Cell Lysis & Disruption Market Size, Share & Trends Report

Cell Lysis & Disruption Market Size, Share & Trends Analysis Report By Cell Type, By Product, By Technique (Physical Disruption, Reagent-based), By Application, By End Use, By Region, And Segment Forecasts, 2019 - 2025

  • Published Date: Jul, 2019
  • Base Year for Estimate: 2018
  • Report ID: GVR-3-68038-320-1
  • Format: Electronic (PDF)
  • Historical Data: 2014 - 2017
  • Number of Pages: 200

Industry Insights

The global cell lysis & disruption market size was valued at USD 3.23 billion in 2018 and is projected to expand at a CAGR of 8.31% during the forecast period. This growth is attributed to the higher adoption of cell lysis and disruption methods during downstream processing to manufacture bio-therapeutics and other animal-based recombinant products.

Rise in investments by various government as well as private organizations in R&D related to biotechnological processes, and academics are expected to further drive the market significantly. Besides, a rise in the prevalence of various disorders and demand for novel therapeutics is expected to propel market growth.

China cell lysis & disruption Market

Expansion in the biopharmaceutical industry would also provide new growth avenues to the market, as retrieval and purification of biopharmaceuticals involve cell lysis & disruption. Moreover, the adoption of biotech processes in pharmaceutical, agricultural, and bio-services industries is expected to drive the market progress as cell lysis holds substantial importance in the course of the bioprocess.

The rise in demand for efficient tumor tissue dissociation equipment has led to the development of novel products based on microfluidics. Microfluidic devices are useful in the efficient dissociation of tumor tissues in single cells and thereby enhance cell recovery concerning number and purity.

Technique Insights

Physical disruption methods were traditionally adopted by major players operating in this space for the extraction of intracellular contents. However, the adoption of these methods has relatively decreased currently owing to the requirement for expensive and cumbersome equipment. Owing to the presence of variability in the apparatus, physical disruption methods are difficult to repeat, thus reducing their market penetration

On the contrary, reagent-based methods do not destroy the biological activity of the final products, are mild, and ideally suited for laboratory samples. The mentioned facts make them a suitable choice for laboratory usage, consequently leading to their dominance in terms of market share in 2018, and over the forecast period.

Product Insights

Reagents and consumables accounted for the largest share in revenue in 2018, out of which enzymes dominated the cell lysis & disruption market and are expected to grow at a faster pace in the coming years as well. Factors attributing to the estimated share include an application for the selective product release, and controlled lysis as these provide biological specificity to the process. Owing to the enzyme specificity, different kits and enzymes are available for bacterial, plant, yeast, and mammalian samples. These enzymes are commercially available in a variety of forms. Major brands include but are not limited to Alfa Aesar, Millipore Sigma, MP Biochemicals LLC, Pierce Biotechnology Inc, and Promega Corporation.

Cell Type Insights

The mammalian cells segment accounted for the largest share in 2018 and is expected to remain dominant throughout the forecast period. This is because mammalian culture systems are extensively used during the bio-manufacturing of viral vaccines, therapeutic proteins, and other recombinant products. Also, the adoption of 3D mammalian culture systems in stem cell and cancer research is anticipated to boost segment growth.

As the efficiency of reagents varies with the type of cell used, key companies have developed reagents that work specifically on mammalian cells. For instance, Merck Millipore provides a range of mammalian lysis reagents that are utilized for the preparation of mammalian phosphorylated, cytosolic, and nuclear proteins. Some of these products are CytoBuster protein extraction reagent, NucBuster protein extraction kit, PhosphoSafe extraction reagent, and ProteoExtract kits.

Application Insights

These methods find wide applications in protein isolation and downstream processing of biopharmaceuticals. The major application areas of protein isolation include proteomics, western blotting, and immunoprecipitation. Demand for efficient and rapid lysis techniques that can extract proteins with minimal breakdown or oxidation is expected to fuel segment growth. Viscosity, which is resultant of the cell debris and genomic contamination is another challenge that needs to be addressed, pronouncing research in this segment. The development of advanced bioprocessing reagents and equipment that can readily complement the established disruption procedures are anticipated to propel growth in the market.

End-Use Insights

Academic and research institutes held the largest market share in 2018. This is due to the presence of a large number of biotechnology institutes that explore molecular biology, and bioprocess techniques, thus using cell lysis protocols.

Global cell lysis & disruption Market

The presence of several protocols for the tumorigenicity testing and research has led to a substantial demand for cell disruption methods in the biospecimen banking facilities. Clinical research carried out for drug development is expected to drive growth in the years to come.

Regional Insights

North America accounted for the largest revenue share of more than 40.0% in 2018. Various government initiatives in the U.S. and Canada that support molecular biology research, precision medicine, and cancer research are expected to impel the cell lysis and disruption market growth in this region. High private, as well as public, investments in target therapeutics and novel drug discovery for the treatment of various complicated and rare diseases are anticipated to drive the demand further. However, Asia Pacific is poised to witness the fastest growth over the forecast period owing to the growing interest of key companies in emerging markets to reap higher profits.

Cell Lysis & Disruption Market Share Insights

Key companies in the market include Thermo Fisher Scientific, Inc.; Merck KGaA; F. Hoffmann-La Roche Ltd; Qiagen NV; Becton Dickinson & Company (BD); Danaher Corporation; Bio-Rad Laboratories, Inc.; Miltenyi Biotec GmbH; Claremont BioSolutions, LLC; Microfluidics International Corporation; Parr Instrument Company; BioVision, Inc.; Covaris, Inc.; and Qsonica LLC. These companies focused on novel product development and acquisitions/collaborations to enhance their market position. For instance, in February 2018, Miltenyi Biotec GmbH received EMA approval for its CliniMACS Prodigy equipment - an automated device for cell production.

Report Scope



The base year for estimation


Actual estimates/Historical data

2014 - 2017

Forecast period

2019 - 2025

Market representation

Revenue in USD Million and CAGR from 2019 to 2025

Regional scope

North America, Europe, Asia Pacific, Latin America, and MEA

Country scope

U.S., Canada, Germany, the U.K., Japan, China, India, Brazil, Mexico, South Africa, and Saudi Arabia

Report coverage

Revenue forecast, competitive landscape, growth factors and trends

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Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2014 to 2025. For this study, Grand View Research has segmented the global cell lysis & disruption market report based on technique, product, cell type, application, end-use, and region:

  • Technique Outlook (Revenue, USD Million, 2014 - 2025)

    • Reagent-based

      • Detergent

      • Enzymatic

    • Physical Disruption

      • Mechanical Homogenization

      • Ultrasonic Homogenization

      • Pressure Homogenization

      • Temperature Treatments

  • Product Outlook (Revenue, USD Million, 2014 - 2025)

    • Instruments

      • High-Pressure Homogenizers

      • Sonicator

      • French Press

      • Microfluidizer

      • Bead Mill

      • Other Instruments

    • Reagents & Consumables

    • Enzymes

      • Detergent Solutions

      • Ionic detergent

      • Nonionic detergent

      • Zwitterionic detergent

    • Kits & Reagents

  • Cell Type Outlook (Revenue, USD Million, 2014 - 2025)

    • Mammalian cells

    • Bacterial cells

    • Yeast/Algae/Fungi

    • Plant cells

  • Application Outlook (Revenue, USD Million, 2014 - 2025)

    • Protein Isolation

    • Downstream Processing

    • Cell Organelle Isolation

    • Nucleic Acid Isolation

  • End-Use Outlook (Revenue, USD Million, 2014 - 2025)

    • Academic & Research Institutes

    • Hospitals & Diagnostic Labs

    • Cell Banks

    • Pharmaceutical & Biotechnology Companies

  • Regional Outlook (Revenue, USD Million, 2014 - 2025)

    • North America

      • The U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

    • Asia Pacific

      • Japan

      • China

      • India

    • Latin America

      • Brazil

      • Mexico

    • MEA

      • South Africa

      • Saudi Arabia

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