GVR Report cover Genome Editing Market Size, Share & Trends Report

Genome Editing Market Size, Share & Trends Analysis Report By Technology (CRISPR, ZFN, TALEN), By Delivery Method (Ex-vivo, In-vivo), By Application, By Mode, By End-use, By Region, And Segment Forecasts, 2023 - 2030

  • Report ID: GVR-1-68038-399-7
  • Number of Pages: 130
  • Format: Electronic (PDF)
  • Historical Range: 2018 - 2021
  • Industry: Healthcare

Genome Editing Market Size & Trends

The global genome editing market size was valued at USD 6.39 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 17.8% from 2023 to 2030. Over the past few years, the market expansion has mostly been driven by growing synthetic gene demand and increasing CRISPR genome editing technology implementation in various biotechnology fields. Additionally, the growth is anticipated to be fueled by rising government funding, an increase in the production of genetically modified crops, and an increase in the number of genomics projects. The growth is also driven by CRISPR-based diagnostic tools which have helped in COVID-19 diagnostics. For instance, a group of academics from Nanyang Technological University created the VaNGuard (Variant Nucleotide Guard) diagnostic test in March 2021. The ability of this test to identify SARS-CoV-2 strains with mutations will increase the use of CRISPR genome editing technology in the diagnostics industry.

U.S. genome editing market size and growth rate, 2023 - 2030

In addition, ongoing technological developments in gene-editing technologies play a significant role in the market's ability to generate profits. For instance, in April 2021, Retron Library Recombineering (RLR) was created by scientists at Harvard's Wyss Institute for Biologically Inspired Engineering. This new gene-editing tool made it possible to run millions of genetic experiments at once and thus increase editing rates.

The growth of the market is fueled by favorable government regulations related to synthetic biology, increasing demand for engineered genes and cells, and rising investments from the government and large companies. The invention and implementation of various unconventional gene editing methods for editing purposes is another significant advancement in gene therapy and molecular biology that has contributed to the market's growth.

Additionally, the accessibility of user-friendly gene therapy systems, the advancement of genome engineering, and the potential for gene therapy to facilitate quick genome-wide analyses of gene function are all contributing to the market growth during the forecast period.

Technology Insights

The CRISPR/Cas9 segment dominated the market and accounted for the largest revenue share of 42.9% in 2022. This method can accurately divide DNA strands and insert new genetic information, making it a useful tool in gene therapy, medication development, and scientific research. CRISPR/Cas9 is a popular alternative for genome editing because of its simplicity, high efficiency, and precision, and it is suitable for a range of applications.

The clinical applications of CRISPR have been widely accepted. This is evident from the growing number of ongoing clinical trials using gene-editing techniques for the treatment of a wide range of diseases such as AIDS, cancer, and genetic diseases. In addition to human health, this technology is witnessing increasing usage in agriculture and animal breeding applications.

Furthermore, the market for TALENs is expected to grow dramatically in the coming years. The TALENs technology's DNA-binding protein may be created to recognize specific DNA sequences, allowing for precise gene editing. There are several uses for this method, including gene therapy, agricultural improvement, and disease models.

The limitations of CRISPR technology have increased in applications of the TALEN technique in some hard-to-edit genomic regions. According to a study published in January 2021, TALEN is found to be a more suitable tool for compact DNA studies. Such studies would increase the adoption of the TALEN technique in research settings in the coming years.

Delivery Method Insights

The ex-vivo delivery method segment generated the highest revenue of USD 3.36 billion in 2022 and is estimated to grow at a CAGR of around 14.3% from 2023 to 2030. This can be attributed to the advantages offered by this mode type such as simplicity of control in DNA modification. The rising clinical trial pipeline that deploys genome processing tools has spurred the ex-vivo delivery segment growth with the increased usage of this delivery method.

As a result of the human genome project (HGP) success, almost 7,000 new human genetic diseases have been discovered. While ex vivo gene editing-based gene therapies like CAR-T have had a significant impact Further, most patients with genetic diseases require in vivo treatments, which necessitate clinically accurate editing tools, and safe and targeted delivery systems that can be scaled to assist the entire patient population, this factor contributing to the growth of the segments.

On the other hand, the in-vivo segment is expected to emerge as the most lucrative segment over the study period. However, focused efforts are being taken to overcome the challenges with growing clinical trials focused on easy target tissues using in-vivo delivery.

Application Insights

The genetic engineering segment held the highest revenue share of 68.8% in 2022. The dominant share is due to the rapidly growing field of gene and stem cell therapy. The usage of CRISPR gene editing in human induced pluripotent stem cells (hiPSCs) related programs has important implications in stem cell research for the treatment of various diseases.

Cell line engineering, which has several applications in biotechnology, gene therapy, and drug development, is used in several research initiatives. It involves manipulating the genetic material in cells to produce or change an organism's features, and it can potentially transform medicine.

The market for cell line engineering is expected to grow rapidly in the near future due to advancements in technology and the increased need for personalized medicine. The clinical application segment dominated the market and accounted for a significant revenue share in 2022. 

Additionally, the efficiency of CHO cell lines is being improved through the widespread application of CRISPR technology. Large-molecule medicines are frequently produced using these cell lines. As a result of the CRISPR tool's application, the biopharmaceutical industry is advancing, fueling the market for genome editing. In addition to genetic engineering, genome editing technologies offer significant growth potential in medical fields like diagnostics and drug development.

The efficacy and safety of UCART123, for instance, are being assessed in patients with R/R acute myeloid leukemia as part of a clinical investigation funded by Cellectis S.A. Based on TALEN gene-editing technology. The use of genome editing in medication discovery and development is anticipated to expand significantly in the upcoming years due to the rising need for innovative, potent treatments for a variety of disorders. New medications that target genes or gene pathways can be created through genome editing, which could result in more effective and specialized treatments for diseases. 

Mode Insights

The contract segment dominated the market with a share of 64.0% in 2022. This can be attributed to the high extent of outsourcing activities in the gene editing space driven by the lower costs and greater flexibility in operations offered by such activities as compared to in-house development. The segment is expected to witness further growth due to the increasing capabilities offered by key entities in this domain. For instance, in December 2022, a CRO company named Crown Bioscience, Inc, collaborated with ERS Genomics Limited to gain access to ERS’s CRISPR/Cas9 patent portfolio and strengthen its market presence in the gene editing space. Such initiatives are expected to boost the outsourcing opportunities in the genome editing domain and can positively affect the market growth.

The in-house segment is expected to grow at a CAGR of 13.4% from 2023 to 2030 owing to the advantages offered by in-house operations such as ownership of supply channels, enhanced process troubleshooting abilities, as well as the potential for future in-house scale-up activities that can prove to be beneficial in the long run. As a result, companies such as Precision BioSciences hold in-house cGMP compliant manufacturing facilities that produce genome-edited products, such as allogeneic CAR T cell therapies. These factors are anticipated to drive the revenue growth for the segment over the forecast period.

End-use Insights

The biotechnology and pharmaceutical companies segment dominated the market and accounted for the major revenue share of 51.2% in 2022. The presence of a growing number of research activities for novel therapeutic development is the major factor contributing to revenue generation. Moreover, global pharmaceutical companies are collaborating with emerging companies to develop novel technologies. Increased research development efforts for novel treatments are the main factor fueling revenue growth.

Additionally, an increase in strategic developments by key market players is anticipated to fuel market expansion. For instance, to create innovative gene treatments employing the CRISPR/Cas9 technology for treating various diseases, CRISPR Therapeutics AG and Capsida Biotherapeutics Inc. formed a strategic agreement in January 2022. According to the agreement, Capsida will donate its adeno-associated virus (AAV) delivery technology, while CRISPR Therapeutics will contribute its expertise in genome editing.

Global genome editing market share and size, 2022

The academic and research institutions segment is expected to grow at a CAGR of 20.1% during 2023-2030. This is due to the increasing usage of technology on college campuses. Many organizations are developing lessons for high school and college students to help students understand gene editing functions.

For instance, in January 2022, the ChristianaCare Gene Editing Institute visited high schools and colleges with its ground-breaking CRISP in Box Educational Toolkit to promote awareness of one of the most potent biomedical technologies that are steadily approaching the point where it will alter the way diseases are treated. This existing kit cannot be used to alter live things due to it only containing safe, artificial elements. Instead, it could be used to demonstrate how CRISPR operates.

Regional Insights

North America dominated the global market with a share of 47.9% in 2022. Owing to the growing investments in the R&D of gene editing technologies. Due to the presence of several biotechnology and pharmaceutical companies working on developing genome editing technologies, the region is projected to maintain its dominance over the projected period.

Further, with increased government funding and support for scientific R&D, the U.S. held the largest market share for genome editing technology in North America. The presence of major players such as Editas Pharmaceuticals, Thermo Fisher Scientific, and CRISPR Therapeutics is also anticipated to fuel market expansion in this region, as is the increasing investment in genomic research.

Genome Editing Market Trends by Region, 2023 - 2030

The Asia Pacific region is anticipated to register the maximum growth at a CAGR of 19.6% from 2023 to 2030. Owing to the government programs promoting the advancement of genomic research, China is the largest market for genome editing technology in the Asia Pacific region.

The region's genome editing market is ready for growth due to the Chinese government's increasing focus on precision medicine and the presence of major players such as BGI and Hebei Senlang Biotechnology. In addition, increasing investment in R&D, a rise in the prevalence of genetic diseases, and government initiatives that support genomic research are all projected to boost the global market for genome editing to significant growth in the coming years.

Key Companies & Market Share Insights

Most players are undertaking licensing agreements with technology developers to enhance their market presence. Key players are engaged in strategic initiatives such as acquisitions, partnerships, and collaborations to help maximize their market share. For instance, in April 2022,Thermo Fisher Scientific launched a new Gibco CTS TrueCut Cas9 Protein, as a high-quality support material and documents are essential as researchers that use the genome editing techniques go from basic research to therapeutic settings. It is a promising option for CAR T-cell therapies study using CRISPR-Cas9 genome editing as it consistently provides higher than 90% efficacy in human primary T-cells and high editing effectiveness in all examined cell lines.

In the past few years, numerous research programs have initiated using CRISPR-based gene editing for finding out viable treatment options for chronic diseases. In May 2023, one such research program was being conducted at the Lewis Katz School of Medicine at the University of Nebraska Medical Center published that they have successfully treated HIV infection in animals. The program used CRISPR to deactivate CCR5 and excise HIV-1 DNA fragments from infected cells. With such developments, the demand for genome editing is likely to grow. Some prominent players in the global genome editing market include:

  • Merck KGaA

  • Cibus, Recombinetics, Inc.

  • Sangamo

  • Editas Medicine

  • Precision Biosciences

  • CRISPR Therapeutics

  • Intellia Therapeutics, Inc.

  • Caribou Biosciences, Inc.

  • Cellectis S.A.

  • AstraZeneca

  • Takara Bio USA

  • Horizon Discovery Group plc

  • Integrated DNA Technologies, Inc.

  • Egenesis Inc.

  • GenScript

  • New England Biolabs

  • OriGene Technologies, Inc.

  • Lonza

  • Thermo Fisher Scientific, Inc.

Genome Editing Market Report Scope

Report Attribute


Market size value in 2023

USD 7.95 billion

Revenue forecast in 2030

USD 24.99 billion

Growth rate

CAGR of 17.8% from 2023 to 2030

Base year for estimation


Historical data

2018 - 2021

Forecast period

2023 - 2030

Report updated

May 2023

Quantitative units

Revenue in USD billion and CAGR from 2023 to 2030

Report coverage

Revenue forecast, company ranking, competitive landscape, growth factors, and trends

Segments covered

Technology, delivery method, application, mode, end-use, region

Regional scope

North America; Europe; Asia Pacific; Latin America; MEA

Country scope

U.S.; Canada; Germany; UK; France; Italy; Spain; Denmark; Sweden; Norway; China; Japan; India; South Korea; Australia; Thailand; Brazil; Mexico, Argentina; South Africa; Saudi Arabia; UAE; Kuwait

Key companies profiled

Merck KGaA; Cibus; Recombinetics, Inc.; Sangamo; Editas Medicine; Precision Biosciences; CRISPR Therapeutics; Intellia Therapeutics, Inc.; Caribou Biosciences, Inc.; Cellectis; AstraZeneca; Takara Bio USA; Horizon Discovery Group plc; Integrated DNA Technologies, Inc.; Egenesis Inc.; GenScript; New England Biolabs; OriGene Technologies, Inc.; Lonza; Thermo Fisher Scientific, Inc.

Customization scope

Free report customization (equivalent up to 8 analyst’s working days) with purchase. Addition or alteration to country, regional & segment scope.

Pricing and purchase options

Avail customized purchase options to meet your exact research needs. Explore purchase options


Global Genome Editing Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2018 to 2030. For this report, Grand View Research has segmented the global genome editing market report based on technology, delivery method, application, mode, end-use, and region:

  • Technology Outlook (Revenue, USD Billion, 2018 - 2030)

    • Meganucleases

    • (CRISPR)/Cas9

    • TALENs/MegaTALs

    • ZFN

    • Others

  • Delivery Method Outlook (Revenue, USD billion, 2018 - 2030)

    • Ex-vivo

    • In-vivo

  • Mode Outlook (Revenue, USD Billion, 2018 - 2030)

    • Contract

    • In-house

  • End-use Outlook (Revenue, USD Billion, 2018 - 2030)

    • Biotechnology & Pharmaceutical Companies

    • Academic & Government Research Institutes

    • Contract Research Organizations

  • Application Outlook (Revenue, USD Billion, 2018 - 2030)

    • Genetic Engineering

      • Cell Line Engineering

      • Animal Genetic Engineering

      • Plant Genetic Engineering

      • Others

    • Clinical Applications

      • Diagnostics

      • Therapy Development

  • Regional Outlook (Revenue, USD Billion, 2018 - 2030)

    • North America

      • U.S.

      • Canada

    • Europe

      • UK

      • Germany

      • France

      • Italy

      • Spain

      • Denmark

      • Sweden

      • Norway

    • Asia Pacific

      • Japan

      • China

      • India

      • South Korea

      • Australia

      • Thailand

    • Latin America

      • Brazil

      • Mexico

      • Argentina

    • Middle East & Africa

      • South Africa

      • Saudi Arabia

      • UAE

      • Kuwait

Frequently Asked Questions About This Report

gvr icn


gvr icn

This FREE sample includes data points, ranging from trend analyses to estimates and forecasts. See for yourself.

gvr icn


We can customize every report - free of charge - including purchasing stand-alone sections or country-level reports, as well as offer affordable discounts for start-ups & universities. Contact us now

Certified Icon

We are GDPR and CCPA compliant! Your transaction & personal information is safe and secure. For more details, please read our privacy policy.