In-vitro Toxicology Testing Market Size, Share & Trends Analysis Report By Technology, By Method (Cellular Assay, Biochemical Assay, In Silica, Ex-vivo), By Application, By End-Use, By Region, And Segment Forecasts, 2018 - 2025

Industry Outlook

The global in-vitro toxicology testing market size was valued at USD 9.76 billion in 2016. It is projected to expand at a CAGR of 11.4% during the forecast period. Significant progress in toxicology science is one of the key trends escalating market growth. Besides this, socio-ethical concerns pertaining to animal tests and high costs associated with conventional animal tests are poised to boost the inclination towards in-vitro toxicology assays.

Furthermore, these assays have enabled rapid assessment of safety and developmental problems. This is offering the pharmaceutical industry with huge cost-saving and timeliness advantages for conducting toxicology screening for their candidate drugs, thereby driving the market.

Significant advancements in vitro toxicology assays to evaluate drug product safety along with assessment of potential effect of pharmaceuticals on cells and tissues are anticipated to bolster revenue generation in the market. With increase in the need for such assays, companies have broadened their portfolio to serve the market demand. 

Growing concerns to reduce animal testing services and promote usage of other alternatives for toxicology are likely to augment the market. Animal welfare agencies are holding prospects of complete replacement of animal testing with in-vitro toxicology testing. The regulatory agencies have also introduced certain policies to reduce the dependence on animal testing.

Furthermore, these assays are good laboratory practice (GLP) compliant and can serve various domains of life science including biotech and pharmaceutical, cosmetic, consumer product, and chemical industries. Such widespread use of assays is estimated to significantly impact revenue generation in this market.

Although the use of in-vitro toxicology testing services continues to expand across various end-user industries, a number of cosmetic and pharmaceutical manufacturers still believe that conventional animal tests are more reliable and provide better insights. This factor is projected to hamper the growth of the market. However, introduction of 3D cell culture systems that mimics the host environment is poised to significantly limit the use of animal models for testing.

Technology Insights

Cell culture technology, high throughput technology, molecular imaging, OMICS technology are the various technology that are employed during in-vitro toxicology tests. Out of all, cell culture technology accounted for the leading share in 2016 due to significant advancements in cell cultivation and cell line production methods.

OMICs is a promising technology that helps in generating comprehensive toxicologically relevant information. This technology facilitates toxicology studies more accurately, rapidly, and with less resource requirement. As a result, the segment is likely to exhibit a noteworthy CAGR during the forecast period.

Application Insights

On the basis of application, the in-vitro toxicology testing market has been segmented into systemic toxicology, dermal toxicology, endocrine disruption, ocular toxicity, and others. Systemic toxicology is poised to dominate the market while the others segment is anticipated to post the highest CAGR during the forecast period.

There are various types of systemic toxicity studies, which include acute systemic toxicity, sub-acute systemic toxicity, sub-chronic systemic toxicity, and chronic systemic toxicity. Therefore, the goal is to generate precise data including information on factors such as minimum dose that results in toxicity, maximally tolerated dose, and plasma concentration. These factors lead to toxicity and margin of safety, which is used to make decisions.

Method Insights

Cellular assay represented the largest share in terms of revenue owing to presence of wide product portfolio of cellular techniques for pharmacovigilance study of drug products. Moreover, presence of a significant number of biotechnology companies that are heavily dependent on cell-based assays to conduct their research activities is playing an important role in propelling the growth of the segment.

Ex-vivo methods are anticipated to register phenomenal growth rate during the forecast period. Growing popularity of stem cell therapy in recent times has impelled scientists to use this technique. This trend is likely to work in favor of the segment growth throughout the forecast period.

End-use Insights

The pharmaceutical industry was the leading segment in 2016 owing to presence of a large number of drug candidates in clinical phase. This has led to higher usage of toxicology tests for pharmacokinetic studies and to understand the potential impact of a drug on patients.

The chemical industry is projected to witness tremendous growth over the forecast period owing to growth in excipients manufacturing for cosmetics and pharmaceutical formulations. Moreover, presence of extensive product portfolio for the market is poised to trigger the application scope of these assays in the chemical industry.

Regional Insights

North America dominated was at the forefront of the market in 2016. Conducive government policies, increasing funds for research studies, and favorable changes in regulatory guidelines supporting in-vitro toxicology assays are contributing to the growth of the regional market.

On the other hand, with constant improvement in healthcare infrastructure coupled with growing pharmaceuticals R&D, Asia Pacific is expected to register the highest CAGR during the forecast period. Moreover, conducting clinical trials in this region is relatively less costly than in western economies. This, in turn, is estimated to attract significant investments from global companies in the APAC market.

In-vitro Toxicology Testing Market Share Insights

Companies are engaged in capitalizing on the immense potential and increase their share in the market. Some of the major companies in the market are Abbott; Covance; GE Healthcare; Quest Diagnostics, Inc.; Thermo Fisher Scientific, Inc.; Bio-Rad Laboratories; Catalent Pharma Solutions; Cyprotex, Agilent Technologies; Charles River Laboratories; Merck KgaA; and Eurofins Scientific, Inc.

Companies are involved in software development to enhance in-silico simulation methods for toxicological profiling of different compounds. In addition, these companies are undertaking focused efforts for their business expansion across the globe, particularly in regions with untapped potential.

Report Scope

Segments Covered in the Report

This report forecasts revenue growth at global, regional, & country levels and provides an analysis of industry trends in each of the sub segments from 2014 to 2025. For the purpose of this study, Grand View Research has segmented the global in-vitro toxicology testing market report on the basis of method, technology, application, end-use, and region:

• Technology Outlook (Revenue, USD Million, 2014 - 2025)

  • Cell Culture Tech

  • High Throughput Tech

  • Molecular Imaging

  • OMICS Tech

• Method Outlook (Revenue, USD Million, 2014 - 2025)

  • Cellular Assay

  • Biochemical Assay

  • In Silica

  • Ex-vivo

• Application Outlook (Revenue, USD Million, 2014 - 2025)

  • Systemic Toxicology

  • Dermal Toxicity

  • Endorine Disruption

  • Occular Toxicity

  • Others

• End-use Outlook (Revenue, USD Million, 2014 - 2025)

  • Pharmaceutical Industry

  • Cosmetics & Household Products

  • Diagnostics

  • Chemicals Industry

  • Food Industry

• Regional Outlook (Revenue, USD Million, 2014 - 2025)

  • North America

    • U.S.

    • Canada

  • Europe

    • Germany

    • U.K.

  • Asia Pacific

    • Japan

    • China

  • Latin America

    • Brazil

  • Middle East & Africa

    • South Africa