The global preparative and process chromatography market size was valued at USD 5.95 billion in 2018 and is expected to grow at a compound annual growth rate (CAGR) of 6.7% from 2019 to 2026. Preparative chromatography is used to isolate a substance from a given sample on a large scale. Thus, the main purpose of this technique is the purification of a particular substance. Some of the major preparative chromatography techniques include liquid chromatography, gas chromatography, and high-performance liquid chromatography (HPLC). Process chromatography, on the other hand, aims at identifying and analyzing compounds in the sample both qualitatively and quantitatively. It is used to analyze the purity and purification performed by preparative chromatography.
Increasing investments by the government to enhance R&D is expected to fuel the market growth during the forecast period. A report published by India Brand Equity Foundation states that the revenue of genetics is estimated to increase to USD 55 million by 2020. In addition, according to the same source, Israel and India have agreed to enhance the cooperation in science and technology for the upcoming years by providing USD 1 million from each in order to support new R&D projects of healthcare and cybersecurity. Small pharmaceutical companies spend less on operating activities and majorly on R&D. According to Investopedia, this share sometimes accounts for up to 50% of their revenue share for a few companies. Therefore, rising R&D investments by the government are expected to drive the market rapidly.
Growing use of chromatography techniques in the food and nutraceuticals industry is anticipated to propel the market growth during the forecast period. Thin-layer chromatography is one of the excellent techniques that can be used for the identification of herbals as well as for its purity evaluations. HPLC technique is also one of the widely used tools for the quantitative analysis of various marker compounds used in food and nutraceutical fields. The potency of HPLC has been improved by the introduction of various new detectors, including diode array detectors, which allow the detection at many wavelengths. The new technology also increases the identification by UV spectral analysis.
Chromatography techniques are also used in the purification of biopharmaceutical products. Increasing demand for biopharmaceutical products is also likely to boost the market growth. Thermo Fisher Scientific Inc. offers a wide portfolio of its purification products that support biopharmaceutical development. The company’s POROS chromatography resins are designed for both process scale and analytical bioseparations. These resins can be used throughout the industry as they offer high throughput and high-performance process scale bioseparations.
A report published by Biotechnology Innovation Organization states that the biopharmaceutical industry had the highest percentage of R&D reinvestments in the U.S. in 2017. Research from emerging and small companies accounted for 70% of the clinical trials in 2017 as they are now at the forefront to search new therapies and cures. Thus, a rise in demand for biopharmaceuticals is expected to increase the demand for new chromatographic products in the near future. However, the high cost of chromatography products and presence of alternative methods are expected to restrain the market growth during the forecast period.
On the basis of type, the market is segmented into preparative and process chromatography. Process chromatography held the largest market share in 2018 owing to growing research activities in the field of biopharmaceuticals. Key market players such as Merck KGaA offer a wide range of analytical HPLC products for the analysis of R&D, quality control, clinical, environmental, and biochemical applications.
Preparative chromatography is estimated to expand at the fastest CAGR over the forecast period owing to its accurate results. This technique is used to separate smaller molecules that differ from each other. This technique is also in the purification of sufficient quantities of a substance which can be further used. The sample goes into fraction collector unlike process chromatography
Affinity chromatography is the primary step followed in the purification workflow and is considered to be the robust purification process. Ion-exchange chromatography is the second step of purification and these resins are considered to be effective for first column purification step. On the other hand, hydrophobic interaction chromatography is a versatile technique and is used for intermediate and final stages of the purification process.
Chromatography columns held a significant share in 2018 due to high penetration of empty columns as well as growing availability of prepacked columns. Prepacked columns are expected to witness high growth opportunities due to their ability to meet manufacturing needs with single-use technologies. They are advantageous to the end users in a way that they save time and resources by reducing the hassle of packing and cleaning.
Based on end use, the market is segmented into the food and nutraceutical industry, biotechnology and pharmaceutical industry, and academic research laboratories. The biotechnology and pharmaceutical industry held the largest market share in 2018 owing to rise in R&D investments. A report published by the U.S. Investments in Medical and Health Research and Development states that R&D investment grew by 27% from 2013 to 2017 in the U.S.
The food and nutraceutical industry is expected to witness significant growth over the forecast period due to the growing food manufacturing industry. Chromatography is widely used in food analysis that includes activities, such as detecting food additives and assessing the quality of the food. Some of the other analyses are the determination of food composition, presence of contaminants in the food, and measuring the nutritional quality of the food.
North America held the largest revenue share of 42.0% in 2018 due to rise in strategic mergers and acquisitions undertaken by key market players. In addition, the rise in R&D investments by pharmaceutical and biotechnology companies and the government and rising healthcare infrastructure in the U.S. are some of the other factors driving the market in the country.
Asia Pacific is expected to witness the fastest growth during the forecast period owing to rising R&D investment and initiatives undertaken by the government. According to Invest India, in 2018, R&D investment accounted for USD 782 billion in India. Rising R&D investments by pharmaceutical and biotechnology companies in this region are anticipated to fuel the market growth during the forecast period.
Rise in product launches by major companies is anticipated to fuel market growth. For instance, in October 2018, Bio-Rad launched Nuvia HP-Q Resins and CHT Ceramic Hydroxyapatite XT Media. CHT XT offers efficient and high-resolution single step clearance of aggregates and other impurities. In addition, CHT XT is used for purification of monoclonal, enzymes, and polyclonal antibodies. Some of the prominent players in the preparative and process chromatography market include:
GE Healthcare
Pall Corporation
Merck KGaA
Bio-Rad Laboratories
Thermo Fisher Scientific Inc.
Shimadzu Corporation
Agilent Technologies
Waters Corporation
Novasep Holding S.A.S
Chiral Technologies, Inc.
Report Attribute |
Details |
Market size value in 2019 |
USD 6.32 billion |
Revenue forecast in 2026 |
USD 9.97 billion |
Growth Rate |
CAGR of 6.7% from 2019 to 2026 |
Base year for estimation |
2018 |
Historical data |
2015 - 2017 |
Forecast period |
2019 - 2026 |
Quantitative units |
Revenue in USD million and CAGR from 2019 to 2026 |
Report coverage |
Revenue forecast, company ranking, competitive landscape, growth factors, and trends |
Segments covered |
Type, end use, region |
Regional scope |
North America; Europe; Asia Pacific; Latin America; MEA |
Country scope |
U.S.; Canada; U.K.; Germany; France; Italy; Spain; Russia; China; India; Japan; South Korea; Australia; Singapore; Brazil; Mexico; Argentina; South Africa; Saudi Arabia; UAE |
Key companies profiled |
GE Healthcare; Pall Corporation; Merck KGaA; Bio-Rad Laboratories; Thermo Fisher Scientific Inc.; Shimadzu Corporation; Agilent Technologies; Waters Corporation; Novasep Holding S.A.S; Chiral Technologies, Inc. |
Customization scope |
Free report customization (equivalent up to 8 analysts working days) with purchase. Addition or alteration to country, regional & segment scope. |
Pricing and purchase options |
Avail customized purchase options to meet your exact research needs. Explore purchase options |
This report forecasts revenue growth at the global, regional, and country levels and provides an analysis on the latest industry trends and opportunities in each of the sub-segments from 2015 to 2026. For the purpose of this study, Grand View Research has segmented the global preparative and process chromatography market report on the basis of type, end use, and region:
Type Outlook (Revenue, USD Million, 2015 - 2026)
Preparative Chromatography
Consumables
Solid Supports and Reagents
Resins
Affinity Resins
Ion-exchange Resins
Size Exclusion Resins
Hydrophobic Interaction Resins
Reversed-Phase Resins
Mixed-mode/Multimode Resins
Columns
Prepacked Columns
Empty Columns
Systems
Liquid Chromatography Systems
Other Chromatography Systems
Services
Process Chromatography
Consumables
Solid Supports and Reagents
Resins
Affinity Resins
Ion-exchange Resins
Size Exclusion Resins
Hydrophobic Interaction Resins
Reversed-Phase Resins
Mixed-mode/Multimode Resins
Columns
Prepacked Columns
Empty Columns
Systems
Services
End-use Outlook (Revenue, USD Million, 2015 - 2026)
Biotechnology & Pharmaceutical Industry
Food & Nutraceutical Industry
Academic Research Laboratories
Regional Outlook (Revenue, USD Million, 2015 - 2026)
North America
The U.S.
Canada
Europe
Germany
The U.K.
France
Italy
Spain
Russia
Asia Pacific
Japan
China
India
South Korea
Australia
Singapore
Latin America
Brazil
Mexico
Argentina
MEA
South Africa
Saudi Arabia
UAE
b. Key factors that are driving the market growth include increasing investments by the government to enhance R&D, growing use of chromatography techniques in the food and nutraceuticals industry, and increasing demand of biopharmaceutical products.
b. The global preparative and process chromatography market size was estimated at USD 6.3 billion in 2019 and is expected to reach USD 6.7 billion in 2020.
b. The global preparative and process chromatography market is expected to grow at a compound annual growth rate of 6.7% from 2019 to 2026 to reach USD 10.0 billion by 2026.
b. North America dominated the preparative and process chromatography market with a share of 41.7% in 2019. This is attributable to rise in major strategic mergers and acquisitions undertaken by key market players.
b. Some of the key players operating in the preparative and process chromatography market include GE Healthcare, Pall Corporation, Merck KGaA, Bio Rad Laboratories, Thermo Fisher Scientific Inc., Shimadzu Corporation, Agilent Technologies, Waters Corporation, Novasep Holding S.A.S, and Chiral Technologies, Inc.
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