Preparative And Process Chromatography Market (2025 - 2033) Size, Share & Trends Analysis Report By Product (Process Chromatography, Preparative Chromatography), By Type (Liquid Chromatography, Gas Chromatography), By End Use, By Region and Segment Forecasts

Preparative And Process Chromatography Market Summary

The global preparative and process chromatography market size was estimated at USD 12.42 billion in 2024 and is projected to reach USD 21.15 billion by 2033, growing at a CAGR of 5.50% from 2025 to 2033. The market growth is driven by the rising demand and approval of monoclonal antibodies in the pharmaceutical and biotechnology sectors.

In addition, the preparative and process chromatography market is driven by the expanding biopharmaceutical industry, the demand for advanced purification techniques, and the need for more efficient and cost-effective processes. For instance, in September 2025, Samsung Biologics expanded biopharma partnerships through end-to-end CDMO services. The key highlights are end-to-end support from early development to commercial production, robust quality systems that strengthen supply chain resilience, and Samsung Biologics' continued capacity expansion and enhanced flexibility to accommodate complex modalities. Moreover, technological advancements and the development of innovative products are expected to boost market growth. For instance, in October 2021, CEM launched the prodigy preparative high-performance liquid chromatography (HPLC) system. The system offers an elevated temperature capability, resulting in enhanced resolution and separation capabilities.

The COVID-19 pandemic had a positive impact on the preparative and process chromatography market due to the increased demand for COVID-19 vaccines and treatment drugs. Similarly, the pharmaceutical and biotechnology industries are expected to grow significantly in the coming years, owing to increased production and demand for preparative and process chromatography. The separation process and preparative chromatography can be used to analyze materials for the coronavirus vaccine.

Further, a chromatography system is a scientific technique that separates specific components from sample mixtures. Analytical and preparative chromatography systems are widely used in both qualitative and quantitative analyses of biotechnological, pharmaceutical, and other elements. The market for chromatography systems is expanding due to a number of factors, including increased demand for insulin and omega-3 fatty acids, growing concerns about food quality and safety, and an aging population.

Furthermore, ongoing research paradigms focusing on the separation and analysis of monoclonal antibodies via mild reverse-phase chromatography are expected to drive growth in the market. Companies are actively developing flexible and robust platforms for the continuous production of monoclonal antibody products, resulting in a greater demand for quality control measures. The industry is expanding due to increased demand for preparative techniques, technological advancements, and the widespread integration of liquid chromatographic methods in downstream processing.

Moreover, affinity chromatography has emerged as an important tool for protein purification. It relies on highly specific interactions between the protein of interest and an immobilized ligand. The Downstream Process (DSP), also known as the product purification process, is one of the most expensive aspects of modern bioprocess protocols, especially for proteins. As a result, in these cases, chromatography is an essential tool throughout the DSP process, from early initial capture to final polishing or finishing.

Preparative techniques have gained widespread acceptance for purifying APIs, with key drivers including increased throughput, cost-effectiveness, and purity. These techniques provide users with adequate material volume at the desired quality for the start of clinical and preclinical trials. This, in turn, opens up new avenues for commercialization with minimal time investment in product development.

Market Concentration & Characteristics

The market is distinguished by ongoing and rapid innovation to address the increasing complexities of bioprocessing. This includes the development of highly specialized chromatography resins with increased binding capacity, selectivity, and chemical stability, allowing for more precise and efficient purification. Furthermore, there has been significant progress in integrating advanced automation and digital monitoring systems, which enable real-time control, reduced human error, and improved reproducibility. Moreover, the emergence of continuous and multi-column technologies transforms traditional batch processes through increasing throughput, improving scalability, and lowering solvent consumption.  

Mergers and acquisitions play an important strategic role. Major industry consolidations enable smaller, specialized companies to broaden their technological capabilities, diversify their product offerings, and strengthen their global market presence.

Regulatory requirements, particularly in the pharmaceutical and biopharmaceutical industries, drive demand for high-purity, validated chromatography solutions that meet Good Manufacturing Practices (GMP) and other global standards.

Product lines have been significantly expanded, including new media types, column formats, and automated systems designed to meet the changing needs of biologics, gene therapies, and other complex molecules.

The market is expanding geographically, with Asia-Pacific leading growth due to increased biopharma activity, while Latin America, the Middle East, and Africa are gradually developing, aided by improved infrastructure and increased local manufacturing capacity.

Product Insights

Process chromatography held the largest share of 59.27% in 2024. These methods are commonly employed in industry to purify a variety of biomolecules. They're designed for large-scale biopharmaceutical manufacturing and process scale-up. Further, the demand for process/analytical chromatography is driven by booming pharmaceutical industries. For instance, as per the European Federation of Pharmaceutical Industries and Associations, in 2023, North America accounted for 53.3% of global pharmaceutical sales, compared to 22.7% in Europe.

Preparative chromatography is expected to exhibit the fastest CAGR during the forecast period owing to its precise results. Chromatography has become a standard laboratory process for a variety of industries because of continuous developments in technology and methodology. The most dependable method of isolating and purifying vast amounts of extremely valuable compounds is preparative chromatography. Implementing single-use technology is considered as a cost-effective solution in terms of labor, costs, capital, and materials. Presently, there are various disposable chromatography column systems conforming to current good manufacturing practices, which are readily accessible for preparative and process chromatography. Single-use batch chromatography systems, such as single-use/disposable chromatography columns and membrane products, are expected to grow in popularity in the bioprocessing industry.

Type Insights

The liquid chromatography segment accounted for the largest share of 27.70% in 2024, owing to the widespread application across several industries. Bioactive compounds are isolated from a variety of sources using various variations of this approach. Liquid chromatography plays a critical role in guaranteeing product quality during the production process. As a result, the rapidly expanding pharmaceutical and specialty chemicals sectors have demonstrated tremendous interest in this area, resulting in significant growth.

The hydrophobic interaction chromatography segment is expected to witness the fastest growth rate of 6.54% over the estimated time period. As this technique has demonstrated its advantages in analyzing protein unfolding and folding and isolating complex protein, it is becoming more widely used in the protein research field. In the near future, the rising demand for monoclonal antibodies in oncology is expected to promote the utilization of this approach.

End Use Insights

The pharmaceutical segment held the largest share of 42.34% in 2024, owing to the widespread use of preparative and process chromatography in drug safety assessments and quality control. This expansion is fueled by rising global pharmaceutical production, increased investments in biologics R&D, and stringent regulatory requirements that require chromatography testing for drug purity and efficacy. HPLC and automated chromatography systems improve precision and throughput, enabling large-scale biopharmaceutical manufacturing. Furthermore, the growing use of single-use chromatography technologies offers cost-effective and scalable options for drug production in accordance with current good manufacturing practices. As a result of the situation and its scope, the need to commercialize and provide access to the most productive, versatile, and novel bioprocessing equipment is anticipated to grow. This is likely to strengthen the pool of companies involved in preparative and process chromatography, promoting market growth even more.

Moreover, the biotechnology sector is the fastest-growing end use segment, focusing strongly on research and development, protein isolation, personalized medicine, and novel therapeutic areas. This segment has the fastest CAGR, driven by advances in preparative chromatography precision and automation and increasing R&D investments in biopharmaceuticals.

Regional Insights

The North America preparative and process chromatography industry dominated with a revenue share of 33.39% in 2024, followed by Europe. The regional market has been driven by the presence of a large number of significant competitors, as well as increased R&D programs for disease management. R&D spending by key players drives regional market growth.

U.S. Preparative and Process Chromatography Market Trends

The preparative and process chromatography industry in the U.S. is a significant and rapidly growing segment of the larger biopharmaceutical and pharmaceutical industries. Increased investments in biopharmaceutical R&D primarily drive this strong growth, advances in technology, and stringent regulatory frameworks established by agencies such as the FDA to ensure drug safety and purity. For example, in September 2025, GSK planned to invest USD 30 billion in R&D and manufacturing in the United States over the next five years. This includes a USD 1.2 billion investment in laboratories, including chromatography, in the U.S. These investments build on GSK's existing strong innovation and manufacturing footprint and capabilities in the U.S., where products are developed and manufactured for the U.S.

Furthermore, the market benefits from a strong presence of key industry players, advanced healthcare infrastructure, and rising demand for high-purity biologics, monoclonal antibodies, and vaccines that necessitate efficient downstream purification procedures. Moreover, the rise of automated and single-use systems improves process scalability and cost-effectiveness, driving market growth.

Europe Preparative and Process Chromatography Market Trends

The preparative and process chromatography industry in Europe is growing rapidly, and expansion is being driven by significant investments in R&D for next-generation biologics such as bispecific antibodies, cell therapies, and mRNA products, which necessitate flexible systems capable of handling a wide range of capture chemistries. Furthermore, pharmaceutical and biopharmaceutical manufacturing facilities in Europe are increasingly implementing advanced technologies, such as continuous multi-column simulated moving bed (SMB) systems and single-use pre-packed columns, to improve production efficiency and GMP compliance.

Furthermore, regulatory pressures for high-purity biologics, as well as rising demand for cannabis and nutraceutical purification in the region, fuel market growth. The European market benefits from mature biopharma clusters, innovation hubs, and a strong emphasis on sustainability, which encourages the use of technologies such as supercritical fluid chromatography to reduce solvent consumption and improve process efficiency. As a result, these trends position Europe as a critical region for preparative and process chromatography innovation and growth in the global landscape.

The UK preparative and process chromatography industry is witnessing significant growth, fueled by increasing investments in the biotechnology and life sciences sectors. According to GVR analysis, the market was primarily driven by technological advancements and collaborations between academia and industry to accelerate drug discovery and manufacturing processes. For instance, in May 2025, BioNTech UK Ltd. granted an agreement with the UK Government to expand the Company's R&D activities for innovative medicines in the UK. BioNTech agreed to invest up to USD 1.33 billion over the next ten years as part of the agreement. The UK Government will support the Company's efforts with a grant of up to USD 171.66 million over ten years, one of the most significant grants in UK history for a pharmaceutical company. The grant is part of the UK government's mission to strengthen the life sciences sector and support innovative companies to accelerate medical progress.

Market trends point to an increase in automation and single-use systems, which improve efficiency, scalability, and regulatory compliance. Adoption of continuous chromatography technologies, as well as advancements in detection methods, will help the market grow. Therefore, the UK market is evolving rapidly, supported by technological progress and strategic collaborations, positioning it as a key player in the global preparative and process chromatography landscape.

The preparative and process chromatography industry in Germany is growing steadily, owing to rising demand for high-purity compounds in pharmaceuticals, biotechnology, and research laboratories. The market benefits from advances in column technology, resin development, and automation, all of which improve compound isolation scalability and efficiency. The regulatory emphasis on product quality and safety in Germany's thriving pharmaceutical sector drives the adoption of these techniques. Furthermore, the growing use of preparative chromatography in food, environmental testing, and chemical industries promotes market growth. Preparative high-performance liquid chromatography (HPLC) is an essential technological advancement in the purification of biologics such as monoclonal antibodies, peptides, and proteins, ensuring physiologically active therapeutic proteins and removing contaminants.

Asia Pacific Preparative And Process Chromatography Market Trends

The Asia Pacific preparative and process chromatography industry is expected to grow at the fastest CAGR over the forecast period. The developing pharmaceutical and biotechnology sectors support the expected growth. The market in the region is driven by regional growth with the presence of countries like China, India. Furthermore, the rising geriatric population in the region fuels market growth.

The preparative and process chromatography industry in China is growing rapidly, driven by the country’s increasing investments in biopharmaceutical manufacturing and research, with a particular focus on biologics such as monoclonal antibodies and vaccines. China is actively building global-standard good manufacturing practice (GMP) facilities, which demand advanced systems for downstream processing and purification. The growing expansion of chromatography across China is a key trend supporting market expansion. For instance, in June 2023, BioLink upgraded Chromatographic Chromatography Resin Manufacturing Site Phase II in Lanzhou, Gansu Province, China. The product range covers upstream bioprocess cell culture, disposable liquid handling, downstream processes such as chromatography, ultrafiltration, and filtration units, and process development services. Additionally, rising regulatory standards and the expansion of the biotechnology and pharmaceutical sectors in China contribute to the robust growth in preparative and process chromatography applications. This makes China one of the fastest-growing markets in the Asia-Pacific region for chromatography technologies.

The Japan preparative and process chromatography industry is driven by its advanced pharmaceutical and biotechnology industries, increasing demand for high purity compounds, and growing generics and solid dosage forms sectors. Process/analytical chromatography currently holds the largest revenue share, but preparative chromatography is the fastest-growing segment. Chromatographic workflows are being improved thanks to technological advancements such as AI-enabled process optimization, real-time monitoring, and predictive maintenance. The pharmaceutical industry is the largest application area, followed by biotechnology and chemicals, thanks to increased biopharma R&D investment and stringent regulations that drive up demand.

Furthermore, Japan's position as a technological leader ensures widespread adoption of advanced systems for drug development, personalized medicine, and bioprocessing, thereby driving Asia-Pacific market growth.

Latin America Preparative And Process Chromatography Market Trends

The Latin America preparative and process chromatography industry is growing steadily, owing to the region's expanding pharmaceutical and biotechnology sectors. Increased investment in drug development, biologics manufacturing, and academic research has increased the demand for efficient purification technologies. Countries such as Brazil, Mexico, and Argentina are seeing increased adoption of advanced chromatography systems as regulatory standards tighten and quality control becomes more important.

In addition, the growing trend of contract manufacturing and outsourcing in the life sciences industry contributes to market expansion. Despite economic fluctuations and infrastructure constraints, the region is poised for further development, aided by government initiatives and international collaborations to improve healthcare and scientific capabilities.

Middle East And Africa Preparative and Process Chromatography Market Trends

The Middle East and Africa preparative and process chromatography industry is growing as biotechnology, pharmaceutical, and research sectors prioritize high-purity separations and quality assurance. Governments are increasingly focusing on developing healthcare infrastructure, local manufacturing, and regulatory frameworks that require more stringent purification and analytical standards.

Further, countries such as Saudi Arabia, the UAE, South Africa, and Egypt are emerging as investment hubs for chromatography equipment and consumables, due to public initiatives and the need to support domestic biologics and pharmaceutical production. Advanced chromatography techniques, particularly liquid chromatography, are becoming more widely used throughout the region, with new applications in food safety, environmental testing, and diagnostics. However, growth is hampered by challenges such as the high cost of specialized equipment, skilled personnel shortages, and supply chain and logistics issues for reagents and resins. As sustainability awareness grows, there is a push for greener chromatography methods and efficient, low-waste systems.

Key Preparative And Process Chromatography Company Insights

Companies engaged in the development of innovative products are expected to intensify the market competition. The key players are focused on continuous innovations and launching products to retain and acquire market share. Moreover, the companies are developing products as per the global demands, along with the integration of advanced technologies in the product.

Recent Developments

• In October 2025, Merck KGaA (Germany) acquired JSR Life Sciences' (US) chromatography business, including preparative and process chromatography. This acquisition strengthened the company's downstream process, offering advanced filtration and chromatography solutions. JSR's innovative Amsphere Protein A resin technology complements the company's existing biologics portfolio and enhances its capabilities to accelerate next-generation therapies by optimizing antibody purification.

• In January 2025, Waters Corporation (U.S.) expanded its MaxPeak Premier Reversed-Phase Column portfolio with MaxPeak Premier OBD Preparative Columns. The new columns were introduced in Washington, DC, at the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products conference. The conference primarily focuses on current and emerging chemistry, manufacturing, and controls (CMC) analytical technology within the changing domestic and international regulatory perspectives.

• In July 2024, Thermo Fisher Scientific launched SurePac Bio 550 SEC MDi and DNAPac RP Semi-Preparative Columns at HPLC 2024. The DNAPac RP semi-preparative column's unique chemistry provides unrivaled performance across a wide pH, temperature, and mobile phase composition range, allowing for precise separations and sample purification.

Preparative And Process Chromatography Market Report Scope

Global Preparative And Process Chromatography Market Report Segmentation

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global preparative and process chromatography market report on the basis of product, type, end use, and region:

• Product Outlook (Revenue, USD Million, 2021 - 2033)

  • Process Chromatography

    • System

      • Multi Use Batch Chromatography Systems

      • Single-Use Batch Chromatography Systems

      • Continuous Chromatography Systems

    • Consumables

      • Reagents

      • Resins

        • Affinity Resins

        • Ion-exchange Resins

        • Size-exclusion Resins

        • Hydrophobic Interaction Resins

        • Reversed Phase Resins

        • Mixed mode/Multi-mode Resins

      • Columns

        • Prepacked Columns

        • Automated Columns

        • Manual Columns

    • Service

  • Preparative Chromatography

    • System

      • Semi-Preparative Chromatography Systems

      • Other Chromatography Systems

    • Consumables

      • Reagents

      • Resins

        • Affinity Resins

        • Affinity Resins

        • Ion-exchange Resins

        • Size-exclusion Resins

        • Hydrophobic Interaction Resins

        • Reversed Phase Resins

        • Mixed-mode/Multi-mode Resins

      • Columns

        • Prepacked Columns

        • Empty Columns

    • Service

• Type Outlook (Revenue, USD Million, 2021 - 2033)

  • Liquid Chromatography

    • HPLC

    • Flash/Column Chromatography

    • Ion-exchange chromatography

    • Size-exclusion chromatography

    • Affinity chromatography

  • Gas Chromatography

  • Thin Layer Chromatography

  • Paper Chromatography

  • Gel-permeation (Molecular Sieve) Chromatography

  • Hydrophobic Interaction Chromatography

• End Use Outlook (Revenue, USD Million, 2021 - 2033)

  • Pharmaceutical

  • Biotechnology

  • Food

  • Nutraceutical

  • Others

• Regional Outlook (Revenue, USD Million, 2021 - 2033)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • Germany

    • UK

    • France

    • Italy

    • Spain

    • Sweden

    • Norway

    • Denmark

  • Asia Pacific

    • Japan

    • China

    • India

    • South Korea

    • Australia

    • Thailand

  • Latin America

    • Brazil

    • Argentina

  • Middle East Africa (MEA)

    • South Africa

    • Saudi Arabia

    • UAE

    • Kuwait