Preparative And Process Chromatography Market To Reach $21.15 Billion By 2033

October 2025 | Report Format: Electronic (PDF)

Preparative And Process Chromatography Market Growth & Trends

The global preparative and process chromatography market size is estimated to reach USD 21.15 billion by 2033, expanding at a CAGR of 5.50% from 2025 to 2033, according to a new report by Grand View Research, Inc. High demand for monoclonal antibodies, rising geriatric population, growing food safety concerns, demand for purification & separation of chemical compounds on a larger scale, growing government investments in synthetic biology & genome, increasing demand for insulin & other biopharmaceutical products, and rising awareness of advances in preparative & process chromatography are expected to propel the market growth during the forecast period.

Furthermore, increased R&D activities in the pharmaceutical and biotechnology industries are boosting the usage of liquid chromatographic techniques in downstream tests, resulting in market growth. The demand for separation and process chromatography systems can be attributed to an increase in research activities in the fields of biotechnology and pharmaceutics, as well as arise in the requirement for separation analysis around the world. Rising government and private-sector investment in separation and process chromatography is a major driver of global market growth.

In addition, technological advancements designed to improve end-product yield recovery are accelerating and enhancing the adoption of these procedures in a variety of applications. Moreover, the growing use of these methodologies has prompted the industry's major players to make strategic expenditures to improve their revenue share. Companies are working hard to develop new items to fulfill shifting consumer needs. Shimadzu Corporation, for example, announced their "Advanced i-Series" HPLC in November 2020. This is a new flagship liquid chromatography machine that can be used remotely. Similarly, in July 2022, Bio-Rad Laboratories launched EconoFit low-pressure prepacked chromatography column packs.

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Preparative And Process Chromatography Market Report Highlights

Process chromatography dominated the market with the largest revenue share in 2024 owing to the growing research activities and adoption of automated systems in the field of biopharmaceuticals.
The liquid chromatographic segment held the largest market share in terms of revenue in 2024 owing to the high demand for preparative HPLC in the therapeutic development process.
The pharmaceutical segment held the largest share in 2024 owing to increasing application in drug safety assessment as an analytical tool for qualitative and quantitative analysis.
North America dominated the market in 2024 owing to the increasing investments in the development of new resin for the isolation and purification of vaccines. Extensive COVID-19 vaccine development efforts in the region have spurred market growth as the process significantly relies on the use of chromatography for the characterization.
Asia Pacific is projected to witness the fastest growth rate over the forecast period. The growing biopharmaceutical sector in the region has increased the demand for antibodies and resins. Extensive R&D activities in the Asian pharmaceutical market result in the growing demand for chromatography products.

Preparative And Process Chromatography Market Segmentation

Grand View Research has segmented the global preparative and process chromatography market based on product, type, end use, and region:

Preparative And Process Chromatography Product Outlook (Revenue, USD Million, 2021 - 2033)

Process Chromatography
- System
  - Multi Use Batch Chromatography Systems
  - Single-Use Batch Chromatography Systems
  - Continuous Chromatography Systems
- Consumables
  - Reagents
  - Resins
    - Affinity Resins
    - Ion-exchange Resins
    - Size-exclusion Resins
    - Hydrophobic Interaction Resins
    - Reversed Phase Resins
    - Mixed mode/Multi-mode Resins
  - Columns
    - Prepacked Columns
    - Automated Columns
    - Manual Columns
- Service
Preparative Chromatography
- System
  - Semi-Preparative Chromatography Systems
  - Other Chromatography Systems
- Consumables
  - Reagents
  - Resins
    - Affinity Resins
    - Affinity Resins
    - Ion-exchange Resins
    - Size-exclusion Resins
    - Hydrophobic Interaction Resins
    - Reversed Phase Resins
    - Mixed-mode/Multi-mode Resins
  - Columns
    - Prepacked Columns
    - Empty Columns
- Service

Preparative And Process Chromatography Type Outlook (Revenue, USD Million, 2021 - 2033)

Liquid Chromatography
- HPLC
- Flash/Column Chromatography
- Ion-exchange chromatography
- Size-exclusion chromatography
- Affinity chromatography
Gas Chromatography
Thin Layer Chromatography
Paper Chromatography
Gel-permeation (Molecular Sieve) Chromatography
Hydrophobic Interaction Chromatography