GVR Report cover Gene Synthesis (Research Use) Market Size, Share & Trends Report

Gene Synthesis (Research Use) Market Size, Share & Trends Analysis Report By Method (Solid-phase, Chip-based), By Research Phase (Pre-clinical, Clinical), By Application, By Service, By End-use, And Segment Forecasts, 2023 - 2030

  • Report ID: GVR-4-68040-114-3
  • Number of Pages: 130
  • Format: Electronic (PDF)
  • Historical Range: 2018 - 2021
  • Industry: Healthcare

Report Overview

The global gene synthesis (research use) market size was valued at USD 1.57 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 16.1% from 2023 to 2030. The rising investment by players in the synthetic biology field and supportive government laws & rules are expected to propel the market growth. Moreover, technological advances in gene synthesis procedures & techniques are projected to boost the demand over the forecast period. For instance, in April 2022, GenScript, a provider of life science research tools & services, announced the launch of the most advanced semiconductor chip for DNA synthesis in the field. This chip provides the highest throughput.

U.S. Gene Synthesis (Research Use) market size and growth rate, 2023 - 2030

The COVID-19 pandemic significantly influenced the global market growth. During the financial downturn due to the pandemic, the gene manufacturing & synthetic biology fields have noticed notable investment growth. Moreover, the players operating in the industry recorded growth and received public and private financing. For instance, Twist Bioscience, a key player in gene synthesis products & services, registered notable growth in 2020. The company introduced a new product line of synthetic viral controls as a response to the pandemic. In March 2020, it also offered fully synthetic SARS-CoV-2 RNA reference sequences useful for developing RT-PCR and NGS assays.

Such increasing investments and funding activities in the industry highlight the growth of the market. Furthermore, the growing market for personalized medicines is anticipated to increase the use of gene synthesis products and services. Personalized medicine is a medical care field that involves developing and designing highly specific drugs tailor-made for the specific genetic nature of the individual or individuals under consideration. Some key advantages of personalized medical products include the development of highly effective, safe disease-specific drugs and the ability to design more targeted cancer therapies.

The paradigm shift from a generalized approach to personalized medicine has facilitated the adoption of predictive and preventive care by introducing better-targeted therapies. The development of targeted therapy and personalized medicine field allows researchers to conduct research using gene synthesis. The market is expected to be driven by the launch of technologically advanced services and products by players in DNA synthesis. The launch of innovative platforms and technologies with technologically cutting-edge specifications that address the increased demand from researchers is expected to support market growth.

For instance, in March 2023, Ansa Biotechnologies, a key provider of next-generation DNA synthesis, introduced de novo synthesis of the longest DNA oligonucleotide at 1005 bases across the world. It was produced in a single synthesis. Such advancements in DNA manufacturing by industry participants support the market growth. However, the need for more skilled individuals in the field of biotechnology and gene synthesis controls the service expansion. Most of the procedures in the market necessitate familiarity with gene synthesis as well as bioinformatics platforms. There are a relatively small number of experts and professionals in gene synthesis procedures. This factor can hamper market growth to an extent.

Method Insights

On the basis of the method, the market is segmented into PCR-based enzyme synthesis, solid-phase synthesis, and chip-based synthesis. The solid-phase synthesis segment held the largest revenue share of 34.5% in 2022. Several factors are attributed to the dominance of this segment, including growing advancements in solid-phase technologies and their applications in numerous s fields for several research purposes. It can be utilized to create modified & canonical polymers of nucleic acids, especially DNA or RNA.

The PCR-based enzyme synthesis method is anticipated to register the fastest CAGR over the forecast period. The growth of this segment can be attributed to the growing adoption of gene synthesis and the limitations involved in the chemical synthesis process. Moreover, the demand for alternative DNA synthesis options is increasing with the growing applications of synthetic biology in various domains. These factors are expected to drive the segment’s growth over the forecast period.

Service Insights

Based on the services, the market is segmented into synthesis of Viral DNA, antibody DNA, and others. The antibody DNA synthesis segment maintained a dominant share of 62.1 % in 2022, in terms of revenue. The high revenue share of the segment is owing to the effectiveness and efficiency of gene synthesis for the development and production of antibodies. In addition, the presence of advanced technologies for gene synthesis supports market growth. Many participants are offering services for antibody DNA synthesis.

These players include Synbio GENEWIZ and GenScript. The viral DNA synthesis segment is expected to grow at the fastest CAGR of 18.9 % from 2023 to 2030. Several viral DNA synthesis service applications are expected to drive the segment growth over the forecast period. A significant growth of the segment is attributed to its ability to construct viral DNA in the lab without relying on an existing virus sample and synthesizing viral genomes, which helps in understanding gene functions.

Application Insights

On the basis of application, the global market has been further segmented into cell & gene therapy development, vaccine development, and others. The gene & cell therapy development application segment dominated the global industry in 2022 and accounted for the largest share of 55.4 % of the overall revenue. The segment is projected to expand further at the fastest growth rate maintaining its dominant position in the market throughout the forecast period.

The highest share and fast-paced growth of this application segment can be attributed to various factors, including a number of initiatives undertaken by biotechnology companies to promote gene & cell therapy and the increasing adoption of cell & gene therapies. The vaccine development segment is also estimated to have significant growth over the forecast period.

Research Phase Insights

On the basis of the research phase, the global market has been further categorized into preclinical and clinical research phases. The clinical research phase segment dominated the global market in 2022 and accounted for the maximum share of 74.5% of the overall revenue. The segment is also anticipated to demonstrate an attractive growth over the forecast period at a CACR of 17.4%. The growth of this segment can be attributed to the growing number of gene and cell therapies and a rise in clinical trials for advanced therapy. Moreover, gene synthesis plays a crucial role in advancing clinical research by transforming diagnostics and therapeutics.

End-use Insights

On the basis of end-use, the market is segmented into academic & government research institutes, biotechnology & pharmaceutical companies, and contract research organizations (CROs). The academic & government research institutions segment dominated the market with a revenue share of 42.6% in 2022. The dominance of this segment was due to the active engagement of these institutions in research to study model organisms using gene synthesis. The increased flexibility and automation in gene synthesis techniques have made it easier for research laboratories to adopt this technology.

Global Gene Synthesis (Research Use) market share and size, 2022

Moreover, the presence of universities and research institutions that conduct research activities on synthetic biology & gene synthesis is expected to support the segment growth. The contract research organization segment is anticipated to register the fastest CAGR of 18.3% from 2023 to 2030. The rising outsourcing practices and the increasing number of biotechnology companies support the growth of this segment. In addition, the segment growth is driven by the expansion of services by many contract research organizations, including GenScript and Eurofins.

Regional Insights

North America dominated the global market with a share of 37.24% in 2022. The presence of several well-established market participants and the development of the synthetic biology field in the region propel the market growth. Some of the key participants operating in North America include GenScript, Azenta, Inc. (GENEWIZ), Boster Biological Technology, Twist Bioscience, ProteoGenix, Inc., Biomatik, and ProMab Biotechnologies, Inc. The regional market growth is driven by an increasing number of initiatives undertaken by key players, such as geographic expansions, technological advancements, and new product launches. For instance, in November 2021, GenScript introduced a highly automated gene synthesis center in New Jersey.

Gene Synthesis (Research Use) Market Trends, by Region, 2023 - 2030

This new facility can provide production support to the customers of the U.S. in case of uncertain scenarios, such as pandemics and changes in trade and customs regulations. Asia Pacific is expected to register the fastest CAGR of 17.4% from 2023 to 2030. The growth is driven by the rising interest in research activities for synthetic biology and the development of therapeutics. Moreover, major players in the market are focusing on countries in this region. For instance, GenScript expanded its services in Singapore in February 2023. The facility in Singapore aims to provide gene synthesis services with 24-hour technical support for researchers.

Key Companies & Market Share Insights

The competition in the global industry is increasing as multiple participants operating in the market are undertaking various strategic initiatives, such as geographic expansions, partnerships, and product launches, to gain a competitive edge. For instance, in May 2023, Thermo Fisher Scientific partnered with Pfizer to enhance the access of Next Generation Sequencing-based testing in over 30 countries. This strategy can help the company expand its products and services worldwide. In January 2022, OriGene Technologies, a key player in the market, updated its logo to highlight the company's expansion from genomics (RNAi/PCR/plasmids) to proteomics (antibody/assays/protein). Such strategies help in increasing the visibility in the market. Some of the prominent players in the global gene synthesis (research use) market include:

  • GenScript

  • Azenta, Inc. (GENEWIZ)

  • Boster Biological Technology

  • Twist Bioscience

  • ProteoGenix

  • Biomatik

  • ProMab Biotechnologies, Inc.

  • Thermo Fisher Scientific, Inc.

  • Integrated DNA Technologies, Inc. (Danaher)

  • OriGene Technologies, Inc.

Gene Synthesis (Research Use) Market Report Scope

Report Attribute


Market size value in 2023

USD 1.81 billion

Revenue forecast in 2030

USD 5.14 billion

Growth rate

CAGR of 16.1% from 2023 to 2030

Base year for estimation


Historical data

2018 - 2021

Forecast period

2023 - 2030

Quantitative units

Revenue in USD million/billion and CAGR from 2023 to 2030

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Method, service, application, research phase, end-use, region

Regional scope

North America, Europe, Asia Pacific, Latin America, Middle East & Africa

Country scope

U.S.; Canada; Germany; UK; France; Italy; Spain; Denmark; Sweden; Norway; The Netherlands; Switzerland; China; Japan; India; South Korea; Australia; Thailand; Brazil; Mexico, Argentina; South Africa; Saudi Arabia, UAE; Kuwait

Key companies profiled

GenScript; Azenta, Inc. (GENEWIZ); Boster Biological Technology; Twist Bioscience; ProteoGenix, Inc.; Biomatik; ProMab Biotechnologies, Inc.; Thermo Fisher Scientific, Inc.; Integrated DNA Technologies, Inc. (Danaher); OriGene Technologies, Inc.

Customization scope

Free report customization (equivalent up to 8 analyst’s working days) with purchase. Addition or alteration to country, regional & segment scope

Pricing and purchase options

Avail customized purchase options to meet your exact research needs. Explore purchase options


Global Gene Synthesis (Research Use) Market Report Segmentation

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest trends in each of the sub-segments from 2018 to 2030. For this study, grand view research has segmented the gene synthesis (research use) market report based on method, service, application, research phase, end-use, and region:

  • Method Outlook (Revenue, USD Million, 2018 - 2030)

    • Solid-phase Synthesis

    • Chip-based Synthesis

    • PCR-based Enzyme Synthesis

  • Service Outlook (Revenue, USD Million, 2018 - 2030)

    • Antibody DNA Synthesis

    • Viral DNA Synthesis

    • Others

  • Application Outlook (Revenue, USD Million, 2018 - 2030)

    • Gene & Cell Therapy Development

    • Vaccine Development

    • Others

  • Research Phase Outlook (Revenue, USD Million, 2018 - 2030)

    • Pre-clinical

    • Clinical

  • End-use Outlook (Revenue, USD Million, 2018 - 2030)

    • Biotechnology and pharmaceutical companies

    • Academic and government research institutes

    • Contract research organizations

  • Regional Outlook (Revenue, USD Million, 2018 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • UK

      • Germany

      • France

      • Italy 

      • Spain

      • Denmark

      • Sweden

      • Norway

      • The Netherlands

      • Switzerland

    • Asia Pacific

      • China

      • Japan

      • India

      • South Korea

      • Australia

      • Thailand

    • Latin America

      • Brazil

      • Mexico

      • Argentina

    • Middle East & Africa

      • South Africa

      • Saudi Arabia

      • UAE

      • Kuwait

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