mRNA Synthesis Raw Materials Market Size, Share & Trends Report

mRNA Synthesis Raw Materials Market Size, Share & Trends Analysis Report By Type (Capping Agents, Nucleotides, Plasmid DNA), By Application, By End-user, By Region, And Segment Forecasts, 2023 - 2030

  • Report ID: GVR-4-68040-022-4
  • Number of Pages: 140
  • Format: Electronic (PDF)
  • Historical Range: 2018 - 2021
  • Industry: Healthcare

Research Methodology

A three-pronged approach was followed for deducing the mRNA synthesis raw materials market estimates and forecasts. The process has three steps: information procurement, analysis, and validation. The whole process is cyclical, and steps repeat until the estimates are validated. The three steps are explained in detail below:

Information procurement: Information procurement is one of the most extensive and important stages in our research process, and quality data is critical for accurate analysis. We followed a multi-channel data collection process for mRNA synthesis raw materials market to gather the most reliable and current information possible.

  • We buy access to paid databases such as Hoover’s and Factiva for company financials, industry information, white papers, industry journals, SME journals, and more.
  • We tap into Grand View’s proprietary database of data points and insights from active and archived monitoring and reporting.
  • We conduct primary research with industry experts through questionnaires and one-on-one phone interviews.
  • We pull from reliable secondary sources such as white papers and government statistics, published by organizations like WHO, NGOs, World Bank, etc., Key Opinion Leaders (KoL) publications, company filings, investor documents, and more.
  • We purchase and review investor analyst reports, broker reports, academic commentary, government quotes, and wealth management publications for insightful third-party perspectives.

Analysis: We mine the data collected to establish baselines for forecasting, identify trends and opportunities, gain insight into consumer demographics and drivers, and so much more. We utilized different methods of mRNA synthesis raw materials market data depending on the type of information we’re trying to uncover in our research.

  • Market Research Efforts: Bottom-up Approach for estimating and forecasting demand size and opportunity, top-down Approach for new product forecasting and penetration, and combined approach of both Bottom-up and Top-down for full coverage analysis.

  • Value-Chain-Based Sizing & Forecasting: Supply-side estimates for understanding potential revenue through competitive benchmarking, forecasting, and penetration modeling.

  • Demand-side estimates for identifying parent and ancillary markets, segment modeling, and heuristic forecasting.

  • Qualitative Functional Deployment (QFD) Modelling for market share assessment.

Market formulation and validation: We mine the data collected to establish baselines for forecasting, identify trends and opportunities, gain insight into consumer demographics and drivers, and so much more. We utilize different methods of data analysis depending on the type of information we’re trying to uncover in our research.

  • Market Formulation: This step involves the finalization of market numbers. This step on an internal level is designed to manage outputs from the Data Analysis step.

  • Data Normalization: The final market estimates and forecasts are then aligned and sent to industry experts, in-panel quality control managers for validation.

  • This step also entails the finalization of the report scope and data representation pattern.

  • Validation: The process entails multiple levels of validation. All these steps run in parallel, and the study is forwarded for publishing only if all three levels render validated results.

mRNA Synthesis Raw Materials Market Categorization:

The mRNA synthesis raw materials market was categorized into four segments, namely type (Capping Agents, Nucleotides, Plasmid DNA), application (Therapeutics Production, Vaccine Production), end-use (Biopharmaceutical & Pharmaceutical Companies, CROs & CMOs, Academic & Research Institutions), and regions (North America, Europe, Asia Pacific, Latin America, Middle East & Africa).

Segment Market Methodology:

The mRNA synthesis raw materials market was segmented into type, application, end-use and regions. The demand at a segment level was deduced using a funnel method. Concepts like the TAM, SAM, SOM, etc., were put into practice to understand the demand. We at GVR deploy three methods to deduce market estimates and determine forecasts. These methods are explained below:

Market research approaches: Bottom-up

  • Demand estimation of each product across countries/regions summed up to from the total market.

  • Variable analysis for demand forecast.

  • Demand estimation via analyzing paid database, and company financials either via annual reports or paid database.

  • Primary interviews for data revalidation and insight collection.

Market research approaches: Top-down

  • Used extensively for new product forecasting or analyzing penetration levels.

  • Tool used invoice product flow and penetration models Use of regression multi-variant analysis for forecasting Involves extensive use of paid and public databases.

  • Primary interviews and vendor-based primary research for variable impact analysis.

Market research approaches: Combined

  • This is the most common method. We apply concepts from both the top-down and bottom-up approaches to arrive at a viable conclusion.

Regional Market Methodology:

The mRNA synthesis raw materials market was analyzed at a regional level. The globe was divided into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa, keeping in focus variables like consumption patterns, export-import regulations, consumer expectations, etc. These regions were further divided into twenty-three countries, namely, the U.S.; Canada; Germany; the UK.; France; Italy; Spain; Denmark; Sweden; Norway; Japan; China; India; South Korea; Australia; Thailand; Brazil; Mexico; Argentina; South Africa; Saudi Arabia; UAE; and Kuwait

All three above-mentioned market research methodologies were applied to arrive at regional-level conclusions. The regions were then summed up to form the global market.

mRNA synthesis raw materials market companies & financials:

The mRNA synthesis raw materials market was analyzed via companies operating in the sector. Analyzing these companies and cross-referencing them to the demand equation helped us validate our assumptions and conclusions. Key market players analyzed include:

  • F. Hoffmann La Roche Ltd. -  F. Hoffmann-La Roche Ltd. develops and produces diagnostic & pharmaceutical products. Globally, it has 26 manufacturing sites with two business segments: Pharmaceuticals and Diagnostics. The pharmaceuticals segment of the company develops drugs for infectious diseases; including cardiovascular, respiratory, & metabolic disorders; cancer; and central nervous system & autoimmune diseases as well. Roche Diagnostics is also involved in several other fields, ranging from patient self-monitoring to clinical laboratory systems. Roche Professional Diagnostics is the company’s largest business segment which provides solutions, tests, & instrument systems to assist reliable and cost-effective delivery of results.


  • Jena Bioscience GmbH -  Jena Bioscience GmbH, a privately held biotechnology research company, was established by a team of researchers from the Max-Planck Institute of Molecular Physiology (Dortmund) back in 1998. The company develops advanced reagents for industries and research spread across the service region consisting of more than 100 countries. Offerings by the Jena Bioscience GmbH include nucleosides, nucleotides and their Analogs, probes, eukaryotic expression system LEXSY, macromolecular crystallography, and recombinant proteins, among others.


  • Merck KGaA -  Merck KGaA is a huge multinational company, which was established in 1668, and is involved in offering healthcare solutions and materials. It operates in three sectors: healthcare, life sciences, and electronics. Headquartered in Darmstadt, Germany; the company has an employee strength of 64,243. The company’s offerings are related to areas such as biopharmaceuticals, consumer health, allergopharma, biosimilar, life science, and performance materials. North America, Europe, Asia, Latin America, Oceania, and Africa are the regions where the company operates through its plants and distribution channels.


  • Yeasen Biotechnology (Shanghai) Co., Ltd.  -  Yeasen Biotechnology, a privately held company established in 2014 and headquartered in Shanghai, China is engaged in the development and production of molecules, cells, and proteins related to biological reagents. The company has independent R&D capabilities of core technologies of antibodies, molecular enzymes, nucleic acids, proteins, and cells, and large-scale production capabilities of related enzymes and raw materials. These products are broadly used in the fields of life science research, diagnostics, and biomedicine. The company is considered an innovator in the market. Some of the key products of the company include T7 High Yield RNA Synthesis Kit Kits, mRNA Isolation Master Kit, mRNA Vaccinia Capping Enzyme GMP-grade mRNA Cap 2'-O-Methyltransferase GMP-grade. 


  • BOC Sciences -  BOC Sciences, considered as one of the market leaders for the mRNA synthesis raw materials market; offers a broad variety of custom services which range from bulk compounds to specialty species in the biotechnology, agrochemical, and pharmaceutical industries The main offerings of the BOC Sciences include small molecule synthesis, biosynthesis, purification, and characterization. In addition, it also provides a wide range of research chemicals and biochemicals including carbohydrates, inhibitors, metabolites, nucleotides, nucleosides, and natural compounds. In December 2021, BOC Sciences introduced pseudoUridine products for RNA modification, to advance the research and development of vaccines. 


  • Thermo Fisher Scientific, Inc. -  The company has a list of offerings in areas such as life sciences, industrial & applied sciences, and clinical diagnostics while operating in over 50 countries worldwide. In addition, it offers instruments for DNA synthesis, transfection, protein expression profiling, sample preparation, antibodies, cell culture media, cell imaging, and protein analysis. In terms of services, it has a range of offerings such as cell line development, custom media modification, and custom assay development. Its product portfolio also includes research tools for studies, including genomics, proteomics, gene splicing, and cellular analysis. The company has a broad portfolio of life sciences brands including Thermo Scientific, Invitrogen, Applied Biosystems, Fisher Scientific, Patheon, PPD, and Unity Lab Services. 


  • Maravai LifeSciences -  Maravai LifeSciences, a company established in 2014 and headquartered in California, U.S. offers solutions for drug development, diagnostics, novel vaccine production, and research. It also offers reagents vital for biologics safety testing and nucleic acid production. The company drives the development of drug therapies & vaccines and supports human disease research activities through its portfolio of reagents, assays, and proprietary technologies. 


  • New England Biolabs -  New England Biolabs (NEB) is engaged in the discovery, production, and commercialization of enzymes for applications in molecular biology. The company offers a variety of native and recombinant enzymes and research reagents for genomic research. Moreover, it focuses on alliances that enable the development of novel technologies to fulfill the demand for molecular diagnostics. The company is managed by a group of scientists and it is registered as a small business with the U.S. Small Business Administration. In August, New England Biolabs launched Faustovirus Capping Enzyme, which is a streamlined, scalable, and affordable mRNA capping solution for research as well as therapeutic uses. 


  • Creative Biogene -  Creative Biogene is one of the emerging biotechnology companies that focuses on the development of high-quality products and services as well as proprietary technology. The company supports research in the field of basic life sciences, preclinical drug discovery, industrial synthetic application, and biomedical development. Some of the key offerings of the company include All-in-One T7 ARCA mRNA Synthesis Kit, All-in-One T7 Cap1 (3' OMe) mRNA Synthesis Kit, T7 RNA Polymerase, and more. Established back in 2005, the company has headquarters in Shirley, New York, United States. In March 2022, the company has launched a range of kits and materials to support mRNA synthesis. 


  • HONGENE -  HONGENE, known in the market for its large sequencing capacities, is a manufacturer of nucleotide and nucleoside products. It typically provides these products to biotech companies to support molecular biology research. The focus of the company is mainly concentrated on activities such as the R&D, and manufacturing of nucleotides, nucleosides, modified nucleosides, gene monomers, and other related products to help clients meet their molecular biology needs. HONGENE is considered as one of the emerging players of the mRNA synthesis raw materials market.

Value chain-based sizing & forecasting

Supply Side Estimates

  • Company revenue estimation via referring to annual reports, investor presentations, and Hoover’s.

  • Segment revenue determination via variable analysis and penetration modeling.

  • Competitive benchmarking to identify market leaders and their collective revenue shares.

  • Forecasting via analyzing commercialization rates, pipelines, market initiatives, distribution networks, etc.

Demand side estimates

  • Identifying parent markets and ancillary markets

  • Segment penetration analysis to obtain pertinent

  • revenue/volume

  • Heuristic forecasting with the help of subject matter experts

  • Forecasting via variable analysis

mRNA Synthesis Raw Materials Market Report Objectives:

  • Understanding market dynamics (in terms of drivers, restraints, & opportunities) in the countries.

  • Understanding trends & variables in the individual countries & their impact on growth and using analytical tools to provide high-level insights into the market dynamics and the associated growth pattern.

  • Understanding market estimates and forecasts (with the base year as 2022, historic information from 2018 to 2021, and forecast from 2023 to 2030). Regional estimates & forecasts for each category are available and are summed up to form the global market estimates.

mRNA Synthesis Raw Materials Market Report Assumptions:

  • The report provides market value for the base year 2022 and a yearly forecast till 2030 in terms of revenue/volume or both. The market for each of the segment outlooks has been provided on region & country basis for the above-mentioned forecast period.

  • The key industry dynamics, major technological trends, and application markets are evaluated to understand their impact on the demand for the forecast period. The growth rates were estimated using correlation, regression, and time-series analysis.

  • We have used the bottom-up approach for market sizing, analyzing key regional markets, dynamics, & trends for various products and end-users. The total market has been estimated by integrating the country markets.

  • All market estimates and forecasts have been validated through primary interviews with the key industry participants.

  • Inflation has not been accounted for to estimate and forecast the market.

  • Numbers may not add up due to rounding off.

  • Europe consists of EU-8, Central & Eastern Europe, along with the Commonwealth of Independent States (CIS).

  • Asia Pacific includes South Asia, East Asia, Southeast Asia, and Oceania (Australia & New Zealand).

  • Latin America includes Central American countries and the South American continent

  • Middle East includes Western Asia (as assigned by the UN Statistics Division) and the African continent.

Primary Research

GVR strives to procure the latest and unique information for reports directly from industry experts, which gives it a competitive edge. Quality is of utmost importance to us, therefore every year we focus on increasing our experts’ panel. Primary interviews are one of the critical steps in identifying recent market trends and scenarios. This process enables us to justify and validate our market estimates and forecasts to our clients. With more than 8,000 reports in our database, we have connected with some key opinion leaders across various domains, including healthcare, technology, consumer goods, and the chemical sector. Our process starts with identifying the right platform for a particular type of report, i.e., emails, LinkedIn, seminars, or telephonic conversation, as every report is unique and requires a differentiated approach.

We send out questionnaires to different experts from various regions/ countries, which is dependent on the following factors:

  • Report/Market scope: If the market study is global, we send questionnaires to industry experts across various regions, including North America, Europe, Asia Pacific, Latin America, and MEA.

  • Market Penetration: If the market is driven by technological advancements, population density, disease prevalence, or other factors, we identify experts and send out questionnaires based on region or country dominance.

The time to start receiving responses from industry experts varies based on how niche or well-penetrated the market is. Our reports include a detailed chapter on the KoL opinion section, which helps our clients understand the perspective of experts already in the market space.

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