Preparative And Process Chromatography Market Size, Share & Trends Analysis Report By Product (Process Chromatography, Preparative Chromatography), By Type, By End Use, And Segment Forecasts, 2021 - 2028

Report Overview

The global preparative and process chromatography market size was valued at USD 7.15 billion in 2020 and is expected to expand at a compound annual growth rate (CAGR) of 11.65% from 2021 to 2028. Large-scale integration of liquid chromatographic techniques in downstream processing, technological advancements, and high demand for preparative techniques have accelerated the growth in this space. Increasing demand and approval of monoclonal antibodies in the pharmaceutical and biotechnology industries are expected to fuel the growth in this space throughout the forecast period. This can be attributed to the higher penetration of the service providers in the antibody separation techniques that are based on chromatographic principles, such as affinity chromatography and column displacement chromatography. 

Moreover, ongoing research paradigms for the separation and analysis of monoclonal antibodies using the mild reverse phase chromatography are anticipated to drive research in this market. Companies are engaged in the development of flexible and robust platforms for continuous production of monoclonal antibody products, thereby increasing the demand for quality control.

Affinity chromatography has emerged as a pivotal tool to purify proteins as it is based on highly specific interactions occurring between the protein of interest and an immobilized ligand. The Downstream Process (DSP) or the product purification process is one of the costliest aspects of modern bioprocess protocols, particularly with respect to proteins. Hence, in these cases, chromatography serves as a crucial tool at all stages of DSP, from early initial capture to the final polishing or finishing steps.

Preparative techniques have gained wide acceptance for the purification of APIs and the key drivers associated with this expanding acceptance include improved throughput, cost-effectiveness, and purity. These techniques offer the users sufficient material volume at the desired quality for the initiation of clinical and preclinical trials. This, in turn, opens alternative routes for commercialization with minimum time invested in product development.

Product Insights

Process chromatography captured the largest share of over 55.0% in 2020. These systems are widely used in industries for diverse biomolecule purifications. They are built for process scale-up and large-scale biopharmaceutical manufacturing. The increasing adoption of automated systems in pharmaceutical companies is primarily driving the segment.

Preparative chromatography is estimated to expand at the fastest CAGR throughout the forecast period owing to its accurate and precise results. These techniques are considered to be the most reliable methods of isolation and purification of larger quantities of highly valuable substances. Continuous advancements in technology and methodology used for chromatography have helped in establishing the technique as a standard laboratory process for various sectors.

The implementation of single-use technology can lead to considerable savings in operating costs, labor, materials, and capital. Currently, the market is marked by the presence of several cGMP-compliant disposable chromatography column systems. The bioprocessing market is likely to see an upsurge in the development of single-use batch chromatography systems, such as single-use/disposable chromatography columns and membrane products.

Type Insights

The liquid chromatography segment accounted for the largest share of 28.11% in 2020 owing to the widespread application across several industries. Depending upon the type, some major preparative and process chromatographic techniques include liquid chromatography (LC), HPLC, and gas chromatography.

Various types of this technique are being employed to isolate bioactive molecules from various sources. In the manufacturing process, LC plays a crucial role in ensuring product quality. Thus, the rapidly growing pharmaceutical and specialty chemicals industries have shown increasing interest in this market space, leading to significant growth.

The hydrophobic interaction chromatography segment is expected to witness the fastest growth throughout the forecast period. This technique is proven to be useful in studying protein folding and unfolding and isolating protein complexes, thus leading to its increasing adoption in the protein research space. Growing demand for monoclonal antibodies in oncology is anticipated to boost the use of this technique in the near future.

End-use Insights

The pharmaceutical segment accounted for the largest share of 42.64% in 2020 owing to the high usage of preparative and process chromatography in drug safety assessment. The demand for the development of an effective vaccine against the novel coronavirus in a reduced timeframe has led to the introduction of unique vaccine strategies, such as viral vector-based vaccines, nucleic acid-based vaccines, and virus-like particle vaccines.

Such a scenario and its dimension are likely to propel the need for commercializing and increasing the accessibility of the most productive, flexible, and innovative bioprocessing tools. This is expected to strengthen the pool of entities operating in the preparative and process chromatography industry, further boosting market expansion.

The food segment is expected to witness significant growth over the forecast period owing to the increasing concerns associated with food. In addition, the presence of a stringent regulatory framework for the food industry has led to efficient monitoring of food products. Furthermore, the flourishing food industry worldwide has led to the increasing use of these techniques for quality assurance.

Regional Insights

North America captured the largest revenue share of 32.11% in 2020, followed by Europe. The presence of a substantial number of key players, coupled with increasing R&D programs for disease management, has driven the regional market. The U.S. is majorly contributing to the regional market growth owing to an increase in R&D spending by major private and public players.

Asia Pacific is anticipated to register a lucrative CAGR during the forecast period. The rapidly developing pharmaceutical and biotechnology sectors in the region are expected to boost the market growth in the region. The geographical expansion of key market players in Asian countries is further driving the regional market.

Key Companies & Market Share Insights

Companies engaged in the development of innovative products are expected to intensify the market competition. Companies are focusing on continuous innovations and launching products to retain and acquire market share. For instance, in August 2020, the new Thermo Scientific Dionex Easion ion chromatographic system was launched by Thermo Fisher Scientific for water analysis. This product reduces the total cost for maintenance and ownership.

Moreover, the companies are developing products as per the global demands, along with the integration of advanced technologies in the product. For instance, in November 2020, Shimadzu Corporation launched “Advanced i-Series” HPLC. This is an improved flagship LC model to support remote work. Some prominent players in the global preparative and process chromatography market include:

• GE Healthcare

• Danaher Corporation

• Merck KGaA

• Bio-Rad Laboratories Inc.

• Thermo Fisher Scientific Inc.

• Shimadzu Corporation

• Agilent Technologies

• Waters Corporation.

• Novasep Holding S.A.S

Preparative And Process Chromatography Market Report Scope

Segments Covered in the Report

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2017 to 2028. For the purpose of this study, Grand View Research has segmented the global preparative and process chromatography market report on the basis of product, type, end-use, and region:

• Product Outlook (Revenue, USD Million, 2017 - 2028)

  • Process Chromatography

    • System

      • Multi-use Batch Chromatography Systems

      • Single-use Batch Chromatography Systems

      • Continuous Chromatography Systems         

    • Consumable

      • Reagents

      • Resins

        • Affinity Resins

        • Ion-exchange Resins

        • Size-exclusion Resins

        • Hydrophobic Interaction Resins

        • Reversed Phase Resins

        • Mixed-mode/Multi-mode Resins

      • Columns

        • Prepacked Columns

        • Automated Columns

        • Manual Columns

    • Service

  • Preparative Chromatography

    • System

      • Semi-preparative Chromatography Systems

      • Other Chromatography Systems

    • Consumable

      • Reagents

      • Resins

        • Affinity Resins

        • Ion-exchange Resins

        • Size-exclusion Resins

        • Hydrophobic Interaction Resins

        • Reversed Phase Resins

        • Mixed-mode/Multi-mode Resins

      • Columns

        • Prepacked Columns

        • Empty Columns

    • Service

• Type Outlook (Revenue, USD Million, 2017 - 2028)

  • Liquid Chromatography

    • HPLC

    • Flash/Column Chromatography

    • Ion-exchange chromatography

    • Size-exclusion chromatography

    • Affinity chromatography

  • Gas Chromatography

  • Thin Layer Chromatography

  • Paper Chromatography

  • Gel-permeation (Molecular Sieve) Chromatography

  • Hydrophobic Interaction Chromatography

• End-use Outlook (Revenue, USD Million, 2017 - 2028)

  • Pharmaceutical

  • Biotechnology

  • Food

  • Nutraceutical

  • Others

• Regional Outlook (Revenue, USD Million, 2017 - 2028)

  • North America

    • U.S.

    • Canada

  • Europe

    • Germany

    • U.K.

    • France

    • Italy

    • Spain

  • Asia Pacific

    • Japan

    • China

    • India

  • Latin America

    • Brazil

    • Mexico

  • Middle East Africa (MEA)

    • South Africa

    • Saudi Arabia