Genome Editing Market Size, Share & Trends Report

Genome Editing Market Size, Share & Trends Analysis Report By Technology (CRISPR, TALEN, ZFN), By Delivery Method (Ex-vivo, In-vivo), By Application (Animal/Plant Cell Editing), By Service, By End-use And Segment Forecasts, 2018 - 2025

  • Published Date: Feb, 2017
  • Base Year for Estimate: 2015
  • Report ID: GVR-1-68038-399-7
  • Format: Electronic (PDF)
  • Historical Data: 2014 - 2015
  • Number of Pages: 185

Report Overview

The global genome editing market size was valued at USD 2.25 billion in 2015. Utilization of the technique in the achievement of therapeutic genetic editing in infected cells and tissues, thereby removing deleterious mutations is anticipated to boost the market with potential growth opportunities.

UK genome editing market, by end-use, 2014 - 2025 (USD Million)

UK genome editing market size

Genome editing technologies based on programmable nucleases such as zinc finger nucleases, and clustered regularly interspaced short palindromic repeat (CRISPR)-associated nuclease Cas9, and transcription activator-like effector nucleases, are responsible for growth with no signs of abatement of the technology in the coming years.

The presence of strong pipeline products is also expected to impact industrial growth over the forecast period. Novel products are designed to aid in the improvement of DNA targeting, with enhanced flexibility, the specificity of the nuclease, and the ease of AAV packaging for delivery.

Utilization of this technique through a number of approaches such as a correction in the deleterious mutations, disruption of viral DNA, or the addition of therapeutic transgenes is expected to boost adoption.

Moreover, there has been significant interest in genome editing in the last few years and pharmaceutical and biotech companies have been racing to enter collaboration agreements with the emerging companies.

Companies are engaged in the development of the products on their own and also by the virtue of strategic partnerships. Several companies are taking advantage of developments in DNA editing technology to develop products for non-medical purposes.

However, toxicity due to off-target effects of nucleases is still a safety concern for the market. In addition, the IP disputes pertaining to CRISPR technology amongst the industry players are anticipated to restrain growth in the near future.

Technology Insights

Given the novelty of the genome editing field, there are many opportunities to optimize the technology. CRISPR, ZFN, and TALENs/MegaTALs are major technologies. PiggyBac, Flp-In, antisense, and Jump-In are the other methods for gene editing and engineering.

CRISPR accounted for the largest share and is expected to dominate the market over the forecast period. Advantages associated with the use of technology such as it can be tailored to treat patient-specific mutations for diseases such as cystic fibrosis are attributive for estimated share.

Genome editing market, by region, 2015 (USD Million)

Genome editing market share

Delivery Method Insights

Ease of control in DNA modification is responsible for the larger share of the ex-vivo method of delivery. Furthermore, the strength and duration of nuclease expression can also be precisely regulated to maximize efficiency and minimize off-target editing.

Owing to the aforementioned advantages, CAR-t technology in the form of ex-vivo products in oncology blood disorders treatment are observed to be prioritized in the therapeutic molecular scissors pipeline. However, a large majority of diseases have to be treated by in vivo delivery as some specialized cells cannot be removed from the body.

Application Insights

Application of this technology for cell line genetic engineering in the form of stem cell therapy and gene therapy accounted for the largest share and is anticipated to register lucrative growth.

The use of the technology for the development of novel molecules that can be targeted for treating diseases such as hematological malignancies and infectious diseases is expected to drive the adoption of this technology in the coming years.

Amidst controversy, there is potential growth for the genome editing market in the field of animal genetic modification to understand gene function modification and tracking and expression analysis. The usage of molecular scissors in this vertical is also expected to drive demand over the forecast period.

End-use Insights

Biotechnology organizations accounted for the largest share. The presence of a large number of research projects carried out in gene engineering for the development of novel therapeutics is responsible for the share. The other end-users for the technology include academic and government research institutions and contract research organizations.

Academic and government research institutes are expected to witness the fastest growth in the coming years owing to the rising adoption of the technology in university-based projects. The introduction of advancements in the genome engineering sector is anticipated to accelerate its uptake in government research projects.

Service Insights

The solution opted by the market entities is the provision of user-friendly kits and partial services to the stem cell researchers so that engineering can be performed themselves while maintaining the required conditions for pluripotency. High cost associated with the development of infrastructure for the set-up of stem cell conditions for implementation is anticipated to restrain the growth of the outsourcing services in the coming years.

Established companies such as Thermo Fisher and Sigma Aldrich Corporation are engaged in the provision of custom vectors for editing and engineering of cell lines. Outsourcing of these services is expected to increase in the coming years, thus boosting growth.

Regional Insights

North America dominated the market in terms of revenue share owing to the higher adoption of advanced techniques in the research institutes based in the U.S. Furthermore, a higher incidence of monogenic diseases in this region is attributive for the estimated share.

For instance, cystic fibrosis is a common, inherited disease that results in severe damage to the lungs and other organs and occurs at a frequency of 1 in 2,500 births in the U.S. Moreover, currently, 122,000 people in the U.S. requiring an organ transplant, a number that is steadily increasing.

Accelerated research in the field of biotechnology and personalized medicine in the economies of Asia Pacific region is expected to boost growth over the forecast period. China is expected to witness the fastest growth in this region.

Genome Editing Market Share Insights

Some of the prominent players operating in this vertical include Caribou Biosciences, Inc., Sangamo, Editas Medicine, Recombinetics, Inc, Thermo Fisher Scientific, Inc., CRISPR THERAPEUTICS, Intellia Therapeutics, Inc., and Sigma Aldrich Corporation.

Most of these companies take advantage of licenses from universities or other companies to use some of the DNA editing technologies. Many of these companies have products either on the market or are very close to launching a product.

The players are engaged in either in-house research or the acquisition of other companies or cross-licensing agreements. Such agreements enable the licensing of new intellectual property based on novel proteins that may not be affected by disputes in order to continue development. 

Genome Editing Market Report Scope

Report Attribute

Details

Market size value in 2020

USD 4.4 billion

Revenue forecast in 2025

USD 8.1 billion

Growth Rate

CAGR of 13.7% from 2016 to 2025

Base year for estimation

2015

Historical data

2014 & 2015

Forecast period

2016 - 2025

Quantitative units

Revenue in USD Million and CAGR from 2016 to 2025

Report coverage

Revenue forecast; company share; competitive landscape; growth factors and trends

Segments covered

Technology, delivery method, application, end-use, service, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S.; Canada; Germany; U.K.; Japan; China; Brazil; South Africa

Key companies profiled

Caribou Biosciences; Inc.; Sangamo; Editas Medicine; Recombinetics; Inc; Thermo Fisher Scientific; Inc.; CRISPR THERAPEUTICS; Intellia Therapeutics; Inc.; Sigma Aldrich Corporation.

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Segments Covered in the Report

This report forecasts revenue growth at the regional & country level and provides an analysis of the latest trends and opportunities in each of the sub-segments from 2014 to 2025. For the purpose of this study, Grand View Research has segmented the genome editing market on the basis of technology, delivery method, application, end-use, service, and regions: 

  • Technology Outlook (Revenue, USD Million; 2014 - 2025)

    • (CRISPR)/Cas9

    • TALENs/MegaTALs

    • ZFN

    • Others

  • Delivery Method Outlook (Revenue, USD Million; 2014 - 2025)

    • Ex-Vivo

    • In-Vivo

  • Application Outlook (Revenue, USD Million; 2014 - 2025)

    • Cell Line Engineering

    • Animal Genetic Engineering

    • Plant Genetic Engineering

    • Other Applications
  • End-use Outlook (Revenue, USD Million; 2014 - 2025)

    • Biotechnology & Pharmaceutical Companies

    • Academic & Government Research Institutes

    • Contract Research Organizations

  • Service Outlook (Revenue, USD Million, 2014 - 2025)

    • Contract

    • In-house

  • Regional Outlook (Revenue, USD Million; 2013 - 2025)

    • North America

      • The U.S.

      • Canada

    • Europe

      • Germany

      • The U.K.

    • Asia Pacific

      • Japan

      • China

    • Latin America

      • Brazil

    • The Middle East and Africa (MEA)

      • South Africa

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