Advanced Research Projects Agency. The collaboration is intended for the development of a prototype for robust manufacturing of therapeutics and vaccines as part of the global nucleic acids on-demand program.

DNA Synthesis Market Trends by Region

The Asia Pacific region is anticipated to witness the fastest growth during the forecast period. An increase in support for biological research and drug discovery is boosting the demand for a consistent supply of synthetic nucleotides for utility in research exercises. Numerous ongoing research studies at the research centers across the region and emerging market players are positively impacting the growth of the market.

Key Companies & Market Share Insights

Key players in the market are focusing on collaborative efforts, technology sharing, and geographical expansion in emerging regional markets. For instance, in January 2020, Evonetix entered into a collaboration with Imec to enhance the production of Evonetix’s proprietary micro-electromechanical systems-based silicon chips to enable the commercial scale platform for the robust growth of the market. Some prominent players in the global DNA synthesis market include:

  • Thermo Fisher Scientific, Inc.

  • Twist Bioscience

  • Bioneer Corporation

  • Eton Bioscience

  • LGC Biosearch Technologies

  • IBA GmbH

  • Eurofins Scientific

  • Integrated DNA Technologies, Inc.

  • Quintara Biosciences

  • GenScript Biotech Corporation

DNA Synthesis Market Report Scope

Report Attribute


Market size value in 2023

USD 3.64 billion

Revenue forecast in 2030

USD 12.76 billion

Growth rate

CAGR of 19.63% from 2023 to 2030

Base year for estimation


Historical data

2018 - 2021

Forecast period

2023 - 2030

Quantitative units

Revenue in USD million and CAGR from 2023 to 2030

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Service type, application, end-use, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S.; Canada; U.K.; Germany; France; Italy; Spain; Denmark; Sweden; Norway; Japan; China; India; Australia; Thailand; South Korea; Brazil; Mexico; Argentina; South Africa; Saudi Arabia; UAE; Kuwait

Key companies profiled

Thermo Fisher Scientific, Inc.; Twist Bioscience; Bioneer Corporation; Eton Bioscience, LGC Biosearch Technologie; IBA GmbH; Eurofins Scientific; Integrated DNA Technologies, Inc.; Quintara Biosciences; GenScript Biotech Corporation

Customization scope

Free report customization (equivalent up to 8 analyst’s working days) with purchase. Addition or alteration to country, regional & segment scope.

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Global DNA Synthesis Market Segmentation

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2018 to 2030. For this report, Grand View Research has segmented the global DNA synthesis market report based on service type, application, end-use, and region:

Global DNA Synthesis Market Segmentation

  • Service Type Outlook (Revenue, USD Million, 2018 - 2030)

    • Oligonucleotide Synthesis

      • Universal Oligonucleotide Synthesis

      • Custom Oligonucleotide Synthesis

    • Gene Synthesis

      • Custom Gene Synthesis

      • Gene Library Synthesis

  • Application Outlook (Revenue, USD Million, 2018 - 2030)

    • Research and Development

    • Diagnostics

    • Therapeutics
  • End-use Outlook (Revenue, USD Million, 2018 - 2030)

    • Biopharmaceutical Companies

    • Academic and Research Institutes

    • Contract Research Organizations

  • Regional Outlook (Revenue, USD Million, 2018 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

      • France

      • Italy

      • Spain

      • Denmark

      • Sweden

      • Norway

    • Asia Pacific

      • Japan

      • China

      • India

      • Australia

      • Thailand

      • South Korea

    • Latin America

      • Brazil

      • Mexico

      • Argentina

    • Middle East & Africa

      • South Africa

      • Saudi Arabia

      • UAE

      • Kuwait

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