Serum-free media (SFM) is formulated without serum to grow a specific type of cells. It contains serum albumin, growth factors, proteins, and many undefined animal-derived products. Increased growth rate, low risk of contamination in the cell cultured medium, and reduced operation cost are some of the benefits of SFM. It allows cell culturing without the use of animal sera.
The following are the advantages of using SFM:
Easy downstream process
Improved detection of cellular mediators
Low risk of infectious agents
The serum-free media applications are monoclonal antibody production using hybridoma medium, recombinant protein production, adenovirus production and growth of neurons, the study of CNS progenitor, cell interaction study, and study of signal transduction, and gene therapy. Many key market players are engaged in the product portfolio expansion that drives the market. For instance, in November 2022, BioPharma Dynamics expanded its cell and gene therapy portfolio to offer the growing demand with the SFM for cell and gene therapy. The company will provide recombinant growth factors, DMSO-free cryopreservation solutions, immune cell media, and stem cell lines-based media.
Along with this, the rise in the prevalence of infectious and chronic diseases, obesity, aging, and early diagnosis and treatment of these diseases drives the market. The increasing demand for recombinant proteins, therapeutics drugs, and growing R&D for the novel product launch, collaborations, mergers, and acquisitions by the market key players are the impelling industry factors. For instance, in March 2021, PromoCell launched 3rd generation melanocyte culture portfolio for the cultivation of human and juvenile melanocytes, which includes M3 (Melanocyte Growth Medium), a BPE-free and PMA-free media. Moreover, advancements in bioprocessing techniques and enhancement of the CROs for improvising the drug discovery process drive the global serum-free culture market. Slow growth rate as compared to the serum enriches media and the requirement of different cell types for the preparation of specific media formulations can be the restraining factors.
The market segmentation is based on type, end-user, and region. The type segment is divided into the types of media formulated, such as CHO cell, protein expression, immunology, insect cell lines, hybridoma cell lines, stem cells, and chemical-based media. The end-user segment is divided into pharmaceutical and biotechnology companies, CROs, academic and research institutes, and others.
The serum-free media market is expected to grow significantly in the coming years, driven by increasing demand from North America, Europe, and Asia Pacific. The U.S. and Canada, the UK, Germany, France, Italy, Spain, Denmark, Sweden, Norway, Japan, China, India, Australia, Thailand, South Korea, Brazil, Mexico, Argentina, Saudi Africa, South Arabia, and the UAE are the major contributors to the market. North America dominates the global market due to the developed healthcare infrastructure presence of major biopharmaceutical and biotechnology companies. Asia-Pacific is anticipated to lead the market in the forecast period due to the increasing number of clinical trials in this region.
CHO Cell Media,
Protein Expression Media,
Insect Cell Media,
Stem Cell Media,
Chemically Defined Media
Pharmaceutical and Biotechnology Companies,
Academic and Research Institute,
Contract Research Organization,
North America (U.S., Canada),
Europe (UK, Germany, France, Italy, Spain, Denmark, Sweden, Norway)
Asia Pacific (Japan, China, India, Australia, Thailand, South Korea)
Latin America (Brazil, Mexico, Argentina),
Middle East & Africa (Saudi Africa, South Arabia, UAE, Kuwait)
Serum-free media have become increasingly popular and are used by a wide range of companies, from small startups to large multinational corporations. Prominent companies operating in the market include Illumina, Inc., Thermo Fisher Scientific, Inc., Sigma Aldrich, HiMedia Laboratories, PAN-Biotech, Danaher Corporation, Merck KGaA, Sartorius AG, PromoCell GmbH, Sino Biological Inc., Lonza Group AG, FUJIFILM Holdings Corporation. These companies are engaged in the development, manufacturing, and marketing of SFM and their accessories to meet the requirements of various industries.
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